Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation

The ADP-ribose polymerase Tankyrase regulates adult intestinal stem cell proliferation during homeostasis inDrosophila

(2016) Zhenghan Wang et al.   DEVELOPMENT

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

(2016) Zhenghan Wang et al.   GENETICS

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

(2016) Laura Mariotti et al.   MOLECULAR CELL

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta

(2016) Estefania Martino-Echarri et al.   PLoS One

Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling

(2016) Amanda A. Riccio et al.   STRUCTURE

Wnt/Wingless Pathway Activation Is Promoted by a Critical Threshold of Axin Maintained by the Tumor Suppressor APC and the ADP-Ribose Polymerase Tankyrase

(2016) Zhenghan Wang et al.   GENETICS

Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity

(2016) Nina Marie Pedersen et al.   PLoS One

Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes

(2015) T. E. Thorvaldsen et al.   MOLECULAR CANCER RESEARCH

LEF1 and B9L Shield  -Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

(2014) M. de la Roche et al.   CANCER RESEARCH

Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling

(2014) D. B. Bernkopf et al.   JOURNAL OF CELL SCIENCE

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor

(2013) Andrew Voronkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structural and Functional Characterization of the Wnt Inhibitor APC Membrane Recruitment 1 (Amer1)

(2011) Kristina Tanneberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

(2011) Marc Fiedler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

(2011) C. Mendoza-Topaz et al.   Open Biology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE