Article
Biochemistry & Molecular Biology
Mikel Portillo-Esnaola, Azahara Rodriguez-Luna, Jimena Nicolas-Morala, Maria Gallego-Rentero, Maria Villalba, Angeles Juarranz, Salvador Gonzalez
Summary: Exposure to UVR can lead to DNA damage in the skin, while FB acts as a potential antioxidant and ROS scavenger to reduce this damage.
Article
Plant Sciences
Hui Sin Lim, Samson Eugin Simon, Yoon-Yen Yow, R. Saidur, Kuan Onn Tan
Summary: The methanolic extract of Lignosus rhinocerus (TM02-ME) has photoprotective effects on UVB-irradiated human keratinocytes, reducing DNA damage and cell death and up-regulating the expression of genes involved in DNA repair and skin barrier function. TM02-ME also increases the expression of pro-survival proteins, providing protection against UVB-induced cell death.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Huan Huo, Yuhan He, Wenchao Chen, Ling Wu, Xinyao Yi, Jianxiu Wang
Summary: In this study, electrochemical impedance spectroscopy was used to monitor UVC-induced DNA damage and photoenzymatic repair. The quantitative and kinetic parameters of the damage and repair processes were obtained using EIS and surface plasmon resonance. This method is simple, sensitive, and holds great potential.
Article
Chemistry, Multidisciplinary
Sarah J. Crucilla, Dian Ding, Gabriella G. Lozano, Jack W. Szostak, Dimitar D. Sasselov, Corinna L. Kufner
Summary: The study demonstrates for the first time that RNA can protect itself from photolesions through an intrinsic UV-induced self-repair mechanism. This mechanism, previously observed only in DNA, is based on charge transfer from CPD-adjacent bases. The findings may shed light on the formation and repair of RNA damage in modern organisms and viruses.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Csaba Hegedus, Tamas Juhasz, Eszter Fidrus, Eszter Anna Janka, Gabor Juhasz, Gabor Boros, Gyorgy Paragh, Karen Uray, Gabriella Emri, Eva Remenyik, Peter Bai
Summary: UVB radiation induces CPD formation and difficult repair in keratinocytes, as well as complex metabolic changes. Overexpression of CPD-photolyase can efficiently repair CPDs and block related signaling pathways.
Article
Biochemistry & Molecular Biology
Jyoti Srivastava, Montana M. Young, Vipin Kumar Yadav, Pravin R. Phadatare, Thomas A. Meyer, Ratan K. Chaudhuri, Sanjay Premi
Summary: The study shows that cyclobutane pyrimidine dimers (CPDs), the carcinogenic DNA photoproducts induced by ultraviolet radiation (UV), can be inhibited by the plant-based phenolic alkanone Acetyl Zingerone (AZ) and its analog 3-(4-Methoxy-benzyl)-Pentane-2,4-dione (MBPD). These inhibitors not only block the formation of dark CPDs (dCPDs) but also reduce the amount of incident CPDs (iCPDs), making them potential additives for sunscreens and other clinical applications.
Review
Biochemistry & Molecular Biology
Karl P. Lawrence, George J. Delinasios, Sanjay Premi, Antony R. Young, Marcus S. Cooke
Summary: Dark cyclobutane pyrimidine dimers (dCPD) are formed post UV-exposure and can be prevented by antioxidants, with further research needed on their spectral dependence and biological properties.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Dermatology
M. Alexandra Carpenter, Meghana Ginugu, Saman Khan, Michael G. Kemp
Summary: Solar radiation leads to DNA damage and the formation of CPDs. We found that a fraction of CPDs formed after UVB exposure can be released into the culture medium through extracellular vesicles, which can then be taken up by other keratinocytes. These findings provide possible mechanisms for the systemic effects of UVB exposure.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Seung-Gi Jin, Dean Pettinga, Jennifer Johnson, Peipei Li, Gerd P. Pfeifer
Summary: The study identified cytosine-deaminated CPD as the primary premutagenic lesion responsible for mutations in melanomas. These lesions were enriched immediately upstream of transcription start sites, indicating a potential mutation-promoting role of bound transcription factors. The genomic sequence specificity of deaminated CPDs matched the mutation signature of melanomas.
Article
Environmental Sciences
Silvina Acosta, Lucia Canclini, Juan Jose Marizcurrena, Susana Castro-Sowinski, Paola Hernandez
Summary: The recombinant CPD-photolyase PhrAHym from the Antarctic bacterium shows a highly efficient repair effect on DNA lesions induced by UVC light in human keratinocytes. This non-cytotoxic enzyme repairs CPD-photoproducts and reduces the formation of gamma H2AX, suggesting its potential as a biotherapeutic agent against UV-induced skin cancer, photoaging, and related diseases.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hironobu Ikehata, Masayuki Yamamoto
Summary: Although NB-UVB is more effective in dermatological phototherapy, it is twice as carcinogenic as BB-UVB at an equivalent inflammatory dose. The differences in mutagenicities between the two UVB types can be attributed to the effective wavelengths for CPD formation, with NB-UVB showing a stronger preference for UVA-specific mutations.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Oncology
Damilola Fajuyigbe, Thierry Douki, Arjan van Dijk, Robert P. E. Sarkany, Antony R. Young
Summary: This study found the presence of dark CPD in human skin, which may be influenced by melanin location and concentration. Repair kinetics of different skin types show no significant differences in CPD formation and repair post-exposure.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chantal E. Holtkamp, Dawid Warmus, Klaudia Bonowicz, Maciej Gagat, Kinga Linowiecka, Agnieszka Wolnicka-Glubisz, Russel J. Reiter, Markus Boehm, Andrzej T. Slominski, Kerstin Steinbrink, Konrad Kleszczynski
Summary: Melatonin is a powerful antioxidant with various benefits, including anti-inflammatory, immunomodulatory, and anti-tumor properties. It has been found to counteract the intracellular disturbances caused by UVB radiation. The mechanisms of action of melatonin and its derivatives are still not fully understood.
Article
Dermatology
Khairuddin Djawad, Irawan Yusuf, Upik Anderiani Miskad, Ilhamjaya Jaya Patellongi, Muhammad Nasrum Massi
Summary: This study demonstrates the protective effect of topical curcumin against DNA damage and epidermal hyperplasia induced by UVB exposure. In acute exposure, topical curcumin shows limited but significant protection against CPD and 8-OHdG expression; while in chronic exposure, all concentrations of topical curcumin exhibit significant inhibition on CPD and 8-OHdG, with the best inhibitory effect on epidermal hyperplasia at 10 μM and 100 μM concentrations.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Toxicology
Kai -Yen Chang, Chao-Hsun Yang, Hsin-Yi Chou, Kuan-Chun Chen, Yu -Chun Huang
Summary: This study investigated the effects of organic UV filters on hyaluronan metabolism and skin hydration. The results showed that these UV filters reduced the extracellular contents of hyaluronan, and their effects on gene expression and oxidative stress varied. Certain UV filters regulated hyaluronan metabolism in human keratinocytes through the PI3K pathway.
TOXICOLOGY IN VITRO
(2023)
Article
Pathology
Mathieu Theriault, Sebastien P. Gendron, Isabelle Brunette, Patrick J. Rochette, Stephanie Proulx
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Ophthalmology
Nataly Trang, Gilles Lalonde, Yolande Dube, Serge Bourgault, Patrick J. Rochette
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2018)
Article
Genetics & Heredity
Marie-Catherine Drigeard Desgarnier, Patrick J. Rochette
Article
Dermatology
Roxanne Berube, Marie-Catherine Drigeard Desgarnier, Thierry Douki, Ariane Lechasseur, Patrick J. Rochette
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Cell & Tissue Engineering
Benjamin Goyer, Mathieu Theriault, Sebastien P. Gendron, Isabelle Brunette, Patrick J. Rochette, Stephanie Proulx
TISSUE ENGINEERING PART A
(2018)
Article
Toxicology
Corinne Zinflou, Patrick J. Rochette
ARCHIVES OF TOXICOLOGY
(2019)
Letter
Dermatology
Alicia Montoni, Kelly M. George, Jeremie Soeur, Christian Tran, Laurent Marrot, Patrick J. Rochette
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Cell & Tissue Engineering
Benjamin Goyer, Ulysse Pereira, Brice Magne, Danielle Larouche, Selia Kearns-Turcotte, Patrick J. Rochette, Ludovic Martin, Lucie Germain
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Biochemical Research Methods
Pascal Deladurantaye, Sebastien Methot, Ozzy Mermut, Pierre Galarneau, Patrick J. Rochette
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Dermatology
M. M. Dorr, R. Guignard, F. A. Auger, P. J. Rochette
Summary: The presence of dermal components positively influences CPD repair in keratinocytes. The cytokine CXCL5 has been identified as an inhibitor of CPD repair, shedding light on a novel role in DNA damage repair.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Geriatrics & Gerontology
Rodrigo Molina Martins, Georgia de Assis Dias Alves, Silvia de Siqueira Martins, Luiz Alexandre Pedro de Freitas, Patrick J. Rochette, Veronique J. Moulin, Maria Jose Vieira Fonseca
REJUVENATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Sebastien J. Methot, Stephanie Proulx, Isabelle Brunette, Patrick J. Rochette
SCIENTIFIC REPORTS
(2020)
Article
Genetics & Heredity
Anne-Sophie Gary, Marie M. Dorr, Patrick J. Rochette
Summary: The mitochondrial mutation T414G has been found to accumulate in aged and sun-exposed skin. The anterior structures of the eye filter UV rays while the posterior portion is exposed to visible light. Age-dependent accumulation of mtDNA(T414G) was observed in the corneal stroma and iris, suggesting it may be a good marker of cumulative solar exposure.
Article
Ophthalmology
Thierry Hamel, Justine Rheault, David Simonyan, Serge Bourgault, Patrick J. Rochette
Summary: The study aimed to determine if the use of a blue light-filtering intraocular lens (IOL) could prevent the onset of wet age-related macular degeneration (AMD). However, results showed no significant correlation between the presence of a blue light filter in the IOL and the occurrence of wet AMD. Patients with non-blue light-filtering IOL were injected later with anti-VEGF compared to patients with blue light-filtering IOL, contradicting the potential clinical benefit of the blue light filter.
CLINICAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Marie M. Dorr, Patrick J. Rochette
Summary: Absorption of UVR by DNA leads to the formation of CPD, which are responsible for skin cancer mutations. Pre-stimulation with CLUV enhances CPD repair efficiency. However, CLUV pre-treatment reduces CPD removal in keratinocytes without increasing sensitivity to UVR-induced cell death. These findings suggest that chronic UVB exposure may increase the risk of skin cancer mutations due to the accumulation of unrepaired CPD and reduced repair efficiency.