Effect of Cellular Location of Human Carboxylesterase 2 on CPT-11 Hydrolysis and Anticancer Activity

Impact of proteolytic enzymes in colorectal cancer development and progression

(2014) László Herszényi   WORLD JOURNAL OF GASTROENTEROLOGY

Selective Cancer Therapy by Extracellular Activation of a Highly Potent Glycosidic Duocarmycin Analogue

(2013) Kai-Chuan Chen et al.   MOLECULAR PHARMACEUTICS

Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β–glucuronidase in tumors

(2011) P-T Huang et al.   CANCER GENE THERAPY

Quantitative Co-Expression of Proteins at the Single Cell Level – Application to a Multimeric FRET Sensor

(2011) Joachim Goedhart et al.   PLoS One

Phase II study of nedaplatin and irinotecan with concurrent thoracic radiotherapy in patients with locally advanced non-small-cell lung cancer

(2010) F Oshita et al.   BRITISH JOURNAL OF CANCER

Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy

(2009) Z. M. Prijovich et al.   MOLECULAR CANCER THERAPEUTICS

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11

(2008) M Wierdl et al.   CANCER GENE THERAPY

Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma

(2008) Hiroki Yano et al.   CANCER SCIENCE

Directed Evolution of a Lysosomal Enzyme with Enhanced Activity at Neutral pH by Mammalian Cell-Surface Display

(2008) Kai-Chuan Chen et al.   CHEMISTRY & BIOLOGY