期刊
PLOS ONE
卷 11, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0161528
关键词
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资金
- Secretaria de Ciencia y Tecnica de la Universidad de Buenos Aires (UBACyT)
- Buenos Aires, Argentina [PICT 0120]
- CONICET
- National Institute on Minority Health and Health Disparities, National Institute of Health [MHIRT 2T37MD001368]
- Science, Technology, and Productive Innovation office (Mincyt) Argentina [AECID A1/041041/11, D/024562/09]
Acinetobacter johnsonii rarely causes human infections. While most A. johnsonii isolates are susceptible to virtually all antibiotics, strains harboring a variety of beta-lactamases have recently been described. An A. johnsonii Aj2199 clinical strain recovered from a hospital in Buenos Aires produces PER-2 and OXA-58. We decided to delve into its genome by obtaining the whole genome sequence of the Aj2199 strain. Genome comparison studies on Aj2199 revealed 240 unique genes and a close relation to strain WJ10621, isolated from the urine of a patient in China. Genomic analysis showed evidence of horizontal genetic transfer (HGT) events. Forty-five insertion sequences and two intact prophages were found in addition to several resistance determinants such as bla(PER-2), bla(OXA-58), bla(TEM-1), strA, strB, ereA, sul1, aacC2 and a new variant of bla(OXA-211), called bla(OXA-498). In particular, bla(PER-2) and bla(TEM- 1) are present within the typical contexts previously described in the Enterobacteriaceae family. These results suggest that A. johnsonii actively acquires exogenous DNA from other bacterial species and concomitantly becomes a reservoir of resistance genes.
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