Article
Microbiology
Rozlyn C. T. Boutin, Hind Sbihi, Ryan J. McLaughlin, Aria S. Hahn, Kishori M. Konwar, Rachelle S. Loo, Darlene Dai, Charisse Petersen, Fiona S. L. Brinkman, Geoffrey L. Winsor, Malcolm R. Sears, Theo J. Moraes, Allan B. Becker, Meghan B. Azad, Piush J. Mandhane, Padmaja Subbarao, Stuart E. Turvey, B. Brett Finlay
Summary: This study found that the composition of gut mycobiota in Canadian infants changes significantly within the first year of life, with early-life environmental factors influencing the composition and development of inhalant allergic sensitization by age 5 years. The study developed a predictive model using a combination of early-life environmental factors and fungal community composition at 1 year old, achieving 81% accuracy in predicting inhalant atopy status at age 5 years.
Article
Immunology
Chuang-Ming Wang, Shun-Ting Yang, Cheng-Chia Yang, Hsiao-Yu Chiu, Hsiang-Yu Lin, Ming-Luen Tsai, Hung-Chih Lin, Yu-Chia Chang
Summary: By analyzing data from two databases, it was found that perinatal factors were associated with the development of asthma phenotypes. Prematurity, male gender, ventilator use, antibiotics use, allergic rhinitis, and atopic dermatitis were among the risk factors identified. It is important to identify specific risk factors for different asthma phenotypes in order to facilitate early diagnosis and treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Multidisciplinary Sciences
Mi-Hyang Jung, Kwang-Il Kim, Jun Hyeok Lee, Ki-Chul Sung
Summary: Patients with hypertension have a higher risk of developing dementia. This study aimed to determine the relative importance of different risk factors in the development of dementia among hypertensive patients. Data from the Korean National Insurance Service database was used in a population-based cohort study. Age, comorbidity burden, and female sex were identified as the strongest predictors of dementia. Physical inactivity, smoking, alcohol consumption, and obesity were also found to contribute to the risk. Overall, controlling comorbidities and promoting physical activity are crucial in preventing dementia in hypertensive patients.
Editorial Material
Medicine, General & Internal
Louis J. Muglia, Katrien Benhalima, Stephen Tong, Susan Ozanne
Summary: This article explores the importance of improving pregnancy health for the lifelong well-being of the mother and offspring. It highlights the immediate and long-term impacts of maternal environmental factors on fetal development and maternal cardiometabolic health. Using 'omics technologies across different platforms, research on preterm birth, metabolic influences, maternal disorders, and their effects on pregnancy outcomes and child health is expected to provide new insights and preventative strategies.
Article
Allergy
Yang-Ching Chen, Ming-Wei Su, Ben M. Brumpton, Yungling L. Lee, Omer Kalayci
Summary: Using a Mendelian randomization design, this study found that obesity, SDB, and poor sleep quality were associated with childhood asthma, with sleep quality showing the largest effect. Prospective survival analysis revealed that obesity was the highest risk factor for incident asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Samuel Schafer, Kevin Wang, Felicia Sundling, Jean Yang, Anthony Liu, Ralph Nanan
Summary: This study investigated how maternal and perinatal risk factors are linked to poorly controlled childhood asthma in a sex-dependent manner. The results showed that maternal BMI and threatened preterm labor had a significant impact on boys, while parity, birth length z-score, and birth weight z-score had a greater influence on girls. Allergic status was a common risk factor for both boys and girls in multiple hospital admissions for asthma.
Article
Pediatrics
Zahra Kanannejad, Mohammad Shomali, Hossein Esmaeilzadeh, Hesamedin Nabavizadeh, Koorosh Nikaein, Zahra Ghahramani, Mohammad Amin Ghatee, Soheila Alyasin
Summary: This study investigated the impact of geoclimatic factors on childhood asthma hospitalization in Fars province, southwest Iran. The results showed that urban setting was the most important risk factor associated with increased childhood asthma hospitalization.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, Research & Experimental
Euripide F. G. A. Avokpaho, Laure Gineau, Audrey Sabbagh, Eloic Atindegla, Arnauld Fiogbe, Sean Galagan, Moudachirou Ibikounle, Achille Massougbodji, Judd L. Walson, Adrian J. F. Luty, Andre Garcia
Summary: The study found a high prevalence of wheezing among children in Benin aged 6-14, with Ascaris lumbricoides infection being a significant risk factor for wheeze. Deworming, improving cooking methods to reduce household air pollution, modifying dietary habits to avoid overweight, and keeping animals out of the house were identified as important interventions to reduce children's risk of wheeze.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Natalie A. Rosenquist, Megan Richards, Jeannette R. Ferber, Matthew J. Strickland, So Young Ryu, Heather Burkin, Ann M. Weber, De-Kun Li, Lyndsey A. Darrow
Summary: Childhood overweight/obesity has a modest mediating effect on the association between prepregnancy BMI and childhood asthma.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Respiratory System
Yabin Hu, Yiting Chen, Shijian Liu, Fan Jiang, Meiqin Wu, Chonghuai Yan, Jianguo Tan, Guangjun Yu, Yi Hu, Yong Yin, Jiajie Qu, Shenghui Li, Shilu Tong
Summary: The study found that male sex, high socioeconomic status, cesarean section delivery, having only one child in the household, and having a family history of allergy were associated with childhood asthma and allergic diseases. On the other hand, longer breastfeeding duration (> 6 months) was inversely associated with these diseases and also reduced the effects of neonatal and familial risk factors.
RESPIRATORY RESEARCH
(2021)
Article
Psychiatry
Raija Lietzen, Sakari Suominen, Lauri Sillanmaki, Pekka Virtanen, Marianna Virtanen, Jussi Vahtera
Summary: This population-based study in Finland found that exposure to multiple adverse childhood experiences (ACEs) increased the risk of asthma in adulthood, with a portion of this risk being mediated by adulthood risk factors for asthma.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Melissa K. Blake, Ruixuan Ma, Erika Viana Cardenas, Parisa Varanloo, Yaray Agosto, Carolina Velasquez, Katheryn A. Espina, Joanne Palenzuela, Sarah E. Messiah, Ruby A. Natale
Summary: This study investigated the association between age at solid food initiation and obesity prevalence in preschool-aged children, taking into account disability status, ethnicity, gestational age, and birth weight. The findings revealed no significant difference in obesity prevalence based on age at solid food introduction. Children with disabilities and preterm births had significantly lower odds of being obese, while Hispanic children and those with higher birth weights were more likely to be obese.
Article
Nutrition & Dietetics
Melissa B. Manus, Stephanie K. Goguen, Meghan B. Azad
Summary: Mothers who produce secretor and non-secretor milk can equally promote infant growth and respiratory health through breastfeeding.
FRONTIERS IN NUTRITION
(2023)
Article
Allergy
Esteban Correa-Agudelo, Lili Ding, Andrew F. Beck, Cole Brokamp, Mekibib Altaye, Robert S. Kahn, Tesfaye B. Mersha
Summary: Racial disparities exist in asthma-related emergency department visits among children, and these disparities are influenced by social, economic, and environmental factors. Insurance, neighborhood socioeconomic deprivation, particulate matter, and outdoor mold mediate the impact of race on emergency department visits.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Eva Yarsky, Tina M. Banzon, Wanda Phipatanakul
Summary: This review aims to assess the prevalence of common allergen exposures and environmental risk factors for asthma in schools, examine the underlying mechanisms of these environmental risk factors, and explore possible prevention strategies. It was found that cockroach, mouse, dust mites, fungi, viral infections, ozone pollution, and cleaning products are common allergen exposures and environmental risk factors in schools which may affect asthma morbidity. Future studies are needed to determine the effects of modifiable risk factors in schools and whether school mitigation strategies can improve asthma symptoms in students with asthma.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Allergy
Meghan H. Shilts, Christian Rosas-Salazar, Kedir N. Turi, Devi Rajan, Seesandra V. Rajagopala, Megan F. Patterson, Tebeb Gebretsadik, Larry J. Anderson, R. Stokes Peebles, Tina V. Hartert, Suman R. Das
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Hongsheng Gui, Albert M. Levin, Donglei Hu, Patrick Sleiman, Shujie Xiao, Angel C. Y. Mak, Mao Yang, Andrea J. Barczak, Scott Huntsman, Celeste Eng, Samantha Hochstadt, Ellen Zhang, Kyle Whitehouse, Samantha Simons, Whitney Cabral, Sami Takriti, Goncalo Abecasis, Thomas W. Blackwell, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, David E. Lanfear, Frank Gilliland, W. James Gauderman, Rajesh Kumar, David J. Erle, Fernando D. Martinez, Hakon Hakonarson, Esteban G. Burchard, L. Keoki Williams
Summary: This study identified a functional variant at the 17q12-21.1 locus associated with early-onset asthma in African American individuals. The lead signal, rs11078928, was found to be the top association for early-onset asthma after meta-analysis across cohorts. Additionally, a haplotype analysis suggested that the asthma association most closely with this variant.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Virology
Samadhan J. Jadhao, Binh Ha, Courtney McCracken, Tebeb Gebretsadik, Christian Rosas-Salazar, James Chappell, Suman Das, Tina Hartert, Larry J. Anderson
Summary: RSV infection plays a major role in respiratory tract diseases in infants and throughout life. The RSV antibody enzyme-linked immunoassay is sensitive for detecting infant infection, and the two G EIAs can indicate the group of an earlier primary infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Allergy
Christian Rosas-Salazar, Kyle S. Kimura, Meghan H. Shilts, Britton A. Strickland, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Seesandra V. Rajagopala, Justin H. Turner, Suman R. Das
Summary: This study found complex associations between SARS-CoV-2 infection and the URT microbiome in adults, with viral load potentially impacting bacterial abundance. Further research is needed to explore how these viral-bacterial interactions can affect the clinical progression of COVID-19.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Pediatrics
Jacob A. Kaslow, Christian Rosas-Salazar, Paul E. Moore
Summary: The significant increase in the use of electronic nicotine delivery systems (ENDS) among adolescents has raised concerns about potential long-term impacts on users, especially young individuals. While there is a wealth of literature on vaping and EVALI in adults, research on pediatric patients is lacking, highlighting the need for further investigation in this area.
PEDIATRIC PULMONOLOGY
(2021)
Review
Gastroenterology & Hepatology
Rachel Bernard, Irtiqa Fazili, Seesandra V. Rajagopala, Suman R. Das, Girish Hiremath
Summary: Further research is necessary to uncover the mechanisms by which the oral microbiome impacts the development and progression of esophageal diseases, as well as to explore if changes in the oral microbiome can influence the natural course of different esophageal conditions.
DIGESTIVE DISEASES
(2022)
Article
Allergy
Christian Rosas-Salazar, Zheng-Zheng Tang, Meghan H. Shilts, Kedir N. Turi, Qilin Hong, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, James D. Chappell, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina Hartert
Summary: The study found that the upper respiratory tract (URT) microbiome during RSV ARI in infancy is associated with the acute local immune response, disease severity, and number of wheezing episodes in the fourth year of life. The diversity of the URT microbiome is related to the course of RSV ARI, and there are complex interactions between the URT microbiome and the immune system.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Charles R. Esther, Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das, Michael H. Freeman, Britton A. Strickland, Hunter M. Brown, Bronson C. Wessinger, Veerain C. Gupta, Kate Von Wahlde, Quanhu Sheng, Li Ching Huang, Daniel R. Bacon, Adam J. Kimple, Agathe S. Ceppe, Takafumi Kato, Raymond J. Pickles, Scott H. Randell, Ralph S. Baric, Justin H. Turner, Richard C. Boucher
Summary: This study assessed the efficacy of a detergent-based virucidal agent in SARS-CoV-2-infected subjects and found that it had no impact on viral load or symptom scores in the clinical trial. Complementary in vitro studies confirmed this lack of efficacy, indicating a failure in drug absorption.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Immunology
Meghan H. Shilts, Christian Rosas-Salazar, Britton A. Strickland, Kyle S. Kimura, Mohammad Asad, Esha Sehanobish, Michael H. Freeman, Bronson C. Wessinger, Veerain Gupta, Hunter M. Brown, Helen H. Boone, Viraj Patel, Mali Barbi, Danielle Bottalico, Meaghan O'Neill, Nadeem Akbar, Seesandra V. Rajagopala, Simon Mallal, Elizabeth Phillips, Justin H. Turner, Elina Jerschow, Suman R. Das
Summary: This study aims to investigate the association between COVID-19 severity and the upper respiratory tract microbiome. The study found that as the severity of COVID-19 increased, the bacterial load, bacterial richness, and within-group microbiome composition dissimilarity in the upper respiratory tract also increased, while the relative abundance of a specific amplicon sequence variant decreased.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jesse O. Wrenn, Suman B. Pakala, Grant Vestal, Meghan H. Shilts, Hunter M. Brown, Sara M. Bowen, Britton A. Strickland, Timothy Williams, Simon A. Mallal, Ian D. Jones, Jonathan E. Schmitz, Wesley H. Self, Suman R. Das
Summary: The clinical outcomes of infections caused by the Omicron variant were compared to those caused by the Delta variant. It was found that infections caused by the Omicron variant were less severe, with significantly lower morbidity and mortality rates, compared to those caused by the Delta variant.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Allergy
Christian Rosas-Salazar, Meghan H. Shilts, Zheng-Zheng Tang, Qilin Hong, Kedir N. Turi, Brittney M. Snyder, Derek A. Wiggins, Christian E. Lynch, Tebeb Gebretsadik, R. Stokes Peebles, Larry J. Anderson, Suman R. Das, Tina V. Hartert
Summary: Exclusive breast-feeding has a protective causal role in reducing the risk of lower respiratory tract infections, asthma, and allergic rhinitis in childhood. This association may be mediated through its impact on the early-life upper respiratory tract and gut microbiome, as well as the immune response in infancy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Mallory G. McKeon, Jean-Nicolas Gallant, Young J. Kim, Suman R. Das
Summary: Certain viruses, such as human papillomavirus (HPV) and Epstein-Barr virus (EBV), are associated with the development of head and neck cancer. This study reviews the mechanisms by which these viruses cause cellular transformation and chronic inflammation, and examines the interplay between viruses, cellular transformation, inflammation, and the local host microbiome in head and neck cancer.
Article
Cardiac & Cardiovascular Systems
Akihiro Nakajima, Satoru Mitomo, Haruhito Yuki, Makoto Araki, Lena Marie Seegers, Iris McNulty, Hang Lee, David Kuter, Midori Ishibashi, Kazuna Kobayashi, Jouke Dijkstra, Hirokazu Onishi, Hiroto Yabushita, Satoshi Matsuoka, Hiroyoshi Kawamoto, Yusuke Watanabe, Kentaro Tanaka, Shengpu Chou, Toru Naganuma, Masaaki Okutsu, Satoko Tahara, Naoyuki Kurita, Shotaro Nakamura, Suman Das, Sunao Nakamura, Ik-Kyung Jang
Summary: This study identified gut bacteria associated with vulnerable coronary plaque and greater plaque burden, which were also associated with elevated inflammatory or prothrombotic biomarkers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Virology
Stephanie Goya, Maria Florencia Lucion, Meghan H. Shilts, Maria del Valle Juarez, Angela Gentile, Alicia S. Mistchenko, Mariana Viegas, Suman R. Das
Summary: Globally, the human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections (LRTIs) in children. This study sequenced the complete genomes of RSV from pediatric patients in Buenos Aires and found that RSV-B was dominant from 2014 to 2016 before being abruptly replaced by RSV-A in 2017. The decrease in RSV genomic diversity observed in Buenos Aires in 2016 may have allowed the RSV-A predominance switch in 2017.