Article
Biology
Marie Ghraichy, Valentin von Niederhausern, Aleksandr Kovaltsuk, Jacob D. Galson, Charlotte M. Deane, Johannes Truck
Summary: This study sequenced the IgH repertoire of different B cell subpopulations in the peripheral blood of healthy adults, revealing distinct characteristics at both individual sequence and repertoire levels through advanced bioinformatic analysis and machine learning. Sorted B cell subpopulations shared similar repertoire characteristics with their in silico separated subsets, and certain IgH repertoire characteristics correlated with the position of the constant region on the IgH locus. Overall, the study provides unprecedented insight into mechanisms of B cell repertoire control in peripherally circulating B cell subpopulations.
Article
Biology
Sindhu Vangeti, Sara Falck-Jones, Meng Yu, Bjorn Osterberg, Sang Liu, Muhammad Asghar, Klara Sonden, Clare Paterson, Penn Whitley, Jan Albert, Niclas Johansson, Anna Farnert, Anna Smed-Sorensen
Summary: The roles and functions of monocytes and dendritic cells (DCs) in the nasopharynx during respiratory viral infections, especially influenza A virus (IAV), are not completely understood. This study examined the frequencies and characteristics of circulating and nasopharyngeal monocytes and DCs in patients with IAV and other respiratory virus infections. The results showed that IAV patients had altered frequencies of monocytes and DCs compared to healthy controls, with increased accumulation of monocytes and DCs in the nasopharynx. Furthermore, older patients exhibited increased monocyte frequencies, suggesting a potential role in disease severity. Proteomic analysis also revealed differential expression of innate immunity-related proteins in IAV and SARS-CoV-2 patients. Overall, these findings provide insights into the tissue-specific and pathogen-specific patterns of monocyte and DC function during respiratory viral infections, emphasizing the importance of comparative investigations in different anatomical sites.
Article
Multidisciplinary Sciences
Chandra Chiappin Cardoso, Camila Matiollo, Carolina Hilgert Jacobsen Pereira, Janaina Santana Fonseca, Helder Emmanuel Leite Alves, Otavio Marcos da Silva, Vivian de Souza Menegassi, Claudia Regina dos Santos, Ana Carolina Rabello de Moraes, Leonardo de Lucca Schiavon, Maria Claudia Santos-Silva
Summary: The study revealed significant disturbances in circulating monocytes and dendritic cells in cirrhotic patients, with unstable cirrhosis patients showing higher frequencies of specific cell subsets. These changes in cell subsets may be associated with disease severity and mortality rates.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Maxime Lecerf, Robin V. Lacombe, Jordan D. Dimitrov
Summary: This study analyzed the sequence correlates of polyreactivity in antibodies and found several sequence patterns that determine polyreactivity. The study also revealed that different B-cell populations use distinct sequence patterns for polyreactive antigen binding. Furthermore, the study demonstrated that human antibodies can use multiple pathways for achieving antigen-binding promiscuity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaochun Liu, Ronghui Zhu, Yang Luo, Shangshang Wang, Yi Zhao, Zhuoqiong Qiu, Yu Zhang, Xiao Liu, Xu Yao, Xiao Li, Wei Li
Summary: This study identified two steady-state (LC1 and LC2) and two activated LC subsets in human skin epidermis and LCs derived from CD34(+) hemopoietic stem cells. LC1 were characterized as classical LCs mainly related to innate immunity and antigen processing, while LC2 were similar to monocytes or myeloid dendritic cells, involving in immune responses and leukocyte activation. These distinct human LC subsets require different developmental regulation and orchestrate reciprocal functions.
Review
Oncology
Alexandre Poirier, Michel L. Tremblay
Summary: Dendritic cells have the ability to mount T cell responses against tumors, but their effectiveness in vaccination against established malignancies is limited. New insights into signaling cascades and targeted strategies have been found to enhance dendritic cell activity and promote anti-tumor therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Environmental Sciences
Fang Bai, Yunlu Jia, Jie Li, Zhongxing Wu, Lin Li, Lirong Song
Summary: This study found that programmed cell death (PCD) in cyanobacterium Microcystis aeruginosa and green algae Chlorella luteoviridis induced by paraquat involved the caspase-dependent pathway. However, the signaling pathway and cascade events of PCD differed between the two species. In M. aeruginosa, cell death was triggered by a rapid increase in free Ca2+ concentration followed by elevated reactive oxygen species (ROS) levels, while in C. luteoviridis, cell death was mediated by the mitochondrial apoptosis pathway along with increased ROS levels and caspase-like activity. Furthermore, the levels of ROS and metacaspase activity were synchronized in both species, implying that paraquat-induced PCD was ROS-mediated.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Nishan Deng, Xiaoshu Zuo, Qibin Lin, Tong Wang, Yun Li, Jieying Zhong, Haiyang Ni, Qianhui Chen, Xuhong Ding, Hongying Yu, Hanxiang Nie
Summary: Low-dose 5-FU treatment inhibits the development of asthma and improves Th2 cell response by inducing apoptotic cell death of moDCs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran, Peter Vandenabeele
Summary: Ferroptosis, a form of cell death characterized by iron accumulation and lipid peroxidation, has lower immunogenicity compared to other cell death modalities, inhibiting the maturation and antigen cross-presentation of immune cells and hence weakening the anti-tumor immune response.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
Summary: 24S-OHC and 25OHC induced the same type of cell death in each of the cell types examined, and the inhibitory effect varied depending on the type of cell death for alpha-Toc and alpha-Toc3.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pediatrics
Xenia Rueckle, Jessica Ruehle, Leonie Judd, Janine Hebel, Stefanie Dietz, Christian F. Poets, Christian Gille, Natascha Koestlin-Gille
Summary: This study investigated the relationship between neonatal immune cells and probiotics in the infant's gut and found that probiotics can enhance the defense function of neonatal monocytes, which may have a positive impact on preventing neonatal intestinal inflammatory diseases.
PEDIATRIC RESEARCH
(2023)
Article
Allergy
Meng Zhang, Qianying Yu, Wei Tang, Yujiao Wu, JiaJia Lv, Lin Sun, Guochao Shi, Min Wu, Jieming Qu, Caixia Di, Zhenwei Xia
Summary: The study revealed that HDM-AEC-EXOs facilitate recruitment, proliferation, migration, and activation of DCs, with CNTN1 playing a critical role. Notch2 receptor is necessary for relaying the CNTN1 signal to activate TH2 cell/TH17 cell immune response. Studies of patients with asthma support the existence of the CNTN1-Notch2 axis observed in cell and mouse models.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Camille Bigenwald, Jessica Le Berichel, C. Matthias Wilk, Rikhia Chakraborty, Steven T. Chen, Alexandra Tabachnikova, Rebecca Mancusi, Harshal Abhyankar, Maria Casanova-Acebes, Ilaria Laface, Guray Akturk, Jenielle Jobson, Zoi Karoulia, Jerome C. Martin, John Grout, Anahita Rafiei, Howard Lin, Markus G. Manz, Alessia Baccarini, Poulikos I. Poulikakos, Brian D. Brown, Sacha Gnjatic, Amaia Lujambio, Kenneth L. McClain, Jennifer Picarsic, Carl E. Allen, Miriam Merad
Summary: The study found that the BRAF(V600E) mutation induces a senescence program in multipotent hematopoietic progenitor cells, leading to the development of LCH disease, suggesting that senescent cells may be a new target for the treatment of LCH.
Article
Cell Biology
Dylan Kwart, Jing He, Subhashini Srivatsan, Clarissa Lett, Jacquelynn Golubov, Erin M. Oswald, Patrick Poon, Xuan Ye, Janelle Waite, Arielle Glatman Zaretsky, Sokol Haxhinasto, Elsa Au-Yeung, Namita T. Gupta, Joyce Chiu, Christina Adler, Samvitha Cherravuru, Evangelia Malahias, Nicole Negron, Kathryn Lanza, Angel Coppola, Min Ni, Hang Song, Yi Wei, Gurinder S. Atwal, Lynn Macdonald, Nicole Stokes Oristian, William Poueymirou, Vladimir Jankovic, Matthew Fury, Israel Lowy, Andrew J. Murphy, Matthew A. Sleeman, Bei Wang, Dimitris Skokos
Summary: This study identifies endogenous cancer cell-derived type I interferons (IFNs) as regulators of monocyte functional polarization, which in turn influences the efficacy of immunotherapies. By analyzing single-cell transcriptomic data from human and mouse tumors, the researchers distinguish and separate immunostimulatory from immunosuppressive tumor monocytes based on surface marker expression. They show that cancer cell-derived IFNs regulated by cGAS-STING pathway can polarize immunostimulatory monocytes and demonstrate that immunosuppressive monocytes can convert into immunostimulatory monocytes upon cancer cell-intrinsic cGAS-STING activation. Moreover, the study finds that human cancer cells can produce type I IFNs that polarize monocytes, and the immunostimulatory monocyte gene signature is enriched in patient tumors that respond to anti-PD-1 immunotherapy.
Article
Biochemistry & Molecular Biology
Joanna Szpor, Joanna Streb, Anna Glajcar, Anna Streb-Smolen, Agnieszka Lazarczyk, Paulina Korta, Karolina Brzuszkiewicz, Robert Jach, Diana Hodorowicz-Zaniewska
Summary: The density of dendritic cells (DCs) with different superficial antigens is associated with various histopathological characteristics of ductal carcinoma in situ (DCIS). CD123(+) and DC-LAMP(+) cells are correlated with tumor size, grading, and neoductgenesis, while CD1a(+) cells are negatively correlated with hormone receptor expression. Additionally, the number of DC-LAMP(+) cells is higher in DCIS with comedo necrosis, ductal spread, lobular cancerization, and comedo-type tumors, while CD1a(+) cells are abundant in cases with Paget disease. DC-LAMP seems particularly promising as a target for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Uriel Trahtemberg, Dror Mevorach
FRONTIERS IN IMMUNOLOGY
(2017)
Letter
Infectious Diseases
E. Lebel, U. Trahtemberg, C. Block, O. Zelig, H. Elinav
CLINICAL MICROBIOLOGY AND INFECTION
(2018)
Article
Cell Biology
Dror Mevorach, Uriel Trahtemberg, Alon Krispin, Mizhir Attalah, Jonathan Zazoun, Adi Tabib, Amir Grau, Inna Verbovetski-Reiner
CLEARANCE OF DYING CELLS IN HEALTHY AND DISEASED IMMUNE SYSTEMS
(2010)
Article
Immunology
Yackov Berkun, Inna Verbovetski, Anat Ben-Ami, Daphna Paran, Dan Caspi, Alon Krispin, Uriel Trahtemberg, Oranit Gill, Yaakov Naparstek, Dror Mevorach
EUROPEAN JOURNAL OF IMMUNOLOGY
(2008)
Article
Multidisciplinary Sciences
Adi Tabib, Alon Krispin, Uriel Trahtemberg, Inna Verbovetski, Mario Lebendiker, Tsafi Danieli, Dror Mevorach
Article
Multidisciplinary Sciences
Mizhir Atallah, Alon Krispin, Uriel Trahtemberg, Sandrine Ben-Hamron, Amir Grau, Inna Verbovetski, Dror Mevorach
Article
Public, Environmental & Occupational Health
Anat Gesser-Edelsburg, Ricky Cohen, Adva Mir Halavi, Mina Zemach, Peter Vernon van Heerden, Sigal Sviri, Shmuel Benenson, Uriel Trahtemberg, Efrat Orenbuch-Harroch, Lior Lowenstein, Dan Shteinberg, Asher Salmon, Allon Moses
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2018)
Article
Immunology
U. Trahtemberg, N. Bazak, S. Sviri, M. Beil, S. Paschke, P. V. van Heerden
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Cell Biology
Uriel Trahtemberg, Fares Darawshe, Ram Elazary, Isaac Ginsburg, Michael Beil, Peter Vernon van Heerden, Sigal Sviri
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Editorial Material
Critical Care Medicine
Uriel Trahtemberg, Arthur S. Slutsky, Jesus Villar
INTENSIVE CARE MEDICINE
(2020)
Article
Rheumatology
Uriel Trahtemberg, Robert Rottapel, Claudia C. Dos Santos, Arthur S. Slutsky, Andrew Baker, Marvin J. Fritzler
Summary: Positive APLA serology was associated with more severe disease regardless of COVID-19 status, with IgG aCL strongly associated with worse disease severity and higher ANA titres regardless of COVID-19 status.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Letter
Anesthesiology
U. Trahtemberg, S. Sviri, M. Mandel, P. V. van Heerden, Z. Agur, M. Beil
ANAESTHESIA AND INTENSIVE CARE
(2016)
Article
Biochemistry & Molecular Biology
Uriel Trahtemberg, Mizhir Atallah, Alon Krispin, Inna Verbovetski, Dror Mevorach
Article
Immunology
R. Zaguri, I. Verbovetski, M. Atallah, U. Trahtemberg, A. Krispin, E. Nahari, E. Leitersdorf, D. Mevorach
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2007)