Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

(2016) Yuneivy Cepero-Donates et al.   CYTOKINE

In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis

(2015) Sébastien M. Labbé et al.   FASEB JOURNAL

Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer

(2015) Kevin C. Conlon et al.   JOURNAL OF CLINICAL ONCOLOGY

Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic Syndrome

(2015) Luiz H. A. Cavalcante-Silva et al.   Frontiers in Physiology

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Preassociation of IL-15 with IL-15R -IgG1-Fc Enhances Its Activity on Proliferation of NK and CD8+/CD44high T Cells and Its Antitumor Action

(2014) S. Dubois et al.   JOURNAL OF IMMUNOLOGY

18F-FDG PET/CT Monitoring of  3 Agonist-Stimulated Brown Adipocyte Recruitment in White Adipose Tissue

(2014) J. W. Park et al.   JOURNAL OF NUCLEAR MEDICINE

Interleukin-15 and Soluble Interleukin-15 Receptor α in Coronary Artery Disease Patients: Association with Epicardial Fat and Indices of Adipose Tissue Distribution

(2014) Elena Dozio et al.   PLoS One

Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

(2014) Nicole G. Barra et al.   PLoS One

UCP1 mRNA does not produce heat

(2013) Jan Nedergaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

The Biology of IL-15: Implications for Cancer Therapy and the Treatment of Autoimmune Disorders

(2013) Thomas A. Waldmann   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

(2013) J. I. Odegaard et al.   SCIENCE

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse

(2012) D. Bobbala et al.   DIABETOLOGIA

IL-15 Overexpression Promotes Endurance, Oxidative Energy Metabolism, and Muscle PPARδ, SIRT1, PGC-1α, and PGC-1β Expression in Male Mice

(2012) LeBris S. Quinn et al.   ENDOCRINOLOGY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

The adipose organ: white-brown adipocyte plasticity and metabolic inflammation

(2012) A. Smorlesi et al.   Obesity Reviews

Interleukin-15 Treatment Induces Weight Loss Independent of Lymphocytes

(2012) Nicole G. Barra et al.   PLoS One

Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice

(2011) N. G. Barra et al.   DIABETES OBESITY & METABOLISM

Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?

(2011) Yoshiaki Tamura et al.   ENDOCRINE JOURNAL

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

(2011) Ana Paula Arruda et al.   ENDOCRINOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles

(2011) Emidio E. Pistilli et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study

(2010) Tore Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative Stress in Normal-Weight Obese Syndrome

(2010) Laura Di Renzo et al.   Obesity

NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse

(2009) Owen P. McGuinness et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of the lipogenic pathway in the development of hepatic steatosis

(2009) C. Postic et al.   DIABETES & METABOLISM

Trans-presentation: A novel mechanism regulating IL-15 delivery and responses

(2009) Spencer W. Stonier et al.   IMMUNOLOGY LETTERS

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-15 Contributes to the Regulation of Murine Adipose Tissue and Human Adipocytes

(2009) Nicole G. Barra et al.   Obesity

Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats

(2008) Emidio E. Pistilli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Effects of IL-15 on Rat Brown Adipose Tissue: Uncoupling Proteins and PPARs

(2008) Vanessa Almendro et al.   Obesity