Review
Behavioral Sciences
Jose Manuel Perez-Garcia, Samuel Suarez-Suarez, Sonia Doallo, Fernando Cadaveira
Summary: This review comprehensively evaluates the impact of binge drinking on neurocognitive functions, and introduces the use of resting-state functional connectivity and neurite orientation dispersion and density imaging techniques. The study finds that binge drinking is associated with structural and functional anomalies in the brain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Nicholas A. Everett, Anita J. Turner, Priscila A. Costa, Sarah J. Baracz, Jennifer L. Cornish
Summary: The study found that peripherally administered oxytocin has inhibitory effects on METH self-administration and reinstatement, with a requirement for vagus nerve signaling involvement, and that this vagal dependency is partially mediated by sex and drug withdrawal.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Ting Ling-Hu, Shao-Bo Liu, Yao Gao, Yu-Mei Han, Jun-Sheng Tian, Xue-Mei Qin
Summary: Depression causes abnormal brain glucose catabolism due to impaired mitochondrial structure and function. Activation of metabolic enzymes in energy-producing pathways is attempted, but a low TCA cycle activity is observed in depression. The strategy of stable isotope-resolved metabolomics and mitochondrial analysis provides insights for investigating depression mechanisms and developing novel antidepressants.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Substance Abuse
Hannah A. A. Wang, Hua-Jun Liang, Thomas M. Ernst, Helenna Nakama, Eric Cunningham, Linda Chang
Summary: This study aimed to investigate the independent and combined effects of chronic heavy methamphetamine (METH) use and having at least one copy of the apolipoprotein E (APOE)-epsilon 4 allele on brain morphometry and cognition, especially in relation to aging. The results showed that METH users, regardless of APOE-epsilon 4 genotype, had lower cognitive performance and specific brain abnormalities compared to non-users. Additionally, APOE-epsilon 4 carriers who were METH users showed the smallest volumes in certain brain regions, suggesting a synergistic effect on brain atrophy.
Article
Cell Biology
Ved Vasishtha Pendyala, Sarah Pribil, Victoria Schaal, Kanika Sharma, Sankarasubramanian Jagadesan, Li Yu, Vikas Kumar, Chittibabu Guda, Lie Gao
Summary: Gabapentin (GBP), a GABA analogue, is primarily used as an anticonvulsant for the treatment of partial seizures and neuropathic pain. However, recent studies have shown that GBP can significantly increase the risk of heart diseases. In this study, using a rat model, researchers found that both acute and chronic GBP treatments suppressed cardiovascular function and resulted in abnormal calcium signaling in cardiomyocytes. These findings provide important evidence of the cardiovascular side effects of GBP.
Article
Biochemical Research Methods
Tanthai Polvat, Tanya Prasertporn, Piyada Na Nakorn, Supitcha Pannengpetch, Wilasinee Suwanjang, Jiraporn Panmanee, Sukhonthar Ngampramuan, Jennifer L. Cornish, Banthit Chetsawang
Summary: This study aimed to investigate the cognitive impairment caused by chronic methamphetamine addiction in mice and explore the potential mechanisms. It was found that methamphetamine administration led to poor cognitive performance in mice, which partially recovered after withdrawal. Treatment with melatonin during withdrawal enhanced the recovery by restoring neuronal impairments.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Neurosciences
Shadab Forouzan, Kristi L. Hoffman, Therese A. Kosten
Summary: The study found that exposure to methamphetamine and its cessation can alter the composition of gut microbiota, with the gut bacteria composition returning to normal after cessation. In addition, acute cessation of methamphetamine induced depressive-like behavior, but did not affect anxiety-like behavior.
PSYCHOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Maria Eugenia Sancho Santos, Pavel Horky, Katerina Grabicova, Christoph Steinbach, Pavla Hubena, Eva Salkova, Ondrej Slavik, Roman Grabic, Tomas Randak
Summary: This study investigated the effects of exposure to a low concentration of METH on brown trout. The trout exhibited lowered activity and metabolic rate, altered brain and gonad morphology, changes in brain metabolome, and higher levels of melatonin. The findings highlight the complex disturbances in aquatic fauna caused by the presence of METH in the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Nutrition & Dietetics
Mickeal N. Key, Amanda N. Szabo-Reed
Summary: Preserving cognitive function and protecting brain structure during aging and neurodegenerative diseases is the goal of non-pharmacologic interventions, such as diet and exercise. This review examines the current trends of diet and exercise interventions and their impact on cognition and brain health. Various diets, including the Mediterranean diet, DASH, MIND, ketogenic diet, intermittent fasting, and weight loss management, as well as exercise approaches such as endurance, resistance, combined programs, yoga, tai chi, and high-intensity interval training, are discussed. While evidence is accumulating regarding the influence of diet and exercise on cognitive performance and brain structure, more research is needed to understand the underlying mechanisms.
Article
Neurosciences
Fabrizio dos Santos Cardoso, Julio Cesar Claudino dos Santos, Francisco Gonzalez-Lima, Bruno Henrique Silva Araujo, Rodrigo Alvaro Brandao Lopes-Martins, Sergio Gomes da Silva
Summary: The study found that transcranial photobiomodulation can enhance brain energy metabolism and cognition, particularly reversing aging-related metabolic changes in older rats. Statistical analysis revealed that photobiomodulation significantly improved metabolic pathways in younger rats, especially in excitatory neurotransmission and oxidative metabolism, while restoring altered pathways in older rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samuel Hogarth, Emily J. Jaehne, Xiangjun Xu, Quenten Schwarz, Maarten van den Buuse
Summary: The aim of this study was to investigate the role of BDNF and dopamine D3 receptors in the effects of chronic methamphetamine on prepulse inhibition (PPI), an endophenotype of psychosis. The results showed that chronic methamphetamine disrupted PPI regulation in male mice with BDNF haploinsufficiency, regardless of D3 receptor knockout. However, there were no effects of BDNF heterozygosity or D3 knockout on PPI regulation in female mice. These findings suggest a significant involvement of BDNF in the long-term effects of methamphetamine on PPI, particularly in male mice.
Review
Neurosciences
Xiaoyou Zhang, Boyi Zong, Wenrui Zhao, Lin Li
Summary: The systematic review found that mind-body exercise modulates brain structure, neural activity, and functional connectivity in regions such as the prefrontal cortex, hippocampus/medial temporal lobe, lateral temporal lobe, insula, and the cingulate cortex. This may explain the beneficial effects of such exercises on health, but more randomized controlled trials with rigorous designs and whole-brain analyses are needed for confirmation.
Article
Neurosciences
Akhil Sharma, Viktoriia Bazylianska, Anna Moszczynska
Summary: PKO rats display a certain resistance to METH neurotoxicity, possibly mediated by lowered DA levels and downregulated mitochondria.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Medicine, General & Internal
Yuansen Li, Deshenyue Kong, Ke Bi, Huayou Luo
Summary: Methamphetamine abuse can impair the intestinal barrier and lead to severe digestive diseases. The gut microbiota play a role in this process through the gut-brain axis.
FRONTIERS IN MEDICINE
(2022)
Article
Psychiatry
Kai Xiao, Yanmin Luo, Xin Liang, Jing Tang, Jin Wang, Qian Xiao, Yingqiang Qi, Yue Li, Peilin Zhu, Hao Yang, Yuhan Xie, Hong Wu, Yong Tang
Summary: Running exercise can alleviate symptoms of depression by reducing the number of microglia and inhibiting their activation in the hippocampus, leading to a decrease in neuroinflammation levels and improvement in depressive-like symptoms.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Austin B. Schwartz, Anshika Kapur, Zhenbo Huang, Raveendra Anangi, John M. Spear, Scott Stagg, Erminia Fardone, Zolan Dekan, Jens T. Rosenberg, Samuel C. Grant, Glenn F. King, Hedi Mattoussi, Debra Ann Fadool
Summary: The olfactory system is modulated by metabolic factors to drive changes in feeding behavior and energy homeostasis. Inhibiting Kv1.3 in the olfactory bulb can enhance excitability of output neurons and lead to metabolic responses, resulting in changes in body weight and energy metabolism.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Mark Marzano, Mayassa J. Bou-Dargham, Allaura S. Cone, Sara York, Shannon Helsper, Samuel C. Grant, David G. Meckes, Qing-Xiang Amy Sang, Yan Li
Summary: The research utilized iron oxide nanoparticles to label stem cells or extracellular vesicles for imaging. Results showed that the nanoparticles had little impact on the metabolic activity of neural progenitor cells, and affected the biogenesis of extracellular vesicles.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Clinical Neurology
Shannon Helsper, F. Andrew Bagdasarian, Xuegang Yuan, Kaya Xu, Jea-Young Lee, Jens T. Rosenberg, Cesario Borlongan, Teng Ma, Samuel C. Grant
Summary: This study evaluated the extended therapeutic application of stem cell therapy for ischemic stroke and monitored it using magnetic resonance imaging (MRI). The results showed that implantation of stem cell aggregates promoted neurological recovery in ischemic stroke, and MRI was able to quantitatively assess the treatment efficacy.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemical Research Methods
Liang Du, Shannon Helsper, Neda Arabzadeh Nosratabad, Wentao Wang, Debra Ann Fadool, Catherine Amiens, Samuel Grant, Hedi Mattoussi
Summary: By designing and preparing water-compatible fluorine-rich polymers as contrast agents, the effectiveness of F-19-based MRI can be enhanced. Further investigation into the effects of introducing additional segmental mobility on the NMR signals.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Biochemical Research Methods
Jens T. Rosenberg, Samuel C. Grant, Daniel Topgaard
Summary: This study attempts to translate state-of-the-art diffusion-relaxation correlation methods from 3T to 21.1T in order to overcome potential hurdles between high signal-to-noise ratio and readily interpretable microstructural information.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Clinical Neurology
Shannon Helsper, Xuegang Yuan, F. Andrew Bagdasarian, Jacob Athey, Yan Li, Cesario Borlongan, Samuel C. Grant
Summary: Compromised hMSC can impair cell therapy efficacy and reverse ischemic recovery. Multinuclear MRI/S provides real-time feedback on ischemic stroke treatment efficacy, which is critical for evaluating therapeutic potency and stroke recovery.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Cell Biology
Xuegang Yuan, Li Sun, Richard Jeske, Dingani Nkosi, Sara B. York, Yuan Liu, Samuel C. Grant, David G. Meckes, Yan Li
Summary: This study presents a promising strategy for scalable production of high-quality extracellular vesicles (EVs) from human mesenchymal stem cells (hMSCs) using 3D aggregates grown under wave motion. The 3D hMSC aggregates promote activation of different pathways involved in EV secretion. Comparison with 2D hMSC-EVs reveals that the quantity of 3D hMSC-EVs is significantly enhanced, with smaller sizes, higher expression of miR-21 and miR-22, and an altered protein cargo. Functionally, 3D hMSC-EVs rejuvenate senescent stem cells and exhibit enhanced immunomodulatory potentials.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Neurosciences
Ronald Kim, Anze Testen, Eden Harder, Natalie E. Brown, Emily A. Witt, Tania J. Bellinger, Janay P. Franklin, Kathryn J. Reissner
Summary: Accumulating evidence suggests significant consequences for astrocytes associated with drug abuse. In male rats, self-administration and abstinence from cocaine leads to reductions in structural features and synaptic colocalization of nucleus accumbens astrocytes, while similar effects are not observed in female rats. These results indicate striking and sexually dimorphic effects of abstinence on astrocytes.
Article
Computer Science, Software Engineering
Parmida Ghahremani, Saeed Boorboor, Pooya Mirhosseini, Chetan Gudisagar, Mala Ananth, David Talmage, Lorna W. Role, Arie E. Kaufman
Summary: NeuroConstruct is a novel end-to-end application for the segmentation, registration, and visualization of brain volumes imaged using wide-field microscopy. It offers various annotation helper functions for precise and effective neurite annotation, as well as automatic neurite segmentation using convolutional neural networks. The application also includes tools for visualizing neurites and aligning serially sectioned samples.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2022)
Article
Biochemistry & Molecular Biology
Chang Liu, Shannon Helsper, Mark Marzano, Xingchi Chen, Laureana Muok, Colin Esmonde, Changchun Zeng, Li Sun, Samuel C. Grant, Yan Li
Summary: Extracellular vesicles (EVs) play significant roles as intracellular mediators, disease biomarkers, and therapeutic agents. Superparamagnetic iron oxide (SPIO) nanoparticles have been shown to improve the targeting ability of EVs. In this study, ultrasound sonication was used to load ultrasmall SPIO (USPIO) nanoparticles onto EVs derived from induced forebrain neural progenitor cortical organoids (iNPCo). The labeled EVs exhibited higher MRI contrast in agarose gel phantoms.
Article
Computer Science, Software Engineering
Saeed Boorboor, Shawn Mathew, Mala Ananth, David Talmage, Lorna W. Role, Arie E. Kaufman
Summary: Recent advances in high-resolution microscopy have enabled scientists to study brain connectivity and predict changes in neural fiber morphology over time using a novel framework called NeuRegenerate. This framework incorporates a deep-learning network called neuReGANerator, which uses a cycle-consistent generative adversarial network (GAN) to translate features of neuronal structures across age-timepoints. The framework also includes visualization tools, such as neuroCompare and neuroMorph, to visualize the differences and transformations in neural projections. The framework is specifically designed for wide-field microscopy volumes and has been demonstrated in the study of cholinergic system changes in mouse brains.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)
Review
Neurosciences
Mala R. Ananth, Prithviraj Rajebhosale, Ronald Kim, David A. Talmage, Lorna W. Role
Summary: Acetylcholine plays a crucial role in cognition. Recent studies have revealed the complex organization and function of cholinergic neurons in the basal forebrain, and their involvement in diverse cognitive behaviors. These findings highlight the importance of cholinergic signaling in cognition.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Alfredo Scigliani, Samuel C. Grant, Hadi Mohammadigoushki
Summary: Surfactants self-assemble in aqueous solutions and play a critical role in energy, biotechnology, and the environment. This study uses non-invasive 1H NMR diffusometry to monitor the self-diffusion dynamics of surfactants in micelles and distinguish various topological transitions. The results highlight the unique sensitivity of 1H NMR diffusometry to micelle topological transitions and provide insights for further research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Meeting Abstract
Clinical Neurology
S. C. Grant, S. W. Holder, N. Abad, H. Alderson, M. G. Harrington
Meeting Abstract
Clinical Neurology
S. W. Holder, H. Alderson, N. Abad, M. G. Harrington, S. C. Grant
