Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme

(2016) Joon H. Park et al.   BIOCHEMISTRY

Evolution under Drug Pressure Remodels the Folding Free-Energy Landscape of Mature HIV-1 Protease

(2016) John M. Louis et al.   JOURNAL OF MOLECULAR BIOLOGY

Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance

(2016) Masaaki Nakashima et al.   Frontiers in Microbiology

Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease

(2015) John M. Louis et al.   BIOCHEMISTRY

Identifying representative drug resistant mutants of HIV

(2015) Xiaxia Yu et al.   BMC BIOINFORMATICS

Highly resistant HIV-1 proteases and strategies for their inhibition

(2015) Irene T Weber et al.   Future Medicinal Chemistry

Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights

(2015) Sarentha Chetty et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Conformational variation of an extreme drug resistant mutant of HIV protease

(2015) Chen-Hsiang Shen et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy

(2014) Margaret T. May et al.   AIDS

Prediction of HIV drug resistance from genotype with encoded three-dimensional protein structure

(2014) Xiaxia Yu et al.   BMC GENOMICS

Conformation of Inhibitor-Free HIV-1 Protease Derived from NMR Spectroscopy in a Weakly Oriented Solution

(2014) Julien Roche et al.   CHEMBIOCHEM

Improved Cross Validation of a Static Ubiquitin Structure Derived from High Precision Residual Dipolar Couplings Measured in a Drug-Based Liquid Crystalline Phase

(2014) Alexander S. Maltsev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Comparative Molecular Dynamics, MM–PBSA and Thermodynamic Integration Study of Saquinavir Complexes with Wild-Type HIV-1 PR and L10I, G48V, L63P, A71V, G73S, V82A and I84V Single Mutants

(2013) Haralambos Tzoupis et al.   Journal of Chemical Theory and Computation

Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1′-Pyrrolidinone or P2-Tris-tetrahydrofuran

(2013) Johnson Agniswamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 Protease with 20 Mutations Exhibits Extreme Resistance to Clinical Inhibitors through Coordinated Structural Rearrangements

(2012) Johnson Agniswamy et al.   BIOCHEMISTRY

Measurement of 15N relaxation rates in perdeuterated proteins by TROSY-based methods

(2012) Nils-Alexander Lakomek et al.   JOURNAL OF BIOMOLECULAR NMR

Interaction of I50V Mutant and I50L/A71V Double Mutant HIV-Protease with Inhibitor TMC114 (Darunavir): Molecular Dynamics Simulation and Binding Free Energy Studies

(2012) Biswa Ranjan Meher et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

(2011) J. M. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV Type 1 Protease L10I Minor Mutation Decreases Replication Capacity and Confers Resistance to Protease Inhibitors

(2010) Fernando Flor-Parra et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters

(2010) Chen-Hsiang Shen et al.   FEBS Journal

Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: Relevance to drug resistance

(2010) Jane M. Sayer et al.   PROTEIN SCIENCE

Modulation of Human Immunodeficiency Virus Type 1 Protease Autoprocessing by Charge Properties of Surface Residue 69

(2009) L. Huang et al.   JOURNAL OF VIROLOGY

Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease

(2009) John M. Louis et al.   PROTEIN SCIENCE

HIV-1 Protease: Structural Perspectives on Drug Resistance

(2009) Irene Weber et al.   Viruses-Basel

The structural biology of HIV assembly

(2008) Barbie K Ganser-Pornillos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

(2008) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir

(2008) Fengling Liu et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations

(2002) Darón I. Freedberg et al.   PROTEIN SCIENCE