Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis

(2016) Jörn M. Schattenberg et al.   GASTROENTEROLOGY

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells

(2015) Stefania Cannito et al.   Oncotarget

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

Circulating Extracellular Vesicles with Specific Proteome and Liver MicroRNAs Are Potential Biomarkers for Liver Injury in Experimental Fatty Liver Disease

(2014) Davide Povero et al.   PLoS One

Inflammasomes and Metabolic Disease

(2013) Jorge Henao-Mejia et al.   Annual Review of Physiology

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells

(2013) D. Povero et al.   Science Signaling

Microparticles: major transport vehicles for distinct microRNAs in circulation

(2012) P. Diehl et al.   CARDIOVASCULAR RESEARCH

Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis

(2012) Sara Galastri et al.   CLINICAL SCIENCE

Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

(2012) Miroslaw Kornek et al.   GASTROENTEROLOGY

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Microparticles, Vascular Function, and Atherothrombosis

(2011) Pierre-Emmanuel Rautou et al.   CIRCULATION RESEARCH

Nonalcoholic steatohepatitis

(2011) Jörn M. Schattenberg et al.   CURRENT OPINION IN LIPIDOLOGY

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

(2011) Qiuwei Pan et al.   GUT

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

(2011) Neeraj Bhala et al.   HEPATOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells

(2011) Erica Novo et al.   JOURNAL OF PATHOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis

(2011) Olivier Morel et al.   Seminars in Immunopathology

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells

(2010) Miroslaw Kornek et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years

(2009) A E Feldstein et al.   GUT

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles

(2009) Alex Yuan et al.   PLoS One

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS

Liver Cell–Derived Microparticles Activate Hedgehog Signaling and Alter Gene Expression in Hepatic Endothelial Cells

(2008) Rafal P. Witek et al.   GASTROENTEROLOGY

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

(2008) Javier Conde-Vancells et al.   JOURNAL OF PROTEOME RESEARCH

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

(2008) Fabio Marra et al.   TRENDS IN MOLECULAR MEDICINE