Article
Medicine, Research & Experimental
Natalia Ivanjko, Nikola Stokovic, Marina Milesevic, Viktorija Rumenovic, Reinhard Windhager, Kuber T. Sampath, Natasa Kovacic, Danka Grcevic, Slobodan Vukicevic
Summary: Bone morphogenetic proteins (BMPs) require a suitable delivery system for treating spinal and bone defects. INFUSE, the only commercially available BMP-based device, has major disadvantages. A novel device called OSTEOGROW, containing BMP6 dispersed within autologous blood coagulum, shows promising results for bone regeneration. This study compares the release dynamics and cellular response of OSTEOGROW and INFUSE implants and demonstrates that OSTEOGROW is superior in inducing bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Gabriel S. Jensen, Noelle E. Leon-Palmer, Kristy L. Townsend
Summary: Research indicates that bone morphogenetic proteins regulate metabolic health by controlling neural plasticity in both the brain and peripheral tissues, impacting energy intake and expenditure. This role helps in understanding metabolic regulation and offers insights into weight loss mechanisms.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Polymer Science
Elena Iulia Oprita, Andreea Iosageanu, Oana Craciunescu
Summary: This paper reviews the complex structure of osteochondral tissue, the importance of icariin in osteochondral regeneration, and the recent development of hydrogels and scaffolds enriched with icariin. Icariin has chondrogenic and osteogenic effects, making it a promising alternative to growth factors. The use of icariin as a therapeutic approach in regenerative medicine is low-cost and has potential.
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Materials Science, Multidisciplinary
Jun Wu, Linjun Jiang, Lingpeng Ju, Yuan Zhang, Ming Li, Xing Liu, Xiangyang Qu
Summary: This study successfully combined bone morphogenetic protein-9 (BMP-9) with deproteinized osteoarticulation (DPOA) to achieve excellent osteogenic and angiogenic effects in a canine femoral condylar defect model, demonstrating outstanding osteoarticular repair outcomes.
MATERIALS & DESIGN
(2021)
Article
Biology
Nancy Q. Liu, Yucheng Lin, Liangliang Li, Jinxiu Lu, Dawei Geng, Jiankang Zhang, Tea Jashashvili, Zorica Buser, Jenny Magallanes, Jade Tassey, Ruzanna Shkhyan, Arijita Sarkar, Noah Lopez, Siyoung Lee, Youngjoo Lee, Liming Wang, Frank A. Petrigliano, Ben Van Handel, Karen Lyons, Denis Evseenko
Summary: The study demonstrates the significance of gp130/STAT3 signaling in the development and homeostasis of chondrocytes in the growth plate and articular cartilage. The findings suggest that the deletion of STAT3 or gp130 in chondrocytes can lead to defective chondrocyte proliferation, growth plate fusion, and dysfunction of the articular cartilage. The study also highlights the positive role of IL-6 family cytokines in the skeletal system.
COMMUNICATIONS BIOLOGY
(2022)
Article
Ophthalmology
Fanying Jiang, Yingyan Qin, Yuanfan Yang, Zhen Li, Baoyue Cui, Rong Ju, Mingxing Wu
Summary: The study aimed to investigate the roles of BMP-4/BMP-7 in fibrotic cataract progression and underlying mechanisms. The results showed that BMP-4/BMP-7 attenuated cataract by inhibiting the proliferation, migration, and EMT of LECs via modulation of the Notch pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Yu-Wen Su, Derick S. K. Wong, Jian Fan, Rosa Chung, Liping Wang, Yuhui Chen, Claire H. Xian, Lufeng Yao, Liang Wang, Bruce K. Foster, Jiake Xu, Cory J. Xian
Summary: This study identified the critical roles of BMP signaling in injury site bony repair and hypertrophic degeneration of the adjacent growth plate in a growth plate drill-hole repair model. Suppression of BMP signaling may attenuate undesirable bony repair at the injury site and suppress premature hypertrophy while potentially rescuing chondrogenesis at the adjacent growth plate.
Article
Endocrinology & Metabolism
Fan Wang, Petri Rummukainen, Matias Pehkonen, Anna-Marja Saamanen, Terhi J. Heino, Riku Kiviranta
Summary: This study reveals that Wnt1 plays an important regulatory role in subchondral bone remodeling, with no effect on the regulation of growth plate or articular cartilage.
Article
Cell & Tissue Engineering
Michael Chau, Zelong Dou, Marta Baroncelli, Ellie B. Landman, Ameya Bendre, Masaru Kanekiyo, Alexandra Gkourogianni, Kevin Barnes, Lars Ottosson, Ola Nilsson
Summary: The synovial microenvironment plays a crucial role in inhibiting hypertrophic differentiation and promoting articular cartilage formation. Through transplantation experiments and cell culture experiments, it has been demonstrated that synoviocytes can secrete factors that directly act on chondrocytes to prevent their hypertrophic differentiation, induce the expression of articular surface markers, and thus have important implications for the development, maintenance, and regeneration of articular cartilage.
NPJ REGENERATIVE MEDICINE
(2022)
Article
Anatomy & Morphology
Piero Antonio Zecca, Marcella Reguzzoni, Marina Protasoni, Mario Raspanti
Summary: In the synovial joints, the transition between the soft articular cartilage and the subchondral bone is mediated by a calcified cartilage layer with similar characteristics to bone. This layer is not directly accessible and is visualized through histological sections of decalcified tissue. This study used conventional histology and scanning electron microscopy to discriminate between the calcified and uncalcified cartilage, revealing a high heterogeneity of the calcified layer and a different mineralization process compared to other hard tissues. Selective removal of the soft matrix allowed for a 3D view of the mineralization front.
Article
Multidisciplinary Sciences
Manman Gao, Xizhe Liu, Peng Guo, Jianmin Wang, Junhong Li, Wentao Wang, Martin J. Stoddart, Sibylle Grad, Zhen Li, Huachuan Wu, Baoliang Li, Zhongyuan He, Guangqian Zhou, Shaoyu Liu, Weimin Zhu, Dafu Chen, Xuenong Zou, Zhiyu Zhou
Summary: A systematic study was conducted using single-cell RNA sequencing technique to characterize 19,952 individual cells from murine hindlimbs at 4 postnatal stages. The study revealed the presence of candidate progenitor sub-clusters in articular cartilage and enthesis, as well as three cellular developmental branches in the growth plate. The transcriptomes and developmental patterns were extensively explored, and the implications for osteoarthritis were discussed. Overall, these findings broaden our understanding of postnatal limb developmental biology and the interconnections between limb development, remodeling, and regeneration.
Article
Hematology
Sarah Warsi, Ulrika Blank, Maria Dahl, Tan Hooi Min Grahn, Ludwig Schmiderer, Silja Andradottir, Stefan Karlsson
Summary: Research has shown that BMP signaling is crucial for self-renewal of adult HSC, mediated in part through TJP1, and non-SMAD pathways operate downstream of BMP in HSC. Deficiency of BMPR-II may lead to increased expression of TJP1, affecting the self-renewal capacity of stem cells.
Article
Biotechnology & Applied Microbiology
Tianyu Gao, Alexander J. Boys, Crystal Zhao, Kiara Chan, Lara A. Estroff, Lawrence J. Bonassar
Summary: This study utilized confocal Raman microspectroscopy to investigate the degradation of articular cartilage, specifically focusing on spatially mapping the loss of glycosaminoglycans (GAGs), providing a technique with high spatial resolution to measure cartilage degradation without tissue sections.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Nissrine Ballout, Agnes Boullier, Walaa Darwiche, Katia Ait-Mohand, Eric Trecherel, Theo Gallego, Cathy Gomila, Linda Yaker, Isabelle Gennero, Jose Kovensky, Jerome Ausseil, Sylvestre Toumieux
Summary: Bone fracture healing is a complex process involving hematoma formation, tissue formation, bony callus formation, and bone remodeling. Current therapeutic strategies for fracture repair include autografts, allografts, and tissue engineering. This study suggests that DP2, a disaccharide compound, may enhance fracture healing by promoting osteoblast differentiation and earlier mineralization in vitro. DP2 might serve as a potential therapeutic candidate for bone fracture repair.
Article
Biotechnology & Applied Microbiology
Julian C. Lui, Max Colbert, Crystal Sao Fong Cheung, Michal Ad, Audrey Lee, Zhongyu Zhu, Kevin M. Barnes, Dimiter S. Dimitrov, Jeffrey Baron
Article
Genetics & Heredity
Youn Hee Jee, Sehoon Won, Julian C. Lui, Melissa Jennings, Philip Whalen, Yue Shanna, Adrian G. Temnycky, Kevin M. Barnes, Tim Cheetham, Matthew G. Boden, Sally Radovick, Richard Quinton, Ellen W. Leschek, Greti Aguilera, Jack A. Yanovski, Stephanie B. Seminara, William F. Crowley, Angela Delaney, Katherine W. Roche, Jeffrey Baron
GENETICS IN MEDICINE
(2020)
Review
Endocrinology & Metabolism
Julian C. Lui
JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Presley H. Nichols, Yue Pan, Benjamin May, Martina Pavlicova, John C. Rausch, Ali A. Mencin, Vidhu V. Thaker
Review
Physiology
Elaine Zhou, Julian Lui
Summary: This review primarily discusses the mechanisms regulating bone length and skeletal proportions.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Youn Hee Jee, Mariam Gangat, Olga Yeliosof, Adrian G. Temnycky, Selena Vanapruks, Philip Whalen, Evgenia Gourgari, Cortney Bleach, Christine H. Yu, Ian Marshall, Jack A. Yanovski, Kathleen Link, Svetlana Ten, Jeffrey Baron, Sally Radovick
Summary: The study found that sporadic congenital hypopituitarism has a significant genetic component, but may less frequently be monogenic with full penetrance, suggesting a more complex etiology.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Birgit Weiss, Birgit Eberle, Ralph Roeth, Christiaan de Bruin, Julian C. Lui, Nagarajan Paramasivam, Katrin Hinderhofer, Hermine A. van Duyvenvoorde, Jeffrey Baron, Jan M. Wit, Gudrun A. Rappold
Summary: Human growth is a complex trait influenced by various gene defects. This study identified genes associated with tall stature and revealed close functional connections between these genes in the context of linear growth.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Julian C. Lui, Adalbert Raimann, Hironori Hojo, Lijin Dong, Paul Roschger, Bijal Kikani, Uwe Wintergerst, Nadja Fratzl-Zelman, Youn Hee Jee, Gabriele Haeusler, Jeffrey Baron
Summary: SP7/Osterix is a critical transcription factor for osteoblast maturation and bone formation. Mutations in SP7 can cause osteogenesis imperfecta type XII, but neomorphic mutations of SP7 have not been reported in humans. In this study, a de novo dominant neomorphic missense variant (c.926 C > G:p.S309W) in SP7 was found in a patient with craniosynostosis, cranial hyperostosis, and long bone fragility. Mice with the corresponding variant also showed a complex skeletal phenotype. The mutation altered the binding specificity of SP7 and resulted in aberrant gene expression.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Julian C. Lui, Jacob Wagner, Elaine Zhou, Lijin Dong, Kevin M. Barnes, Youn Hee Jee, Jeffrey Baron
Summary: A new type of overgrowth disorder caused by a genetic variant in the SPIN4 gene, an epigenetic reader, has been identified. The variant affects cell proliferation, canonical WNT signaling, and leads to overgrowth both in humans and mice. This study expands our understanding of epigenetic regulation of human growth.
Article
Pediatrics
Alyson Weiner, Presley Nichols, Virginia Rahming, Mahalakshmi Gopalakrishnamoorthy, Sharon E. Oberfield, Ilene Fennoy
GLOBAL PEDIATRIC HEALTH
(2022)