Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene

TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

(2016) Joanne Hsieh et al.   NATURE

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis

(2016) Tamer Sallam et al.   NATURE

A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation

(2015) Brenda S. Hijmans et al.   FASEB JOURNAL

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

(2015) Ellen W. Demerath et al.   HUMAN MOLECULAR GENETICS

Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation

(2015) Jeff G. Blackinton et al.   NUCLEIC ACIDS RESEARCH

CCTOP: a Consensus Constrained TOPology prediction web server

(2015) László Dobson et al.   NUCLEIC ACIDS RESEARCH

Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

(2015) Daniel B. Graham et al.   Nature Communications

Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation

(2014) Jae Ho Lee et al.   HEPATOLOGY

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

The UPS and downs of cholesterol homeostasis

(2014) Laura J. Sharpe et al.   TRENDS IN BIOCHEMICAL SCIENCES

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

(2013) Pingping Li et al.   CELL

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

(2012) Petri Pehkonen et al.   BMC GENOMICS

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor

(2012) Vincenzo Sorrentino et al.   CURRENT OPINION IN LIPIDOLOGY

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia

(2012) Mohammad Mahdi Motazacker et al.   EUROPEAN HEART JOURNAL

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system

(2012) Yien Che Tsai et al.   MOLECULAR BIOLOGY OF THE CELL

CircaDB: a database of mammalian circadian gene expression profiles

(2012) Angel Pizarro et al.   NUCLEIC ACIDS RESEARCH

A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis

(2011) Albert Neutzner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

(2011) Y. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol, the central lipid of mammalian cells

(2010) Frederick R Maxfield et al.   CURRENT OPINION IN CELL BIOLOGY

The TRC8 Ubiquitin Ligase Is Sterol Regulated and Interacts with Lipid and Protein Biosynthetic Pathways

(2010) J. P. Lee et al.   MOLECULAR CANCER RESEARCH

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage

(2009) Masato Irisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver X Receptor Ligands Suppress Ubiquitination and Degradation of LXRα by Displacing BARD1/BRCA1

(2009) Kang Ho Kim et al.   MOLECULAR ENDOCRINOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism