Article
Otorhinolaryngology
Su Il Kim, Su Jin Jeong, Oh Eun Kwon, Jung Min Park, Young Chan Lee, Young-Gyu Eun, Seong-Gyu Ko
Summary: This study aimed to compare the characteristics of reflux in proton pump inhibitor (PPI) nonresponders vs responders in patients with laryngopharyngeal reflux (LPR) using 24-hour multichannel intraluminal impedance-pH (MII-pH) monitoring. The study found that proximal all reflux time in various MII parameters may be helpful in predicting the response to PPI therapy in patients with LPR, providing insights for personalized therapeutic schemes for LPR patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Endocrinology & Metabolism
Chih-Yuan Wang, Kuo-Chin Huang, Chia-Wen Lu, Chih-Hsun Chu, Chien-Ning Huang, Harn-Shen Chen, I-Te Lee, Jung-Fu Chen, Ching-Chu Chen, Chung-Sen Chen, Chang-Hsun Hsieh, Kai-Jen Tien, Hung-Yu Chien, Yu-Yao Huang, Jui-Pao Hsu, Guang-Tzuu Shane, Ai-Ching Chang, Yen-Chieh Wu, Wayne Huey-Herng Sheu
Summary: R-form verapamil (R-Vera) is a novel approach for treating type 2 diabetes mellitus (T2DM), as it can significantly improve glycemic control and enhance the survival of pancreatic beta-cells, with a high level of safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Rheumatology
Rana S. Hinman, Sarah E. Jones, Rachel K. Nelligan, Penelope K. Campbell, Michelle Hall, Nadine E. Foster, Trevor Russell, Kim L. Bennell
Summary: This study compared the perceptions of patients who did or did not respond to a physical therapist-supported exercise and physical activity program. The study found that both responders and nonresponders had similar themes and subthemes, including engagement, personal attitudes and expectations, beliefs about osteoarthritis and exercise, importance of adherence, and perceived strength gains with exercise.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Endocrinology & Metabolism
Silvio E. Inzucchi, Melanie J. Davies, Kamlesh Khunti, Prabhav Trivedi, Jyothis T. George, Isabella Zwiener, Odd Erik Johansen, Naveed Sattar
Summary: The study investigated the effects of different baseline cardio-metabolic risk factors on the treatment outcomes of empagliflozin when added to metformin as a second-line therapy for type 2 diabetes patients. The results showed that empagliflozin significantly reduced HbA1c, body weight, and systolic blood pressure, with greater efficacy in patients with higher baseline values of HbA1c and body weight. Adverse events were consistent with the known safety profile of empagliflozin.
DIABETES OBESITY & METABOLISM
(2021)
Article
Allergy
Mehmet Erdem Cakmak, Nida Oztop, Osman Ozan Yegit, Oezlem Ozdedeoglu
Summary: This study aimed to evaluate the clinical features and laboratory data of patients with severe eosinophilic asthma who were classified as super-responders, partial responders, or nonresponders to mepolizumab treatment. The results showed that the baseline eosinophil count, eosinophil/lymphocyte ratio, and FEV1 (%) were important predictors of response to mepolizumab treatment.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Rana Taheri, Faranak Kazerouni, Reza Mirfakhraei, Saeid Kalbasi, Seyedeh Zahra Shahrokhi, Ali Rahimipour
Summary: This study investigated the association of rs543159 and rs1317652 variants in the SLC22A3 gene with response to metformin monotherapy in newly diagnosed patients with T2DM. The results suggest that these genetic variations may be correlated with variability in treatment response.
Article
Biochemistry & Molecular Biology
Silke Conen, Catherine J. Gregory, Rainer Hinz, Richard Smallman, Fabiana Corsi-Zuelli, Bill Deakin, Peter S. Talbot
Summary: This study aimed to measure TSPO availability in patients with schizophrenia and compare it with healthy controls using PET imaging. The results showed that older individuals had higher TSPO levels, but a diagnosis of schizophrenia was not significantly associated with TSPO levels.
MOLECULAR PSYCHIATRY
(2021)
Article
Dermatology
Jonathan I. Silverberg, Eric L. Simpson, Jacob Pontoppidan Thyssen, Thomas Werfel, Tracy E. Cardillo, Stephanie Colvin, Evangeline Pierce, Yun-Fei Chen, Sherry Chen, Lawrence Eichenfield
Summary: Baricitinib combined with topical corticosteroids (TCS) has shown sustained efficacy in treating adults with moderate-to-severe atopic dermatitis (AD) over a 68-week period.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bilal Jawed, Shadab Ahmed, Syed Qamar Abbas, Zeeshan Ahmed, Shomaiza Andleeb, Salman Ashfaq Ahmad, Muhammad Asif, Erum Akhter, Salman Ahmed, Muhammad Waleed Hussain, Adnan Iqbal, Azfar Athar Ishaqui
Summary: This study aimed to evaluate the effectiveness of empagliflozin add-on therapy in diabetic patients already on metformin and glimepiride. The results showed that the addition of empagliflozin provided better control over blood sugar without exacerbating toxicity of the existing regimen.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Psychiatry
Ali Reza Shafiee-Kandjani, Negin Nezhadettehad, Sara Farhang, Richard Bruggeman, Dariush Shanebandi, Mohammadbagher Hassanzadeh, Hosein Azizi
Summary: This study aimed to evaluate the serum expression of miR-26a, miR-106a, and miR-125b as genetic factors and serum levels of IL-6, IL-1β, and TNF-a as pro-inflammatory factors in an Iranian Azeri population. The results showed higher levels of IL-6, IL-1β, TNF-a, miR-26a, and miR-106a in the patient group compared to the control group, with miR-26a possibly being a suggestive biomarker for early-stage schizophrenia. The relationship between other miRNAs and cytokines is still not well understood, prompting further research in this fascinating field.
Article
Medicine, Research & Experimental
Bhaven K. Mehta, Monica E. Espinoza, Jennifer M. Franks, Yiwei Yuan, Yue Wang, Tammara Wood, Johann E. Gudjonsson, Cathie Spino, David A. Fox, Dinesh Khanna, Michael L. Whitfield
Summary: This study analyzed the efficacy of abatacept in patients with early diffuse systemic sclerosis and found that patients in the inflammatory intrinsic subset showed the most significant clinical improvement. Gene expression analysis revealed that patients treated with abatacept had improved gene expression moving toward the normal-like subset. The study provides an example of precision medicine in systemic sclerosis clinical trials.
Article
Clinical Neurology
Pei Xue, Xiao Tan, Christian Benedict
Summary: The American Diabetes Association recommends a target of less than 7% for treating type 2 diabetes mellitus. It is uncertain if poor sleep affects this goal. A study using data from 5703 patients on metformin monotherapy found that a higher poor sleep score, including elements such as snoring, was associated with a glycated haemoglobin of >= 7%. However, adjusting for health and lifestyle factors eliminated the significant associations.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Health Care Sciences & Services
Kuang-Hua Huang, Ya-Fang Tsai, Chiachi Bonnie Lee, Shuo-Yan Gau, Tung-Han Tsai, Ning-Jen Chung, Chien-Ying Lee
Summary: The study investigates the relationship between metformin use and the risk of dementia among patients with diabetes. It found that low-dose metformin use is associated with a reduced risk of dementia, while high-dose metformin use does not have a protective effect. Prospective clinical trials are needed to evaluate the underlying mechanisms between metformin dosage and the risk of dementia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ayca Diren, Deniz Kanca Demirci, Nurdan Gul, Burcin Karacanli, Aykut Baykut, Yildiz Tutuncu, Oguz Ozturk, Ilhan Satman, Hulya Yilmaz-aydogan
Summary: This study compared serum cytokine levels between MODY patients and healthy controls, and demonstrated inflammatory features in MODY subtypes. The results showed that MODY patients had lower levels of anti-inflammatory cytokines IL-1 beta, IL-6, TNF-alpha, IL-31, and sCD40L compared to healthy controls, while MODY3 patients had higher levels of IL-17A and IL-23.
Article
Psychiatry
Isabel Ruiz-Delgado, Berta Moreno-Kuestner, Monica Garcia-Medina, Maria Luisa Barrigon, Fermin Gonzalez-Higueras, Raguel Lopez-Carrilero, Irene Barrios-Mellado, Ana Barajas, Esther Pousa, Esther Lorente-Rovira, Eva Grasa, Jordi Cid, Paula Barrau-Sastre, Steffen Moritz, Susana Ochoa, Spanish Metacognition Group
Summary: This multicenter randomized clinical trial found that Metacognitive Training (MCT) is an effective psychological intervention for improving memory, attention, and executive function in first-episode psychosis patients.
PSYCHIATRY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Abdolkarim Mahrooz, Yasaman Shokri, Atena Variji, Mehryar Zargari, Ahad Alizadeh, Ehsan Mehtarian
Summary: Developing laboratory assays to evaluate HDL functions and improving cardiovascular disease risk assessment by investigating new cardiometabolic risk factors based on substituting paraoxonase 1 (PON1) as a critical enzyme in the functionality of HDL for that of HDL-C may help predict the risk of coronary artery disease. The study found that the new cardiometabolic ratios remained significant as independent variables after multivariate adjustment, providing optimal discriminating cutoffs for CAD. Substituting PON1 activity for HDL-C in atherogenic lipid ratios can enhance CAD risk assessment by providing an index of HDL activity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Medical Laboratory Technology
Anvarsadat Kianmehr, Durdi Qujeq, Abouzar Bagheri, Abdolkarim Mahrooz
Summary: Vascular endothelial cells respond to physicochemical stimuli, with oxidized low-density lipoprotein contributing to atherosclerosis. MicroRNAs play a role in cellular homeostasis under stress and can serve as therapeutic targets and biomarkers.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Medicine, General & Internal
Parastoo Karimi Aliabadi, Mehrnoush Sohrab, Amirhossein Hessami, Mahdi Afshari, Zahra Kashi, Motahareh Kheradmand, Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei, Mahmood Moosazadeh
Summary: This study found that serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were higher in patients with MetS compared to controls. Individuals with ALT levels >= 40 had significantly higher chances of having MetS, high triglycerides, and fasting blood glucose. Those with AST levels >= 40 had a 1.45 times higher chance of having MetS compared to individuals with normal AST levels.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Mohammad Amin Khazeei Tabari, Mohammad Amir Mishan, Mona Moradi, Mohanna Khandan, Hooman Khoshhal, Abdolkarim Mahrooz, Abouzar Bagheri
Summary: Aspirin, a commonly prescribed drug, has therapeutic effects on cardiovascular and metabolic disorders as well as malignancies through various molecular pathways. Changes in noncoding RNA expression profiles during aspirin treatments suggest a close relationship between these regulatory molecules and aspirin effects on gene expressions. Understanding the molecular networks involved in aspirin efficacy could optimize therapies for this popular drug.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Majid Davari, Yahya Bayazidi, Abbas Kebriaeezadeh, Alireza Esteghamati, Fatemeh Bandarian, Zahra Kashi, Adele Bahar, Sepideh Yousefi
Summary: The study evaluated the quality of care indicators in T2DM using retrospective patient-level data from 2013 to 2017 in 15 Tertiary Diabetes Care Centers in Iran. The results showed that the management of T2DM was far from optimal control in both processes and outcome-related indicators. Only a small percentage of patients received HbA1c and LDL tests, and very few patients met all the optimal process-related quality indicators.
BMC ENDOCRINE DISORDERS
(2022)
Correction
Psychiatry
Farid Najafi, Yahya Pasdar, Behzad Karami Matin, Satar Rezaei, Ali Kazemi Karyani, Shahin Soltani, Moslem Soofi, Shahab Rezaeian, Alireza Zangeneh, Mehdi Moradinazar, Behrooz Hamzeh, Zahra Jorjoran Shushtari, Mansour Sajjadipour, Saeid Eslami, Maryam Khosrojerdi, Sahar Shabestari, Amir Houshang Mehrparvar, Zahra Kashi, Azim Nejatizadeh, Mohammadreza Naghipour, Shahrokh Sadeghi Boogar, Ali Fakhari, Bahman Cheraghian, Haydeh Heidari, Parviz Molavi, Mohammad Hajizadeh, Yahya Salimi
Article
Cardiac & Cardiovascular Systems
Abdolkarim Mahrooz, Omeh Farveh Khosravi-Asrami, Ahad Alizadeh, Neda Mohmmadi, Abouzar Bagheri, Zahra Kashi, Adele Bahar, Mani Nosrati, Mike Mackness
Summary: This study aimed to investigate whether the prediction of coronary artery disease (CAD) risk in type 2 diabetes (T2D) patients could be improved by using high-density lipoprotein (HDL)-bound paraoxonase 1 (PON1) activity instead of HDL cholesterol (HDL-C) concentration. The results showed that PON1 and the ratio of nonHDL-C/PON1 significantly improved the prediction of severe CAD in T2D patients and in patients with HbA1c≥7%, age≥50 years, or low HDL-C.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Imaging Science & Photographic Technology
Mahsa Esfehani, Melika Ghasemi, Amirhassan Katiraee, Maryam Tofangchiha, Ahad Alizadeh, Farnaz Taghavi-Damghani, Luca Testarelli, Rodolfo Reda
Summary: This study assessed the accuracy of gender estimation using mandibular morphometric indices on panoramic radiographs of an Iranian population. The results showed that all indices, except for the gonial angle, were significantly different between males and females and can be used for gender determination. The best model included five indices (bicondylar breadth, condylar height, coronoid height, minimum ramus width, and superior border of mental foramen) for gender determination.
JOURNAL OF IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Hamideh Mohammadi-Berenjestanaki, Elaheh Mohammadali, Mina Khasayesi, Alireza Rafiei, Zahra Kashi, Narges Mirzaei-Ilali, Zahra Hosseini-khah
Summary: This study found that the ACE2 rs2106809 gene polymorphism is associated with the severity of COVID-19. The G/G genotype is associated with more severe disease and adverse outcomes.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, General & Internal
Masoumeh Ramezani, Marjan Bolbolian, Mohaddeseh Aliakbari, Ahad Alizadeh, Maryam Tofangchiha, Seyed Mohammad Faegh, Romeo Patini, Giuseppe D'Amato
Summary: This study aimed to compare the accuracy of three types of apex locators versus digital radiography for working length determination, and found that all tested methods showed acceptable accuracy in determining working length in maxillary premolars.
CLINICS AND PRACTICE
(2022)
Article
Medicine, General & Internal
Kaveh Haddadi, Mohammad Sahebi, Abdolkarim Mahrooz, Masoud Shayestch Azar, Muhammad Bagher Hashemi-Soteh
Summary: This study found an association between Aggrecan gene VNTR polymorphism and lumbar intervertebral disc degeneration in the population in the North of Iran, with a higher chance of disc degeneration in individuals with fewer VNTR repeats. Moreover, a mutant allele (C) of VDR gene TaqI polymorphism was found to be associated with disc degeneration.
CASPIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Abdolkarim Mahrooz
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Abdolkarim Mahrooz, Giovanna Muscogiuri, Raffaella Buzzetti, Ernesto Maddaloni
Summary: The COVID-19 virus can cause various alterations in glucose metabolism, affecting the pathophysiology of pre-existing diabetes or creating new disease mechanisms. Controlling metabolic complications may be a useful therapeutic target against COVID-19.
Review
Medicine, Research & Experimental
Vahid Akbari Kordkheyli, Mohammad Amir Mishan, Abbas Khonakdar Tarsi, Abdolkarim Mahrooz, Mozhgan Rezaei Kanavi, Ali Hafezi-Moghadam, Abouzar Bagheri
Summary: Diabetic retinopathy (DR) is a major cause of blindness worldwide due to the increasing prevalence of diabetes. Studies show that altered expression of proteins like vascular endothelial growth factor (VEGF) plays a crucial role in vascular dysfunction during DR. MicroRNAs (miRNAs) are key regulators of gene expression and are closely related to DR development by regulating gene expressions. Research on miRNA-dependent pathways and the role of VEGF in DR can improve therapeutic and diagnostic approaches for this condition.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
