R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates  -Catenin Signaling and Tumorigenesis in Multiple Cancer Types

(2015) C. Chartier et al.   CANCER RESEARCH

Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3

(2015) Matthias Zebisch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

(2015) Elaine E. Storm et al.   NATURE

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

RSPO fusion transcripts in colorectal cancer in Japanese population

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

Intestinal Subepithelial Myofibroblasts Support the Growth of Intestinal Epithelial Stem Cells

(2014) Nan Ye Lei et al.   PLoS One

The structural basis of R-spondin recognition by LGR5 and RNF43

(2013) P.-H. Chen et al.   GENES & DEVELOPMENT

Structural basis for R-spondin recognition by LGR4/5/6 receptors

(2013) D. Wang et al.   GENES & DEVELOPMENT

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling

(2013) Weng Chuan Peng et al.   PLoS One

R-Spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea

(2013) Olivier Papapietro et al.   Nature Communications

The R-spondin family of proteins: Emerging regulators of WNT signaling

(2012) Yong-Ri Jin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Identification of novel transcripts in annotated genomes using RNA-Seq

(2011) A. Roberts et al.   BIOINFORMATICS

The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair

(2011) Stefan Koch et al.   GASTROENTEROLOGY

Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice

(2011) E Diez et al.   GENES AND IMMUNITY

Craniofacial malformation in R-spondin2 knockout mice

(2009) Wakako Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

(2009) Yutao Yan et al.   PLoS One

Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice

(2009) Payel Bhanja et al.   PLoS One

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development

(2008) O. Kazanskaya et al.   DEVELOPMENT

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE