Article
Nutrition & Dietetics
Xiaohua Huang, Yong Zhuo, Dandan Jiang, Yingguo Zhu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Lun Hua, Yuanfeng Zou, Chao Huang, Lixia Li, De Wu, Bin Feng
Summary: Maternal low-protein diet during puberty and adulthood may disrupt metabolic gene expression in the liver of offspring and exacerbate insulin resistance and hepatic steatosis in offspring fed a high-fat diet.
Article
Endocrinology & Metabolism
Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Lin
Summary: The study demonstrated that maternal consumption of a high-fat diet during pregnancy and lactation had multigenerational effects on hippocampal synaptic plasticity and cognitive function in male offspring. Central insulin resistance may play a crucial role in the link between maternal diet and cognitive impairment across generations.
Article
Multidisciplinary Sciences
Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Summary: Maternal and offspring high-fat diet leads to platelet hyperactivation in male mouse offspring, suggesting a novel 'double-hit' effect.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Dawid Gawlinski, Kinga Gawlinska, Irena Smaga
Summary: Evidence suggests that exposure to a maternal high-fat diet during pregnancy and lactation can induce changes in offspring's brain structure and function, leading to behavioral alterations such as depressive-like phenotype. This study revealed that the maternal high-fat diet triggered several epigenetic mechanisms in the brains of rat offspring, potentially impacting the next generation.
Article
Microbiology
Jun Zou, Vu L. Ngo, Yanling Wang, Yadong Wang, Andrew T. Gewirtz
Summary: Maternal diet during lactation has a long-lasting impact on offspring microbiota composition, affecting gut health and susceptibility to obesity and associated disorders.
CELL HOST & MICROBE
(2023)
Article
Biochemistry & Molecular Biology
Pengjie Zhang, Yanping Liu, Dan Zhu, Xionghui Chen, Yueming Zhang, Xiuwen Zhou, Qin Huang, Min Li, Youguo Chen, Miao Sun
Summary: The study suggests that high fat diet intake during pregnancy induces insulin resistance in the skeletal muscle of old male offspring rats, possibly through retrograde regulation of Sirt3-Glut4.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Genetics & Heredity
Beguem Harmancioglu, Seray Kabaran
Summary: Maternal high-fat diet during pregnancy is associated with excessive weight gain and fetal fat mass increase. It also leads to increased activation of proinflammatory cytokines. Maternal insulin resistance and inflammation contribute to increased adipose tissue lipolysis, resulting in elevated levels of free fatty acids in the fetus (>35% of energy from fat).
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Holly Hinrichs, Austin Faerber, Monica Young, Samuel J. Ballentine, Michael D. Thompson
Summary: Maternal exercise may protect offspring from progression of NAFLD, according to a study on female mice fed a high fat, fructose, cholesterol (HFFC) diet. The exercise reduced inflammation and fibrosis in the offspring, and also resulted in changes in metabolism. The findings suggest that maternal exercise could be a potential approach to prevent developmentally programmed liver disease in offspring.
Article
Food Science & Technology
Aline F. P. Souza, Juliana Woyames, Rosiane A. Miranda, Lorraine S. Oliveira, Bruna Caetano, Isabela L. Martins, Manuella S. Souza, Cherley B. Andrade, Thais Bento-Bernardes, Flavia F. Bloise, Rodrigo S. Fortunato, Isis H. Trevenzoli, Luana L. Souza, Carmen C. Pazos-Moura
Summary: This study investigates the effects of maternal high-fat diet on the liver mitochondrial responses to fructose intake in adult offspring. It found that moderate maternal high-fat diet can increase the intensity of liver mitochondrial alterations induced by fructose in offspring. The findings suggest that maternal diet can influence the risk of fructose damage in the liver of adult offspring.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Food Science & Technology
Marcela Nascimento Sertorio, Debora Estadella, Daniel Araki Ribeiro, Luciana Pellegrini Pisani
Summary: High-fat diet intake can negatively impact the reproductive health of male offspring, leading to issues such as impaired testosterone production, abnormal sperm generation, and prostate problems. Studying the male offspring of overweight and/or obese parents can help improve the quality of human semen.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Summary: Maternal high-fat diet before and during pregnancy may predispose female offspring to insulin resistance in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
ChengCheng Lin, Qiang Lei, MengNa Yu, YuHang Lin, HuiZhen Lu, YangPing Huang, Hong Wang, HuiQin Xu, YuanShao Lin
Summary: Maternal consumption of a high-fat diet can lead to multigenerational programming of the HPA axis and behaviors in adult male descendants, including enhanced HPA axis activity, heightened stress responses, and increased susceptibility to depression-like behaviors.
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Maternal high-fat diet is linked to offspring hypertension, and potential mechanisms have been revealed through animal studies. Reprogramming interventions can prevent high-fat-diet-induced hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Purevsuren Losol, Lindert P. Mercken, Helena L. Fisk, Philip C. Calder, John W. Holloway, Christopher Torrens
Summary: This study investigated the impact of maternal fat intake on PUFA status, gene expression, inflammatory markers, and lung function in offspring. The results showed that excessive maternal fat intake can modify hepatic PUFA status in offspring through regulation of gene expression and lead to respiratory dysfunction in the offspring.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Aynaz Tajaddini, Michael D. Kendig, Kelly V. Prates, R. Frederick Westbrook, Margaret J. Morris
Summary: Maternal obesity increases the risk of health complications in offspring, and the effects can be exacerbated by offspring exposure to unhealthy diets. This study found that offspring from obese mothers who were fed an unhealthy "cafeteria" diet had smaller size, more abdominal fat, and altered gene expression in the liver. Additionally, maternal obesity enhanced the negative effects of postweaning unhealthy diet on male offspring, while having minimal impact on female offspring. These findings highlight the importance of understanding the sex-specific detrimental effects of maternal obesity on offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Renan Fudoli Lins Vieira, Vitor Rosetto Munoz, Rafael Lima Junqueira, Fellipe de Oliveira, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Suleyma de Oliveira Costa, Marcio Alberto Torsoni, Adelino S. R. da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Iman Zaghloul, Rania A. Mekary, Jose Rodrigo Pauli
Summary: Time-restricted feeding (TRF) alone can reduce weight gain and increase fatty acid oxidation, while TRF combined with aerobic exercise (TRF+Exe) shows additional benefits such as increased oxygen consumption and ketone body production. TRF+Exe also attenuates the negative effects of high-fat diet on insulin signaling pathway and leads to improved liver metabolism and glucose homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Food Science & Technology
Penelope Lacrisio Reis Menta, Maria Emilia Rabelo Andrade, Livia Furquim de Castro, Luisa Martins Trindade, Melissa Tainan Silva Dias, Josiane Erica Miyamoto, Raisa Magno dos Santos, Geovanni Dantas Cassali, Raquel Franco Leal, Ana Paula Badan Ribeiro, Renato Grimaldi, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni, Adriana Souza Torsoni, Valbert Nascimento Cardoso, Marciane Milanski
Summary: The study suggests that adding interesterified fat to a normal lipid diet may have adverse effects on intestinal mucosa, leading to increased intestinal permeability, bacterial translocation, and damage to the intestinal epithelium.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Lucas Dantas Maia Forte, Natalia de Almeida Rodrigues, Andre Vitor Cordeiro, Thais de Fante, Lais Angelica de Paula Simino, Adriana de Souza Torsoni, Marcio Alberto Torsoni, Claudio Alexandre Gobatto, Fulvia Barros Manchado-Gobatto
Summary: The acute metabolic and molecular response to exercise may differ depending on the intensity and duration of the exercise. This study investigated the effects of acute exercise at different intensities, but with equal total load, on molecular and physiological responses in swimming rats. The results showed that blood lactate concentration was the only biomarker sensitive to acute exercise, and hepatic and muscle glycogen depletion and gene expression changes were associated with exercise intensity.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2022)
Article
Biochemistry & Molecular Biology
Carolina Panzarin, Lais Angelica de Paula Simino, Mariana Camargo Silva Mancini, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: The modulation of hepatic miR-370-122-Let7 miRNA may play a crucial role in the early stages of NAFLD, preceding changes in glycemic homeostasis and adiposity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Public, Environmental & Occupational Health
T. Fante, L. A. P. Simino, Marina Figueiredo Fontana, Andressa Reginato, Thomaz Guadagnini Ramalheira, Hosana Gomes Rodrigues, Patricia Cristina Lisboa, Egberto Gaspar de Moura, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: Offspring of obese dams are more susceptible to developing nonalcoholic fatty liver disease but are programmed to be protected from the damage promoted by a high fat diet, despite a lower impact on survival rate after surgery.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Clinical Neurology
Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Lais Angelica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteves
Summary: The pathophysiology of restless legs syndrome (RLS) is related to dopaminergic dysfunction, reduced iron, and variations in gene expression. This study used spontaneously hypertensive rats (SHR) as an animal model to evaluate gene and protein expression, sleep patterns, and cardiovascular parameters associated with RLS. The study found that SHR had higher blood pressure, altered sleep patterns, lower expression of certain proteins and genes, and lower serum concentrations of ferritin.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Mina Desai, Adrianna S. Torsoni, Marcio A. Torsoni, Agnlia Eisaghalian, Monica G. Ferrini, Michael G. Ross
Summary: Developmental programming studies using mouse models have investigated the effects of different housing temperatures on obesity development in offspring. The results showed that male offspring displayed increased body weight and adiposity when housed at thermoneutral temperature, while female offspring were not affected by housing temperature.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Robert Haddad Tovolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bobbo, Rodrigo S. Carraro, Carina Solon, Nathalia R. Dragano, Marcio A. Torsoni, Eliana P. Araujo, Licio A. Velloso
Summary: Maternal obesity is a significant risk factor for obesity, cardiovascular, and metabolic diseases in offspring. It leads to inflammation in the hypothalamus of the offspring, affecting the function of neurons that regulate food intake and energy expenditure. Maternal obesity-induced structural and functional damage to the offspring's hypothalamic BBB, but breastfeeding by lean mothers can partially reverse these effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Keryma Chaves da Silva Mateus, Ivan Luiz Padilha Bonfante, Amanda Veiga Sardeli, Renata Garbellini Duft, Arthur Fernandes Gaspari, Joice Cristina dos Santos Trombeta, Joseane Morari, Bruno Rodrigues, Marcio Alberto Torsoni, Mara Patricia Traina Chacon-Mikahil, Licio Augusto Velloso, Claudia Regina Cavaglieri
Summary: The aim of this study was to investigate the effects of different types of exercise on the expression of CHRNA7, CHRFAM7A, and TNF-alpha genes in individuals with normal weight and overweight with type 2 diabetes. The results showed that individuals with overweight and type 2 diabetes had higher baseline expression of CHRFAM7A and TNF-alpha. However, after exercise, the expression of CHRFAM7A increased in individuals with normal weight, especially in aerobic exercise.
Article
Food Science & Technology
Alana Carolina Costa Veras, Larissa da Silva Bruzasco, Ana Beatriz Profiro Lopes, Beatriz da Silva Franco, Alessandro Spencer de Souza Holanda, Andrea Maculano Esteves, Marciane Milanski, Adriana Souza Torsoni, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni
Summary: The consumption of saturated fatty acids in coconut oil can lead to insulin and leptin resistance, inflammation, and obesity. This study investigated the effects of coconut oil supplementation on leptin signaling in healthy mice. The results showed that coconut oil induced endoplasmic reticulum stress and leptin resistance in the hypothalamus, favored lipogenesis in adipose tissue, and impaired STAT3 and JAK2 signaling.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Public, Environmental & Occupational Health
Maisa Furlanetto Marchetti, Graziele Maria da Silva, Carolina Neves Freiria, Flavia Silva Arbex Borim, Tabatta Renata Pereira de Brito, Marciane Milanski, Ligiana Pires Corona
Summary: This study found an association between zinc deficiency and cognitive decline in community-dwelling older adults. Older adults with zinc deficiency had significantly lower scores on the memory test. Zinc deficiency was also associated with other factors such as low schooling level, lack of a partner, risk of malnutrition, and a history of encephalic vascular accident.
CIENCIA & SAUDE COLETIVA
(2022)