Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Brunty, Kristeena Ray Wright, Brenda Mitchell, Nalini Santanam
Summary: Activation of trimethylation of histone 3 lysine 27 (H3K27me3) by EZH2 plays a role in endometriosis, with higher expression of PRC2 complex components like JARID2, miR-155, and FOXP3 noted in patient tissues. MiR-155 affects the PRC2 complex but has minimal impact on JARID2 expression, suggesting alternative pathways may be involved. A novel crosstalk between miR-155, the PRC2 complex, JARID2, and PHF19 has been identified, providing potential epigenetic targets for further study in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Shashi Bala, Yuan Zhuang, Prashanth Thevkar Nagesh, Donna Catalano, Adam Zivny, Yanbo Wang, Jun Xie, Guangping Gao, Gyongyi Szabo
Summary: This study investigated the therapeutic effect of miR-155 inhibition in liver fibrosis and found that miR-155 deficiency can significantly reduce liver fibrosis. The study also revealed that miR-155 regulates activation of hepatic stellate cells partly via STAT3 signaling.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Biochemistry & Molecular Biology
Yi-Yung Hung, Chen-Kai Chou, Yi-Chien Yang, Hung-Chun Fu, El-Wui Loh, Hong-Yo Kang
Summary: This study found that in patients with major depressive disorder, the expression levels of miR-146a in exosomes were higher, and patients who achieved remission showed lower levels of various microRNAs before treatment and increased levels after treatment. Let-7e, miR-145, and miR-146a showed acceptable discrimination between the remission and non-remission groups.
Review
Oncology
Katerina Kalkusova, Pavla Taborska, Dmitry Stakheev, Daniel Smrz
Summary: MiR-155 is a significant regulator of immune responses against tumors, particularly in different immune cell populations, and it can impact the process of cancer immunoediting. Its role in cellular communication is also important. MiR-155 targeting is increasingly used in cancer immunotherapy.
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pathology
Fatemeh Rajabi, Hossein Mozdarani
Summary: This study aimed to investigate whether miR-155, miR-19a, and miR-15a can predict cellular radiosensitivity in breast cancer patients. The findings revealed that miR-155 and miR-19a could be used as bioindicators for predicting cellular radiosensitivity in breast cancer patients.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Immunology
Hui Yu, Lei Qin, Yunzhi Peng, Wenhui Bai, Zhanli Wang
Summary: The study revealed that exosomes released from hypertrophic cardiomyocytes induced inflammatory responses in macrophages through miR-155, activating various signaling pathways, which may play a crucial role in the development of cardiac hypertrophy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zahra Saadatian, Yaser Mansoori, Lida Nariman-Saleh-Fam, Abdolreza Daraei, Sepideh Zununi Vahed, Shadan Navid, Ziba Nariman-Saleh-Fam
Summary: This study evaluated the alteration of miR-200c, miR-125b, miR-27b, miR-203, and miR-155 in patients with coronary artery stenosis and insignificant coronary artery stenosis compared to healthy individuals. The results showed that three of these miRNAs have the potential to differentiate between coronary artery stenosis patients and healthy individuals, suggesting they could be novel diagnostic biomarkers.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Immunology
Mahmoud Mahami-Oskouei, Behrooz Norouzi, Ehsan Ahmadpour, Tohid Kazemi, Adel Spotin, Zahra Alizadeh, Roghayeh Ghorbani Sani, Milad Asadi
Summary: The study compared the expression levels of miR-146a and miR-155 in the plasma of patients with hydatidosis and healthy individuals. The results indicated an increased level of both miR-146a and miR-155 in all hydatidosis patients compared to the control group, with no correlation observed in the level of miR-155 between the two groups. Upregulation of miR-146a and miR-155 in plasma may lead to the development of novel biomarkers for echinococcosis, potentially serving as important biomarkers for determining the severity of hydatidosis.
MICROBIAL PATHOGENESIS
(2021)
Article
Infectious Diseases
Yung-Che Chen, Chang -Chun Hsiao, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu -Ping Chang, Chia-Cheng Tseng, Chiu-Ping Lee, Po-Yuan Hsu, Ting-Ya Wang, Po-Wen Wang, Ting-Wen Chen, Meng-Chih Lin
Summary: This study explores a new approach for treating active tuberculosis (TB) by screening and validating microRNAs with immune-regulatory functions. The research identified differentially expressed microRNAs associated with TB and revealed their roles in regulating autophagy, apoptosis, and macrophage phagocytosis. The findings provide evidence for microRNA-based host-directed immunotherapy and offer new therapeutic targets for treatment-refractory TB.
JOURNAL OF INFECTION
(2022)
Article
Medicine, Research & Experimental
Jose L. Sanchez-Gloria, Roxana Carbo, Mabel Buelna-Chontal, Horacio Osorio-Alonso, Adrian Henandez-Diazcouder, Rosa Luz de la Fuente-leon, Julio Sandoval, Fausto Sanchez, I. Rubio-Gayosso, Fausto Sanchez-Munoz
Summary: Chronic cold exposure exacerbates MCT-induced pulmonary arterial hypertension in rats, resulting in increased levels of inflammatory markers and miRNAs in plasma EVs and lungs.
Article
Immunology
Ji Young Kim, Patrick Stevens, Manjula Karpurapu, Hyunwook Lee, Joshua A. A. Englert, Pearlly Yan, Tae Jin Lee, Navjot Pabla, Maciej Pietrzak, Gye Young Park, John W. W. Christman, Sangwoon Chung
Summary: By utilizing a mouse model and studying clinical patients, we discovered the important role of ETs in asthma, with miR-155 inhibition showing therapeutic benefits in severe asthma. Targeting dsDNA release may be a potential therapeutic target for mitigating neutrophilic asthma phenotype.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Sumel Ashique, Kirti Gupta, Gaurav Gupta, Neeraj Mishra, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Harish Dureja, Flavia Zacconi, Brian G. Oliver, Keshav Raj Paudel, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: This study summarizes the research on the use of vitamin D for COVID-19 treatment and prevention. Vitamin D supplementation is considered an effective option to enhance immune response and prevent the spread of infection. Vitamin D acts as an immunomodulator, treating infected lung tissue by improving immune response and suppressing inflammatory reactions.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Respiratory System
Senani N. H. Rathnayake, Benedikt Ditz, Jos van Nijnatten, Tayyaba Sadaf, Philip M. Hansbro, Corry A. Brandsma, Wim Timens, Annemarie van Schadewijk, Peter S. Hiemstra, Nick H. T. ten Hacken, Brian Oliver, Huib A. M. Kerstjens, Maarten van den Berge, Alen Faiz
Summary: This study uses scRNA-seq to analyze the effects of smoking on the cellular composition and gene expression of the bronchial-mucus-barrier. It found that smoking alters the cell composition, increases mucus production, and leads to gene expression changes in the bronchial-mucus-barrier. However, these effects can be partially reversed within a year of smoking cessation. The CD methodology can predict goblet cell percentages from RNA-seq.
Article
Respiratory System
Venkata Sita Rama Raju Allam, Stelios Pavlidis, Gang Liu, Nazanin Zounemat Kermani, Jennifer Simpson, Joyce To, Sheila Donnelly, Yi-Ke Guo, Philip M. Hansbro, Simon Phipps, Eric F. Morand, Ratko Djukanovic, Peter Sterk, Kian Fan Chung, Ian Adcock, James Harris, Maria B. Sukkar
Summary: The study showed that MIF protein correlates with clinical and molecular features of severe neutrophilic asthma and reduces the biological activity of annexin-A1 through interaction, promoting glucocorticoid resistance of neutrophilic inflammation.
Article
Biochemistry & Molecular Biology
Vamshikrishna Malyla, Keshav Raj Paudel, Gabriele De Rubis, Nicole G. Hansbro, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer is a major global cause of cancer-related deaths due to a lack of early diagnostics and effective treatments. In a study, EVs derived from A549 lung adenocarcinoma cells were transferred to healthy human bronchial epithelial cells. It was found that the EVs carry oncogenic proteins involved in promoting tumor growth and invasion through the EMT pathway regulated by beta-catenin. This study suggests that cancer-cell-derived EVs can induce tumorigenesis in neighboring healthy cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Vyoma K. Patel, Sukriti Vishwas, Rajan Kumar, Gabriele De Rubis, Shakti D. Shukla, Keshav Raj Paudel, Bikash Manandhar, Thakur Gurjeet Singh, Dinesh Kumar Chellappan, Monica Gulati, Indu Pal Kaur, Venkata Sita Rama Raju Allam, Philip M. Hansbro, Brian G. Oliver, Ronan MacLoughlin, Sachin Kumar Singh, Kamal Dua
Summary: Asthma is a chronic inflammatory airway disease that presents a huge burden worldwide. Overproduction of pro-inflammatory cytokines triggers an uncontrolled inflammatory response known as 'cytokine storm', leading to disease progression and fatal consequences. Targeting cytokine overproduction and signaling may provide a promising approach for asthma treatment. This review discusses pharmacological strategies, drug delivery systems, and clinical trial findings that may overcome the limitations of current therapies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vinod Kumar Kannaujiya, Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Dinesh Kumar Chellappan, Sachin Kumar Singh, Ronan MacLoughlin, Gaurav Gupta, Dikaia Xenaki, Pradeep Kumar, Philip Michael Hansbro, Brian Gregory George Oliver, Peter Richard Wich, Kamal Dua
Summary: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide, and current treatment options are limited. Inhibition of NF kappa B, a master regulator of NSCLC, shows promise as an innovative therapeutic strategy. This study demonstrates the encapsulation of a hydrophilic NF kappa B decoy ODN into a dextran-based nanoparticle system, which effectively inhibits NF kappa B activity and exhibits promising anticancer activity against NSCLC.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Immunology
Gaetano Scaramuzzo, Nucera Francesco, Alessio Asmundo, Roberto Messina, Matilde Mari, Federica Montanaro, Matt D. Johansen, Francesco Monaco, Guido Fadda, Giovanni Tuccari, Nicole G. Hansbro, Philip M. Hansbro, Trevor T. Hansel, Ian M. Adcock, Antonio David, Paul Kirkham, Gaetano Caramori, Carlo Alberto Volta, Savino Spadaro
Summary: The SARS-CoV-2 infection can cause either asymptomatic cases or the severe disease COVID-19, which is characterized by varying levels of severity. Severe COVID-19 and death mainly result from acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The understanding of the molecular pathogenesis of COVID-19-related ARDS (c-ARDS) is still limited. This review discusses the genetic susceptibility to COVID-19, the pathogenesis, local and systemic biomarkers associated with c-ARDS, and therapeutic options targeting the cell signaling pathways of c-ARDS.
JOURNAL OF INFLAMMATION-LONDON
(2023)
Review
Chemistry, Medicinal
Jesus Shrestha, Keshav Raj Paudel, Hojjatollah Nazari, Vivek Dharwal, Sajad Razavi Bazaz, Matt D. Johansen, Kamal Dua, Philip M. Hansbro, Majid Ebrahimi Warkiani
Summary: The global burden of respiratory diseases is significant, with a large number of people suffering and dying prematurely every year. The recent global COVID-19 pandemic, along with increased air pollution and wildfires, highlights the need to identify effective therapeutic measures. The use of advanced culture technologies, such as organoids and lung-on-a-chip models, has gained attention for their potential to replicate human diseased states and evaluate drug responses.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Cell Biology
Theodore S. Kapellos, Kevin Babler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J. M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feisst, Ali Oender Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Haendler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze
Summary: Systemic inflammation is a characteristic feature of late-stage severe lung disease, while the molecular, functional, and phenotypic changes in peripheral immune cells in the early stages of the disease remain poorly understood. In this study, using single-cell analyses, the researchers found that blood neutrophils are already increased in early-stage COPD, and the changes in their molecular and functional states correlate with the decline of lung function. Further investigation using a murine cigarette smoke exposure model revealed similar molecular changes in blood neutrophils and precursor populations in the blood and lung. The findings suggest that systemic molecular alterations in neutrophils and their precursors are present in the early stages of COPD, and may serve as potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
Review
Medicine, General & Internal
Nikhil T. Awatade, Peter A. B. Wark, Andrew S. L. Chan, S. M. Abdullah Al Mamun, Nurul Yaqeen Mohd Esa, Kazuto Matsunaga, Chin Kook M. Rhee, Philip M. Hansbro, Sukhwinder Singh Sohal
Summary: Chronic obstructive pulmonary disease (COPD) is a major contributor to illness and death worldwide. While COPD patients appear to be at higher risk for severe COVID-19 outcomes, it is still uncertain if they are more susceptible to acquiring SARS-CoV-2 infection. This comprehensive review examines the relationship between COPD and COVID-19, exploring the evidence on susceptibility to infection and disease severity. The review also considers factors such as smoking, corticosteroid use, socioeconomic factors, and genetics that may influence this association. The importance of managing COPD patients during the pandemic to minimize the risk of severe COVID-19 outcomes is highlighted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Vijay Kumar Panthi, Kamal Dua, Sachin Kumar Singh, Gaurav Gupta, Philip M. Hansbro, Keshav Raj Paudel
Summary: Cancer-related death is a global burden and conventional chemotherapy has limitations. Metronomic chemotherapy (MCT) is suggested as an alternative approach. Nanoformulations-based MCT has shown promising antitumor activity in preclinical and clinical settings. However, challenges and unanswered questions remain, and further research is necessary before implementing this treatment modality.
Review
Biochemistry & Molecular Biology
Mohammad Imran, Xuping Jin, Masood Ali, Pronalis Tapfumaneyi, Pauline Lelasseur, Laure Carlo, Axelle Jude, Alice Le Bourg, Bhavesh Panchal, Arianna Dick, Keshav Raj Paudel, Philip M. Hansbro, Yousuf Mohammed
Summary: In addition to respiratory symptoms, COVID-19 infection and lifestyle changes during quarantine can also cause various skin manifestations, including redness, COVID toes, hives or urticaria rash, water blisters, and patterned discoloration. These symptoms are related to skin type and vitamin D deficiency, and individuals with lighter skin have a higher chance of developing these manifestations. Extensive use of personal protective equipment and alcohol-based sanitizers can also lead to skin damage and irritation.
Article
Medicine, Research & Experimental
Vamshikrishna Malyla, Keshav Raj Paudel, Gabriele De Rubis, Nicole G. Hansbro, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer has the highest mortality rate worldwide, and cigarette smoking is a major etiological factor. This study found that cigarette smoke extract treatment can upregulate WNT/ss-β-catenin signaling and induce tumorigenesis in healthy human bronchial epithelial cells. Furthermore, extracellular vesicles obtained from cigarette smoke exposed cells were found to induce migration and upregulate oncology proteins in recipient cells.
Article
Multidisciplinary Sciences
Nikhil T. Awatade, Andrew T. Reid, Kristy S. Nichol, Kurtis F. Budden, Punnam Chander Veerati, Prabuddha S. Pathinayake, Christopher L. Grainge, Philip M. Hansbro, Peter A. B. Wark
Summary: This study compared the morphology and functional responses of primary bronchial epithelial cells differentiated using two commonly used culture media, PneumaCult and bronchial epithelial growth medium. The results showed distinct structural and functional differences between the two media.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Ilaria Salvato, Luca Ricciardi, Jessica Dal Col, Annunziata Nigro, Giorgio Giurato, Domenico Memoli, Assunta Sellitto, Erwin Pavel Lamparelli, Maria Assunta Crescenzi, Monica Vitale, Alessandro Vatrella, Francesco Nucera, Paola Brun, Federico Caicci, Paola Dama, Thomas Stiff, Leandro Castellano, Sobia Idrees, Matt D. Johansen, Alen Faiz, Peter A. Wark, Philip M. Hansbro, Ian M. Adcock, Gaetano Caramori, Cristiana Stellato
Summary: AU-rich-element factor-1 (AUF-1), an RNA-binding protein, is involved in posttranscriptional regulation of genes related to inflammation and cellular senescence, both of which are pathogenic mechanisms in chronic obstructive pulmonary disease (COPD). Decreased expression of AUF-1 is observed in bronchiolar epithelium of COPD patients and in human airway epithelial cells exposed to cytokines and cigarette smoke. This study identifies AUF-1-targeted transcripts and demonstrates its association with inflammation and senescence-related pathways in COPD.
FRONTIERS IN IMMUNOLOGY
(2023)