Article
Biochemistry & Molecular Biology
Elise L. Kessler, Jiong-Wei Wang, Bart Kok, Maike A. Brans, Angelique Nederlof, Leonie van Stuijvenberg, Chenyuan Huang, Aryan Vink, Fatih Arslan, Igor R. Efimov, Carolyn S. P. Lam, Marc A. Vos, Dominique P. de Kleijn, Magda S. C. Fontes, Toon A. B. van Veen
Summary: Deficiency of TLR2 alleviates adverse cardiac remodeling caused by chronic pressure overload, with TLR2 and TLR4 both contributing to this process. The findings provide insights into potential therapeutic targets for preventing or intervening in cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yuichi Sasaki, Yoshiyuki Ikeda, Yoshihiro Uchikado, Yuichi Akasaki, Junichi Sadoshima, Mitsuru Ohishi
Summary: This study demonstrated that estrogen-induced mitochondrial autophagy plays a key role in delaying vascular senescence. The Rab9-dependent alternative autophagy is responsible for estrogen-induced mitochondrial autophagy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Xinwei Lv, Xiaohui Shi, Mutalifu Maihemuti, Danping Yang, Dong Xiao
Summary: This study demonstrates that high mobility group box 1 (HMGB1), toll-like receptor 2 (TLR2), and toll-like receptor 4 (TLR4) can serve as serum biomarkers for assessing the risk of left ventricular diastolic dysfunction (LVDD) in patients with sepsis. HMGB1, TLR2, and TLR4 show significant correlation with the gold standard marker cardiac troponin I (cTnl) and exhibit high sensitivity and specificity in diagnosing LVDD. These biomarkers have the potential to assist clinical management of patients with sepsis.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Cell Biology
Shuai Zhang, Juanjuan Duan, Yu Du, Jinlu Xie, Haijing Zhang, Changyu Li, Wensheng Zhang
Summary: This study explored the profiles of long non-coding RNAs (lncRNAs) in the liver genomes of SAMP8 and SAMR1 mouse models, revealing that certain lncRNAs play a role in liver aging and could serve as potential targets for molecular-based diagnosis and therapy of age-related liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ana Paula Azevedo Macedo, Adelino Sanchez Ramos da Silva, Vitor Rosetto Munoz, Eduardo Rochete Ropelle, Jose Rodrigo Pauli
Summary: The redistribution of body fat induced by aging is associated with changes in mitochondria, leading to metabolic and inflammatory issues. Studying this process is crucial for mitigating the health problems associated with aging.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Nanoscience & Nanotechnology
Lu Diao, Min Li, Jin Tao, Xiaojun Xu, Yiqi Wang, Ying Hu
Summary: This study investigated the therapeutic effects of TAT-CLs-DHA/siRNA on lupus-prone MRL/Ipr mice and its impact on B cell responses. The results showed that TAT-CLs-DHA/siRNA suppressed the proliferation and activation of B cells through the TLR4 signaling pathway and significantly reduced lupus-related symptoms in the mice. Furthermore, the study revealed that TAT-CLs-DHA/siRNA modulated the B-cell intrinsic pathway by downregulating expression of certain molecules.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zhiyue Li, Qiang Zeng, Shengquan Hu, Zhanyan Liu, Shuting Wang, Yu Jin, Limin Li, Hanlin Ou, Zhengzhi Wu
Summary: This study aimed to evaluate the effects of Chaihu Shugan San (CSS) on the microbiota-gut-brain axis and cognitive deficits in senescence-accelerated mouse prone 8 (SAMP8) mice. The results showed that CSS significantly improved learning function, memory deficits, neuronal injury, synaptic injuries, and Aβ deposition in the brain of aged SAMP8 mice. Additionally, CSS also improved the composition of the intestinal microbiota in aged SAMP8 mice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Li-Ya Lee, Wayne Chou, Wan-Ping Chen, Ming-Fu Wang, Ying-Ju Chen, Chin-Chu Chen, Kwong-Chung Tung
Summary: The study demonstrated that Hericium erinaceus mycelium enriched with erinacine A improved learning and memory in mice, reduced levels of aging-related biomarkers, such as iNOS, TBARS, and 8-OHdG, in a dose-dependent manner. This suggests that Hericium erinaceus mycelium may have potential neuroprotective effects in delaying brain aging.
Article
Nutrition & Dietetics
Shigeru Katayama, Chizuru Okahata, Masashi Onozato, Takaaki Minami, Masanaga Maeshima, Kazuaki Ogihara, Shinya Yamazaki, Yuta Takahashi, Soichiro Nakamura
Summary: Long-term administration of buckwheat can improve cognitive performance in senescence-accelerated mouse prone 8 (SAMP8) mice by activating the ERK/CREB signaling pathway and histone H3 acetylation to increase hippocampal BDNF production.
Article
Nutrition & Dietetics
Ming-Yu Chou, Yue-Ching Wong, Shih-Yi Wang, Ching-Hsin Chi, Teng-Hsu Wang, Mao-Jung Huang, Ping-Hsiu Huang, Po-Hsien Li, Ming-Fu Wang
Summary: This study evaluated the benefits of feeding Huang qi and its complexes to aging mice and found that it enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory. These findings support the development and value-added of astragalus-related products in the functional food market.
FRONTIERS IN NUTRITION
(2023)
Article
Neurosciences
Julia Companys-Alemany, Joan Roig-Soriano, Andreea L. Turcu, Miguel Chillon, Santiago Vazquez, Merce Pallas, Christian Grinan-Ferre
Summary: A new NMDA receptor antagonist was found to have neuroprotective and neurogenic effects in aged mice.
Article
Geriatrics & Gerontology
Teruhide Hoshino, Yoshiaki Kato, Keisuke Sugahara, Akira Katakura
Summary: The study aimed to elucidate the molecular biological changes associated with aging in the extensor digitorum longus muscle of senescence-accelerated mouse prone 8 mouse model. Metabolome analysis revealed fluctuated metabolites, such as Val, putrescine, and His, which decreased with age. The findings suggest potential increases in cell senescence and fatigue in the muscle with aging.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Li Miao, Fei Huang, Ying-Ying Sun, Wei Jiang, Yong-Jin Chen, Min Zhang
Summary: Psychological stress induces pathological changes, oxidative stress, and inflammation in masseter muscles. Curcumin can significantly alleviate these changes, potentially through the HMGB1/TLR4/NF-kappa B pathway, exerting anti-inflammatory and antioxidant effects.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Biochemistry & Molecular Biology
Dezheng Zhou, Xin Lv, Yalan Wang, Huan Liu, Suhui Luo, Wen Li, Guowei Huang
Summary: Folic acid supplementation reduced deoxyuridine monophosphate accumulation, decreased uracil misincorporation in telomeres, alleviated telomere length shortening, increased TS expression, leading to decreased neurocyte apoptosis rates, and improved cognitive performance in SAMP8 mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Zhenshu Li, Ke Cai, Yue Sun, Dezheng Zhou, Jing Yan, Suhui Luo, Guowei Huang, Yuxia Gao, Wen Li
Summary: Folic acid supplementation can improve cognitive performance and inhibit neural stem cell apoptosis in the aging brain. However, its role in age-associated telomere attrition is still unclear.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Psychiatry
Alexandre P. Diaz, Brisa S. Fernandes, Joao Quevedo, Marsal Sanches, Jair C. Soares
Summary: Treatment-resistant bipolar depression (TRBD) is common in patients with bipolar disorders, but there are limited interventions. This review identified promising new interventions for TRBD, including both pharmacological and non-pharmacological treatments. More research is needed to personalize current treatments.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Gislaine Z. Reus, Morgana S. Abitante, Luana M. Manosso, Airam B. de Moura, Laura A. Borba, Maria Eduarda M. Botelho, Ana Caroline Darabas, Julia P. Demo, Joao Paulo Behenck, Camila O. Arent, Leandro Garbossa, Larissa Joaquim, Taiane A. Cardoso, Fabricia Petronilho, Joao Quevedo
Summary: This study investigated the effects of early stress, represented by maternal deprivation, on behavior and oxidative stress in rats. It was found that maternal deprivation can promote anxiety-like behavior and impair memory, while also increasing oxidative stress and altering antioxidant defenses. However, environmental enrichment was able to reverse these changes, although its effects were dependent on sex and developmental period.
MOLECULAR NEUROBIOLOGY
(2023)
News Item
Biochemistry & Molecular Biology
Giselli Scaini, Joao Quevedo
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Roberta Eduarda Grolli, Amanda Gollo Bertollo, Joao Paulo Behenck, Laura de Araujo Borba, Marcos Eduardo Plissari, Silvio Jose Batista Soares, Aline Manica, Larissa da Silva Joaquim, Fabricia Petronilho, Joao Quevedo, Margarete Dulce Bagatini, Gislaine Zilli Reus, Zuleide Maria Ignacio
Summary: This study evaluated the effects of chronic mild stress on depressive-like behaviors, oxidative stress, and inflammation in rats, as well as the possible antidepressant, antioxidant, and anti-inflammatory effects of quetiapine. The results showed that chronic stress increased depressive-like behaviors, while quetiapine significantly reduced these behaviors. Chronic stress also increased MPO activity and IL-6 levels in the serum of rats, which were both significantly reduced by quetiapine.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Tatiana Barichello, Vijayasree V. Giridharan, Carlos Henrique R. Catalao, Cristiane Ritter, Felipe Dal-Pizzol
Summary: Sepsis is a life-threatening disorder caused by an unregulated immune response to infection. This response triggers a complex process that promotes the production of inflammatory mediators, resulting in the disruption of blood-brain barrier function and the activation of glial cells. These changes lead to sepsis-associated encephalopathy, which can contribute to cognitive deterioration and increased susceptibility to cognitive decline later in life.
Article
Clinical Neurology
Taiane de Azevedo Cardoso, Ritele H. Silva, Jessica L. Fernandes, Camila O. Arent, Graziela Amboni, Laura A. Borba, Alex Paulo Z. Padilha, Maria Eduarda M. Botelho, Amanda L. Maciel, Tatiana Barichello, Rodrigo Morales, Silvia Jose B. Soares, Margarete D. Bagatini, Claudia Dallagnol, Marta Elisa Brighenti, Zuleide Maria Ignacio, Joao Quevedo, Luciane B. Ceretta, Gislaine Z. Reus
Summary: This study investigates the influence of COVID-19 infection on mental health and finds that individuals with COVID-19 show greater severity of depressive symptoms, higher levels of stress, and greater C-reactive protein (CRP) than those without COVID-19. There is a positive correlation between stress and severity of anxiety, depression, and insomnia in individuals with or without COVID-19. CRP levels are associated with the severity of depressive and anxiety symptoms, as well as stress levels, in individuals with COVID-19.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Debora de A. Simoes Moreira, Luis Eduardo Gauer, Guilherme Teixeira, Amanda Carolina Fonseca da Silva, Stefanie Cavalcanti, Joao Quevedo
Summary: This study compared the efficacy and tolerability of electroconvulsive therapy (ECT) and ketamine for different depression outcomes. The results showed no significant difference between ketamine and ECT in reducing the severity of depressive symptoms and response to therapy. However, there was a significant decrease in the risk of muscle pain with ketamine compared to ECT during treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Taise Possamai-Della, Jose Henrique Cararo, Jorge M. Aguiar-Geraldo, Jefte Peper-Nascimento, Alexandra I. Zugno, Gabriel R. Fries, Joao Quevedo, Samira S. Valvassori
Summary: This study evaluated the effects of prenatal stress on behavior, HPA-axis, and epigenetic parameters in stressed dams and their offspring. It found that prenatal stress led to abnormal emotional behavior in female offspring, accompanied by hyperactivity of the HPA-axis and epigenetic adaptations in the activity of HDAC and DNMT, as well as acetylation in H3K9 and H3K14. In addition, prenatal stressed female offspring showed increased levels of ACTH compared to their male counterpart.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Camila N. C. Lima, Emese H. C. Kovacs, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine, Gabriel R. Fries
Summary: Bipolar disorder (BD) is associated with premature mortality and aging, including accelerated epigenetic aging. Suicide attempts (SA) are significantly higher in BD and are linked to decreased lifespan, biological aging, and poorer clinical outcomes. This study investigated the relationship between GrimAge, an epigenetic clock, and SA in BD individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
News Item
Biochemistry & Molecular Biology
Samira S. Valvassori, Joao Quevedo, Giselli Scaini
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Brisa S. Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao
Summary: The objective of this study was to determine whether tryptophan and kynurenine pathway metabolites are altered in Alzheimer's disease (AD) through a systematic review and meta-analysis. The results showed a shift towards the kynurenine pathway in both the brain and periphery, with increased production of kynurenic acid in the brain but decreased production in peripheral blood. There were also dissociations between central and peripheral levels, as well as between plasma and serum for some metabolites. Overall, changes in the kynurenine pathway are suggested to be a core component of AD, but more research is needed to confirm and consolidate these findings.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Leonardo Baldacara, Cesar Augusto Trinta Weber, Miriam Gorender, Roberta R. Grudtner, Sandra Peu, Ana Luiza Silva Teles, Ives Passos Cavalcante, Joao Quevedo, Antonio Geraldo da Silva
Summary: This article evaluates the effectiveness of crisis hotlines in preventing suicide through a systematic review. The findings indicate that crisis hotlines are effective when included in broader prevention programs and staffed by trained professionals. However, further research is needed to identify key components that enhance effectiveness.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Mehmet Enes Inam, Brisa S. Fernandes, Estela Salagre, Iria Grande, Eduard Vieta, Joao Quevedo, Zhongming Zhao
Summary: This study conducted a systematic review and meta-analysis to examine the KYN pathway metabolites in cerebrospinal fluid samples from patients with schizophrenia, bipolar disorder, and major depressive disorder. The results showed that KA levels were increased in schizophrenia, while the levels of TRP and KYN did not differ significantly. In bipolar disorder and major depressive disorder, there were no significant alterations in TRP and KA levels, although there may be a trend of increased KA levels and elevated QA levels in major depressive disorder. However, more studies are needed to confirm these findings.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)