Article
Radiology, Nuclear Medicine & Medical Imaging
Chunxiang Zhang, Xin Zhao, Zitao Zhu, Kaiyu Wang, Brianna F. Moon, Bohao Zhang, Sayed Noman Sadat, Jinxia Guo, Jieaoxue Bao, Ding Zhang, Xiaoan Zhang
Summary: This study aimed to investigate the value of diffusion tensor imaging (DTI) combined with serum C-reactive protein (CRP) and procalcitonin (PCT) in evaluating alterations of white matter (WM) microstructure in preterm infants with necrotizing enterocolitis (NEC). The results showed that preterm infants with NEC had reduced FA values and elevated MD values in specific WM regions, and these changes were correlated with serum CRP and PCT levels. The combination of WM, CRP, and PCT showed improved performance in detecting and evaluating WM microstructure alterations in preterm infants with NEC.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Clara F. Weber, Evelyn M. R. Lake, Stefan P. Haider, Ali Mozayan, Pratik Mukherjee, Dustin Scheinost, Nigel S. Bamford, Laura Ment, Todd Constable, Seyedmehdi Payabvash
Summary: This study evaluated the impact of age on white matter microstructure and connectome disruption in patients with Autism Spectrum Disorder (ASD). The findings showed that there is an age-dependent effect on white matter microstructure, with adolescents and young adults exhibiting ASD-related abnormalities. These abnormalities were observed in both diffusion tensor imaging (DTI) metrics and connectome edge density (ED), suggesting a more widespread involvement of the connectome in ASD compared to DTI metrics. Machine learning models were also used to predict ASD diagnoses based on DTI and ED metrics, achieving reasonable accuracy.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neuroimaging
Rahil Rahimi, Mahsa Dolatshahi, Fatemeh Abbasi-Feijani, Sara Momtazmanesh, Giulia Cattarinussi, Mohammad Hadi Aarabi, Lorenzo Pini
Summary: The pathophysiology of migraine as a headache disorder is still undetermined, but DTI studies have provided valuable insights into the microstructural changes associated with this disease. Alterations in diffusion parameters have been observed in various brain regions, including white matter tracts, subcortical areas, and the cortex. These changes show variability across migraine cycle phases, and are also observed in patients with depressive/anxiety symptoms. However, there are inconsistent findings regarding the differences between chronic and episodic migraine. Overall, migraine is associated with microstructural changes in widespread regions of the brain, which may reflect neuronal damage and plasticity mechanisms.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuan Sun, Cui Zhao, Si-Yu Chen, Yan Chang, Yu-Liang Han, Ke Li, Hong-Mei Sun, Zhen-Fu Wang, Ying Liang, Jian-Jun Jia
Summary: This study validates the potential of FW-DTI indices as biomarkers of AD and demonstrates the good accuracy of FW-DTI in classifying MCI subtypes. There is a significant association between FW-DTI indices and memory and visuospatial function.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Jing Jing, Yijun Zhou, Yuesong Pan, Xueli Cai, Wanlin Zhu, Zhe Zhang, Zixiao Li, Chang Liu, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Zhenzhou Wu, Suying Wang, Haijun Niu, Wei Wen, Tao Liu, Tiemin Wei, Yongjun Wang, Perminder S. Sachdev
Summary: This study investigated the white matter integrity in prediabetes and diabetes and found that microstructural abnormalities in white matter are already present in the prediabetes stage with impaired fasting glucose/ impaired glucose tolerance and are associated with higher glucose measures.
Article
Clinical Neurology
Chunxue He, Mingqiang Gong, Gengxiao Li, Yunxia Shen, Longyin Han, Bin Han, Mingwu Lou
Summary: The study investigated white matter alterations in post-stroke cognitive impairment patients at the subacute stage using diffusion kurtosis and tensor imaging. Results showed significant changes in white matter microstructure and cognitive performance in PSCI patients. DKI was more sensitive in detecting subtle white matter changes compared to DTI metrics, offering valuable insights for understanding PSCI mechanisms and cognitive rehabilitation in the subacute stage.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
Summary: Through contrastive analysis, we identified white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI). The results showed that compared to the non-NP group, the NP group exhibited higher values of FA in the posterior body and splenium of the corpus callosum, which may be related to central sensitization or network hyperexcitability.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Arashk Mallahzadeh, Mahan Shafie, Mahdi Tahvilian, Mohammad Sadeghi, Golsa Moslemian, Pouria Barzin, Maryam Bemanalizadeh, Mahsa Mayeli, Mohammad Hadi Aarabi
Summary: Using diffusion MRI connectometry, this study found that the integrity of white matter in certain tracts is associated with behavioral activation and inhibition, expanding our knowledge of the neural networks associated with risk-taking and reward-seeking behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
Ciara J. Molloy, Sinead Nugent, Arun L. W. Bokde
Summary: This study characterized age-related white matter changes by evaluating patterns of overlap between diffusion measures, showing different overlapping patterns reflecting underlying biological changes with aging. Results indicated that cognitively healthy aging adults had low WMH load, emphasizing the importance of considering WMH impact in aging studies of white matter.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Neurosciences
Nick Teller, Jordan A. Chad, Alexander Wong, Hayden Gunraj, Xiang Ji, Maged Goubran, Asaf Gilboa, Eugenie Roudaia, Allison Sekuler, Nathan Churchill, Tom Schweizer, Fuqiang Gao, Mario Masellis, Benjamin Lam, Chris Heyn, Ivy Cheng, Robert Fowler, Sandra E. Black, Bradley J. MacIntosh, Simon J. Graham, J. Jean Chen
Summary: By comparing simulation and experimental data, it is found that correlated diffusion imaging method performs better in detecting the effect of COVID-19, which reveals less restricted diffusion in the frontal lobe and more restricted diffusion in the cerebellar white matter in patients, consistent with existing studies.
HUMAN BRAIN MAPPING
(2023)
Article
Multidisciplinary Sciences
Dong-Kyun Lee, Hyeongrae Lee, Vin Ryu, Sung-Wan Kim, Seunghyong Ryu
Summary: This study found that alterations in white matter microstructure may be a common neuroanatomical characteristic of bipolar disorder, regardless of being psychotic or non-psychotic. Both psychotic and non-psychotic bipolar disorder patients showed decreased fractional anisotropy (FA) and increased mean diffusion (MD) in certain white matter areas compared to healthy controls. However, psychotic bipolar disorder patients showed more widespread connectivity disruptions in the brain.
Article
Clinical Neurology
Yaomin Guo, Kangqiang Peng, Ying Liu, Linchang Zhong, Chao Dang, Zhicong Yan, Ying Wang, Jinsheng Zeng, Weixi Zhang, Zilin Ou, Gang Liu
Summary: Large-scale white matter structural networks in patients with blepharospasm undergo extensive reorganization, characterized by alterations in network integration and segregation, increased efficiency in multiple cortical and subcortical regions, and distinct hub distribution patterns. These changes may be due to both dystonia-specific abnormalities and facial hyperkinetic movements.
MOVEMENT DISORDERS
(2021)
Article
Gastroenterology & Hepatology
Yang Hu, Zhenzhen Jia, Lei Zhang, Zhida Zhang, Hao Li, Zongxin Tan, Shuai Lv, Karen M. von Deneen, Shijun Duan, Guangbin Cui, Yongzhan Nie, Yi Zhang
Summary: This study found that functional constipation is associated with white-matter microstructural changes in brain regions responsible for sensory and emotional information processing. These changes are more related to psychological symptoms rather than constipation itself.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maurizio Bergamino, Megan R. Nelson, Asfia Numani, Matthew Scarpelli, Deborah Healey, Alberto Fuentes, Gregory Turner, Ashley M. Stokes
Summary: This study used VBM and FW-DTI techniques to investigate a mouse model of AD, and found grey matter atrophy and white matter microstructural abnormalities in the model, manifested as decreased grey matter density and decreased FW-FA. Additionally, the presence of amyloid and tau in the model was confirmed by histopathology. These findings indicate neurodegenerative changes and white matter microstructural abnormalities in the 3xTg-AD model, characterized by increased FW, decreased FW-FA, and decreased grey matter density.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)