Article
Biochemistry & Molecular Biology
Elise L. Kessler, Jiong-Wei Wang, Bart Kok, Maike A. Brans, Angelique Nederlof, Leonie van Stuijvenberg, Chenyuan Huang, Aryan Vink, Fatih Arslan, Igor R. Efimov, Carolyn S. P. Lam, Marc A. Vos, Dominique P. de Kleijn, Magda S. C. Fontes, Toon A. B. van Veen
Summary: Deficiency of TLR2 alleviates adverse cardiac remodeling caused by chronic pressure overload, with TLR2 and TLR4 both contributing to this process. The findings provide insights into potential therapeutic targets for preventing or intervening in cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Menglong Wang, Mengmeng Zhao, Junping Yu, Yao Xu, Jishou Zhang, Jianfang Liu, Zihui Zheng, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Cheng Wei, Jun Wan
Summary: This study investigated the effects of the selective NLRP3 inhibitor MCC950 on heart failure (HF) induced by pressure overload in obese mice and its metabolic mechanism. The results showed that MCC950 improved cardiac hypertrophy, fibrosis, and inflammation in obese mice. It also promoted M2 macrophage infiltration and regulated fatty acid and glucose uptake and utilization. Additionally, MCC950 affected the phosphorylation of AKT and AMPK in obese mice with HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jamie Francisco, Jin Guan, Yu Zhang, Yasuki Nakada, Satvik Mareedu, Eunah Sung, Che-Ming Hu, Shinichi Oka, Peiyong Zhai, Junichi Sadoshima, Dominic P. Del Re
Summary: Inflammation is a crucial factor in cardiovascular disease, and Yes-associated protein (YAP) has been found to play a key role in modulating inflammation in ischemic injury. This study investigated the role of YAP in non-ischemic cardiac inflammation. The results showed that YAP activation in myeloid cells contributes to cardiac inflammation and fibrosis during pressure overload stress. Inhibition of YAP may be a potential therapeutic target for non-ischemic heart disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Immunology
Mengmeng Zhao, Jishou Zhang, Yao Xu, Jianfang Liu, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Menglong Wang, Jun Wan
Summary: The study revealed that the NLRP3 inhibitor MCC950 could reverse cardiac remodeling induced by transverse aortic constriction (TAC), improving cardiac dysfunction, reducing cardiac hypertrophy and fibrosis, and decreasing inflammation and macrophage infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Genetics & Heredity
Dan Yang, Han-Qing Liu, Fang-Yuan Liu, Nan Tang, Zhen Guo, Shu-Qing Ma, Peng An, Ming-Yu Wang, Hai-Ming Wu, Zheng Yang, Di Fan, Qi-Zhu Tang
Summary: This review describes the diversity and modulation mechanisms of cardiac macrophages in pressure overload-induced cardiac remodeling, highlighting their emerging role as therapeutic targets.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Yusha Xiao, Lihua Ni, Hongjie Shi, Kang Yang, Jianguo Yang, Jinping Zhao, Jinping Liu, Pengcheng Luo
Summary: Heart failure (HF) is the end stage of many cardiovascular diseases, and cardiac remodeling is the main pathophysiological process leading to cardiac function deterioration in HF patients. Inflammation plays a crucial role in stimulating myocardial remodeling, which is significantly related to patient prognosis. SAA1, a lipid-binding protein involved in inflammation, has rarely been studied in the heart. This research aimed to investigate the role of SAA1 in cardiac remodeling using SAA1-deficient and wild-type mice. The results showed that SAA1 deficiency hindered cardiac fibrosis after 8 weeks of transverse aortic banding, but did not significantly affect cardiomyocyte hypertrophy. Additionally, SAA1 deficiency had no significant effect on cardiac fibrosis and hypertrophy in the sham group.
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Lin Zhao, Xian-yun Jiang, Jing-jing Zhang, Jia-min Gou, Xiao-yu Yu, Shu-jin Wu, Lei Li
Summary: Apoptosis, or programmed cell death, plays a critical role in the development of heart failure. Sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, has been shown to inhibit apoptosis in myofibroblasts, non-muscle cells in the heart. In this study, the researchers investigated the role of the SPC receptor, calmodulin (CaM), in cardiomyocyte apoptosis and the associated signaling pathways. They found that SPC administration improved survival rate, cardiac hypertrophy, and cardiac fibrosis in mice with pressure overload-induced heart failure. In cardiomyocytes, SPC treatment inhibited cardiomyocyte hypertrophy, fibroblast-to-myofibroblast transition, and cell apoptosis. This was accompanied by reduced levels of pro-apoptotic proteins and phosphorylation of CaM, JNK, and p38, as well as increased levels of a cardiomyocyte-protective protein. The protective effect of SPC was annulled by a compound that increased CaM function. The researchers also demonstrated that SPC-mediated inhibition of cardiomyocyte apoptosis involved the regulation of p38 and JNK phosphorylation, which was downstream of CaM. These findings provide new evidence for SPC regulation of cardiomyocyte apoptosis and suggest it as a potential therapeutic target for cardiac remodeling following stress overload.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Cardiac & Cardiovascular Systems
Tiqun Yang, Tianxin Long, Tailai Du, Yili Chen, Yugang Dong, Zhan-Peng Huang
Summary: Cardiac remodeling is a pathological process triggered by stress, leading to heart failure through cardiomyocyte hypertrophy, apoptosis, fibroblast proliferation, and activation. Circular RNAs have been implicated in various cardiovascular diseases as important regulators in disease pathogenesis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Satoshi Kawaguchi, Bruno Moukette, Marisa N. Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K. Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J. Conway, Il-man Kim
Summary: miR-150 is downregulated during heart failure and correlates with patient outcomes. It protects against myocardial infarction by reducing cardiomyocyte apoptosis and targets small proline-rich protein 1a. Knockdown of SPrr1a improves cardiac dysfunction and fibrosis post-MI.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Xiaochen He, Rui Xu, Lihong Pan, Umesh Bhattarai, Xiaoguang Liu, Heng Zeng, Jian-Xiong Chen, Michael E. Hall, Yingjie Chen
Summary: Inhibition of NK1.1 signaling effectively attenuates systolic overload-induced cardiac fibrosis, dysfunction, and consequent pulmonary remodeling in immunocompetent mice through modulating the cardiopulmonary inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Xin Liu, Guo-Ping Shi, Junli Guo
Summary: Pressure overload and heart failure are major causes of cardiovascular morbidity and mortality, where innate immune cells and inflammatory mediators play crucial roles. Different innate immune cells, including mast cells, macrophages, monocytes, neutrophils, dendritic cells, eosinophils, and natural killer T cells, exhibit varying levels of activity in these pathological processes, with some exacerbating cardiodysfunction and others displaying cardioprotective activities. Overall, immune regulation of cardiac innate immune cells holds promise as a therapeutic approach in experimental cardiac disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
William W. Du, Jindong Xu, Weining Yang, Nan Wu, Feiya Li, Le Zhou, Sheng Wang, Xiangmin Li, Alina T. He, Kevin Y. Du, Kaixuan Zeng, Jian Ma, Juanjuan Lyu, Chao Zhang, Chi Zhou, Katarina Maksimovic, Burton B. Yang
Summary: The upregulation of circNlgn in patients with cardiac disease leads to cardiac overload. The novel peptide Nlgn173 binds to nuclear structural proteins and regulators, ultimately contributing to cardiac fibrosis and heart disease. Therapeutic implications may be derived from understanding this dysregulation mechanism.
CIRCULATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shuai Wang, You Zhou, Yuanyuan Luo, Rongsheng Kan, Jingwen Chen, Haochen Xuan, Chaofan Wang, Junhong Chen, Tongda Xu, Dongye Li
Summary: Transverse-tubules (T-tubules) play a key role in excitation-contraction coupling in cardiomyocytes, and this study investigated how sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) regulates T-tubules during myocardial ischemia/reperfusion (I/R) to improve cardiac function. The results showed that calpain activation during I/R led to proteolytic cleavage of junctophilin-2 (JPH2), altering T-tubule network and contraction function in cardiomyocytes and in vivo cardiac functions. Through suppressing calpain activity and regulating [Ca2+](i), SERCA2a ameliorated cardiomyocyte T-tubule remodeling and improved cardiac function in myocardial I/R.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Pearl Quijada, Shuin Park, Peng Zhao, Kamal S. S. Kolluri, David Wong, Kevin D. Shih, Kai Fang, Arash Pezhouman, Lingjun Wang, Ali Daraei, Matthew D. Tran, Elle M. Rathbun, Kimberly N. Burgos Villar, Maria L. Garcia-Hernandez, Thanh T. D. Pham, Charles J. Lowenstein, M. Luisa Iruela-Arispe, S. Thomas Carmichael, Eric M. Small, Reza Ardehali
Summary: The role of pericytes in ischemia-induced remodeling in the heart was investigated. Pericytes migrated to the injury site and expressed profibrotic genes, leading to increased vessel leakage after myocardial infarction. Single-cell RNA-Seq analysis revealed the induction of genes related to vascular permeability, extracellular matrix production, basement membrane degradation, and TGF-beta signaling. Targeting TGF-beta receptor 1 in pericytes reduced fibrosis and improved cardiac function after MI, while genetic ablation of pericytes resulted in excessive vascular permeability, declined cardiac function, and increased mortality. These findings highlight the importance of pericytes in controlling vascular homeostasis and the fibrotic response to acute ischemic injury, providing insights for novel therapeutic approaches.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Dan Yang, Di Fan, Zhen Guo, Fang-Yuan Liu, Ming-Yu Wang, Peng An, Zheng Yang, Qi-Zhu Tang
Summary: The study demonstrates that SENP1 plays a protective role in cardiac remodeling and dysfunction by inhibiting STAT3 signaling, providing a new direction for the treatment of cardiac hypertrophy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Elisa Dal Canto, Sharon Remmelzwaal, Adriana Johanne van Ballegooijen, M. Louis Handoko, Stephane Heymans, Vanessa van Empel, Walter J. Paulus, Giel Nijpels, Petra Elders, Joline W. J. Beulens
Summary: This study evaluated the diagnostic performance of echocardiographic markers for HFpEF and LVDD, finding that a multivariable model showed the highest diagnostic performance, left atrial strain had reasonable performance, and adding exercise E/e ' improved the sensitivity of HFpEF diagnostic algorithms. Larger, well-designed studies are needed to further evaluate the potential diagnostic role of novel tools in current diagnostic algorithms.
HEART FAILURE REVIEWS
(2022)
Article
Multidisciplinary Sciences
Sharon Remmelzwaal, Joline W. J. Beulens, Petra J. M. Elders, Coen D. A. Stehouwer, Zhenyu Zhang, M. Louis Handoko, Yolande Appelman, Vanessa van Empel, Stephane R. B. Heymans, Lutgarde Thijs, Jan A. Staessen, A. Johanne van Ballegooijen
Summary: This study did not show consistent associations between LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers.
Article
Cardiac & Cardiovascular Systems
Anne Russcher, Job Verdonschot, Marijke W. A. Molenaar-de Backer, Stephane R. B. Heymans, Aloys C. M. Kroes, Hans L. Zaaijer
Summary: This study suggests that B19V DNA in the blood of DCM patients becomes undetectable or greatly reduced after treatment with endonuclease, whereas DNA in the blood of recent B19V infections remains unaffected. This indicates that circulating viral DNA in DCM patients with presumed parvovirus-associated DCM does not consist of intact viral particles.
Article
Virology
Monika Z. Ballmann, Svjetlana Raus, Ruben Engelhart, Gyozo L. Kajan, Abdelaziz Beqqali, Patrick W. F. Hadoke, Chantal van der Zalm, Tibor Papp, Lijo John, Selina Khan, Satish Boedhoe, Katarina Danskog, Lars Frangsmyr, Jerome Custers, Wilfried A. M. Bakker, Hilde M. van der Schaar, Niklas Arnberg, Angelique A. C. Lemckert, Menzo Havenga, Andrew H. Baker
Summary: The study introduces a chimeric human adenovirus, HAdV-20-42-42, which shows promise in gene therapy and vaccine development. It is capable of stable propagation, transducing cardiovascular cells effectively, and inducing potent T-cell responses. This novel vector expands the toolbox for vaccine development, providing valuable additions to the field.
JOURNAL OF VIROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rudolf A. de Boer, Stephane Heymans, Johannes Backs, Lucie Carrier, Andrew J. S. Coats, Stefanie Dimmeler, Thomas Eschenhagen, Gerasimos Filippatos, Lior Gepstein, Jean-Sebastien Hulot, Ralph Knoll, Christian Kupatt, Wolfgang A. Linke, Christine E. Seidman, C. Gabriele Tocchetti, Jolanda van der Velden, Roddy Walsh, Petar M. Seferovic, Thomas Thum
Summary: This article discusses the pathogenesis, clinical presentation, and new medications and therapeutic approaches for genetic cardiomyopathies. With the use of contemporary research methods and tools, our understanding of cardiomyopathies has deepened, opening up new avenues for precision medicine.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Theresa A. McDonagh, Marco Metra, Marianna Adamo, Roy S. Gardner, Andreas Baumbach, Michael Boehm, Haran Burri, Javed Butler, Jelena Celutkien, Ovidiu Chioncel, John G. F. Cleland, Andrew J. S. Coats, Maria G. Crespo-Leiro, Dimitrios Farmakis, Martine Gilard, Stephane Heymans, Arno W. Hoes, Tiny Jaarsma, Ewa A. Jankowska, Mitja Lainscak, Carolyn S. P. Lam, Alexander R. Lyon, John J. McMurray, Alexandre Mebazaa, Richard Mindham, Claudio Muneretto, Massimo Francesco Piepoli, Susanna Price, Giuseppe M. C. Rosano, Frank Ruschitzka, Anne Kathrine Skibelund
Summary: All experts involved in the development of the guidelines have declared their interests, and the declarations have been compiled and published in a supplementary report. The report can be accessed on the ESC website. The supplementary data provide background information and detailed discussion of the data that form the basis for the guidelines.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Susana Ravassa, Begona Lopez, Joao Pedro Ferreira, Nicolas Girerd, Erwan Bozec, Pierpaolo Pellicori, Beatrice Mariottoni, Franco Cosmi, Mark Hazebroek, Job A. J. Verdonschot, Joe Cuthbert, Johannes Petutschnigg, Maria U. Moreno, Stephane Heymans, Jan A. Staessen, Burkert Pieske, Frank Edelmann, Andrew L. Clark, John G. F. Cleland, Faiez Zannad, Javier Diez, Arantxa Gonzalez
Summary: The HOMAGE randomized trial showed that spironolactone reduced left atrial volume index (LAVI), E:A ratio, and a marker of collagen synthesis in patients at risk of heart failure. Patients with low serum collagen cross-linking benefited more from spironolactone treatment on left atrial remodeling and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Elmir Omerovic, Rodolfo Citro, Eduardo Bossone, Bjorn Redfors, Johannes Backs, Bastian Bruns, Michele Ciccarelli, Liam S. Couch, Dana Dawson, Guido Grassi, Massimo Iacoviello, Guido Parodi, Birke Schneider, Christian Templin, Jelena R. Ghadri, Thomas Thum, Ovidiu Chioncel, C. Gabriele Tocchetti, Jolanda van der Velden, Stephane Heymans, Alexander R. Lyon
Summary: The scientific statement on the pathophysiology of Takotsubo syndrome discusses various aspects including catecholamines, the sympathetic nervous system, vascular responses, the role of the nervous systems, gender differences, sex hormones, genetics, and chronic abnormalities of cardiovascular physiology in survivors. The limitations of current clinical and preclinical studies, implications for clinical management, and future research perspectives are also highlighted.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Massimo F. Piepoli, Marianna Adamo, Andrea Barison, Reinaldo B. Bestetti, Jan Biegus, Michael Boehm, Javed Butler, Jonathan Carapetis, Claudio Ceconi, Ovidiu Chioncel, Andrew Coats, Maria G. Crespo-Leiro, Giovanni de Simone, Heinz Drexel, Michele Emdin, Dimitros Farmakis, Martin Halle, Stephane Heymans, Tiny Jaarsma, Ewa Jankowska, Mitja Lainscak, Carolyn S. P. Lam, Maja-Lisa Lochen, Yuri Lopatin, Aldo Maggioni, Benedetta Matrone, Marco Metra, Katharine Noonan, Ileana Pina, Eva Prescott, Giuseppe Rosano, Petar M. Seferovic, Karen Sliwa, Simon Stewart, Alicia Uijl, Ilonca Vaartjes, Roel Vermeulen, W. M. Monique Verschuren, Maurizio Volterrani, Stephan von Haehling, Arno Hoes
Summary: This article discusses the growing epidemic of heart failure and the importance of prevention in reducing hospital readmission rates and its clinical and economic burden. It aims to provide evidence-based information and effective preventive measures. By analyzing risk factors and population attributable risks in different continents, potential opportunities for prevention and strategies are identified. The article also lists potential interventions that have been shown to be effective in preventing heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Job A. J. Verdonschot, JoAo Pedro Ferreira, Anne Pizard, Pierpaolo Pellicori, Hans-Peter Brunner La Rocca, Andrew L. Clark, Franco Cosmi, Joe Cuthbert, Nicolas Girerd, Olivia J. Waring, Michiel H. T. M. Henkens, Beatrice Mariottoni, Johannes Petutschnigg, Patrick Rossignol, Mark R. Hazebroek, John G. F. Cleland, Faiez Zannad, Stephane R. B. Heymans
Summary: This study aimed to evaluate the effects of spironolactone and the characteristics of biomarkers associated with obesity. Proteomic analysis revealed a distinct biomarker profile in obese patients, reflecting adipogenesis and glucose intolerance. Additionally, obesity significantly modified the effect of spironolactone on systolic blood pressure.
JOURNAL OF CARDIAC FAILURE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Stephane Heymans, Leslie T. Cooper
Summary: The risk of acute myocarditis associated with COVID-19 mRNA vaccination is rare and usually resolves quickly, while the risks of hospitalization and death from COVID-19 are greater. Therefore, COVID-19 vaccination is recommended for adolescents and adults.
NATURE REVIEWS CARDIOLOGY
(2022)
Editorial Material
Genetics & Heredity
Maarten M. G. van den Hoogenhof, Hamid El Azzouzi, Abdelaziz Beqqali
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Ian R. McCracken, Ross Dobie, Matthew Bennett, Rainha Passi, Abdelaziz Beqqali, Neil C. Henderson, Joanne C. Mountford, Paul R. Riley, Chris P. Ponting, Nicola Smart, Mairi Brittan, Andrew H. Baker
Summary: The study aims to characterize the transcriptome of human foetal cardiac endothelium using single-cell RNA sequencing (scRNA-seq) to provide insights into cellular heterogeneity and transcriptional dynamics underlying endothelial specification. Results reveal distinct endothelial cell populations, endocardial contribution to coronary vasculature, and arterial specification of capillary endothelium. Transcriptional signatures defining endothelial subpopulations are largely conserved between human and mouse, with MECOM playing a role in maintaining arterial endothelial identity.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Paolo Carai, Anna Pia Papageorgiou, Sophie Van Linthout, Sophie Deckx, Sebastiaan Velthuis, Esther Lutgens, Erwin Wijnands, Carsten Tschoepe, Christina Schmuttermaier, Julia Kzhyshkowska, Elizabeth Anne Vincent Jones, Stephane Heymans
Summary: This study reveals the immune-suppressive role of stabilin-1 in limiting myocardial damage during viral myocarditis, by regulating the recruitment of anti-inflammatory monocytes to the site of inflammation.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ana-Mishel Spiroski, Ian R. McCracken, Adrian Thomson, Marlene Magalhaes-Pinto, Mukesh K. Lalwani, Kathryn J. Newton, Eileen Miller, Cecile Benezech, Patrick Hadoke, Mairi Brittan, Joanne C. Mountford, Abdelaziz Beqqali, Gillian A. Gray, Andrew H. Baker
Summary: This study investigated the tissue remodeling effects of human embryonic stem cell-derived endothelial cell product (hESC-ECP) therapy on infarcted heart and found that it reduces infarct size and preserves functional myocardium. By examining the interactions between cells and immune regulation, this research provides new therapeutic avenues for improving cardiac outcomes following myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)