Review
Biochemistry & Molecular Biology
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Summary: Chemokines are a family of cytokines that play important roles in cancer progression. The CCL2-CCR2 axis is a major chemokine signaling pathway that impacts tumor progression significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wei Tu, Jin Gong, Zhenzhen Zhou, Dean Tian, Zhijun Wang
Summary: Colorectal cancer liver metastasis is a significant clinical problem, and tumor-associated macrophage (TAM) recruitment and M2 polarization are closely associated with elevated TCF4 expression in the metastatic site. TCF4 deficiency reduces TAM infiltration and M2 polarization, mediated by the regulated CCL2 and CCR2 expression. These findings suggest that the TCF4-CCL2-CCR2 axis plays a crucial role in CRC liver metastasis by enhancing TAMs recruitment and M2 polarization.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jyotsana Singhal, Prakash Kulkarni, David Horne, Sanjay Awasthi, Ravi Salgia, Sharad S. Singhal
Summary: The study demonstrated that blocking RLIP can mitigate the harmful effects of p53 loss and inhibit the growth of human breast cancer. Treatment with 2HF reduces mammary hyperplasia and carcinoma incidence, decreases tumor cell proliferation, and increases apoptosis.
MOLECULAR CARCINOGENESIS
(2021)
Article
Ophthalmology
Feifei Yu, Wei Jiang, Li Zhang, Nan Jiang
Summary: The effects of indoleamine 2,3-dioxygenase (IDO) on macrophage polarization, phagocytosis, and killing in Aspergillus fumigatus keratitis were investigated. In vivo and in vitro experiments were conducted in mice and mouse peritoneal macrophages infected with A. fumigatus. The study found that IDO can promote the polarization of macrophages to the M1 type by blocking the CCL2/CCR2 signaling pathway, inhibiting the phagocytosis and killing function of macrophages.
Article
Medicine, Research & Experimental
Shin Ung Kang, Soo Youn Cho, Hyojin Jeong, Jinil Han, Ha Yeong Chae, Hobin Yang, Chang Ohk Sung, Yoon-La Choi, Young Kee Shin, Mi Jeong Kwon
Summary: The study demonstrated that MMP11 expression in mononuclear inflammatory cells, predominantly macrophages, is an independent negative prognostic factor in breast cancer. Furthermore, MMP11-overexpressing macrophages promote migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling, suggesting a pro-tumoral role of MMP11 in macrophages in HER2-positive breast cancer through interaction with cancer cells and other cells in the tumor microenvironment.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Saverio Gentile, Najmeh Eskandari, Michael A. Rieger, Bruce D. Cuevas
Summary: MEKK1 plays a role in regulating stroma cell gene expression and affects the function of breast tumor cells. Loss of MEKK1 leads to decreased ability of fibroblasts to induce tumor cell invasion, indicating its crucial role in the microenvironment that supports metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Lei Tian, Shancheng Guo, Zhiye Zhao, Yuxu Chen, Chunmei Wang, Qingzhang Li, Ye Li
Summary: The study reveals that miR-30a-3p plays a crucial role in regulating autophagy in the mammary glands of mice during lactation and involution. It negatively regulates autophagy by targeting Atg12 gene in mammary epithelial cells. Further experiments confirmed that overexpression of miR-30a-3p inhibits autophagy and alters mammary structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Lidianne Narducci Monteiro, Diego Carlos dos Reis, Breno Souza Salgado, Geovanni Dantas Cassali
Summary: High levels of intratumoral (iTAM), stromal (sTAM), and total macrophages (tTAM) are associated with advanced clinical stage and vascular invasion in canine mammary tumors. Additionally, tTAM is related to larger tumor size, while elevated levels of sTAM and tTAM are correlated with nodal metastasis and a poor prognosis based on survival analysis.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Physiology
Yoshihiko Chiba, Kaori Okumura, Sayuri Tamaki, Yurika Yasuhara, Wataru Suto, Motohiko Hanazaki, Hiroyasu Sakai
Summary: The study found changes in the gene expression of the CCL2/CCR2 axis in bronchial smooth muscle cells of allergic asthma mice, potentially contributing to airway hyperresponsiveness.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Oncology
Raghd Al Olabi, Abd El Aziz Hendy, Mohamad Basem Alkassab, Karla Alnajm, Manahel Elias, Mary Ibrahim, James R. R. Carlyle, Andrew P. P. Makrigiannis, Mir Munir A. Rahim
Summary: NK cells are regulated by activating and inhibitory receptors, with NKR-P1B receptor recognizing Clr-b ligand. In mice, NKR-P1B:Clr-b interactions serve as a "missing-self" recognition system to monitor Clr-b levels. This system plays an important role in tumor immunosurveillance and functional homeostasis in NK cells.
Article
Biochemistry & Molecular Biology
Lyndsey A. A. Reich, Ana S. S. Leal, Edmund Ellsworth, Karen T. T. Liby
Summary: RXR agonists have shown efficacy in cancer models, but their downstream effects on gene expression vary. In this study, the effects of the novel RXR agonist MSU-42011 and the FDA approved agonist bexarotene on gene expression in HER2+ mammary tumors were analyzed. Both agonists regulated cancer-related gene categories, but the specific pathways affected differed. Understanding these differential effects can contribute to the development of targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Chenxue Mei, Fanxiang Meng, Xiao Wang, Siqi Yan, Qianqian Zheng, Xiaoqing Zhang, Wenda Fu, Junxiu Xue, Shengyi Wang, Yan He, Xun Sun, Xuefeng Jiang, Yuanyuan Wang
Summary: The study found that CD30L may promote the inflammatory response by inducing the homing and differentiation of monocytes via the CCL2/CCR2 axis and NF-kappa B signaling pathway. These findings provide a novel target for monocyte-based immunotherapy against inflammatory bowel diseases (IBD).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Julia Ettlin, Alina Bauer, Lennart Opitz, Alexandra Malbon, Enni Markkanen
Summary: Cancer-associated stroma (CAS) plays a crucial role in the development and progression of epithelial tumors, including breast cancer. By analyzing RNA-sequencing data from canine mammary tumors, researchers identified differentially expressed genes related to CAS between metastatic and non-metastatic tumors, with implications for pathways such as chemotaxis, apoptosis regulation, immune response, and TGF-beta signaling.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2023)
Article
Endocrinology & Metabolism
Xinying Qi, Yanping Xing, Xuezhen Wang
Summary: The study found that CCL2 is associated with inflammatory cytokines in GDM patients, with high expression in visceral adipose tissue and placenta of GDM mice. Blocking CCL2 helps to alleviate GDM symptoms and improve inflammation.
HORMONE AND METABOLIC RESEARCH
(2021)