ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers

(2016) H. Jang et al.   BIOCHEMICAL JOURNAL

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

(2016) Olga Blaževitš et al.   Scientific Reports

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers

(2015) Arafath K. Najumudeen et al.   BIOCHEMISTRY

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

(2015) Man-Tzu Wang et al.   CELL

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation

(2015) Masayuki Yamashita et al.   Cell Stem Cell

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

(2015) Xiaolin Nan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly homologous proteins exert opposite biological activities by using different interaction interfaces

(2015) Anat Iosub Amir et al.   Scientific Reports

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

(2015) Maja Šolman et al.   eLife

The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering

(2014) Camilo Guzmán et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

(2014) Camilo Guzmán et al.   PLoS One

ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells

(2013) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

(2013) Yong Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of ASPP2 by RAS/MAPK Pathway Is Critical for Its Full Pro-Apoptotic Function

(2013) Nadia Godin-Heymann et al.   PLoS One

ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63

(2013) L. Tordella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Application of In Vivo FRET Biosensors to Identify Protein Prenylation and Nanoclustering Inhibitors

(2012) Monika Köhnke et al.   CHEMISTRY & BIOLOGY

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into the expanding complexity of the tumor suppressor ASPP2

(2011) Kerstin M. Kampa et al.   CELL CYCLE

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction

(2009) Kerry L. Inder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

(2009) K. M. Kampa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

(2008) R. Shalom-Feuerstein et al.   CANCER RESEARCH

A novel switch region regulates H-ras membrane orientation and signal output

(2008) Daniel Abankwa et al.   EMBO JOURNAL

The Structure and Interactions of the Proline-rich Domain of ASPP2

(2008) Shahar Rotem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

(2008) M. P. Quinlan et al.   MOLECULAR AND CELLULAR BIOLOGY

Galectin-1 Is a Novel Structural Component and a Major Regulator of H-Ras Nanoclusters

(2008) Liron Belanis et al.   MOLECULAR BIOLOGY OF THE CELL