Article
Endocrinology & Metabolism
Goh Eun Chung, Eun Ju Cho, Min Joo Kim, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Kyungdo Han, Yoon Jun Kim, Jung-Hwan Yoon, Dong Wook Shin, Su Jong Yu
Summary: The study found that a higher fatty liver index (FLI) is associated with an increased risk of hip and vertebral fractures among individuals aged 50 and above. This association is more prominent in non-obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Chia-Hsin Liu, Chi-You Liao, Ming-Hsin Yeh, James Cheng-Chung Wei
Summary: This study aimed to analyze the National Health Insurance Research Database (NHIRD) in Taiwan, investigate the association between human papillomavirus (HPV) infection and the risk of breast carcinoma. The findings revealed that patients with HPV had a higher risk of developing breast cancer, particularly in older age groups. Additionally, hypertension, chronic obstructive pulmonary disease, and diabetes mellitus were significant risk factors for breast cancer.
Article
Endocrinology & Metabolism
Eun Ji Lee, Cheol Min Shin, Dong Ho Lee, Kyungdo Han, Sang Hyun Park, Yoo Jin Kim, Hyuk Yoon, Young Soo Park, Nayoung Kim
Summary: Individuals who underwent cholecystectomy have an increased risk of fractures, especially vertebral and hip fractures. The risk of vertebral fractures following cholecystectomy is more prominent in the younger population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Heng-Ching Liao, Fang-Ju Lin, Chien-Ning Hsu, Susan Shur -Fen Gau, Chi-Chuan Wang
Summary: This study examined the use of methylphenidate and atomoxetine in patients diagnosed with attention deficit hyperactivity disorder (ADHD) in Taiwan between 2004 and 2017. The study investigated the initial treatment for ADHD, the time between diagnosis and prescription, and medication-switching patterns. The majority of patients (98.2%) received methylphenidate, while atomoxetine use increased over time. The study also found that the prevalence of pharmacotherapy for ADHD was relatively low.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Phuong Thao Do, Li-Ying Chen, Lung Chan, Chaur-Jong Hu, Li-Nien Chien
Summary: This study investigated the long-term incidence and risk factors for poststroke epilepsy (PSE) in young adults. The study found that stroke severity, aphasia, malignancy, and drug abuse were associated with an increased risk of PSE, while statin use was associated with a lower risk. Decreasing the severity of stroke, using statin medication, and controlling unhealthy behaviors can potentially reduce the development of PSE. Identification and intervention based on risk factors could lead to early management of PSE and reduce its harmful effects.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Fan-Wen Lin, Ming-Hsin Yeh, Cheng-Li Lin, James Cheng-Chung Wei
Summary: There is a special association between breast cancer and second primary lung cancer in Taiwanese women, particularly in younger groups and in those without any comorbidities, which is supposed to increase public awareness.
Article
Psychology, Clinical
Yi-An Hung, Shih-Cheng Liao, Chia-Ming Chang, Shu-Sen Chang, Albert C. Yang, Yi-Ling Chien, Chi-Shin Wu, Susan Shur-Fen Gau
Summary: This study aimed to estimate the population-attributable risk of psychiatric disorders associated with suicide among Taiwanese youth aged 10-24 years. The findings suggest that major depressive disorder, dysthymia, and sleep disorder are strongly associated with youth suicides.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Dongyeop Kim, Jee Hyun Kim, Tae-Jin Song
Summary: This study found that variability in serum total cholesterol (TC) is associated with the risk of osteoporotic fractures. Higher TC variability was significantly associated with an increased risk of overall osteoporotic fractures, as well as vertebral and hip fractures. Maintaining stable TC levels may help reduce the risk of osteoporotic fractures in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Daye Diana Choi, Kyung-Ah Park, Mi Yang, Seonwoo Kim, Ji Hyun Roh, Sei Yeul Oh
Summary: The study found that South Korean children and adolescents with strabismus had a higher relative risk for various types of mental disorders such as developmental disorder, autism, ADHD, and OCD compared to the controls, while they had a relatively lower risk of tic disorder.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chun-Kai Chang, Wu-Chien Chien, Wan-Fu Hsu, Hao-Yu Chiao, Chi-Hsiang Chung, Yuan-Sheng Tzeng, Shao-Wei Huang, Kuang-Ling Ou, Chih-Chien Wang, Shyi-Jou Chen, Der-Shiun Wang
Summary: This cohort study in Taiwan found that patients exposed to fluoroquinolones were at a significantly higher risk of tendon disorders. Patients under 18 and over 60 years old, those with chronic kidney disease, diabetes, rheumatologic disease, cardiac disease, lipid disorder, or obesity, as well as those who concomitantly used statins, aromatase inhibitors, or glucocorticoids, had a significantly higher risk of tendon disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Developmental
Mao-Hsiu Hua, Kai-Lin Huang, Ju-Wei Hsu, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Cheng-Ta Li, Wei-Chen Lin, Tzeng-Ji Chen, Mu-Hong Chen
Summary: The study revealed that adolescents with ADHD were more likely to experience pregnancy and early pregnancy compared to their counterparts without ADHD. Long-term use of ADHD medication was associated with a decreased risk of subsequent early pregnancy.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Medicine, General & Internal
Wan-Ting Hsu, Charles Fox Sherrod, Babak Tehrani, Alexa Papaila, Lorenzo Porta, Tzu-Chun Hsu, Wang-Huei Sheng, Chien-Chang Lee
Summary: Using the National Health Insurance Research Database of Taiwan, a study found that patients with sepsis had an increased risk of out-of-hospital cardiac arrest (OHCA) after hospital discharge, especially among those with cardiovascular disease.
Article
Endocrinology & Metabolism
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo, Kyung-Do Han
Summary: This study found a significant increase in the risk of insomnia in patients with diabetic retinopathy (DR). Men and younger age groups were more vulnerable to insomnia. Sex, age, DM duration, and chronic kidney disease (CKD) status interacted with DR status to further increase the risk of insomnia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Chuck Lin, Stella Chin-Shaw Tsai, Jing-Yang Huang, Frank Cheau-Feng Lin
Summary: The prevalence of breast cancer has increased globally, and there is evidence suggesting a correlation between HPV and breast cancer. A study in Taiwan found that HPV patients had a higher risk of developing breast cancer compared to non-HPV patients, and this risk was also influenced by age, insurance providers, and comorbidities.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Tsung-Po Chen, Hui-Chieh Yu, Tai-Hsin Lin, Yu-Hsun Wang, Yu-Chao Chang
Summary: This population-based cohort study in Taiwan found an association between obesity and the development of chronic periodontitis (CP), with obese patients having a 1.12-fold increased risk of CP compared to non-obese patients. The risk was higher in patients aged 65 or older. Differences in CP risk between obesity and non-obesity groups were not observed by sex.
Review
Clinical Neurology
Oloruntoba J. Oluboka, Martin A. Katzman, Jeffrey Habert, Atul Khullar, Margaret A. Oakander, Diane McIntosh, Roger S. McIntyre, Claudio N. Soares, Raymond W. Lam, Larry J. Klassen, Robert Tanguay
Summary: Major depressive disorder (MDD) is the leading cause of disability worldwide, and comorbid chronic pain exacerbates disability and healthcare burden. Managing patients with both MDD and chronic pain can be challenging due to shared underlying mechanisms. Current treatment guidelines address comorbid conditions such as anxiety and cardiovascular disease, but not chronic pain. Rapidly and aggressively treating depression according to guideline recommendations, using antidepressants with analgesic properties, while also addressing pain, is recommended based on clinical experience.
Article
Clinical Neurology
Roger S. McIntyre, David G. Daniel, Eduard Vieta, Istvan Laszlovszky, Pascal J. Goetghebeur, Willie R. Earley, Mehul D. Patel
Summary: Post hoc analyses suggest that cariprazine may have potential benefits in improving cognitive symptoms in patients with bipolar I disorder and schizophrenia.
Review
Psychiatry
Smadar V. Tourjman, Gabriella Buck, Didier Jutras-Aswad, Atul Khullar, Shane McInerney, Gayatri Saraf, Jairo V. Pinto, Stephane Potvin, Marie-Josee Poulin, Benicio N. Frey, Sidney H. Kennedy, Raymond W. Lam, Glenda MacQueen, Roumen Milev, Sagar V. Parikh, Arun Ravindran, Roger S. McIntyre, Ayal Schaffer, Valerie H. Taylor, Michael van Ameringen, Lakshmi N. Yatham, Serge Beaulieu
Summary: This task force report examines the association between cannabis use and bipolar disorder, major depressive disorder, and comorbid cannabis use disorder. The results indicate that cannabis use is associated with worsened course and functioning of both mood disorders, particularly in bipolar disorder. However, the treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Psychiatry
Joshua D. Rosenblat, M. Ishrat Husain, Yena Lee, Roger S. McIntyre, Rodrigo B. Mansur, David Castle, Hilary Offman, Sagar Parikh, Benicio N. Frey, Ayal Schaffer, Kyle T. Greenwaym, Nicolas Garel, Serge Beaulieu, Sidney H. Kennedy, Raymond W. Lam, Roumen Milev, Arun Ravindran, Valerie Tourjman, Michael Van Ameringen, Lakshmi N. Yatham, Valerie Taylor
Summary: There is currently only low-level evidence to support the efficacy and safety of psychedelics for major depressive disorder.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Clinical Neurology
Muhammad Youshay Jawad, Shakila Meshkat, Aniqa Tabassum, Andrea Mckenzie, Joshua D. Di Vincenzo, Ziji Guo, Nabiha Batool Musavi, Lee Phan, Felicia Ceban, Angela T. H. Kwan, Ranuk Ramachandra, Gia Han Le, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger Ho, Taeho Greg Rhee, Roger S. McIntyre
Summary: Nonalcoholic fatty liver disease (NAFLD) is associated with psychiatric disorders, in particular mood disorders, due to various reasons such as dysregulation of the hypothalamic-pituitary-adrenal axis, metabolic syndrome, and chronic perceived stress. The clinical manifestations and treatment strategies of mood disorders can increase the susceptibility of patients to develop NAFLD. Regular screenings for NAFLD are recommended in patients with mood disorders exhibiting signs of increased risk to ensure better diagnosis and holistic care for both conditions.
Article
Neurosciences
Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Sebastian Badulescu, Kayla M. Teopiz, Aniqa Tabassum, Felicia Ceban, Andrea Mckenzie, Shakila Meshkat, Joshua D. Rosenblat, Roger C. Ho, Roger S. McIntyre
Summary: Ketamine has emerged as a novel and effective antidepressant, with the potential to improve various domains of depressive symptomatology. While its effectiveness in reducing depression severity is well-studied, more research is needed to explore its effects on cognition, anhedonia, suicidality, and psychosocial functionality. Findings suggest that ketamine is most effective in reducing suicidality but further studies are required to assess its effectiveness in other domains.
Article
Clinical Neurology
William S. H. Kim, Mikaela K. Dimick, Danielle Omrin, Rachel H. B. Mitchell, Daniel Riegert, Anthony Levitt, Ayal Schaffer, Susan Belo, John Iazzetta, Garfield Detzler, Mabel Choi, Stephen Choi, Nathan Herrmann, Roger S. McIntyre, Bradley J. MacIntosh, Beverley A. Orser, Benjamin I. Goldstein
Summary: A study found that an anesthetic gas containing nitrous oxide can significantly reduce depression severity in patients with bipolar disorder. Patients who used nitrous oxide had greater reductions in depression severity on the same day compared to the placebo group. Baseline cerebral blood flow predicted the decrease in depression severity with nitrous oxide, but not with midazolam. The findings suggest differential associations of nitrous oxide versus midazolam with bipolar depression severity and cerebral hemodynamics.
Article
Clinical Neurology
Farhan Fancy, Nelson B. Rodrigues, Joshua D. Di Vincenzo, Edmond H. Chau, Rickinder Sethi, Muhammad I. Husain, Hartej Gill, Aniqa Tabassum, Andrea Mckenzie, Lee Phan, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This study observed the real-world effectiveness of repeated ketamine infusions for treatment-resistant bipolar depression. Results showed that ketamine significantly reduced depressive symptoms, suicidal thoughts, and anxiety, while improving functioning. The more infusions received, the more significant the reduction in symptoms.
Article
Clinical Neurology
Giovanni Martinotti, Bernardo Dell'Osso, Giorgio Di Lorenzo, Giuseppe Maina, Alessandro Bertolino, Massimo Clerici, Stefano Barlati, Gianluca Rosso, Marco Di Nicola, Matteo Marcatili, Giacomo d'Andrea, Clara Cavallotto, Stefania Chiappini, Sergio De Filippis, Giuseppe Nicolo, Pasquale De Fazio, Ileana Andriola, Raffaella Zanardi, Domenica Nucifora, Stefania Di Mauro, Roberta Bassetti, Mauro Pettorruso, Roger S. McIntyre, Stefano L. Sensi, Massimo di Giannantonio, Antonio Vita
Summary: This study aimed to compare the efficacy of esketamine in treating unipolar and bipolar treatment-resistant depression (TRD) and provide preliminary evidence of its effectiveness in bipolar TRD (B-TRD). The results showed that esketamine significantly reduced depressive symptoms in B-TRD patients compared to TRD patients, and it had a better anxiolytic action in B-TRD patients. The low risk of side effects confirmed the safety of this treatment.
Review
Clinical Neurology
Elena Koning, Alexandra McDonald, Alexander Bambokian, Fabiano A. Gomes, Jacob Vorstman, Michael Berk, Jennifer Fabe, Roger S. McIntyre, Roumen Milev, Rodrigo B. Mansur, Elisa Brietzke
Summary: Bipolar disorder (BD) is a chronic mental disorder characterized by depressive and manic episodes, circadian rhythm disruption, and changes in energetic metabolism. Metabolic jet lag is considered a core component of BD pathophysiology, associated with irregular eating rhythms and circadian desynchronization of energetic metabolism.
Article
Environmental Sciences
Yuxiao Zhao, Yueying Zhang, Kayla M. Teopiz, Leanna M. W. Lui, Roger S. McIntyre, Bing Cao
Summary: This study investigated the association between depression, vascular diseases (hypertension, myocardial infarction, stroke), diabetes mellitus, and functional impairment in middle-aged and elderly Chinese people. The results showed that depression was associated with functional decline in individuals with vascular disease/diabetes mellitus, highlighting the importance of treating depression in addition to managing vascular diseases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Psychiatry
Michael E. Thase, Zahinoor Ismail, Stine R. Meehan, Catherine Weiss, Stephane Alexandre Regnier, Klaus Groes Larsen, Roger S. McIntyre
Summary: In this study, a subset of 10 items from the IDS-SR was identified that can measure life engagement in MDD. Different approaches, including expert selection, patient interviews, and PCA, consistently identified these items. These findings suggest the potential for creating an IDS-SR life engagement subscale.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Neurosciences
Muhammad Youshay Jawad, Saleha Qasim, Menglu Ni, Ziji Guo, Joshua D. Di Vincenzo, Giacomo d'Andrea, Aniqa Tabassum, Andrea Mckenzie, Sebastian Badulescu, Iria Grande, Roger S. McIntyre
Summary: The scoping review synthesized the current literature on the use of ketamine in bipolar depression. The preliminary evidence suggests that ketamine is a promising treatment with minimal risk and some effectiveness. Future studies should focus on ketamine's role in acute and maintenance treatment phases, as well as its effects on recurrence prevention and anti-suicidal measures.
Article
Neurosciences
Joanna K. Szmyd, Karol Lewczuk, Kayla M. Teopiz, Roger S. McIntyre, Adam Wichniak
Summary: This pilot study assessed patients' cognitive functioning with the Polish version of the THINC-it tool and analyzed its association with self-reported quality of life. The results suggest that the THINC-it tool has utility as a cognitive measure in adults with schizophrenia in both clinical and research settings.
Article
Psychiatry
Elysha Ringin, David W. Dunstan, Roger S. McIntyre, Neville Owen, Michael Berk, Susan L. Rossell, Mats Hallgren, Tamsyn E. Van Rheenen
Summary: This study examined the impact of physical activity and sedentary behavior on cognitive function in individuals with bipolar disorder. The results showed a negative association between physical activity and passive sedentary behavior with cognitive function, and a positive association between mentally-active sedentary behavior and cognitive function. These associations were stronger in individuals with bipolar disorder.
MENTAL HEALTH AND PHYSICAL ACTIVITY
(2023)