Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

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Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3βin vivo

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Catch me if you can: targeting the mitochondrial permeability transition pore in myocardial infarction

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How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario

(2015) Macarena S. Arrázola et al.   Frontiers in Cellular Neuroscience

Wnt/β-Catenin Signaling in Alzheimer’s Disease

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Wnt-5a Ligand Modulates Mitochondrial Fission-Fusion in Rat Hippocampal Neurons

(2014) Juan A. Godoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

(2014) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of glycogen synthase kinase 3 ameliorates liver ischemia/reperfusion injury via an energy-dependent mitochondrial mechanism

(2014) Hailong Fu et al.   JOURNAL OF HEPATOLOGY

In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

(2014) J. Y. Vargas et al.   JOURNAL OF NEUROSCIENCE

PHO-ERK1/2 interaction with mitochondria regulates the permeability transition pore in cardioprotective signaling

(2014) Sauri Hernández-Reséndiz et al.   LIFE SCIENCES

Wnt signaling in the nervous system and in Alzheimer's disease

(2014) N. C. Inestrosa et al.   Journal of Molecular Cell Biology

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury

(2013) Zhen Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

(2013) Rodrigo A Quintanilla et al.   Molecular Neurodegeneration

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca2+ in mitochondrial dynamics

(2013) Carmen Silva-Alvarez et al.   Frontiers in Cellular Neuroscience

GSK-3 and mitochondria in cancer cells

(2013) Federica Chiara et al.   Frontiers in Oncology

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study

(2012) Martin Picard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults

(2011) E.M. Kawamoto et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

(2011) S. A. Barrientos et al.   JOURNAL OF NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The role of Wnt signaling in neuroprotection

(2010) W. Cerpa et al.   DRUG NEWS & PERSPECTIVES

Signal transduction to the permeability transition pore

(2010) Andrea Rasola et al.   FEBS LETTERS

Wnt signaling activation reduces neuropathological markers in a mouse model of Alzheimer's disease

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Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

(2009) Tatiana Brustovetsky et al.   CELL CALCIUM

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

(2009) Viacheslav Li et al.   EXPERIMENTAL NEUROLOGY

Cyclophilin D Interacts with Bcl2 and Exerts an Anti-apoptotic Effect

(2009) Roman A. Eliseev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/β-catenin signaling pathway

(2009) Macarena S. Arrázola et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Myocardial Protection Against Ischemia/Reperfusion Injury

(2009) Tetsuji Miura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture

(2009) I. Marchionni et al.   NEUROSCIENCE

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

(2009) A. Rasola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oligomeric BAX induces mitochondrial permeability transition and complete cytochrome c release without oxidative stress

(2008) Tsyregma Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

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