Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis

Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens

(2016) Eric Scocchera et al.   ACS Medicinal Chemistry Letters

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

(2015) Santosh Keshipeddy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors

(2015) Arundhati C. Lele et al.   ACS Medicinal Chemistry Letters

A Focused Screen Identifies Antifolates with Activity on Mycobacterium tuberculosis

(2015) Anuradha Kumar et al.   ACS Infectious Diseases

Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

(2014) Kristen M. Lamb et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Folate Pathway Disruption Leads to Critical Disruption of Methionine Derivatives in Mycobacterium tuberculosis

(2014) Molly R. Nixon et al.   CHEMISTRY & BIOLOGY

Methotrexate: an old new drug in autoimmune disease

(2014) Paola Cipriani et al.   Expert Review of Clinical Immunology

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

(2014) Narendran G-Dayanandan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genomic insights into tuberculosis

(2014) James E. Galagan   NATURE REVIEWS GENETICS

Bactericidal Activity and Mechanism of Action of AZD5847, a Novel Oxazolidinone for Treatment of Tuberculosis

(2013) V. Balasubramanian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Elucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate Reductase

(2013) Kristen M. Lamb et al.   BIOCHEMISTRY

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

(2013) Janet L. Paulsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3D-QSAR and Cell Wall Permeability of Antitubercular Nitroimidazoles against Mycobacterium tuberculosis

(2013) Sang-Ho Lee et al.   MOLECULES

Antifolates as effective antimicrobial agents: new generations of trimethoprim analogs

(2013) Wangda Zhou et al.   MedChemComm

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

(2012) Kathleen M. Frey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MycPermCheck: the Mycobacterium tuberculosis permeability prediction tool for small molecules

(2012) Benjamin Merget et al.   BIOINFORMATICS

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

(2012) Kishore Viswanathan et al.   PLoS One

High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

(2012) Anuradha Kumar et al.   PLoS One

Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity

(2011) Janet L. Paulsen et al.   Chemical Biology & Drug Design

The challenge of new drug discovery for tuberculosis

(2011) Anil Koul et al.   NATURE

Global tuberculosis drug development pipeline: the need and the reality

(2010) Zhenkun Ma et al.   LANCET

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

Clinical experience with the combined use of lopinavir/ritonavir and rifampicin

(2009) Rafaëlla FA Lʼhomme et al.   AIDS

Pharmacokinetics of Antituberculosis Drugs in Pulmonary Tuberculosis Patients with Type 2 Diabetes

(2009) R. Ruslami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetic interactions between rifabutin and lopinavir/ritonavir in HIV-infected patients with mycobacterial co-infection

(2009) H. Khachi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

(2009) Kathleen M. Frey et al.   JOURNAL OF MOLECULAR BIOLOGY

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase

(2009) Kathleen M. Frey et al.   JOURNAL OF STRUCTURAL BIOLOGY

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

(2009) V. Makarov et al.   SCIENCE