Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells

(2015) Troy Hutchens et al.   DIABETES

Palmitate-Induced Impairments of β-Cell Function Are Linked With Generation of Specific Ceramide Species via Acylation of Sphingosine

(2015) Levon Manukyan et al.   ENDOCRINOLOGY

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

(2014) Nie Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides

(2013) Sarojini J. K. A. Ubhayasekera et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells

(2013) Isabel Göhring et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity

(2013) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells

(2013) Azazul Chowdhury et al.   JOURNAL OF PROTEOME RESEARCH

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

(2012) M. Ferdaoussi et al.   DIABETOLOGIA

EasyProt — An easy-to-use graphical platform for proteomics data analysis

(2012) Florent Gluck et al.   Journal of Proteomics

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

(2012) Sofia A. Andersson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

(2011) J. K. Kruit et al.   DIABETES

General Statistical Modeling of Data from Protein Relative Expression Isobaric Tags

(2011) Florian P. Breitwieser et al.   JOURNAL OF PROTEOME RESEARCH

Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells

(2011) Ernest Sargsyan et al.   Lipids in Health and Disease

Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

(2010) Wissal El-Assaad et al.   ENDOCRINOLOGY

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Relative Quantification of Proteins in Human Cerebrospinal Fluids by MS/MS Using 6-Plex Isobaric Tags

(2008) Loïc Dayon et al.   ANALYTICAL CHEMISTRY

Effects of elevated fatty acid and glucose concentrations on pancreatic islet functionin vitro

(2008)   DIABETES OBESITY & METABOLISM

Diazoxide-induced β-cell rest reduces endoplasmic reticulum stress in lipotoxic β-cells

(2008) Ernest Sargsyan et al.   JOURNAL OF ENDOCRINOLOGY

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

(2008) Mayumi Ishikawa et al.   JOURNAL OF LIPID RESEARCH

Robust Prediction of the MASCOT Score for an Improved Quality Assessment in Mass Spectrometric Proteomics

(2008) Thomas Koenig et al.   JOURNAL OF PROTEOME RESEARCH