LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3

(2015) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway

(2015) Fang Liang et al.   MEDICAL ONCOLOGY

Targeted Deletion of the Murine Lgr4 Gene Decreases Lens Epithelial Cell Resistance to Oxidative Stress and Induces Age-Related Cataract Formation

(2015) Jun Zhu et al.   PLoS One

A Naturally Occurring Lgr4 Splice Variant Encodes a Soluble Antagonist Useful for Demonstrating the Gonadal Roles of Lgr4 in Mammals

(2014) Pei-Jen Hsu et al.   PLoS One

Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium

(2014) Alla V. Kuznetsova et al.   Journal of Ophthalmology

GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling

(2013) Yong-Bin Zhu et al.   Asian Pacific Journal of Cancer Prevention

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

(2013) Jinhua Wu et al.   CARCINOGENESIS

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits

(2013) Unnur Styrkarsdottir et al.   NATURE

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

(2011) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation

(2010) Zhenlian Wang et al.   FEBS LETTERS

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA