Article
Immunology
Qi Wang, Yun Xie, Qian He, Yan Geng, Jiru Xu
Summary: Silencing lncRNA-Cox2 can modulate macrophage polarization and inflammatory response by inhibiting the CREB/C/EBP beta pathway, thereby restraining the progression of sepsis in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pauline Pfander, Ann-Kathrin Eiers, Ute Burret, Sabine Vettorazzi
Summary: Immune response control is crucial to prevent detrimental effects of excessive cytokine production. Interleukin-10 (Il-10) produced by macrophages acts as an anti-inflammatory cytokine that counteracts inflammatory responses through regulation by factors such as c-Maf and Cdk5. Inhibiting Cdk5 may enhance the c-Maf-Il-10 axis and improve anti-inflammatory therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Haranatha R. Potteti, Lalith K. Venkareddy, Patrick M. Noone, Aparna Ankireddy, Chandramohan R. Tamatam, Dolly Mehta, Chinnaswamy Tiruppathi, Sekhar P. Reddy
Summary: This study demonstrates the crucial role of Nrf2 in optimal A20 transcriptional induction in macrophages in response to endotoxin, and shows that this regulation occurs in a contextual manner.
Article
Chemistry, Multidisciplinary
Yihua Bei, Yujiao Zhu, Meng Wei, Mingming Yin, Lin Li, Chen Chen, Zhenzhen Huang, Xuchun Liang, Juan Gao, Jianhua Yao, Petra H. van der Kraak, Aryan Vink, Zhiyong Lei, Yuxiang Dai, Huihua Chen, Yueyang Liang, Joost P. G. Sluijter, Junjie Xiao
Summary: It is observed that HIPK1 is increased during pathological cardiac hypertrophy. Both genetic ablation and gene therapy targeting HIPK1 are protective against pathological hypertrophy and heart failure in vivo. HIPK1 inhibition prevents cardiomyocyte hypertrophy and transcription of pathological response genes.
Review
Immunology
Yan Lin Fu, Rene E. Harrison
Summary: Phagocytosis is a crucial process for the uptake of large particulate matter by specialized cells in the body, enabled by cell surface receptors. Professional phagocytes, including macrophages, neutrophils and dendritic cells, play a key role in innate immunity through engaging target cells for destruction and recycling in phagosomes. Macrophages, in particular, produce a variety of cytokines that modulate the inflammatory response to microbes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stephanie Solier, Michele Mondini, Lydia Meziani, Arnaud Jacquel, Catherine Lacout, Tom Vanden Berghe, Yvon Jule, Jean-Claude Martinou, Gerard Pierron, Julie Riviere, Marc Deloger, Corinne Dupuy, Anny Slama-Schwok, Nathalie Droin, Peter Vandenabeele, Patrick Auberger, Eric Deutsch, Jamel El-Benna, Pham My-Chan Dang, Eric Solary
Summary: Circulating monocytes are recruited to damaged tissues to generate macrophages that modulate disease progression. Activation of caspase-3 and caspase-7, located near mitochondria, is involved in the generation of monocyte-derived macrophages stimulated by Colony-stimulating factor-1 (CSF-1). A non-conventional pathway that involves caspases and activates NOX2 is responsible for CSF1-driven monocyte differentiation, and targeting this pathway may have therapeutic implications for modulating macrophage polarization in damaged tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Summary: DHC ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Medicine, Research & Experimental
Qun Ren, Zhaowen Liu, Longhuo Wu, Guoqiang Yin, Xunlu Xie, Weihao Kong, Jianguo Zhou, Shiwei Liu
Summary: Inflammation, a mechanism of the human body, is involved in many diseases. CCAAT/enhancer binding protein beta (C/EBP β) plays a crucial role in inflammatory responses and the development of inflammation-related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Jila Nasirzade, Zahra Kargarpour, Layla Panahipour, Reinhard Gruber
Summary: The study demonstrates that acid dentin lysate can reduce the polarization of macrophages towards the inflammatory phenotype and decrease osteoclastogenesis in bone marrow cultures.
Article
Immunology
Michelle Hoffner O'Connor, Ana Berglind, Meaghan M. Kennedy Ng, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Shehzad Z. Sheikh
Summary: This study found that the BET inhibitor (+)-JQ1 can alter the functionality of macrophages and suppress inflammatory gene expression, thereby mitigating the inflammatory response in colitis. This finding provides new insights into potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Keying Zhu, Yang Wang, Heela Sarlus, Keyi Geng, Erik Nutma, Jingxian Sun, Shin-Yu Kung, Cindy Bay, Jinming Han, Jin-Hong Min, Irene Benito-Cuesta, Harald Lund, Sandra Amor, Jun Wang, Xing-Mei Zhang, Claudia Kutter, Andre Ortlieb Guerreiro-Cacais, Bjorn Hogberg, Robert A. Harris
Summary: This study reveals the promise of TOP1 inhibitors for microglial modulation and highlights the therapeutic strategy of TOP1 inhibition in myeloid cells for neuroinflammatory diseases. The designed nanosystem shows enhanced specificity to myeloid cells and prevents the degradation of the DNA scaffold, offering a potential treatment for diseases with dysfunctional myeloid cells.
Article
Biochemistry & Molecular Biology
Ryuta Muromoto, Ami Sato, Yuki Komori, Kota Nariya, Yuichi Kitai, Jun-ichi Kashiwakura, Tadashi Matsuda
Summary: This study investigates how transcription factors C/EBPb and STAT1 regulate the NFKBIZ promoter, revealing opposing roles in NFKBIZ transcription.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Yuhong Xiao, Ye Yuan, Yuhui Yang, Bo Liu, Zhanyuan Ding, Jun Luo, Shengsong Chen, Lingling Yu
Summary: ObjectiveGTP cyclohydrolase 1 (GCH1) has been reported to protect against ferroptosis. This study aimed to investigate whether GCH1 could reduce lipopolysaccharide (LPS)-induced macrophage polarization and inflammation by inhibiting ferroptosis. Bioinformatics analysis and experimental studies were performed to elucidate the function of GCH1 in macrophages.
INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Jason S. Holsapple, Ben Cooper, Susan H. Berry, Aleksandra Staniszewska, Bruce M. Dickson, Julie A. Taylor, Paul Bachoo, Heather M. Wilson
Summary: Extracorporeal Shock Wave Therapy (ESWT) plays a crucial role in promoting wound healing by enhancing angiogenesis, reducing macrophage numbers, and increasing macrophage activation. Shockwave treatment boosts the uptake of apoptotic cells by macrophages, promotes healing-associated cytokine and growth factor gene expressions, and modulates macrophage morphology through mechanotransduction pathways, contributing to wound resolution. These findings reveal shockwaves as important regulators of macrophage functions linked with wound healing, representing an underappreciated role of clinically applied shockwaves that could be utilized for other macrophage-mediated disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Claire E. Dodd, Charlie J. Pyle, Rebecca Glowinski, Murugesan V. S. Rajaram, Larry S. Schlesinger
JOURNAL OF IMMUNOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Charlie J. Pyle, Abul K. Azad, Audrey C. Papp, Wolfgang Sadee, Daren L. Knoell, Larry S. Schlesinger
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Ming-Jie Liu, Shengying Bao, Marina Galvez-Peralta, Charlie J. Pyle, Andrew C. Rudawsky, Ryan E. Pavlovicz, David W. Killilea, Chenglong Li, Daniel W. Nebert, Mark D. Wewers, Daren L. Knoell
Article
Biochemical Research Methods
Mark R. Cronan, Molly A. Matty, Allison F. Rosenberg, Landry Blanc, Charlie J. Pyle, Scott T. Espenschied, John F. Rawls, Veronique Dartois, David M. Tobin
Article
Biology
Molly A. Matty, Daphne R. Knudsen, Eric M. Walton, Rebecca W. Beerman, Mark R. Cronan, Charlie J. Pyle, Rafael E. Hernandez, David M. Tobin