Article
Veterinary Sciences
Ahmad Nadzri Nur-Farahiyah, Kiven Kumar, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Nazrina Camalxaman
Summary: This study investigated virus shedding in captive wild felids in Malaysia, focusing on four infectious viruses of cats. Only one Malayan tiger tested positive for canine parvovirus (CPV) and was identified as CPV-2a subtype. Genome sequencing revealed high similarity to known CPV strains and provided valuable information on the genomic characteristics of captive wild felids.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Hao, Yanchao Li, Xiangyu Xiao, Bo Chen, Pei Zhou, Shoujun Li
Summary: Canine parvovirus (CPV-2) is a significant pathogen in dogs. Despite the development of vaccines, CPV-2 continues to circulate in the dog population. CPV-2c is replacing CPV-2a as the dominant variant in Asia, South America, North America, and Africa, with evidence of spillover.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Weslei de Oliveira Santana, Vinicius Proenca Silveira, Jonas Michel Wolf, Diessy Kipper, Sergio Echeverrigaray, Claudio Wageck Canal, Uwe Truyen, Vagner Ricardo Lunge, Andre Felipe Streck
Summary: Canine parvovirus type 2 (CPV-2) is a significant pathogen for dogs and has evolved into two major lineages worldwide. A distinct lineage exclusive to Brazil has been identified, which is not related to previous CPV-2 classifications. The study also revealed that the main CPV-2 lineages evolved over several years and spread globally. CPV-2 experienced a major dissemination increase in the late 1980s/early 1990s, followed by a period of stability and a minor increase from 2000 to 2004.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Infectious Diseases
Tuong Nguyen Manh, Chutchai Piewbang, Anudep Rungsipipat, Somporn Techangamsuwan
Summary: CPV-2c strains in Vietnam exhibit a similar evolutionary pattern to the Asian CPV-2 clade with unique mutations. The study found high substitution rates in both structural and nonstructural proteins of CPV-2, suggesting potential positive selection sites.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Robert A. Lopez-Astacio, Oluwafemi F. Adu, Daniel J. Goetschius, Hyunwook Lee, Wendy S. Weichert, Brian R. Wasik, Simon P. Frueh, Brynn K. Alford, Ian E. H. Voorhees, Joseph F. Flint, Sarah Saddoris, Laura B. Goodman, Edward C. Holmes, Susan L. Hafenstein, Colin R. Parrish
Summary: Canine parvovirus (CPV) is a small DNA virus that causes serious diseases in dogs worldwide. In this study, in vitro selection and deep sequencing were used to investigate the escape mutations in CPV induced by two antibodies. The results provide insights into the selection of viral variants and the interactions between antibodies and receptors.
JOURNAL OF VIROLOGY
(2023)
Article
Microbiology
Pengfei Fu, Dongchang He, Xuan Cheng, Xinrui Niu, Congrong Wang, Yiqian Fu, Kun Li, Heshui Zhu, Weifei Lu, Jiang Wang, Beibei Chu
Summary: This study investigated the epidemic profile and genetic diversity of CPV-2 in Henan province, China. CPV-2c was found to be the dominant genotype in the region. Phylogenetic analysis grouped the strains with Asian strains. Adaptive analyses identified positive selection and parallel evolution sites in the VP2 protein. Several amino acid mutations, including a unique mutation, were observed in the VP2 proteins of CPV-2c strains.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Yashu Tang, Na Tang, Jingru Zhu, Min Wang, Yang Liu, Yanli Lyu
Summary: This study investigated the prevalence of feline parvovirus in Beijing, China, and analyzed the genetic features and evolution of the detected viruses. The findings suggest that CPV-2 variants circulating in cats might be derived from dogs, and new mutations were identified in the sequences.
BMC VETERINARY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
M. L. Marenzoni, M. B. Conti, E. Rossi, R. Rinoldo, R. Franceschini, E. Tesei, F. Porciello, S. Mancini, B. Favi, M. Gamboni, P. Boni, O. Raffaele, C. Desario, M. P. Franciosini, C. Buonavoglia, N. Decaro
Summary: The study developed a protocol for environmental sampling to detect parvoviruses of dogs and cats. Molecular assays were the most sensitive methods, able to identify even very low amounts of viral DNA. The protocol is important for identifying possible sources of infection and evaluating the efficacy of disinfection protocols in the environment.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Virology
Zhaoyang Wang, Yajun Jiang, Ting Xin, Weifeng Yuan, Xiaoyu Guo, Honglei Zhou, Hongfei Zhu, Hong Jia
Summary: This study investigated the genetic variation of canine parvovirus (CPV) in Tangshan, China and found 17 CPV-2c variants, 4 new CPV-2a variants, and 1 new CPV-2b variant. Analysis revealed that the CPV-2c strains in Tangshan were closely related to Asian strains and distantly related to European strains. Amino acid sequence analysis indicated several mutations in the CPV-2c strains in this study compared to European strains. These findings provide a comprehensive understanding of CPV variants circulating in China.
ARCHIVES OF VIROLOGY
(2022)
Review
Behavioral Sciences
Ludwig Huber, Lucrezia Lonardo
Summary: An important question in the study of canine cognition is how dogs understand humans. Evidence suggests that dogs are sensitive to the gaze and attention of others, and they might have the ability to take the perspective of others and understand their beliefs and intentions. Recent studies have shown that dogs can differentiate between human informants based on their visual access to information, and they can also understand and react to misleading suggestions.
Article
Infectious Diseases
Emily Kwan, Maura Carrai, Gianvito Lanave, Jennifer Hill, Kylie Parry, Mark Kelman, Joanne Meers, Nicola Decaro, Julia A. Beatty, Vito Martella, Vanessa R. Barrs
Summary: This study identified CPV variants circulating in Australian dogs, with CPV-2b emerging as the dominant antigenic variant. There were indications of possible introduction of CPV strains from Asia, and evolutionary intermediates between CPV-2 and FPV were found. The study also revealed the presence of intermediates between CPV-2a-like viruses and CPV-2.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Microbiology
Bixia Chen, Xiaohui Zhang, Jie Zhu, Lijing Liao, Endong Bao
Summary: The study identified two new variants of canine parvovirus (CPV-2) in China, with CPV-2c variant gaining more epidemiological advantage over the new CPV-2a variant. Analysis of VP2 protein sequences showed several amino acid substitutions. Close relationship was found between Chinese strains and other Asian strains, as well as concerns about intercontinental transmission.
Article
Microbiology
Rasika Jinadasa, Sayani Ghosh, Simon Hills, Thushini Premalal, Ushani Atapattu, Manohari Fuward, Wasantha Kalupahana, Magdalena Dunowska
Summary: The study identified multiple CPV-2 subtypes circulating in Sri Lanka, likely driven by both local evolution and introduction from other countries. The similarity of CPV-2 obtained from cats and dogs suggests that cats may play a role in the epidemiology of CPV-2 in Sri Lanka.
Article
Biotechnology & Applied Microbiology
Lixuan Zhou, Hongchao Wu, Mengmeng Du, Huanhuan Song, Ningning Huo, Xiao Chen, Xiaorui Su, Weiguo Li, Lulu Wang, Jie Wang, Baicheng Huang, Feifei Tan, Kegong Tian
Summary: A chimeric antibody 11D9, derived from dogs and produced by CHO-S cells, showed high neutralizing activity and therapeutic effects against CPV-2 in animal experiments.
Article
Parasitology
Reza Faraji, Mostafa Sadeghi, Sayed-Hamidreza Mozhgani, Violetta Vasinioti, Linda Amarachi Ndiana, Costantina Desario, Farzad Beikpour, Nicola Decaro
Summary: This study investigated the prevalence and genomic features of CanineCV in Iranian dogs. A total of 203 dog fecal samples were collected and screened by real-time PCR. Thirteen dogs (6.4%) tested positive for CanineCV DNA, with all cases being co-infections with the highly virulent CPV. Phylogenetic analysis revealed that the Iranian CanineCV sequences are more closely related to Turkish strains. The study provides new insights into the molecular epidemiology of CanineCV and its role as a co-infectious pathogen.