Article
Virology
Pathum Ekanayaka, Byeong-Hoon Lee, Asela Weerawardhana, Kiramage Chathuranga, Jong-Hyeon Park, Jong-Soo Lee
Summary: Research has shown that the Foot-and-mouth disease virus protein VP3 interacts specifically with the transmembrane domain of MAVS, inhibiting the localization of MAVS to mitochondria and suppressing the type-I IFN response, thus promoting viral replication.
Article
Biochemistry & Molecular Biology
Sang-Hun Kim, Hyeon Jun Shin, Chang Min Yoon, Sei Won Lee, Lokesh Sharma, Charles S. Dela Cruz, Min-Jong Kang
Summary: The study identified a novel role of PINK1 in regulating MAVS signaling, where PINK1 interacts with and stabilizes MAVS, inhibiting its multimeric aggregation. PINK1 deficiency enhances MAVS-mediated antiviral innate immune and NLRP3 inflammasome signaling, affecting pulmonary pathobiology in response to viral infection and fibrotic injury.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Immunology
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
Summary: Our research reveals that BAG6 is a critical regulator in the RIG-I/VISA-mediated innate immune response. It inhibits the aggregation of VISA and attenuates the recruitment of TRAF2, thereby inhibiting the activation of the RLR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jack Chun-Chieh Hsu, Maudry Laurent-Rolle, Joanna B. Pawlak, Hongjie Xia, Amit Kunte, Jia Shee Hee, Jaechul Lim, Lawrence D. Harris, James M. Wood, Gary B. Evans, Pei-Yong Shi, Tyler L. Grove, Steven C. Almo, Peter Cresswell
Summary: This study reveals a novel antiviral mechanism in which viperin inhibits both cellular and viral RNA translation by activating a ribosome collision-dependent pathway. The SAM activity and enzymatic product of viperin play crucial roles in translation repression. This research highlights the significance of translational repression in the antiviral response and identifies viperin as a translation regulator in innate immunity.
Article
Fisheries
Zhaoyuan Chen, Yingyi Cao, Jiayi Huang, Yaqi Tan, Jing Wei, Jun Xiao, Jun Zou, Hao Feng
Summary: The study cloned and characterized the NLK homolog bcNLK in black carp, demonstrating its association with MAVS and inhibition of MAVS-mediated antiviral signaling.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Microbiology
Jin Dai, Chantal A. Agbemabiese, Ashley N. Griffin, John T. Patton
Summary: This study investigates the role of VP3 and NSP1 proteins in the degradation of MAVS and IRF3 in rotavirus-infected cells. The results demonstrate that VP3 is responsible for the depletion of MAVS and contributes to the suppression of IFN production, supporting the activity of NSP1 as the major interferon antagonist of the virus.
Article
Fisheries
Wanzhen Li, Yingyi Cao, Zhaoyuan Chen, Yaqi Tan, Yuhan Dai, Jing Wei, Jun Xiao, Hao Feng
Summary: The study showed that bcTRADD plays an important role in the immune response of teleost fish, regulating the transcriptional activity of the NF-KB promoter but having little effect on the IFN promoter. Additionally, bcTRADD was found to suppress the antiviral signaling mediated by bcMAVS in black carp.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Microbiology
Yunqiang Chen, Yuheng Shi, Jing Wu, Nan Qi
Summary: MAVS functions as a crucial switch in immune signal transduction against RNA viruses, forming aggregates upon viral infection to activate interferon signaling and maintain immune homeostasis. Viruses and hosts target MAVS for regulation, with researchers focusing on post-translational modifications like ubiquitination and phosphorylation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Yuhan Dai, Yingyi Cao, Zhaoyuan Chen, Jiayi Huang, Jun Xiao, Jun Zou, Hao Feng
Summary: Our study reveals that black carp RIPK3 interacts with RIPK1 to inhibit MAVS-mediated antiviral signaling in teleost fish for the first time.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Developmental Biology
Dhwani N. Rupani, Fredrik I. Thege, Vidhi Chandra, Hajar Rajaei, Robert W. Cowan, Sonja M. Wormann, Olivereen Le Roux, Prerna Malaney, Sara L. Manning, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Florencia McAllister
Summary: ADAR1 is an RNA-binding protein that converts adenosine (A) to inosine (I). Its editing function alters post-transcriptional RNA processing, making it a crucial regulator of gene expression. In pancreatic development and homeostasis, Adar1 prevents aberrant activation of the Mavs-mediated innate immune pathway to maintain pancreatic stability.
Article
Critical Care Medicine
Menachem Ailenberg, Andras Kapus, Chung Ho Leung, Katalin Szaszi, Philip Williams, Caterina DiCiano-Oliveira, John C. Marshall, Ori D. Rotstein
Summary: Resuscitation of trauma patients after hemorrhagic shock causes global ischemia/reperfusion (I/R), leading to oxidative stress, inflammation, and organ dysfunction. Activation of the mitochondrial antiviral signaling protein (MAVS) pathway may play a role in I/R-induced inflammation and injury.
Article
Microbiology
Kaizhao Huang, Shunjie Pei, Yi Sun, Xi Xu, Yangyang Fang, Meimei Lai, Guangxin Xiang, Feng Xu, Xiaoqun Zheng
Summary: In this study, the relationship between MFN1 and IFN1 during HCMV infection was investigated. The results showed that HCMV infection caused mitochondrial fusion, and MFN1 positively regulated this process and the IFN1 response. Knockdown of MFN1 or MAVS inhibited the HCMV-induced IFN1 production. The MFN1 agonist leflunomide induced IFN1 production.
MICROBIOLOGY SPECTRUM
(2023)
Article
Clinical Neurology
Yanyan Jiang, Yilin Liu, Yawen Zhao, Yiming Zheng, Meng Yu, Jianwen Deng, Hongjun Hao, Wei Zhang, Zhaoxia Wang, Yun Yuan
Summary: Compared to antibody-negative DM, anti-MDA5 DM showed different distribution of mitochondrial pathology and less severe morphology, along with enhanced but less intensive MAVS-IFN1 signaling pathway activity in muscles. This disparity suggests potentially different mechanisms of muscle injury between the two DM groups.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ghaffar Muharram, Marion Thepaut, Pierre-Emmanuel Lobert, Teddy Grandjean, Olivier Boulard, Myriam Delacre, Emmrich Wakeford, Richard Wheeler, Lionel Franz Poulin, Ivo Gomperts Boneca, Frank Lafont, Marie-Cecile Michallet, Didier Hober, Ken Cadwell, Mathias Chamaillard
Summary: More than 90% of non-bacterial gastroenteritis is caused by human noroviruses (NoVs), which persist in some individuals and lead to significant outbreaks and high mortality in developing countries. NoVs primarily transmit through the fecal-oral route. This study reveals the exacerbation of colitis severity caused by norovirus is dependent on bacterial sensing by Nod2.
Review
Immunology
Jialu Zhang, Yaohong Zhu, Xiaojia Wang, Jiufeng Wang
Summary: Cholesterol and its metabolite 25HC play crucial roles in viral entry and replication, as well as serving as regulators of innate immune response. In addition to interferon regulation, 25HC modulates cholesterol metabolism, autophagy, and inflammation through signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2023)