Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Review
Immunology
Yi Ren, Henrik Baecker, Michael Mueller, Arne Kienzle
Summary: The immune system has a significant impact on bone metabolism in various pathological and inflammatory conditions. Myeloid-derived suppressor cells (MDSCs) are a group of cells that can suppress immune responses and mediate bone remodeling. They can both cause bone erosion through differentiation into osteoclasts and alleviate immune reactions. This review discusses the influence of MDSCs on bone metabolism and potential therapeutic targets for improving bone health.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Kathryn Cole, Kristina Pravoverov, James E. Talmadge
Summary: Metastasis, the spread of primary tumor cells to distant organs, is the main cause of cancer mortality, and understanding its timing and mechanisms is crucial. Tumor cells may enter a dormant state during metastasis before forming occult lesions, regulated by immune responses and interactions. Myeloid-derived suppressor cells play a major role in tumor progression, potentially promoting escape from dormancy and the development of occult metastases.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Oncology
Kathryn Cole, Zaid Al-Kadhimi, James E. Talmadge
Summary: The establishment of primary tumor cells in distant organs, known as metastasis, is the main cause of cancer mortality and an important target for cancer treatment. Understanding the metastatic progression and the mechanisms involved is crucial for developing effective therapeutic approaches. Myeloid derived suppressor cells (MDSCs) play a role in tumor escape from immune responses and tumor progression. However, their role in dormancy and tumor recurrence needs further investigation. Assessing the impact of therapies on MDSCs is challenging due to the complexity of multimodality interventions.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Oncology
Sheng-Yung Fu, Fang-Hsin Chen, Chun-Chieh Wang, Ching-Fang Yu, Chi-Shiun Chiang, Ji-Hong Hong
Summary: The study demonstrates that PMN-MDSCs infiltrate TRAMP-C1 tumors after high-dose radiation therapy, promoting tumor growth. Their spatial distribution within the tumor suggests their involvement in the development of tumor necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Cheng Cui, Penglin Lan, Li Fu
Summary: Gastrointestinal cancer is the most common type of cancer worldwide, with increasing incidence and mortality rates. Myeloid-derived suppressor cells (MDSCs) play a key role in regulating the immune response to tumors and may serve as prognostic markers and therapeutic targets in cancer patients.
CANCER COMMUNICATIONS
(2021)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Geriatrics & Gerontology
Qianling Jiang, Jielin Duan, Luc Van Kaer, Guan Yang
Summary: Myeloid-derived suppressor cells (MDSCs), a heterogeneous cell population consisting mostly of immature myeloid cells, have been found to play a role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Accumulation of MDSCs has been observed in inflamed tissues and lymphoid organs of MS patients and EAE mice, but their contribution to the pathogenesis of MS/EAE remains unclear. This review aims to summarize our current understanding of MDSC subsets and their potential roles in MS/EAE pathogenesis. We also discuss the potential utility and obstacles in using MDSCs as biomarkers and cell-based therapies for MS.
Review
Surgery
Xia Zheng, Jie Shao, Sihui Wei, Yu Gu, Jun Qian
Summary: Increased expression of SOCS3 in tumor mass is associated with better disease-free survival (DFS) and overall survival (OS), suggesting it could be a novel and reliable biomarker for predicting the risk of cancer recurrence and mortality.
FRONTIERS IN SURGERY
(2022)
Review
Cell Biology
Houhui Shi, Kai Li, Yanghong Ni, Xiao Liang, Xia Zhao
Summary: T cell-based immunotherapy plays a crucial role in cancer treatment, but many patients still do not benefit from it. Researchers have identified myeloid-derived suppressor cells (MDSCs) as a key factor in immunotherapy resistance and are exploring combination therapies to improve efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Luisa Sanchez-Leon, Carlos Jimenez-Cortegana, Silvia Silva Romeiro, Carmen Garnacho, Luis de la Cruz-Merino, Daniel J. Garcia-Dominguez, Lourdes Hontecillas-Prieto, Victor Sanchez-Margalet
Summary: Breast cancer is the most diagnosed tumor in women with diverse molecular profiles. Despite the advancements in early detection and therapy, patients with metastatic disease have low survival rates. Immunotherapy, due to its ability to modulate the immune system, has emerged as a promising alternative. This review focuses on the new immunotherapies in breast cancer in the last five years and discusses the role of myeloid-derived suppressor cells as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aixia Dou, Jing Fang
Summary: Myeloid cells play a crucial role in tumor development, with pro-tumor and anti-tumor functions that impact tumor cells, tumor microenvironment, and immune system.
Article
Cardiac & Cardiovascular Systems
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki
Summary: In this study, prophylactic anti-Ly6G antibody administration was found to have a protective effect against ischemic stroke by reducing activated neutrophil infiltration and neutrophil extracellular trap formation in the brain parenchyma, as well as suppressing polymorphonuclear myeloid-derived suppressor cell accumulation. This study may provide a novel therapeutic approach for ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Oncology
Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao
Summary: Metastasis is a complex process that relies on the interaction between tumor cells and host organs, with the formation of a pre-metastasis niche being crucial. Myeloid-derived suppressor cells play a key role in this process, and targeting these cells as a therapeutic strategy may help inhibit the formation of the pre-metastasis niche and curb tumor metastasis.
FRONTIERS IN ONCOLOGY
(2022)