Article
Chemistry, Multidisciplinary
Xi Chen, Wen-Tao Wu, Yu-Ting Jiao, Yi-Ran Kang, Xin-Wei Zhang, Wei-Hua Huang
Summary: Intracellular H2S is crucial for regulating cell metabolism, but its quantification is hindered by the limited sensing materials and sensor passivation. In this study, we functionalized conductive nanowires with MoS2 and quercetin to develop single nanowire sensors with excellent electrocatalytic and anti-poisoning performance, enabling accurate quantification of H2S within single cells.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cell Biology
Wanli Lin, Ying Chen, Bomeng Wu, Ying Chen, Zuwei Li
Summary: A prognostic PRG signature containing five genes (NLRP7, NLRP1, NLRP2, NOD1, and CASP6) was identified for LUAD patients through comprehensive bioinformatics analysis. Additionally, a lncRNA KCNQ1OT1/miR-335-5p/NLRP1/NLRP7 regulatory axis was discovered, which may play a significant role in the progression of LUAD. Further research is needed to validate these findings.
CELL DEATH DISCOVERY
(2021)
Article
Immunology
Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang
Summary: We found that C. trachomatis L2 infection induced pyroptosis in mouse macrophages, which was accompanied by activation of caspase-1 and caspase-11 as well as gasdermin D (GSDMD) activation. Inhibition of these inflammatory caspases suppressed GSDMD activation. Importantly, the pyroptosis response significantly inhibited the intracellular growth of C. trachomatis, suggesting it can be utilized as an intrinsic mechanism to restrict C. trachomatis infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Ashley J. Russo, Swathy O. Vasudevan, Santiago P. Mendez-Huergo, Puja Kumari, Antoine Menoret, Shivalee Duduskar, Chengliang Wang, Juan M. Perez Saez, Margaret M. Fettis, Chuan Li, Renjie Liu, Arun Wanchoo, Karthik Chandiran, Jianbin Ruan, Sivapriya Kailasan Vanaja, Michael Bauer, Christoph Sponholz, Gregory A. Hudalla, Anthony T. Vella, Beiyan Zhou, Sachin D. Deshmukh, Gabriel A. Rabinovich, Vijay A. Rathinam
Summary: Studies have identified galectin-1 as a new DAMP that promotes inflammation by inhibiting CD45. The release of galectin-1 during cytosolic LPS sensing is detrimental and affects endotoxin shock.
Article
Chemistry, Physical
Arina V. Dobrovolskaya, Sergei V. Chapek, Oleg A. Usoltsev, Evgeny Naranov, Dmitry N. Gorbunov, Alexander L. Trigub, Anton L. Maximov, Alexander V. Soldatov, Aram L. Bugaev
Summary: An efficient approach using X-ray absorption spectroscopy (XAS) was proposed to monitor the nucleation of palladium nanoparticles from Pd(II) acetate. By passing an X-ray beam through a microfluidic channel, the data quality was significantly improved for in situ monitoring of the early stages of nanoparticle formation. The time evolution of Pd(II) and Pd(0) fractions was quantified using linear combination analysis of Pd foil and Pd acetate reference spectra. This work demonstrates the application of XAS in microfluidics for studying chemical systems and obtaining structural information under reaction conditions with 4d metals.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Marco Deiana, Maelle Mosser, Tangui Le Bahers, Elise Dumont, Marta Dudek, Sandrine Denis-Quanquin, Nasim Sabouri, Chantal Andraud, Katarzyna Matczyszyn, Cyrille Monnereau, Laure Guy
Summary: The study introduces a light-activated functional material capable of remotely controlling the formation of duplex and G-quadruplex nucleic acids at the cellular level, along with a novel extended heteroaromatic structure with remarkable binding properties. This work lays the groundwork for the future design and development of a new generation of light-activated target-selective G4-binders.
Article
Microbiology
David E. Place, Shelbi Christgen, Shraddha Tuladhar, Peter Vogel, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti
Summary: This study shows the importance of pyroptosis and apoptosis in host-mediated control of Burkholderia infection. Loss of key components of these pathways results in increased cell death and bacterial intercellular spread during infection. In the absence of these pathways, host control of infection is compromised, leading to higher mortality rates in mice.
Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Eui-Kyu Noh, Jeong Yi Kim, Ho-Min Yu, Jun Young Sung, Lan Jeong Ju, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
Summary: Radotinib induces apoptosis in multiple myeloma cells and inhibits MM cell growth and progression through various mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Yujia Zhang, Yan Liu, Ting Zhang, Xueqin Gong, Zeyan Wang, Yuanyuan Liu, Peng Wang, Hefeng Cheng, Ying Dai, Baibiao Huang, Zhaoke Zheng
Summary: A single-particle spectroscopy technique is used to quantitatively monitor the spatial distribution of oxygen vacancies (OVs) on different facets. Taking monoclinic BiVO4 as an example, by tracking the photoluminescence (PL) lifetimes and spectra of different facets before and after hydrogen treatment, we confirm that the PL emission originates from the OV state and determine that OVs are more likely to be generated on the {010} facets. This anisotropic defect engineering significantly prolongs the carrier lifetime and accelerates the activation of molecular oxygen.
Article
Biophysics
Renhui Zhan, Wenfei Guo, Xiaonan Gao, Xiaojun Liu, Kehua Xu, Bo Tang
Summary: A novel Au-Se nanoprobe was developed for real-time monitoring of hypoxia-induced cardiomyocyte apoptosis pathway, assessing cardiomyocyte state, and evaluating the efficacy of ROS scavenger in alleviating cardiomyocyte apoptosis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Multidisciplinary
Ezgi Onur Sahin, Siyuan Zhang, Christina Scheu, Claudia Weidenthaler
Summary: This study investigates the crystallization behavior of amorphous sodium tantalate and reveals that a composite of natrotantite and distorted perovskite, along with a considerable amount of amorphous solid, is obtained during heating the amorphous starting material. The findings are expected to shed light on the changes in band gap energy and photocatalytic performance of this semiconductor material.
Article
Agricultural Engineering
Sijie Huang, Mengmeng Shen, Zhiyong Jason Ren, Houkai Wu, Hao Yang, Buchun Si, Jianhan Lin, Zhidan Liu
Summary: The study developed two upflow air-cathode chamber microbial fuel cells for in situ monitoring of biohydrogen and biomethane reactors. Through Illumina MiSeq sequencing and principal component analysis, it was found that the microbial communities in UMFCs showed a high level of stability with distinct shifts in community structure, emphasizing the importance of hydrogenotrophic methanogens in methane production.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Max Rautenberg, Biswajit Bhattacharya, Julia Witt, Mohit Jain, Franziska Emmerling
Summary: This study provides the first in situ real-time monitoring of the mechanochemical formation mechanism of mixed-ligand MOFs and reveals that binary phases can serve as intermediates or competing products in one-pot and stepwise synthesis.
Article
Biochemistry & Molecular Biology
Liqi Yao, Clay Clark
Summary: The caspase-hemoglobinase fold is conserved and allows for species-specific stabilization or destabilization of folding intermediates. The pH-dependent conformational change in the native dimer may provide a reversible mechanism for controlling caspase activity in the cell.
BIOSCIENCE REPORTS
(2022)
Article
Biochemical Research Methods
Stipe Lukin, Krunoslav Uzarevic, Ivan Halasz
Summary: This protocol details the setup and use of Raman spectroscopy for monitoring solid-state reactions in vibratory ball mills, providing insights into mechanochemical reactions. The use of translucent reaction jars and Raman spectroscopy offers a convenient in situ monitoring method, along with data analysis software for qualitative analysis of reaction paths.
Article
Chemistry, Applied
Jintong Liu, Lin Yao Ye, Yan Yang Mo, Hong Yang
Summary: A fluorescent sensing system based on MOF was designed for rapid and accurate detection of Dufulin, showing potential for assessing pesticide levels in real samples.
Article
Agriculture, Multidisciplinary
Li Ya Ma, Ai Ping Zhang, Jintong Liu, Nan Zhang, Min Chen, Hong Yang
Summary: The research indicates that the OsARM gene expression in rice is associated with DNA demethylation and has a detoxifying effect on ATZ toxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Jintong Liu, Lin Yao Ye, Yue Zhang, Hong Yang, Lin Zhou, Elan Luo, Jianping Lei
Summary: An aptamer-based nonenzymatic autonomous DNA walking machine has been developed for monitoring trace malathion contamination. The machine shows high stability, sensitivity, and biocompatibility, and can be applied to actual samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jintong Liu, Bernardino J. Cordova Wong, Tianrui Liu, Hong Yang, Lin Yao Ye, Jianping Lei
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Environmental Sciences
Zhao Jie Chen, Jintong Liu, Nan Zhang, Hong Yang
Summary: This study demonstrates that rice ACE genes can respond to toxic agrochemicals MTR and FSA by increasing their transcriptional level and enhancing protein activity. These ACE genes may protect rice by regulating biotic and abiotic stress responses and detoxification of xenobiotics.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Multidisciplinary
Xiao Yan Zhai, Zhao Jie Chen, Jintong Liu, Nan Zhang, Hong Yang
Summary: In this study, a new cytochrome P450 gene, CYP76C6, was discovered in rice, which plays a critical role in accelerating the degradation of isoproturon (IPU). Overexpression of CYP76C6 improved rice growth, attenuated IPU-induced cellular damage, and repressed IPU accumulation. The study provides insights into the mechanism of IPU decay in rice crops and its potential application in reducing environmental risks and ensuring food safety and human health.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Genetics & Heredity
Yuxin Qiao, Zhao Jie Chen, Jintong Liu, Zhang Nan, Hong Yang
Summary: In this study, we used bioinformatics and high-throughput sequencing to identify pesticide-induced ABC transporter genes in rice. We categorized these genes into subfamilies and investigated their distribution on chromosomes. Additionally, we analyzed the cis-acting elements and carried out phylogenetic and docking analysis. The results provide valuable information for studying the regulation of pesticide metabolism and transport in plants.
Article
Environmental Sciences
Na Li, Jing Jing Zhang, Jintong Liu, Nan Zhang, Hong Yang
Summary: This study developed a genetically improved rice genotype by overexpressing a novel glycosyl-transferase gene named OsGT1 to accelerate the removal of butachlor residues in rice crop and its growth environment. The overexpression of OsGT1 significantly improved the growth of rice and attenuated the cellular damage caused by butachlor. The concentrations of butachlor in different parts of the rice plant were reduced, and the OsOE lines accumulated more degradative products than the wild-type, suggesting that more butachlor molecules were catabolized.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Zhao Jie Chen, Xiao Yan Zhai, Jintong Liu, Nan Zhang, Hong Yang
Summary: This study unveiled a novel mechanism for the catabolism of pesticides MTR and FSA facilitated by an uncharacterized enzyme ACE1 in rice and assessed its potential for bioremediation to minimize the risks to crop production and food safety.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xiao Fan Yao, Nan Zhang, Jintong Liu, Hong Yang
Summary: Propachlor is a widely used herbicide for weeding in farmland, but it has become a serious environmental pollutant. This study investigated the impact of dissolved organic matter and a reference surfactant on the behavior of propachlor in soil, finding that they reduced sorption and increased mobility of the herbicide.
Article
Nanoscience & Nanotechnology
Jintong Liu, Yan Yang Mo, Heng Zhang, Jie Tang, Han Bao, Liuyu Wei, Hong Yang
Summary: Developing sensitive practical sensors for monitoring pesticide residues in edible foods and environmental samples is of vital importance for food safety and environmental protection. In this study, a target triggered porphyrin metal-organic framework (MOF)-based nanosystem was designed with the dual functionality of sensitive detection and controllable degradation of the triazophos pesticide. The intelligent multifunctional MOF system demonstrated the potential of programmable systems for jointly controllable tracking and elimination of pesticide residues in the environment, providing a new pathway for designing a precise mechanism for stimulus-triggered degradation of pesticide residues accompanied by sensitive detection for environmental friendliness and food safety.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Yuxin Qiao, Nan Zhang, Jintong Liu, Hong Yang
Summary: Agrochemicals such as pesticide residues pose ecotoxic risks to plant, animal, and human health. This study investigated the toxicology and degradation mechanisms of the widely used pesticide ametryn (AME) in rice crops. AME was found to be absorbed by rice roots, causing repression of plant elongation and reduction in dry weight and chlorophyll concentration. Transcriptome and metabolome analysis revealed AME-responsive genes and step-wise catabolism of AME in rice. The study also identified AME metabolites and conjugates that are closely related to differentially expressed genes, differentially accumulated metabolites, and activities of antioxidative enzymes. These findings contribute to the development of genetically engineered rice for bioremediation of AME-contaminated soils and reduction of AME accumulation in rice crops.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Zhao Jie Chen, Yuxin Qiao, Nan Zhang, Hong Yang, Jintong Liu
Summary: The constant use of oxyfluorfen (OFF) pesticide in farmland contaminates the soil and poses risks to crop growth and human health. To prevent food crops from being contaminated with OFF, understanding its absorption and degradation mechanisms is crucial. In this study, we characterized a new gene, OsACE2, which encodes a protein that can facilitate OFF degradation in rice. By overexpressing OsACE2, the growth of rice plants in a hydroponic medium was improved, with reduced oxidative stress caused by OFF. Additionally, we identified several metabolites of OFF and their pathways of degradation in rice.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Agriculture, Multidisciplinary
Yuxin Qiao, Yun Lv, Zhao Jie Chen, Jintong Liu, Hong Yang, Nan Zhang
Summary: This study investigated the toxicity, metabolic mechanism, and resultant pathways of bentazone (BNTZ) in rice. It was found that the growth of rice was compromised when treated with BNTZ at 0.2-0.8 mg/L (529.95-1060.05 g a.i./ha), and the activities of certain enzymes were elevated under BNTZ stress. Genome-wide RNA-sequencing analysis revealed that the degradative pathways of BNTZ in rice involve glycosylation, hydrolysis, acetylation, and conjugation processes catalyzed by enzymes. These findings provide valuable insights into the metabolic and detoxic mechanisms of BNTZ.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Chemistry, Analytical
Haomin Fu, Zhiyuan Xu, Hanlin Hou, Rengan Luo, Huangxian Ju, Jianping Lei
Summary: Electrochemiluminescence (ECL) has gained attention for its high sensitivity, stability, and low background. Framework-based ECL platforms utilizing nanocrystals, such as metal-organic frameworks and covalent organic frameworks, have been developed for sensitive analysis of biomarkers and molecules. Integration of fluorescent ligands into frameworks improves ECL properties, and functionalized framework topologies enable target recognition for signal readout. This review summarizes recent advances in framework functions and constructions of framework-based ECL platforms, demonstrating theoretical innovation and potential applications in ECL biosensing systems.
Article
Chemistry, Multidisciplinary
Alexander M. Prophet, Kritanjan Polley, Gary J. Van Berkel, David T. Limmer, Kevin R. Wilson
Summary: The oxidation kinetics of iodide by ozone at the air-water interface is studied in single microdroplets. Molecular simulations and kinetic modeling are used to understand the underlying multiphase mechanism.
Article
Chemistry, Multidisciplinary
Rong Zhang, Jiajing Lan, Fei Wang, Shumei Chen, Jian Zhang
Summary: By utilizing 1,1'-ferrocene dicarboxylic acid as a chelating and surface protection ligand, we have synthesized multi-nuclear indium oxide clusters with varying nuclear sizes, including heptanuclear and thirteen-nuclear clusters. These clusters possess labile coordination sites, allowing for structural modification and self-assembly, resulting in the formation of various cluster structures.
Article
Chemistry, Multidisciplinary
Hui Wang, Hui Liu, Mingsen Wang, Jiaheng Hou, Yongjun Li, Yuancheng Wang, Yingjie Zhao
Summary: Two supramolecular complexes were prepared using CBs and M1, and their single-crystal structures were analyzed by SCXRD. The unexpected 1:2 self-assembly structure between M1 and CB[8] was discovered for the first time. These complexes exhibit unique photophysical properties and provide valuable information about the structure and photophysical properties of supramolecular complexes.
Article
Chemistry, Multidisciplinary
Chang-Hee Lee, Sookil Park, Sanggil Kim, Ji Young Hyun, Hyun Soo Lee, Injae Shin
Summary: The epidermal growth factor receptor (EGFR) is a cell-surface glycoprotein involved in cell proliferation and tumor development. This study used a fluorescently labeled EGFR to investigate its time-dependent endocytosis in live cells and found that appended glycans affect EGFR internalization. Additionally, the study detected sialic acid residues attached to EGFR on the live cell surface using FRET-based imaging. This research provides valuable insights into the cellular functions of EGFR.
Article
Chemistry, Multidisciplinary
Subhankar Sahu, Lokesh Kumar, Sumita Das, Dipti Gupta, Ruchi Anand
Summary: This study proposes a strategy that combines organic electronics with biosensor scaffolds to create a compact device for monitoring environmental aromatic pollution. By coupling biosensing protein MopR with an organic electrochemical transistor (OECT), a sensor module capable of efficient detection of phenol was designed. Exclusive phenol detection with minimal loss of sensitivity could be achieved in complex pollutant mixtures and real environmental samples.
Review
Chemistry, Multidisciplinary
Changseok Lee, Hyung-Joon Kang, Sungwoo Hong
Summary: The formation of C-N bonds through hydroamination reactions catalyzed by nickel hydrides has been a topic of recent interest. This approach offers a way to efficiently transform a variety of alkene and alkyne substrates into compounds enriched with C-N bonds. The review provides a concise overview of the underlying reaction mechanisms and aims to stimulate further progress in NiH-catalytic techniques and catalyst design.
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Dmitry L. Lipilin, Mikhail O. Zubkov, Mikhail D. Kosobokov, Alexander D. Dilman
Summary: This article describes a direct photocatalytic method for the thiolation of unprotected acids, which was previously challenging. By using a thionocarbonate reagent with an N-O bond, the efficient conversion of carboxylic acids to thiols is achieved.
Article
Chemistry, Multidisciplinary
Jason Malenfant, Lucille Kuster, Yohann Gagne, Kouassi Signo, Maxime Denis, Sylvain Canesi, Mathieu Frenette
Summary: Raman microscopy can reveal compound-specific vibrational fingerprints without sample preparation. The combination of efficient theoretical calculations and a user-friendly software can accurately predict peak positions and provide match scores to assist with structure determination.
Article
Chemistry, Multidisciplinary
Jayoh A. Hernandez, Paul S. Micus, Sean Alec Lois Sunga, Luca Mazzei, Stefano Ciurli, Gabriele Meloni
Summary: Essential trace metals play crucial roles in the survival and virulence of bacterial pathogens. Helicobacter pylori requires nickel for colonization and persistence in the stomach, and NixA is an essential nickel transporter in this process. This study characterizes the selectivity and electrogenic nature of NixA-mediated nickel transport.
Article
Chemistry, Multidisciplinary
Tarali Devi, Kuheli Dutta, Jennifer Deutscher, Stefan Mebs, Uwe Kuhlmann, Michael Haumann, Beatrice Cula, Holger Dau, Peter Hildebrandt, Kallol Ray
Summary: This study emphasizes the importance of subtle electronic changes and secondary interactions in the stability of biologically relevant metal-dioxygen intermediates. It also shows that the role of the chloride ligand in stabilizing the Fe-III-(OOBu)-Bu-t moiety can extend to other anions, including the thiolate ligand.
Article
Chemistry, Multidisciplinary
Jacqueline R. Santhouse, Jeremy M. G. Leung, Lillian T. Chong, W. Seth Horne
Summary: By studying the folding kinetics and mechanism of the BdpA sequence, researchers found that altering the backbone connectivity can affect protein folding. This suggests that protein mimetic chains have a significant degree of plasticity in transitioning between unfolded and folded states.
Article
Chemistry, Multidisciplinary
Divanshu Gupta, Ralf Einholz, Holger F. Bettinger
Summary: This study presents the first direct spectroscopic evidence of a cyclic seven-membered iminoborane. Compared to linear amino-iminoboranes, this cyclic iminoborane exhibits weakened bond strength and lower Lewis acidity value. The study suggests that the reduced ring strain of cyclic iminoborane prevents nitrogen fixation but allows facile (2 + 2) cycloaddition reaction with C2H4.
Article
Chemistry, Multidisciplinary
Renny Mathew, Aniruddha Mazumder, Praveen Kumar, Julie Matula, Sharmarke Mohamed, Petr Brazda, Mahesh Hariharan, Brijith Thomas
Summary: This study reveals the packing arrangement of partially disordered nitro-perylenediimide (NO2-PDI) using a synergistic approach that combines 3D ED, ssNMR, and DFT techniques. By overcoming these challenges, this methodology opens up new avenues for material characterization, driving exciting advancements in the field.