Article
Biochemistry & Molecular Biology
Kaidi Ma, Yongsong Bai, Jibo Li, Zhongshuai Ren, Jianping Li, Jing Zhang, Anshan Shan
Summary: The study aimed to investigate the protective ability of Lactobacillus rhamnosus GG (LGG) against deoxynivalenol (DON)-induced kidney injury in piglets. The results showed that LGG supplementation alleviated the damage of DON to the kidney antioxidant system and improved mitochondrial abnormalities and dysfunction.
Article
Agriculture, Dairy & Animal Science
Yongsong Bai, Kaidi Ma, Jibo Li, Zhongshuai Ren, Jing Zhang, Anshan Shan
Summary: This study demonstrates that the probiotic Lactobacillus rhamnosus GG (LGG) can ameliorate intestinal damage caused by deoxynivalenol (DON) exposure by improving intestinal barrier function and suppressing intestinal inflammation through the TLR4/NF-kappa B signaling pathway. Furthermore, LGG supplementation can modulate the composition of intestinal microbiota by increasing the relative abundances of beneficial bacteria and reducing the relative abundances of harmful bacteria. These findings provide a theoretical basis for the application of LGG in alleviating the adverse effects induced by DON exposure.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Immunology
Zhaoxi Deng, Jinyan Dai, Yusen Wei, Yanfei Ma, Yingying Mao, Jinzhi Zhang, Weidong Hua, Haifeng Wang
Summary: Lactobacillus rhamnosus GG can help protect the intestinal barrier function and reduce inflammation caused by early weaning stress in piglets. The luxS mutant has a decreased ability to maintain intestinal tissue morphology and promote mucus secretion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Feng He, Xueying Jin, Chunfeng Wang, Jingtao Hu, Shuai Su, Lei Zhao, Tingting Geng, Yuan Zhao, Li Pan, Nan Bao, Hui Sun
Summary: Most studies have shown that probiotics have a positive effect on the nutritional metabolism of the body, but the mechanism is unclear. This study found that feeding L. Rhamnosus GG ATCC53103 and L. Plantarum JL01 could improve nitrogen utilization rate in weaned piglets by modulating the gut microbiota. The changes in gut microbiota structure and metabolites were observed, suggesting the potential mechanism behind the improvement in nitrogen metabolism.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Veterinary Sciences
Tingting Geng, Feng He, Shuai Su, Kecheng Sun, Lei Zhao, Yuan Zhao, Nan Bao, Li Pan, Hui Sun
Summary: The combination of L. rhamnosus GG ATCC53103 and L. plantarum JL01 significantly improves growth performance and immunity of weaned piglets by regulating cytokine levels and enhancing the accumulation of beneficial metabolites in the blood.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Food Science & Technology
Srijita Sireswar, Gargi Dey, Sutapa Biswas
Summary: The study found that a sea buckthorn beverage fortified with probiotics demonstrated better restorative potential on intestinal barrier function and mucosal damage, stronger antioxidant activity, and inhibition of Toll-like receptor expression and pro-inflammatory gene upregulation induced by DSS in zebrafish.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Immunology
Yu-Bei Jin, Xin Cao, Chun-Wei Shi, Bo Feng, Hai-Bin Huang, Yan-Long Jiang, Jian-Zhong Wang, Gui-Lian Yang, Wen-Tao Yang, Chun-Feng Wang
Summary: Gut microbes play a crucial role in the development of B cells in pigs, particularly in the gut lamina propria (LP). Treatment with Lactobacillus rhamnosus GG (LGG) was found to promote early B cell differentiation and development, affecting the composition of Ig CDR3 repertoires and stimulating IgA production in the intestinal LP. Furthermore, the p40 protein derived from LGG activates specific signaling pathways in intestinal epithelial cells, inducing the secretion of a proliferation-inducing ligand (APRIL) that promotes IgA production in B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Taiyu Zhai, Wenbo Ren, Pingping Wang, Lei Zheng
Summary: Gut microbiota plays an important role in atherosclerosis, and probiotic Lactobacillus rhamnosus GG can effectively inhibit the generation of AS plaques. It participates in the antiatherosclerotic mechanism by altering the composition of gut microbiota and metabolites.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yongsong Bai, Qingwei Meng, Cheng Wang, Kaidi Ma, Jibo Li, Jianping Li, Anshan Shan
Summary: This study demonstrates that Lactobacillus rhamnosus GG (LGG) improves deoxynivalenol (DON)-induced anorexia by modulating gut microbiota. LGG enhances intestinal barrier function, reduces intestinal inflammation, promotes food intake, and decreases weight loss. Antibiotic treatment and fecal microbiota transplant experiments confirm that gut microbiota is the primary vector for DON toxic effects and an essential mediator of LGG protection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone, Massimo Libra
Summary: This study found that LGG-SN has anti-proliferative activity against colon cancer and metastatic melanoma cells and enhances the efficacy of anti-cancer drugs. This suggests that LGG could be a new therapeutic approach in oncology to reduce chemotherapy-related side effects and overcome resistance issues, improving the treatment response in cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yun Ji, Xiaoxiao Fan, Yunchang Zhang, Ju Li, Zhaolai Dai, Zhenlong Wu
Summary: This study showed that dietary supplementation with 2% glycine can improve the growth performance of weaned piglets by enhancing the intestinal immunological barrier function and altering the microbial composition.
Article
Microbiology
Kasey Schalich, Seesandra Rajagopala, Suman Das, Ryan O'Connell, Fang Yan
Summary: This study reveals the regulatory effects of intestinal epithelial cell-derived components on the expression and metabolism of Lactobacillus rhamnosus GG at the molecular level, providing mechanistic insights into the interactions between the gut microbiota and the host.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Linda J. Urbanski, Silvia Bua, Andrea Angeli, Reza Zolfaghari Emameh, Harlan R. Barker, Marianne Kuuslahti, Vesa P. Hytonen, Seppo Parkkila, Claudiu T. Supuran
Summary: We studied the biochemical and inhibition characteristics of an alpha-carbonic anhydrase (LrhCA) from probiotic bacteria Lactobacillus rhamnosus GG. LrhCA showed moderate catalytic activity and inhibition by sulfonamide compounds. The best inhibitors were identified as 5-((4-aminophenyl)sulfonamido)-1,3,4-thiadiazole-2-sulfonamide, 4-(2-hydroxymethyl-4-nitrophenyl-sulfonamidoethyl)-benzenesulfonamide, and benzolamide. Acetazolamide, a clinical drug, had no significant effect on cell growth in L. rhamnosus GG culture. These findings are important for understanding the potential off-target effects of carbonic anhydrase inhibitors.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)