Article
Biochemistry & Molecular Biology
Kyota Ishii, Mayuko Hido, Misaki Sakamura, Nantiga Virgona, Tomohiro Yano
Summary: This study demonstrated that T3, TOS, and T3E enhance the sensitivity of the proteasome inhibitor BTZ in solid cancers by modulating the activity of NFE2L1. Inactivation of NFE2L1 by T3, TOS, and T3E is essential to potentiate the cytotoxic effect of BTZ in solid cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Yilin Bai, Bingqian Su, Xuan Cheng, Qianwen Liu, Lei Zeng, Pengfei Fu
Summary: This study found that gossypol has a significant inhibitory effect on pseudorabies virus (PRV). The anti-PRV effect of gossypol does not involve direct inactivation of the virus, stimulation of interferon-beta, reactive oxygen species or ATP, or induced autophagy. Gossypol exerts its anti-PRV effect by inhibiting the adsorption of the virus on the cell surface.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Oncology
Gregoire Quinet, Wendy Xolalpa, Diana Reyes-Garau, Nuria Profitos-Peleja, Mikel Azkargorta, Laurie Ceccato, Maria Gonzalez-Santamarta, Maria Marsal, Jordi Andilla, Fabienne Aillet, Francesc Bosch, Felix Elortza, Pablo Loza-Alvarez, Brigitte Sola, Olivier Coux, Rune Matthiesen, Gael Roue, Manuel S. Rodriguez
Summary: The research identified an enrichment of autophagy-lysosome system (ALS) components in bortezomib (BTZ)-resistant cells in mantle cell lymphoma (MCL) patients. By blocking proteaphagy, the normal proteasomal activity was reactivated and the BTZ antitumor effect was restored in vitro and in vivo models of BTZ resistance. These findings suggest a proteolytic switch from the ubiquitin-proteasome system (UPS) to ALS in B-cell lymphoma refractory to proteasome inhibition, opening up new therapeutic avenues for treatment-resistant tumors.
Article
Biology
Min Seung Lee, So Hyun Lim, Ah-Ran Yu, Chi Yeon Hwang, Insug Kang, Eui-Ju Yeo
Summary: The study showed that proteasome inhibitors bortezomib and carfilzomib induce apoptosis and endoplasmic reticulum stress in melanoma cells, leading to potential therapeutic effects against melanoma. Combination therapy of carfilzomib and bortezomib at submaximal concentrations synergistically reduced tumor growth, suggesting a promising strategy for the treatment of melanoma.
Review
Biochemistry & Molecular Biology
Jianhao Liu, Ruogang Zhao, Xiaowen Jiang, Zhaohuan Li, Bo Zhang
Summary: Bortezomib is a proteasome inhibitor that has been approved for the treatment of multiple myeloma and other hematological cancers. However, its limited specificity, poor permeability, and low bioavailability hinder its applications. Recent research has focused on the development of BTZ-based drug delivery systems.
Article
Oncology
Tiit Ord, Daima Ord, Minna U. Kaikkonen, Tonis Ord
Summary: Proteasome inhibitors, like bortezomib, are used in the treatment of certain cancers, but resistance may develop. This study explores the molecular mechanisms behind liver cancer cells' resistance to bortezomib, focusing on the role of the eIF2 alpha-ATF4 stress response pathway and the pseudokinase TRIB3. Their findings suggest that TRIB3, by limiting ATF4 activity, contributes to bortezomib resistance, while pharmacological activation of eIF2 alpha-ATF4 pathway can sensitize cells to bortezomib.
Article
Cell Biology
Yen-Chun Wang, Li-Ting Wang, Ta Hung, Yi-Ren Hong, Chung-Hwan Chen, Cheng-Jung Ho, Chihuei Wang
Summary: For the past two decades, p53 has been considered the primary sensor initiating apoptosis, but our studies indicate that it may not play a role in doxorubicin-induced apoptosis in prostate cancer, glioblastoma, and osteosarcoma. The transcriptional activity of p53 seems to be more related to cell cycle arrest rather than apoptosis in response to severe cellular stress. Additionally, a proteasome inhibitor, bortezomib, can induce apoptosis independently of p53 in glioblastoma and osteosarcoma.
CELL DEATH DISCOVERY
(2022)
Review
Immunology
Naeemeh Khalesi, Shahla Korani, Mitra Korani, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Autoimmune diseases are conditions where the immune system cannot distinguish self from non-self, leading to tissue injury. The proteasome inhibitor bortezomib has shown effectiveness in treating patients with ADs resistant to conventional therapies.
INFLAMMOPHARMACOLOGY
(2021)
Review
Cell Biology
Yuvraj Anandrao Jagtap, Prashant Kumar, Sumit Kinger, Ankur Rakesh Dubey, Akash Choudhary, Ravi Kumar Gutti, Sarika Singh, Hem Chandra Jha, Krishna Mohan Poluri, Amit Mishra
Summary: Disturbance in mitochondrial functions is a defining characteristic of neurodegenerative diseases, such as Parkinson's, ALS, and Alzheimer's. Misfolded proteins play a role in the impairment of mitochondrial pathways, exacerbating disease progression. However, the impact of mitochondrial dysfunction on other organelles and cellular processes remains understudied. Investigating the interplay between mitochondria and neurodegeneration can provide valuable insights for targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mingyu Chen, Sarun Juengpanich, Shijie Li, Win Topatana, Ziyi Lu, Qiang Zheng, Jiasheng Cao, Jiahao Hu, Esther Chan, Lidan Hou, Jiang Chen, Fang Chen, Yu Liu, Sukanda Jiansirisomboon, Zhen Gu, Suparat Tongpeng, Xiujun Cai
Summary: This study reports on a targeted therapy for gallbladder cancer using pH-responsive nanoparticles encapsulating bortezomib and mediated by estrogen-induced endocytosis. The treatment effectively inhibits proteasomes and induces apoptosis under tumor microenvironment and laser irradiation.
Article
Cell Biology
Darin Bloemberg, Joe Quadrilatero
Summary: This study found that intermittent toxic stress can induce cellular senescence, while intermittent nutrient withdrawal does not. Autophagy plays a crucial role in senescence induced by toxic stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Mohummad Aminur Rahman, Agnete S. T. Engelsen, Shahin Sarowar, Christian Bindesboll, Even Birkeland, Dorota Goplen, Maria L. L. Lotsberg, Stian Knappskog, Anne Simonsen, Martha Chekenya
Summary: The study found that bortezomib can enhance the efficacy of temozolomide by inhibiting autophagic flux, thereby increasing the treatment effect on glioblastoma and increasing the occurrence of cell apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Suresh Udutha, Roshan M. Borkar, G. Shankar, T. Sony, Aishwarya Jala, E. Vamshi Krisna, T. Kiran Kumar, S. Misra, S. Prabhakar, R. Srinivas
Summary: Bortezomib (BTZ) is a potent reversible inhibitor of proteasome used in the treatment of multiple myeloma. Studies on its degradation under various conditions identified 16 degradation products, with some showing toxicity in vitro cell toxicity tests. Further in silico studies suggested potential hepatotoxicity and genotoxicity of BTZ and its degradation products.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Guangtao Gao, Yong Xu, Jingjing Gan, Xinya Cao, Xiaoqing Dong, Mengkun Fang, Ying Du, Peipei Xu, Junyi Che, Bing Chen
Summary: This study reports a targeting strategy for multiple myeloma using platelet membrane-coated nanoparticles encapsulating BTZ. Compared to non-targeted BTZ, the nanoparticle system shows significant improvements in selectivity, cellular uptake, and anticancer effects, demonstrating a high potential for multiple myeloma patients.
Article
Pharmacology & Pharmacy
Xiuhui Chen, Yanhong Chen, Yitao Ou, Wenjie Min, Shuli Liang, Lei Hua, Yinghua Zhou, Cheng Zhang, Peifeng Chen, Zhongjin Yang, Wenhui Hu, Ping Sun
Summary: The abnormal activation of NLRP3 inflammasome is important in the pathogenesis of psoriasis. Bortezomib, a marketed drug for treating multiple myeloma, specifically inhibits NLRP3 inflammasome activation and may be a potential therapeutic drug for psoriasis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Birgit Lohberger, Dietmar Glaenzer, Nicole Eck, Katharina Stasny, Anna Falkner, Andreas Leithner, Dietmar Georg
Summary: To overcome resistance to radiotherapy in chondrosarcomas, the combined treatment of DNA repair inhibitors (VE-821) with particle irradiation was investigated. The study showed that this combined treatment increased the radiosensitivity of chondrosarcoma cells and suppressed efficient DNA repair mechanisms, thus improving the efficiency of radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Johannes Nikolaus Woltsche, Maria Smolle, Dieter Szolar, Marko Bergovec, Andreas Leithner
Summary: The prevalence of cartilaginous tumors in the shoulder joint is 0.43%, which is lower than previously estimated.
SKELETAL RADIOLOGY
(2023)
Article
Oncology
Johannes Nikolaus Woltsche, Maria Anna Smolle, Dieter Szolar, Marko Bergovec, Andreas Leithner
Summary: This study found that the overall prevalence of cartilage lesions around the knee joint is 1.45%, with an increasing prevalence of ECs over time and a constant prevalence of ACTs.
Article
Medicine, General & Internal
Sebastian Martin Klim, Patrick Reinbacher, Maria Anna Smolle, Andrzej Hecker, Michael Maier, Joerg Friesenbichler, Andreas Leithner, Lukas Leitner, Alexander Draschl, Jan Lewis, Kevin Brunnader, Werner Maurer-Ertl
Summary: This study found that short-stem total hip arthroplasty (THA) enables improved reconstruction of femoral anteversion (FA) compared to straight-stem THA. However, a substantial postoperative gender-related FA difference was detectable, which may need to be considered by surgeons when determining the final stem anteversion. Further research is needed to investigate the impact of the postoperative gender-related FA difference on clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Maria Anna Smolle, Angelika Kogler, Dimosthenis Andreou, Susanne Scheipl, Marko Bergovec, Christoph Castellani, Holger Till, Martin Benesch, Florian Posch, Joanna Szkandera, Freyja-Maria Smolle-Juettner, Andreas Leithner
Summary: This retrospective study analyzed the impact of metastasectomy on post-metastasis survival in bone sarcoma patients with lung metastases. The study found that metastasectomy was associated with better survival rates, suggesting that it should be considered as a treatment option for these patients.
Article
Medicine, General & Internal
Alexander Draschl, Georg Hauer, Stefan Franz Fischerauer, Angelika Kogler, Lukas Leitner, Dimosthenis Andreou, Andreas Leithner, Patrick Sadoghi
Summary: This study evaluated the performance of ChatGPT in answering questions about periprosthetic joint infections (PJI) of the hip and knee. The findings showed that ChatGPT's free-text responses were mostly reliable and useful, although there were variations in performance across different questions and subtopics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Patrick Reinbacher, Gregor A. Schittek, Alexander Draschl, Andrzej Hecker, Andreas Leithner, Sebastian Martin Klim, Kevin Brunnader, Amir Koutp, Georg Hauer, Patrick Sadoghi
Summary: This study compared the effects of local periarticular infiltration (LIA) and ultrasound-guided regional anesthesia (USRA) with ropivacaine and dexmedetomidine as an additive agent in primary total knee arthroplasty (TKA). The results showed that patients in the LIA group had better postoperative well-being in the early postoperative phase of up to six weeks but experienced higher pain scores at six weeks. LIA can improve short-term well-being and potentially benefit faster knee recovery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Maria Anna Smolle, Hana Murtezai, Tobias Niedrist, Florian Amerstorfer, Nina Hoerlesberger, Lukas Leitner, Sebastian Martin Klim, Reingard Glehr, Raju Ahluwalia, Andreas Leithner, Mathias Glehr
Summary: This study analysed and compared the vancomycin elution kinetics of four biodegradable, osteoconductive antibiotic carriers used in clinical practice. The results showed different elution rates and antibiotic concentration patterns for each carrier. The carrier made of allogenic bone chips exhibited the highest elution rate, while the carrier with separately added vancomycin showed a more consistent antibiotic-releasing profile.
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This study investigated the impact of diffuse-type Tenosynovial giant cell tumor (D-TGCT) on treatment strategies and quality of life for patients. The results showed that patients who switched to an active treatment strategy had higher scores for pain and interference, while patients who remained off-treatment had lower scores at the 2-year follow-up. These findings are important for guiding the treatment and management of D-TGCT.
Article
Orthopedics
Mustafa Hariri, Georg Hauer, Maria Smolle, Patrick Sadoghi, Andreas Leithner, Benjamin Panzram, Christian Merle, Tobias Renkawitz, Tilman Walker
Summary: This study compared clinical outcomes between fixed-bearing and mobile-bearing unicompartmental knee replacement surgeries. The results showed that patients who underwent the mobile-bearing surgery had a greater range of motion in the knee joint, while other parameters had no significant differences between the two groups. Both surgical designs are suitable for improving clinical outcomes and range of motion for patients with knee osteoarthritis.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Ines Vielgut, Lisa Putzl, Ingrid Thomuller, Jasminka Igrec, Iva Brcic, Thomas Valentin, Ulrike Wittig, Richard Zettl, Patrick Sadoghi, Andreas Leithner, Stefan Fischerauer, Susanne Scheipl
Summary: This study provides an overview of tuberculosis (TB) trends in Austria and analyzes a retrospective series of musculoskeletal TB cases. The results show a significant reduction in overall TB incidence rates in Austria, with musculoskeletal TB mainly affecting elderly native Austrians and younger patients with a migration background. The spine is the most common manifestation site, and secondary deformities are frequently observed.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Georg Hauer, Patrick Sadoghi, Maria Smolle, Sabrina Zaussinger, Joerg Friesenbichler, Andreas Leithner, Werner Maurer-Ertl
Summary: This study found that stem design has no impact on the time until resumption of sexual activity in patients under 65 years old. Female obese individuals who are aware of their artificial joint in daily life are at increased risk of delayed return to sexual activity after surgery.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Maria Anna Smolle, Ewald Musser, Georg Hauer, Ines Vielgut, Lukas Leitner, Reinhard Ehall, Andreas Leithner, Patrick Sadoghi
Summary: This retrospective study aimed to compare the amount of postoperative weight loss in TKA patients with BMI trends in the general population. The results showed a significant decrease in BMI after TKA, but there was no significant difference compared to the general population. Patients with initially higher BMI were more likely to lose weight postoperatively. Therefore, individualized patient education programs should be strengthened to promote a healthy lifestyle.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Patrick Reinbacher, Ulrike Wittig, Georg Hauer, Alexander Draschl, Andreas Leithner, Patrick Sadoghi
Summary: The nationwide lockdown during the COVID-19 pandemic had a negative impact on the early clinical outcome parameters of elective primary TKA due to restrictions in postoperative care. Standardized physiotherapy protocols are believed to improve clinical outcomes and underscore the importance of appropriate postoperative care during this pandemic.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Ulrike Wittig, Maximilian Moshammer, Ines Vielgut, Georg Hauer, Patrick Reinbacher, Andreas Leithner, Patrick Sadoghi
Summary: This study compared the epidemiological differences and outcomes of different designs used in knee arthroplasty. The results showed variations in the types of designs used across different countries, with fixed-bearing being the most commonly used type.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)