Article
Multidisciplinary Sciences
Negar Sarmadi, Hossein Poustchi, Fatemeh Ali Yari, Amir Reza Radmard, Sara Karami, Abbas Pakdel, Parisa Shabani, Ali Khaleghian
Summary: The study found that impaired anti-inflammatory activity of apoB-depleted plasma was associated with NAFLD, as indicated by the lower ability to inhibit the expression of adhesion molecules in inflammation-induced endothelial cells. This association remained significant even after adjusting for obesity indices.
Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
Review
Biochemistry & Molecular Biology
Yasuhiro Endo, Masanori Fujita, Katsunori Ikewaki
Summary: Cardiovascular disease (CVD) is the leading cause of death in Western countries. Recent epidemiology studies have shown a U-shaped relationship between high-density lipoprotein cholesterol (HDL-C) levels and CVD mortality, with increased mortality in patients with extremely high HDL-C levels. HDL-C raising therapy using nicotinic acids or CETP inhibitors has shown limited efficacy in reducing CVD events. As a result, the focus has shifted to evaluating HDL functionality as a novel biomarker for CVD risk. This review provides an overview of the current status and future perspectives on HDL functions, based on findings from basic research and clinical trials.
Article
Biochemistry & Molecular Biology
Johanna F. Schachtl-Riess, Stefan Coassin, Claudia Lamina, Egon Demetz, Gertraud Streiter, Richard Hilbe, Florian Kronenberg
Summary: The study found that the per-well method for measuring CEC had lower rejection rates and coefficients of variation compared to the time zero method, and the use of four controls on each plate improved assay performance for both methods. Additionally, the choice of lysis reagents, cell numbers, and assay setup significantly impact the quality and reliability of CEC quantification.
JOURNAL OF LIPID RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Carla Borras, Aina Mercer, Sonia Sirisi, Daniel Alcolea, Joan Carles Escola-Gil, Francisco Blanco-Vaca, Mireia Tondo
Summary: This work aims to review the mechanisms of high-density lipoprotein (HDL)-mediated cholesterol trafficking in the central nervous system (CNS) in the context of Alzheimer's disease (AD). It explores the relationship between HDL-mediated cholesterol transport and Aβ peptide accumulation and apolipoprotein E (ApoE)-mediated cholesterol transport. The existing data suggest decreased cholesterol efflux and impaired cholesterol entry into neurons among patients with AD. However, most studies in this field have been performed in cells that are not physiologically relevant for CNS pathology, which is a major flaw. Further investigations are needed to clarify the role of cholesterol trafficking in AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alberto Cordero, Natalia Munoz-Garcia, Teresa Padro, Gemma Vilahur, Vicente Bertomeu-Gonzalez, David Escribano, Emilio Flores, Pilar Zuazola, Lina Badimon
Summary: This study investigated the role of lipoprotein functionality as well as particle number and size in patients with acute coronary syndrome (ACS) and on-target LDL-C levels. It was found that ACS patients had higher susceptibility to LDL oxidation and lower HDL-antioxidant capacity. They also had lower HDL-C and Apolipoprotein A-I levels compared to non-ACS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Soudabeh Fallah, Gunther Marsche, Maryam Mohamadinarab, Samaneh Mohassel Azadi, Hooman Ghasri, Reza Fadaei, Nariman Moradi
Summary: This study found reduced CEC in H. pylori infected patients, especially ABCA1-mediated CEC, which is associated with decreased ApoA-I and increased inflammation.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Hubert Scharnagl, Christian Wadsack, Gunther Marsche
Summary: Preeclampsia is associated with increased cardiovascular risk for both mother and child. This study investigated the effects of preeclampsia on lipid metabolism, HDL composition, and function in mothers and neonates. Preeclampsia was linked to dyslipidemia in mothers, including high triglycerides and low HDL-cholesterol levels. Mothers with preeclampsia showed shifts in HDL subclasses and increased levels of HDL-associated apolipoprotein C-II. Neonates born to mothers with preeclampsia had increased total cholesterol levels and reduced HDL cholesterol efflux capacity. These findings suggest that preeclampsia affects both maternal and neonatal lipoprotein metabolism.
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Antonino Picataggi, Amrith Rodrigues, Debra A. Cromley, Hu Wang, Joel P. Wiener, Viktor Garliyev, Jeffrey T. Billheimer, Brian C. Grabiner, Jessica A. Hurt, Allen C. Chen, Xianlin Han, Daniel J. Rader, Domenico Pratico, Nicholas N. Lyssenko
Summary: ABCA7 functions differently from ABCA1 in lipid efflux and HDL synthesis. ABCA7 exhibits more efficient efflux of serine-lipid and phosphatidylinositol to apo A-I, but less efflux of cholesterol compared to ABCA1. Shotgun lipidomic analysis reveals lower phosphatidylcholine content and higher serine-lipid and phosphatidylinositol content in ABCA7-HDL, whereas ABCA1-HDL contains more cholesterol.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Cardiac & Cardiovascular Systems
Johanna F. Schachtl-Riess, Sebastian Schoenherr, Claudia Lamina, Lukas Forer, Stefan Coassin, Gertraud Streiter, Azin Kheirkhah, Yong Li, Heike Meiselbach, Silvia Di Maio, Kai-Uwe Eckardt, Anna Koettgen, Florian Kronenberg
Summary: This study aimed to identify the genetic and non-genetic determinants of HDL-mediated cholesterol efflux capacity (CEC). CEC was measured using serum samples from participants in the German Chronic Kidney Disease (GCKD) study. The results showed that HDL-cholesterol and triglycerides were the main determinants of CEC, and the KLKB1 and CLSTN2 loci were significantly associated with CEC.
Article
Biochemistry & Molecular Biology
Shiva Ganjali, Susan Hosseini, Manfredi Rizzo, Anatol Kontush, Amirhossein Sahebkar
Summary: This study evaluated the capacity of high-density lipoprotein (HDL) to transport cholesterol from lipid-loaded macrophages and aimed to find a reliable and low-cost biomarker for assessing the risk of premature cardiovascular events in patients with familial hypercholesterolemia (FH). HDL subfractions (HDL2 and HDL3) were isolated and their cholesterol efflux capacity (CEC%) was measured in FH patients and healthy subjects. The results showed that both HDL2 and HDL3 had reduced CEC% in homozygous FH patients compared to heterozygous FH patients and healthy subjects. Logistic regression analysis revealed a strong inverse association between CEC% and the homozygous form of FH. Decreased HDL cholesterol efflux capacity may help identify homozygous FH patients at increased risk for premature cardiovascular diseases. Prospective studies are needed to further evaluate this hypothesis.
Article
Cardiac & Cardiovascular Systems
Damien Denimal, Serge Monier, Isabelle Simoneau, Laurence Duvillard, Bruno Verges, Benjamin Bouillet
Summary: This study found that the improvement of cholesterol efflux capacity (CEC) of high-density lipoproteins (HDLs) in relation to a decrease in the carbamylation of HDLs may contribute to reducing cardiovascular risk in type 1 diabetes (T1D) patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Mohamad O. Ahmed, Rachel E. Byrne, Agnieszka Pazderska, Ricardo Segurado, Weili Guo, Anjuli Gunness, Isolda Frizelle, Mark Sherlock, Khalid S. Ahmed, Anne McGowan, Kevin Moore, Gerard Boran, Fiona C. McGillicuddy, James Gibney
Summary: The size of HDL particles, rather than the level of HDL-cholesterol, is independently associated with enhanced total CEC. Individuals with type 1 diabetes have larger HDL particle size, but even after adjustment, total and ABCA1-independent CEC are increased in type 1 diabetes.
Article
Biochemistry & Molecular Biology
Maria Pia Adorni, Marta Biolo, Francesca Zimetti, Marcella Palumbo, Nicoletta Ronda, Paolo Scarinzi, Paolo Simioni, Maria Giovanna Lupo, Nicola Ferri, Lorenzo Previato, Franco Bernini, Alberto Zambon
Summary: Achilles tendon xanthoma formation is related to macrophage cholesterol accumulation and is influenced by lipoprotein dysfunctions. The HDL capacity to promote cholesterol efflux is increased in patients with ATX, while ABCG1-mediated HDL-CEC is decreased and serum CLC is increased. These lipoprotein dysfunctions are correlated with ATX thickness in FH patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Public, Environmental & Occupational Health
Pauli Ohukainen, Jyrki K. Virtanen, Mika Ala-Korpela
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Peripheral Vascular Disease
Joonatan Palmu, Emmi Tikkanen, Aki S. Havulinna, Erkki Vartiainen, Annamari Lundqvist, Matti O. Ruuskanen, Markus Perola, Mika Ala-Korpela, Pekka Jousilahti, Peter Wurtz, Veikko Salomaa, Leo Lahti, Teemu Niiranen
Summary: This study examines the association between metabolic biomarkers and hypertension using cross-sectional and longitudinal data from a large population sample in Finland. The results suggest that serum lipids and abnormalities in glucose metabolism are associated with the onset of hypertension. The use of serum metabolite determination could improve the identification of individuals at high risk of developing hypertension.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Scott T. Chiesa, Marietta Charakida, Georgios Georgiopoulos, Justin D. Roberts, Simon J. Stafford, Chloe Park, Juha Mykkanen, Mika Kahonen, Terho Lehtimaki, Mika Ala-Korpela, Olli Raitakari, Milla Pietiainen, Pirkko Pussinen, Vivek Muthurangu, Alun D. Hughes, Naveed Sattar, Nicholas J. Timpson, John E. Deanfield
Summary: GlycA is associated with the development of cardiovascular disease risk and predicts the risk of hypertension and metabolic syndrome. In contrast, CRP has little correlation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Ville-Petteri Makinen, Mari Karsikas, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This study investigated metabolic ageing trends in two large cohorts using new methods, revealing that women gained more weight but showed milder metabolic changes compared to men. Temporal sex differences were observed for certain metabolic markers, and individuals with different weight changes exhibited divergent patterns in certain metabolic measures.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Qin Wang, Tom G. Richardson, Eleanor Sanderson, Matthew J. Tudball, Mika Ala-Korpela, George Davey Smith, Michael Holmes
Summary: This study used Mendelian randomization analysis to evaluate the causes and consequences of atrial fibrillation (AF). The results showed that body mass index, height, systolic blood pressure, and genetic liability to coronary artery disease are independent causal risk factors for AF. Additionally, several proteins were identified as having therapeutic potential for AF.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Letter
Public, Environmental & Occupational Health
Tianqi Li, Andrei Ihanus, Pauli Ohukainen, Marjo-Riitta Jarvelin, Johannes Kettunen, Ville-Petteri Makinen, Tuulia Tynkkynen, Mika Ala-Korpela
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Panu K. Luukkonen, Sami Qadri, Noora Ahlholm, Kimmo Porthan, Ville Mannisto, Henna Sammalkorpi, Anne K. Penttila, Antti Hakkarainen, Tiina E. Lehtimaki, Melania Gaggini, Amalia Gastaldelli, Mika Ala-Korpela, Marju Orho-Melander, Johanna Arola, Anne Juuti, Jussi Pihlajamaki, Leanne Hodson, Hannele Yki-Jarvinen
Summary: This study demonstrated that the mechanisms underlying the metabolic and genetic components of NAFLD are fundamentally different. The metabolic component is characterized by hepatic oversupply of substrates, while the genetic component is characterized by impaired hepatic mitochondrial function.
JOURNAL OF HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Sanna Kuusisto, Minna K. Karjalainen, Therese Tillin, Antti J. Kangas, Michael Holmes, Mika Kahonen, Terho Lehtimaki, Jorma Viikari, Markus Perola, Nishi Chaturvedi, Veikko Salomaa, Olli T. Raitakari, Marjo-Riitta Jarvelin, Johannes Kettunen, Mika Ala-Korpela
Summary: The association between HDL-CEC and CHD is inconsistent, and the genetic architecture of HDL-CEC is limited. In contrast to HDL-C, apolipoprotein A-I, and most HDL subclass particle concentrations, HDL-CEC is not unequivocally associated with CHD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Biochemistry & Molecular Biology
Tianqi Li, Tuulia Tynkkynen, Andrei Ihanus, Siyu Zhao, Ville-Petteri Makinen, Mika Ala-Korpela
Summary: This study systematically compared the effects of seven different normalization schemes in quantitative urinary metabolomics. It found that normalization methods have a significant impact on the associations between intra-urine metabolites, but only minor influences on epidemiological regression analyses with clinical/physiological measures. Multimetabolite normalization schemes showed consistent results with the customary creatinine reference. However, further research is needed for better understanding of intra-urine metabolite associations and nuanced interpretation of epidemiological associations.
Editorial Material
Public, Environmental & Occupational Health
Mika Ala-Korpela
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Mika Ala-Korpela, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Johannes Kettunen, Olli T. Raitakari, Ville-Petteri Makinen
Summary: This study tested whether cross-sectional modeling can distinguish slow vs accelerated aging in a human population. A machine learning model was trained to predict age and tested against longitudinal data. The results showed that the cross-sectional proxy failed to predict longitudinal observations, suggesting that differences in starting points may explain diverging aging rates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Sport Sciences
Miia Lehtovirta, Feitong Wu, Suvi P. Rovio, Olli J. Heinonen, Tomi T. Laitinen, Harri Niinikoski, Hanna Lagstrom, Jorma S. A. Viikari, Tapani Ronnemaa, Antti Jula, Mika Ala-Korpela, Olli T. Raitakari, Katja Pahkala
Summary: Physical activity during adolescence is significantly associated with the metabolic profile, including serum lipoproteins, amino acids, and glucose metabolism. These results support recommendations for physical activity during adolescence to promote health and reduce future disease risks.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Endocrinology & Metabolism
Ville-Petteri Makinen, Johannes Kettunen, Terho Lehtimaki, Mika Kahonen, Jorma Viikari, Markus Perola, Veikko Salomaa, Marjo-Riitta Jarvelin, Olli T. Raitakari, Mika Ala-Korpela
Summary: This observational study examines the complex temporal associations between body-mass index (BMI), waist-hip ratio (WHR), and circulating metabolomics. It uses longitudinal and cross-sectional population-based datasets and new systems epidemiology tools. The results show that age-associated weight variation in adults between 24 and 49 manifests as temporal divergence in BMI and uniform progression of WHR.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Multidisciplinary Sciences
Noora Oikarinen, Terhi Jokelainen, Laura Heikkilae, Marjukka Nurkkala, Janne Hukkanen, Tuire Salonurmi, Markku J. Savolainen, Anna-Maria Teeriniemi
Summary: Success in long-term weight management relies on psychological and behavioral factors. This study investigates the association between eating self-efficacy (ESE) and various eating behaviors and difficulties in weight management. Participants with low ESE showed lower cognitive restraint (CR) and higher levels of uncontrolled eating (UE), emotional eating (EE), and binge eating (BE) compared to those with high ESE. The risk of low ESE was increased by high levels of UE, EE, and BE in men, and by low CR, high UE, and high EE in women. These findings highlight the importance of considering eating behavior tendencies when counseling individuals with overweight and obesity.
SCIENTIFIC REPORTS
(2023)