Article
Nutrition & Dietetics
Clare Stradling, G. Neil Thomas, Karla Hemming, Stephen Taylor, Shahrad Taheri
Summary: The study demonstrated the feasibility of adopting a Mediterranean Portfolio diet in people living with HIV, which may lead to short-term improvements in diet quality, blood pressure, and LDL-cholesterol.
CLINICAL NUTRITION
(2021)
Article
Peripheral Vascular Disease
Ching-Way Chen, Yin-Yi Han, Jing-Shiang Hwang, Manfredi Rizzo, Shizuya Yamashita, Sandy Huey-Jen Hsu, Ta-Chen Su
Summary: This study investigates the association between vitamin D deficiency and novel biomarkers of atherogenic dyslipidemia in young adults. The results show a significant correlation between vitamin D levels and lower levels of various lipid profile markers. Individuals with vitamin D levels below 30 ng/mL have a higher risk of developing atherogenic dyslipidemia in a dose-response manner. The study also suggests that vitamin D does not significantly affect atherogenic lipid markers through insulin resistance markers or high-sensitivity C-reactive protein.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Nutrition & Dietetics
Arpita Basu, Kenneth Izuora, Nancy M. Betts, Jefferson W. Kinney, Arnold M. Salazar, Jeffrey L. Ebersole, R. Hal Scofield
Summary: The study suggests that consuming two-and-a-half servings of strawberries for four weeks significantly improves insulin resistance, lipid particle profiles, and serum PAI-1 in obese adults with elevated serum LDL-C.
Article
Nutrition & Dietetics
Mengjie Yuan, Martha R. Singer, Richard T. Pickering, Lynn L. Moore
Summary: The study found that higher intake of saturated fats from dairy sources in females was associated with lower levels of body fat and larger LDL particle sizes, while saturated fats from nondairy sources were inversely associated with the triglyceride:HDL ratio. In males, higher intake of dairy-derived saturated fats was associated with a less atherogenic profile, including lower levels of inflammatory markers and improved lipid particle sizes and concentrations.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Nicholas G. Norwitz, Adrian Soto-Mota, David Feldman, Stefanos Parpos, Matthew Budoff
Summary: Emerging evidence suggests that leanness and good metabolic health markers may predict larger increases in LDL cholesterol (LDL-C) in response to carbohydrate restriction. Specifically, a recent cohort study identified a subgroup of individuals, known as Lean Mass Hyper-Responders (LMHR), who exhibit exceptional increases in LDL-C despite low triglycerides and high HDL-C levels. This case study presents the results of one subject, LM, who experienced a significant increase in LDL-C after adopting a ketogenic diet for ulcerative colitis management. The findings suggest that the LMHR phenotype is not dependent on saturated fat intake but may be inversely associated with changes in BMI. Interestingly, computed tomography angiography revealed no evidence of plaque formation in LM after more than 2 years of hypercholesterolemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Julia T. Stadler, Sonja Lackner, Sabrina Morkl, Nathalie Meier-Allard, Hubert Scharnagl, Alankrita Rani, Harald Mangge, Sieglinde Zelzer, Sandra J. Holasek, Gunther Marsche
Summary: Anorexia nervosa has detrimental effects on lipid metabolism and increases atherosclerotic risk factors.
Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Zahra Heidari, Zahra Kiani, Masoumeh Atefi, Azadeh Zareie, Mehrnaz Shojaei, Gholamreza Askari, Prashant Kesharwani, Mohammad Bagherniya
Summary: This meta-analysis evaluated the effects of the DASH diet on lipid profiles based on clinical controlled trials. The results showed that following the DASH diet significantly reduced serum triglycerides and low-density lipoprotein cholesterol levels, but had no significant effect on serum total cholesterol and high-density lipoprotein cholesterol levels. Therefore, the DASH diet can be considered as a strategy for the prevention and complementary management of dyslipidemia.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Sei Kim, Hye Kyung Jeon, Gyeonghee Lee, Youbin Kim, Hae Young Yoo
Summary: This study investigates the genetic impact of dyslipidemia according to sex and explores the associations between genetic variants and dietary patterns. It finds that dyslipidemia is substantially linked to genetic variations and lifestyle factors, with distinct sex-specific characteristics. The study suggests the potential for implementing sex-specific strategic interventions to prevent dyslipidemia, considering the influence of genetic factors and dietary patterns.
Article
Biochemistry & Molecular Biology
Beatrix Paton, Elisabet Foguet-Romero, Manuel Suarez, Jordi Mayneris-Perxachs, Noemi Boque, Antoni Caimari, Nuria Canela, Pol Herrero
Summary: The consumption of diets rich in saturated fats is associated with higher mortality. Adopting healthy habits, such as adhering to a Mediterranean diet, has been shown to have a preventive effect on cardiovascular diseases and dyslipidemia. However, the effects of an suboptimal diet on brain function and structure are still poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yulong Lan, Dan Wu, Zhiwei Cai, Yuancheng Xu, Xiong Ding, Weiqiang Wu, Shaocong Lan, Lan Chen, Zheng Guo, Lois Balmer, Xingang Li, Manshu Song, Shouling Wu, Jingli Gao, Wei Wang, Youren Chen
Summary: Both chronic inflammation and atherogenic dyslipidemia are associated with an increased risk of developing type 2 diabetes, especially in young adults. The study suggests that a combined assessment and management of these two factors is important in preventing diabetes, particularly in young adults.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medicine, General & Internal
Meleeka Akbarpour, Divya Devineni, Yufan Gong, Nathan D. Wong
Summary: This study examined lipid levels and treatment status in patients with diabetes mellitus (DM), finding a lack of guideline-recommended use of high-intensity statins and inadequately controlled LDL-C among high-risk DM patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Sunniva Larsen, Kirsten B. Holven, Jacob J. Christensen, Arnar Flatberg, Amanda Rundblad, Lena Leder, Rune Blomhoff, Vibeke Telle-Hansen, Marjukka Kolehmainen, Carsten Carlberg, Mari C. Myhrstad, Magne Thoresen, Stine M. Ulven
Summary: This study aimed to explore the molecular mechanisms of replacing dietary SFA with PUFA on CVD risk using a whole transcriptome approach. It found that an 8-week intervention modulated PBMC gene expression and pathways related to CVD risk.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Hayley G. Law, Frederick J. Meyers, Lars Berglund, Byambaa Enkhmaa
Summary: This article discusses the new evidence regarding the current dietary recommendations to reduce saturated fatty acid (SFA) intake for modulating an individual's global risk of cardiovascular disease (CVD). While it is known that reducing dietary SFA intake has a beneficial effect on LDL cholesterol concentrations, there is increasing evidence of an opposite effect on lipoprotein(a) (Lp(a)) concentrations. This study highlights the contrasting effects of reducing dietary SFA intake on LDL cholesterol and Lp(a), two highly atherogenic lipoproteins.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Xincen Wang, Qinsheng Chen, Xiaoxu Wang, Peixu Cong, Jie Xu, Changhu Xue
Summary: Ether-phospholipids in sea urchins, particularly PE-P and PC-O, have potential lipid-regulating effects in high-fat-induced atherosclerotic hamsters. PE-P is more effective than PC-O in decreasing total cholesterol and LDL cholesterol concentrations in serum. These lipid effects may be attributed to modulation of lipid metabolism and regulation of gene expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yin-Yi Han, Sandy Huey-Jen Hsu, Ta-Chen Su
Summary: This study found that vitamin D deficiency is more common in females, smokers, alcohol drinkers, individuals at a younger age, and those who do not exercise regularly. Additionally, high levels of sdLDL-C were associated with low serum vitamin D levels and were more common among individuals with certain risk factors like smoking and alcohol consumption. The study also revealed a strong negative correlation between low vitamin D status and atherogenic dyslipidemia biomarkers in middle-aged adults without cardiovascular disease.
Editorial Material
Nutrition & Dietetics
Patty W. Siri-Tarino, Ronald M. Krauss
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Nutrition & Dietetics
Penny M. Kris-Etherton, Ronald M. Krauss
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Nutrition & Dietetics
Ronald M. Krauss, Penny M. Kris-Etherton
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Editorial Material
Nutrition & Dietetics
Ronald M. Krauss, Penny M. Kris-Etherton
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Pharmacology & Pharmacy
Yu-Lin Kuang, Elizabeth Theusch, Ronald M Krauss, Marisa W Medina
Summary: Statins have varying efficacy in reducing low-density lipoprotein levels and cardiovascular disease risk among individuals, with a small but significant risk of adverse effects such as myopathy and diabetes. Identifying biomarkers to predict patients who would benefit most from statin treatment without increasing risk of side effects could have a significant impact on public health. This review discusses the use of lymphoblastoid cell lines in studying statin pharmacogenomics and different approaches to identify genetic markers associated with individual differences in statin response.
Article
Cardiac & Cardiovascular Systems
Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia-Garcia, Stanley L. Hazen, W. H. Wilson Tang
Summary: This study found that fecal microbiome composition cannot predict systemic TMAO levels, possibly because the abundance of known genes related to TMAO production is not sufficient to predict bacterial metabolic activity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)