Article
Nanoscience & Nanotechnology
Tarek A. Ahmed, Ehab M. M. Ali, Abdelsattar M. Omar, Alshaimaa M. Almehmady, Khalid M. El-Say
Summary: This study explored an innovative approach to enhance the anticancer activity of Ezetimibe through the development of drug nano-formulations. The prepared nano-micelle formulations showed small size, close to zero zeta potential, and high entrapment efficiency. Molecular docking and cell experiments demonstrated that the TPGS-based nano-micelle formulation exhibited the highest cytotoxic activity against MCF-7 and T47D cancer cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
S. Salwey, G. Coxon, F. Pianosi, M. B. Singer, C. Hutton
Summary: Reservoirs are important for water supply and management, but they are often excluded or poorly represented in hydrological models due to a lack of open-access data. To address this issue, we developed hydrological signatures that can detect reservoir impacts on downstream flow using only downstream flow records. We applied these signatures to catchments in Great Britain and found that water abstractions from reservoirs cause deficits in the water balance, and pre-defined flow releases reduce variability in downstream flow. We also identified catchments significantly impacted by reservoirs and provided insights into local reservoir operations.
WATER RESOURCES RESEARCH
(2023)
Article
Chemistry, Analytical
Parthena Chorti, Abbas Parvez Kazi, Al-Monsur Jiaul Haque, Michael Wiederoder, Dionysios C. Christodouleas
Summary: This study introduces a new electrochemical immunoassay for targeted detection of bacteria, which can support portable bacteria biosensors for field use. By using disposable syringes and a flow-through detection cell, the proposed assay can analyze higher sample volumes efficiently.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Brian Roehrich, Eric Z. Liu, Ravit Silverstein, Lior Sepunaru
Summary: The EIS technique can detect and characterize single particles colliding with an electrode in solution, providing more information than traditional methods and isolating capacitive, resistive, and diffusional processes to enhance measurement precision of particle sizes.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Hui Wang, Shu-Min Wang, Wei Zhao, Hong-Yuan Chen, Jing-Juan Xu
Summary: In this study, a facile and sensitive dual mode sensing strategy for evaluating amantadine (AMD) levels was proposed by coupling plasmonic Au nanorods (NRs) with supramolecular SH-cyclodextrin (CD) through a strong Au-S bond. This strategy showed linearly proportional response to AMD concentration, and had low detection limits. Furthermore, it was successfully applied to the detection of AMD in human serum samples with excellent selectivity and sensitivity.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Huihui Kuang, Danyu Wang, Zachary Schneiderman, Michael Tsapatsis, Efrosini Kokkoli
Summary: In this work, supramolecular architectures were formed from the assembly of single-tail single stranded DNA (ssDNA)-amphiphiles. The ssDNA-amphiphiles self-assembled into various nanostructures, and the increase of the hydrophobic block led to changes in the structure.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biophysics
Sanjida Yeasmin, Bo Wu, Ye Liu, Ahasan Ullah, Li-Jing Cheng
Summary: In this study, a molecularly imprinted polymer (MIP)-based electrochemical sensor with enhanced sensitivity for the detection of cortisol was developed. The sensor utilized a nano gold-doped poly-o-PD film, which facilitated charge transfer and blocked the charge transfer when cortisol occupied the binding cavities, resulting in enhanced detection response and sensitivity. The sensor exhibited high affinity and selectivity towards cortisol and showed promising potential for point-of-care testing applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Sarunya Phunpee, Uracha R. Ruktanonchai, Suwabun Chirachanchai
Summary: Multistimuli-responsive polymers are important for controlled release, but their decoration is limited due to their derivation from vinyl-based monomers. In this study, polymers with different critical solution temperatures were introduced onto chitosan and hyaluronic acid, resulting in a polymer system with a multiresponsive window. By adjusting the mole ratio and pH, the encapsulation and release of lysozyme were controlled repeatably.
Article
Nanoscience & Nanotechnology
Xiumin Yang, Sijia Lv, Liyong Gan, Chun Wang, Zhi Wang, Zhonghai Zhang
Summary: A single-atom catalyst (Fe SAs/-N-C) with excellent stability and conductivity was successfully fabricated via high-temperature calcination using the NiFe layered double hydroxide (LDH)/ZIF-8 composite as precursors. The carbon nanotubes produced with the help of Ni catalyst formed an island-bridge-like 3D network structure, greatly enhancing the exposure of active sites and electron transfer. The Fe SAs/-N-C with Fe-N-4 as the catalytic active site was employed for the electrochemical sensing of CA, showing satisfactory sensitivity, selectivity, and long-term stability. This work expands the application range of single-atom catalysts and provides a significant reference for the synthesis of hybrid double-atom catalysts.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Isabella Sampaio, Felipe Domingues Quatroni, Juliana Naomi Yamauti Costa, Valtencir Zucolotto
Summary: A single chip that distinguishes between Zika and Dengue infections has been developed. The chip uses the non-structural protein 1 (NS1) as biomarkers and can also detect the spike proteins present in the SARS-CoV-2. This portable diagnostic test offers a point-of-care solution for the simultaneous detection of Zika, Dengue, and other viral infections.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Analytical
Omid Heydari Shayesteh, Reza Mahjub, Akram Ranjbar, Katayoun Derakhshandeh, Mahdi Jamshidi
Summary: Accurate determination of narrow therapeutic index drugs is crucial for clinicians to make clear judgments regarding drug therapy for patients. Traditional analytical techniques have limitations, leading to high interest in nano/(bio)sensing technology.
Article
Chemistry, Analytical
Sepideh Shariati, Ali Ghaffarinejad, Eskandar Omidinia
Summary: In this study, a sensitive, low-cost, label-free electrochemical nano biosensor was used to detect the diagnostic biomarker miR-155 for multiple sclerosis (MS). The biosensor demonstrated a wide dynamic range and low detection limit, and was successfully applied in human serum.
MICROCHEMICAL JOURNAL
(2022)
Article
Electrochemistry
Jagadeesh Sure, D. Sri Maha Vishnu, Carsten Schwandt
Summary: In this study, nano-size equiatomic CoCrFeNi HEA powder was successfully prepared by electro-deoxidation method, which showed a well-formed crystal structure and accurate composition, providing an effective approach for the production of high-entropy alloy powders.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Fan Gao, Ziyue Chen, Li Zhou, Xuefeng Xiao, Lin Wang, Xingchao Liu, Chenggang Wang, Qiuhong Guo
Summary: In this study, Bellidifolin was successfully encapsulated in polyethylene glycol 15-hydroxy stearate to form nano-micelles. These nano-micelles demonstrated good stability and sustained release characteristics, and showed increased cellular uptake capacity, inhibition of cardiac fibroblast proliferation, and improvement of myocardial fibrosis.
Article
Biophysics
Sima Singh, Numan Arshid, Stefano Cinti
Summary: Detection of extracellular vesicles is a challenge that requires a multidisciplinary approach to develop flexible, miniaturized point-of-care devices. Materials scientists and engineers have worked on this platform to create devices for exosome detection based on nanomaterials. Challenges and potential solutions for expanding clinical applications were discussed.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.