Article
Chemistry, Multidisciplinary
Moon Young Jun, Rajendra Karki, Keshav Raj Paudel, Nisha Panth, Hari Prasad Devkota, Dong-Wook Kim
Summary: Liensinine showed significant anti-oxidative activity by inhibiting serum lipid peroxidation and reducing NO generation in macrophage cells. It also suppressed proliferation and enzymatic activity in vascular smooth muscle cells as well as expression of inflammatory markers. These findings suggest the potential preventive effect of liensinine on vascular inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, Research & Experimental
Ayman M. Mahmoud, Omnia A. M. Abd El-Ghafar, Mohammed A. Alzoghaibi, Emad H. M. Hassanein
Summary: This study demonstrated that the melatonergic agonist agomelatine is protective against gentamicin-induced kidney injury in rats by reducing oxidative stress and inflammation. AGM suppressed TLR-4 signaling, increased antioxidants, and upregulated SIRT1 and PPAR gamma in the kidney of GM-intoxicated rats.
Article
Nutrition & Dietetics
Tsung-Yuan Yang, Yi-Liang Wu, Meng-Hsun Yu, Tung-Wei Hung, Kuei-Chuan Chan, Chau-Jong Wang
Summary: The study found that mulberry leaf extract and neochlorogenic acid can inhibit the proliferation and migration of rat aortic vascular smooth muscle cells under diabetic conditions. These effects may be achieved through the inhibition of FAK/small GTPase proteins, PI3K/Akt, and Ras-related signaling.
Article
Cell Biology
Lan Jin, Yunhe Chen, Dan Cheng, Zhikai He, Xinyi Shi, Boyu Du, Xueyan Xi, Yujing Gao, Yang Guo
Summary: Colorectal cancer is a highly aggressive and lethal cancer, with autophagy playing a complex role in its pathobiology. The transcriptional coactivator YAP has been found to negatively regulate autophagy in CRC cells, promoting tumor progression by upregulating the apoptosis-inhibitory protein Bcl-2 through TEAD interaction, thereby suppressing autophagy-related cell death. Targeting the YAP/Bcl-2 pathway may hold promise as a potential therapeutic strategy against CRC.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Ling Lin, Youwen Xu, Hongfei Ge, Susu He, Peng Wang
Summary: The study reveals that CHD4 plays a crucial role in repressing apoptosis and promoting cancer development in lung adenocarcinoma. Functional analyses show that CHD4 can elevate the levels of PHF6, thereby enhancing the proliferation of LAC cells and suppressing their apoptosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Liping Huang, Yanlin Ma, Lu Chen, Jiang Chang, Mei Zhong, Zhijian Wang, Ying Sun, Xia Chen, Fei Sun, Lu Xiao, Jianing Chen, Yingjun Lai, Chuming Yan, Xiaojing Yue
Summary: Preeclampsia is a life-threatening disease in pregnant women associated with mitochondrial-mediated placental oxidative stress. The down-regulation of Rnd3 in primary trophoblasts from PE patients leads to excessive ROS generation, cell apoptosis, and mitochondrial damage. Rnd3 acts as a protective factor in placental mitochondria through the PPARγ-UCP2 signaling pathway.
Article
Cardiac & Cardiovascular Systems
Dan-dan Feng, Bin Zheng, Jing Yu, Man-li Zhang, Ying Ma, Xiao Hao, Jin-kun Wen, Xin-hua Zhang
Summary: The study demonstrates that 17 beta-Estradiol inhibits proliferation and oxidative stress in vivo and in vitro by promoting BHLHE40 expression, thereby suppressing MAPK signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yu-Ge Zhu, Yun-Xia Lv, Chen-Yi Guo, Zhi-Min Xiao, Qun-Guang Jiang, Huang Kuang, Wen-Hua Zhang, Ping Hu
Summary: The study demonstrates that harmine significantly inhibits the proliferation and migration of U251-MG and U373-MG cells by suppressing the FAK/AKT signaling pathway. These results suggest that harmine could be a promising drug for glioblastoma therapy.
Article
Medicine, Research & Experimental
Jiali Shi, Shanshan Sun, Shuqiao Xing, Changgang Huang, Yuqian Huang, Qian Wang, Xiumin Xue, Zhichao Chen, Yongjie Wang, Zhihui Huang
Summary: Fraxinellone was found to inhibit the proliferation and growth of GBM cells in vitro, as well as suppress their migration and induce apoptosis. The mechanism of action involved the downregulation of SIRT3 signaling and the inhibition of GBM tumorigenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Chuanming Tong, Chuan Wang, Yajie Wang, Xiongsheng Xiao
Summary: TNRC6C-AS1 regulates the expression of LPAR5 by competitively adsorbing miR-513c-5p, impacting the progression of thyroid cancer. This novel signaling pathway may serve as a potential target for cancer therapy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Qiang Li, Zhili Liu, Luping Ma, Weiqi Yin, Kan Zhang
Summary: This study reveals that knockdown of CACYBP inhibits proliferation and migration and weakens tumor growth in prostate cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Xinyu Shao, Jue Wu, Shunying Yu, Yuqing Zhou, Chunli Zhou
Summary: AKR1B10 functions as a tumor suppressor in gastric cancer, with its expression level significantly impacting patient prognosis. Reduced AKR1B10 expression enhances proliferation and migration of GC cells.
Article
Biochemistry & Molecular Biology
Dongbao Li, Yuhong Wang, Chao Dong, Tao Chen, Anqi Dong, Jiayu Ren, Weikang Li, Gege Shu, Jiaoyang Yang, Wenhao Shen, Lei Qin, Lin Hu, Jin Zhou
Summary: This study revealed that CST1 promotes gastric cancer metastasis and progression by regulating GPX4 and inhibiting ferroptosis. High CST1 expression is associated with poor prognosis, and it inhibits ferroptosis by stabilizing GPX4 and reducing intracellular ROS levels, enhancing migration, invasion, and epithelial-mesenchymal transition of gastric cancer cells. CST1 may serve as a new oncological marker and therapeutic target for gastric cancer metastasis.
Article
Biochemistry & Molecular Biology
Jingyu Wang, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Mei Li, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Chenghong Zhang, Ying Zhao, Ying Gao
Summary: Atherosclerosis, a chronic inflammatory disease and leading cause of death worldwide, has been linked to dysregulation of microRNAs (miRNAs). In this study, miR-520c-3p was found to reduce atherosclerotic plaque size and collagen content, and inhibit proliferation and migration of VSMCs by targeting RelA/p65, indicating a potential therapeutic strategy for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Plant Sciences
Junjie Liang, Caiyi Yang, Pengcheng Li, Meiling Zhang, Xueqian Xie, Xuting Xie, Yunliang Chen, Qing Wang, Lian Zhou, Xia Luo
Summary: Astragaloside IV activates PPAR gamma signaling and reduces DNA damage to inhibit the occurrence of CAC.
Article
Cell Biology
Ming-Jie Zhang, Yun Liu, Zi-Cheng Hu, Yi Zhou, Yan Pi, Lu Guo, Xu Wang, Xue Chen, Jing-Cheng Li, Li-Li Zhang
HISTOCHEMISTRY AND CELL BIOLOGY
(2017)
Article
Cell Biology
Ming-Jie Zhang, Yi Zhou, Lei Chen, Xu Wang, Yan Pi, Chun-Yan Long, Meng-Jiao Sun, Xue Chen, Chang-Yue Gao, Jing-Cheng Li, Li-Li Zhang
HISTOCHEMISTRY AND CELL BIOLOGY
(2016)
Article
Cell Biology
Tong Yang, Lu Guo, Lizhao Chen, Jingcheng Li, Qiong Li, Yan Pi, Jie Zhu, Lili Zhang
Article
Cell Biology
Jingyu Chen, Yazhou Wu, Zhi Chen, Bin Yi, Lili Zhang, Changlin Yin, Hua Feng
Article
Cardiac & Cardiovascular Systems
Li Li Zhang, Dao Yan Liu, Li Qun Ma, Zhi Dan Luo, Ting Bing Cao, Jian Zhong, Zhen Cheng Yan, Li Juan Wang, Zhi Gang Zhao, Shan Jun Zhu, Mark Schrader, Florian Thilo, Zhi Ming Zhu, Martin Tepel
CIRCULATION RESEARCH
(2007)