Article
Biochemistry & Molecular Biology
Anna Valentino, Stefania Leuci, Umberto Galderisi, Gianrico Spagnuolo, Michele Davide Mignogna, Gianfranco Peluso, Anna Calarco
Summary: We have found a different miRNA expression profile in plasma-derived exosomes (P-EVs) from MPV patients compared to healthy controls, with a significant downregulation of miR-148a-3p in MPV patients. Bioinformatics analysis predicted MMP7 as a potential target of miR-148a-3p. In vitro experiments showed that treatment with Dsg3 autoantibodies downregulated miR-148a-3p and upregulated MMP7 expression, leading to cell dissociation, which was prevented by overexpression of miR-148a-3p.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tiantongfei Jiang, Weiwei Zhou, Zhenghong Chang, Haozhe Zou, Jing Bai, Qisen Sun, Tao Pan, Juan Xu, Yongsheng Li, Xia Li
Summary: The study comprehensively explores the crucial role of immune system gene regulation in the development of various types of cancer, identifying potential immunology regulons and clinically relevant genes. Analyzing regulon atlas across cancers helps researchers gain insights into the relationships between immune cell infiltrations, checkpoint expression, and cancer prognosis. Developing a user-friendly resource like ImmReg will facilitate the future development of RNA-based cancer immunotherapies.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Sarah Carden, Elisa Vitiello, Ivan Rosa e Silva, James Holder, Valentina Quarantotti, Kamal Kishore, Valar Nila Roamio Franklin, Clive D'Santos, Takashi Ochi, Mark van Breugel, Fanni Gergely
Summary: This study presents CAPture-MS, a powerful method for efficient purification of centrosome proteomes from mammalian cells, which allows for the analysis of cell type-dependent heterogeneity, hierarchical interactions, and identification of unknown components in centrosomes.
DEVELOPMENTAL CELL
(2023)
Article
Construction & Building Technology
Zeynep Duygu Tekler, Adrian Chong
Summary: This study performs occupancy prediction based on a minimum sensing strategy using a comprehensive set of sensor data and a proposed feature selection algorithm. The findings highlight the crucial features for predicting occupancy across all space types as indoor CO2 levels and Wi-Fi connected devices.
BUILDING AND ENVIRONMENT
(2022)
Article
Neurosciences
Alberto De Luca, Andrada Ianus, Alexander Leemans, Marco Palombo, Noam Shemesh, Hui Zhang, Daniel C. Alexander, Markus Nilsson, Martijn Froeling, Geert-Jan Biessels, Mauro Zucchelli, Matteo Frigo, Enes Albay, Sara Sedlar, Abib Alimi, Samuel Deslauriers-Gauthier, Rachid Deriche, Rutger Fick, Maryam Afzali, Tomasz Pieciak, Fabian Bogusz, Santiago Aja-Fernandez, Evren Ozarslan, Derek K. Jones, Haoze Chen, Mingwu Jin, Zhijie Zhang, Fengxiang Wang, Vishwesh Nath, Prasanna Parvathaneni, Jan Morez, Jan Sijbers, Ben Jeurissen, Shreyas Fadnavis, Stefan Endres, Ariel Rokem, Eleftherios Garyfallidis, Irina Sanchez, Vesna Prchkovska, Paulo Rodrigues, Bennet A. Landman, Kurt G. Schilling
Summary: This study aimed to investigate the generalizability of existing dMRI signal representations to different diffusion encoding parameters and brain tissue types, organized a community challenge named MEMENTO for fair comparisons among algorithms. Results showed that most submissions performed well in predicting SDE data, while predicting DDE and DODE data was more challenging.
Article
Medicine, Research & Experimental
Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Yoshiro Tahara, Keisuke Fujii, Isao Tawara, Yoshihiro Miyahara, Kana Okamori, Hideo Yagita, Seiya Imoto, Rui Yamaguchi, Mitsuhiro Komura, Satoru Miyano, Masahiro Goto, Shin-ichi Sawada, Akira Asai, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada, Hiroshi Shiku
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Oncology
Takuya Kakimoto, Akihiko Matsumine, Shinichi Kageyama, Kunihiro Asanuma, Takao Matsubara, Tomoki Nakamura, Takahiro Iino, Hiroaki Ikeda, Hiroshi Shiku, Akihiro Sudo
Article
Oncology
Wenjie Gong, Jean-Marc Hoffmann, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Brigitte Neuber, Angela Hueckelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Mueller-Tidow, Hiroshi Shiku, Michael Schmitt, Leopold Sellner
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2019)
Article
Oncology
Mikiya Ishihara, Yasutaka Tono, Yoshihiro Miyahara, Daisuke Muraoka, Naozumi Harada, Shinichi Kageyama, Takeshi Sasaki, Yasuhide Hori, Norihito Soga, Katsunori Uchida, Taizo Shiraishi, Eiichi Sato, Hideki Kanda, Toshiro Mizuno, Gill A. Webster, Hiroaki Ikeda, Naoyuki Katayama, Yoshiki Sugimura, Hiroshi Shiku
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Cell Biology
Eriko Fukuda, Masatoshi Mori, Hiroshi Shiku, Yoshihiro Miyahara, Yoshifumi Kawamura, Koji Ogawa, Toshihiko Ogura, Naoki Goshima
Article
Hematology
Koji Kawamura, Yukie Tanaka, Hideki Nakasone, Yuko Ishihara, Shinichi Kako, Seiichiro Kobayashi, Yuetsu Tanaka, Tsukasa Ohmori, Kaoru Uchimaru, Sachiko Okamoto, Junichi Mineno, Hiroshi Shiku, Satoshi Nishimura, Yoshinobu Kanda
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Oncology
Naoko Imai, Isao Tawara, Makiko Yamane, Daisuke Muraoka, Hiroshi Shiku, Hiroaki Ikeda
Article
Immunology
Kenta Sukegawa, Kiyomi Shitaoka, Hiroshi Hamana, Eiji Kobayashi, Yoshihiro Miyahara, Keisuke Fujii, Kei Tsuda, Shiori Saeki, Takuya Nagata, Tatsuhiko Ozawa, Shigeru Saito, Tsutomu Fujii, Atsushi Muraguchi, Hiroshi Shiku, Hiroyuki Kishi
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda, Hiroshi Shiku
Article
Cell Biology
Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Hiroaki Tateno, Asako Shimoda, Takanori Ichiki, Koichi Furukawa, Jun Hirabayashi, Kazunari Akiyoshi, Hiroshi Shiku
Summary: The study proposes an effective method for preparing high-performance exosomes (EXOs) using an anion-exchange method. This method allows for the large-scale separation of bioactive EXOs and MV-like EVs, providing valuable insights for research on reliable bioactivity and drug discovery of extracellular vesicles.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Oncology
Hiroyasu Oda, Mikiya Ishihara, Yoshihiro Miyahara, Junko Nakamura, Yuji Kozuka, Motoh Iwasa, Akira Tsunoda, Yoshiki Yamashita, Kanako Saito, Toshiro Mizuno, Hiroshi Shiku, Naoyuki Katayama
CASE REPORTS IN ONCOLOGY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Yoshihiro Miyahara, Kunihiko Yamashita, Hiroshi Miyazaki, Linan Wang, Junko Nakamura, Makiko Yamane, Katsuya Miki, Hiroshi Shiku
Article
Hematology
Eun Jeong Park, Onmanee Prajuabjinda, Zay Yar Soe, Samuel Darkwah, Michael G. Appiah, Eiji Kawamoto, Fumiyasu Momose, Hiroshi Shiku, Motomu Shimaoka
Meeting Abstract
Oncology
Daisuke Muraoka, Naohiro Seo, Tae Hayashi, Keisuke Fujii, Hiroaki Ikeda, Kazunari Akiyoshi, Naozumi Harada, Hiroshi Shiku
Meeting Abstract
Oncology
Shinichi Kageyama, Mikiya Ishihara, Shigehisa Kitano, Yoshihiro Miyahara, Hidefumi Kato, Hideyuki Mishima, Noboru Yamamoto, Hiroaki Iwase, Hiroyoshi Hattori, Takeshi Funakoshi, Takashi Kojima, Takashi Watanabe, Hiroshi Shiku