Article
Medicine, Research & Experimental
Zahra Mirsanei, Neda Heidari, Ali Hazrati, Yahya Asemani, Bahare Niknam, Zahra Yousefi, Reza Jafari
Summary: OLEU, the most prevalent phenolic component in olive varieties, exhibits powerful antioxidant and anti-inflammatory properties. This study investigated the effects of OLEU on LPS-stimulated macrophage cells and found that OLEU could reduce oxidative stress and modulate cytokine expression, suggesting its potential as a therapeutic approach for inflammatory diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Dilly, Miguel Romero, Stephanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok
Summary: ROS in cancer cells play a crucial role in regulating cell death, stemness maintenance, and metabolic reprogramming, which are associated with resistance to chemo/immunotherapy. This paper introduces new inhibitors of NADPH oxidase (NOX), which is important in the tumor microenvironment. One of the inhibitors, called Nanoshutter-1 (NS1), decreases tumor-promoting M2 macrophages in human blood monocytes. NS1 disrupts the NOX2 complex in the macrophages' membrane and mitochondria, leading to vasodilation of blood vessels and potential reduction of hypoxia. By targeting specific cells, NOX2-specific inhibitors could provide precision therapies.
Article
Immunology
Thiranut Jaroonwitchawan, Hideki Arimochi, Yuki Sasaki, Chieko Ishifune, Hiroyuki Kondo, Kunihiro Otsuka, Shin-ichi Tsukumo, Koji Yasutomo
Summary: This study demonstrates that activation of FXR promotes polarization of macrophages towards M2 phenotype, indicating the important role of FXR in M2 macrophage polarization and suggesting the potential therapeutic efficacy of FXR agonists in M2 macrophage-related conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ying Wang, Steven S. Welc, Michelle Wehling-Henricks, Ying Kong, Connor Thomas, Enca Montecino-Rodriguez, Kenneth Dorshkind, James G. Tidball
Summary: Intramuscular macrophages play key roles in regulating skeletal muscle response to injury and disease. Changes in the numbers and phenotype of these macrophages during aging can influence the aging process. A study using a mouse model with a myeloid cell-specific mutation of Spi1 showed that this mutation reduced the numbers of M2 phenotype macrophages in aging muscles, and also reduced age-related muscle fibrosis and sarcopenia. These findings highlight the significance of intramuscular M2-biased macrophages in promoting detrimental, age-related changes in muscle.
Article
Immunology
Stefan Wolf, Jenna H. Rannikko, Reetta Virtakoivu, Paolo Cinelli, Gunther Felmerer, Anna Burger, Pietro Giovanoli, Michael Detmar, Nicole Lindenblatt, Maija Hollmen, Epameinondas Gousopoulos
Summary: Lipedema is a chronic and progressive disorder characterized by the painful and disproportionate increase of subcutaneous fat in the extremities. This study reveals that CD163+ macrophages play a critical role in lipedema and re-polarization of these macrophages can normalize the accumulation of cellular lipids. These findings provide new insights into the pathophysiology of lipedema and suggest potential treatment options.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Shaohong Fang, Song Sun, Hengxuan Cai, Xiaoyi Zou, Shanjie Wang, Xinran Hao, Xin Wan, Jiangtian Tian, Zhaoying Li, Zhongze He, Wei Huang, Chenchen Liang, Zhenming Zhang, Liming Yang, Jinwei Tian, Bo Yu, Bo Sun
Summary: The research suggests that serum IRGM levels may be related to plaque rupture in STEMI patients, and deficiency of IRGM/Irgm1 can increase plaque stability by suppressing macrophage apoptosis through inhibiting ROS generation and MAPK signaling transduction. Targeting IRGM may represent a new treatment strategy for the prevention and treatment of acute cardiovascular deaths caused by plaque rupture.
Article
Cell Biology
Eva Fige, Zsolt Sarang, Laszlo Sos, Zsuzsa Szondy
Summary: Clearing apoptotic cells by differentiating monocytes into macrophages is crucial for resolving inflammation. Retinoids, including DHR, retinol, and all-trans retinoic acid, directly act on retinoic acid receptors to enhance the expression of several genes that facilitate efferocytosis. This process is mediated by bone morphogenetic protein (BMP)-2 and the Smad3 transcription factor. Additionally, retinoids upregulate the expression of the vitamin D receptor and vascular endothelial growth factor A, promoting the generation of pro-reparative M2 macrophages during monocyte differentiation.
Article
Immunology
Gangjie Qiao, Wenbin Ji, Zhaonan Sun, Xiulan Wang, Peiyuan Li, Haowen Jia, Lingling Duan, Feng Qi
Summary: Isosteviol, a sweetener derived from Stevia rebaudiana, has been found to have various biological activities. This study investigated the protective mechanism of isosteviol in burn injury and found that it can reduce inflammation by promoting an increase in the M2 macrophage ratio and increasing the expression of MMP9 during acute inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Wei Zhang, Li Xu, Xiaoyan Zhang, Jianqing Xu, Jun-O Jin
Summary: This study investigates the potential effect of FimH on macrophage polarization and activation. The results show that FimH promotes M1 macrophage activation and repolarizes M2 macrophages into the M1 phenotype via the TLR4 signaling pathway. Moreover, FimH reprograms tumor-associated macrophages in the tumor microenvironment and enhances the anti-tumor activity of immune checkpoint blockade.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
In-Gu Lee, Yong-Hyun Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun, Jeongkyu Kim, Young-Jin Seo, So-Hee Hong
Summary: Gal-4 enhances the immunostimulatory activity of M2 macrophages upon viral infection, leading to the reinforced antiviral functionality of CD4(+) T cells.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Oncology
Bei Zhao, Xiaodan Hui, Jie Wang, Hairong Zeng, Yu Yan, Qing Hu, Guangbo Ge, Tao Lei
Summary: Our study demonstrated that matrine inhibited M2-like macrophage polarization, reduced the production of anti-inflammatory cytokines, and induced M2 surface markers via mTOR/PI3K/Akt signaling pathway in LLCs. Matrine partially blocked LLCs metastasis and inhibited M2-like macrophage-induced EMT in vitro, while promoting T-cell proliferation and decreasing the ratio of CD206(+)/F4/80(+) in vivo. These findings suggest that suppression of M2-like macrophages polarization of TAMs is a potential mechanism underlying the anti-metastasis effects of matrine in lung cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Danlu Chi, Yuejiao Zhang, Xinwei Lin, Qimei Gong, Zhongchun Tong
Summary: This study aimed to investigate the effect of caspase-1 inhibition on PANoptosis in macrophages infected with Enterococcus faecalis. The results showed that caspase-1 inhibitor could simultaneously inhibit pyroptosis and apoptosis in macrophages, but necroptosis still occurred.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Li Cao, Qinghai Tan, Rui Zhu, Lanxiang Ye, Gaiping Shi, Zhenglin Yuan
Summary: Inhibition of MIR4435-2HG suppresses M1 polarization and promotes M2 polarization of macrophages, thereby alleviating intestinal inflammation in mice with ulcerative colitis through the JAK1/STAT1 signaling pathway.
Article
Immunology
Benedikt F. Scherr, Martin F. Reiner, Flavia Baumann, Kerstin Hoehne, Tobias Mueller, Korcan Ayata, Joachim Mueller-Quernheim, Marco Idzko, Gernot Zissel
Summary: This study investigated the effect of ATP on the differentiation of human monocytes into macrophage subtypes. The results showed that ATP can dose-dependently inhibit the differentiation of monocytes into M2-like macrophages. This effect is not mediated by P2X and P2Y receptors.
Article
Immunology
Feixiang Duan, Xiaowu Wang, Hongwei Wang, Yongqiang Wang, Yan Zhang, Jiawei Chen, Xiandong Zhu, Bicheng Chen
Summary: This study found that GDF11 can improve SAP, reduce M1 macrophage polarization, and promote M2 macrophage polarization. GDF11 regulates macrophage polarization through the TGF beta R1/smad2 pathway. The findings of this study reveal the mechanism by which GDF11 regulates macrophage polarization in pancreatic tissues and highlights the protective role of GDF11 in SAP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)