Article
Critical Care Medicine
Linda Xu, Jeffrey B. Ware, Junghoon J. Kim, Pashtun Shahim, Erika Silverman, Brigid Magdamo, Cian Dabrowski, Leroy Wesley, My Duyen Le, Justin Morrison, Hannah Zamore, Cillian E. Lynch, Dmitriy Petrov, H. Isaac Chen, James Schuster, Ramon Diaz-Arrastia, Danielle K. Sandsmark
Summary: Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. The study found that TBI participants had globally elevated CBF in both acute and chronic phases, with focal hypo- and hyperperfusion present in brain tissue. Furthermore, acute elevation in CBF post-TBI may play a reparative role and be associated with better clinical outcomes in the long term.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Neurosciences
Yuyang Wang, Qing Chen, Xinyu Zhang, Kai Wang, Hongwei Cheng, Xingui Chen
Summary: Patients with mild traumatic brain injury (MTBI) have varying degrees of impairment in decision-making abilities, particularly under tasks of ambiguity and risk. Accurate identification of impairments in the early stages is crucial for timely intervention and prevention of long-term cognitive consequences.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Liheng Wu, Yanghui Liu, Liangfu Zhu, Tianxiao Li, Li'na Wang, Yang Zhang, Zhilong Zhou, Ying Xing, Meiyun Wang, Bulang Gao
Summary: This study investigates the value of MRI arterial spin labeling (ASL) in evaluating the blood-brain barrier permeability and the risk of hemorrhage transformation (HT) in patients with anterior circulation subacute ischemic stroke (SIS) treated with endovascular recanalization. The results showed that patients with HT had significantly higher rCBF value, Ktrans, and rKtrans. The ASL imaging sequence demonstrated high consistency with the DCE sequence and Xper CT imaging. Overall, the MRI ASL sequence plays an important role in evaluating the blood-brain barrier permeability and the risk of hemorrhagic transformation in patients with anterior circulation SIS following endovascular recanalization.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sven Bambach, Mark Smith, P. Pearse Morris, Norbert G. Campeau, Mai-Lan Ho
Summary: Arterial spin labeling (ASL) is a noncontrast MRI technique used for quantitative evaluation of brain perfusion. This article discusses advanced applications of ASL across the lifespan, presenting case examples from children and adults with various pathologies. The article highlights the subtleties and pitfalls of ASL interpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Veterinary Sciences
Anne-Cecile Hoffmann, Yannick Ruel, Kirsten Gnirs, Stella Papageorgiou, Luca Zilberstein, Sarah Nahmani, Nathalie Boddaert, Hugues Gaillot
Summary: The study tested the feasibility of ASL using a 1.5 Tesla scanner in dogs and cats, providing recommendations for optimal quantification of cerebral blood flow. By implementing ASL sequences and optimizing CBF, valuable values for the characterization of various brain diseases in dogs and cats were obtained.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyuan Fan, Zhentao Zuo, Tianye Lin, Zhichao Lai, Hui You, Jianxun Qu, Juan Wei, Bao Liu, Feng Feng
Summary: The study aimed to investigate whether preoperative arterial spin labeling (ASL) MRI can predict cerebral hyperperfusion after carotid endarterectomy (CEA) in patients with carotid stenosis. The study found that ASL can non-invasively predict cerebral hyperperfusion after CEA in patients with carotid stenosis based on the presence of arterial transit artifacts (ATAs).
EUROPEAN RADIOLOGY
(2022)
Article
Psychiatry
J. M. Batail, I. Corouge, B. Combes, C. Conan, M. Guillery-Sollier, M. Verin, P. Sauleau, F. Le Jeune, J. Y. Gauvrit, G. Robert, C. Barillot, J. C. Ferre, D. Drapier
Summary: This study investigated the neurovascular mechanisms underlying apathy in depression using neuroimaging techniques. The results showed a negative correlation between cerebral blood flow in the left anterior cingulate cortex (ACC) and the severity of apathy, highlighting the significance of this region in depressed individuals.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. Franklin, Isabell K. Bones, Anita A. Harteveld, Lydiane Hirschler, Marijn van Stralen, Qin Qin, Anneloes de Boer, Johannes M. Hoogduin, Clemens Bos, Matthias J. P. van Osch, Sophie Schmid
Summary: Flow-based ASL techniques provide an alternative to spatially selective techniques with similar performance in the brain and comparable performance in the kidney, with VSI-ASL showing the most potential in brain imaging. Further improvements are needed in kidney imaging to match FAIR's performance.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Xiaoyan Bai, Wei Wang, Xueyan Zhang, Zhangxuan Hu, Xue Zhang, Yingkui Zhang, Hefei Tang, Yaqing Zhang, Xueying Yu, Ziyu Yuan, Peng Zhang, Zhiye Li, Xun Pei, Yonggang Wang, Binbin Sui
Summary: This study investigated the perfusion variances of bilateral amygdala in migraine patients. The results showed increased cerebral blood flow and arterial cerebral blood volume in the left amygdala of chronic migraine patients. The increased perfusion parameters of bilateral amygdala were positively correlated with MIDAS score in chronic migraine patients.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Yin Liu, Liyan Lu, Fengfang Li, Yu-Chen Chen
Summary: This review summarizes the application of multimodal MRI techniques in mild traumatic brain injury (mTBI), as well as its benefits and drawbacks.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neuroimaging
Efrosini Papadaki, Eleftherios Kavroulakis, Katina Manolitsi, Dimitrios Makrakis, Emmanouil Papastefanakis, Pelagia Tsagaraki, Styliani Papadopoulou, Alexandros Zampetakis, Margarita Malliou, Antonios Vakis, Panagiotis Simos
Summary: This study investigated the relationship between hemodynamic changes and psychoemotional status in patients with chronic mild traumatic brain injury (mTBI) compared to healthy volunteers. Results revealed that mTBI patients scored lower in cognitive domains and had higher rates of anxiety and depression symptoms, while also exhibiting significantly reduced cerebral blood flow values in specific brain regions. Depressive symptomatology was associated with lower perfusion in the left anterior cingulate gyrus and higher perfusion in the putamen, bilaterally, within the mTBI group, highlighting specific associations between regional perfusion and mental health symptoms.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Lindner, Divya S. Bolar, Eric Achten, Frederik Barkhof, Antonio J. Bastos-Leite, John A. Detre, Xavier Golay, Matthias Guenther, Danny J. J. Wang, Sven Haller, Silvia Ingala, Hans R. Jaeger, Geon-Ho Jahng, Meher R. Juttukonda, Vera C. Keil, Hirohiko Kimura, Mai-Lan Ho, Maarten Lequin, Xin Lou, Jan Petr, Nandor Pinter, Francesca B. Pizzini, Marion Smits, Magdalena Sokolska, Greg Zaharchuk, Henk J. M. M. Mutsaerts
Summary: This article provides guidance on the clinical applications of arterial spin labeling (ASL) MRI, focusing on disease-specific considerations for sequence optimization and interpretation. It updates and expands on the recommendations from the 2015 ASL consensus paper, which lacked guidance on disease-specific parameters. The article covers various clinical scenarios, including acute ischemic stroke, brain tumors, and pediatric neuroradiology applications.
MAGNETIC RESONANCE IN MEDICINE
(2023)