Article
Biochemistry & Molecular Biology
Jose A. Martina, Eutteum Jeong, Rosa Puertollano
Summary: TFEB-S401 phosphorylation is linked to the transcriptional control of monocyte differentiation.
Review
Chemistry, Medicinal
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino, Girolamo Pelaia
Summary: The p38 MAPK subgroup plays a crucial role in the pathogenesis of asthma and COPD by regulating the expression of various inflammatory mediators and fibrogenic factors. Studies suggest that p38 MAPK may be a potential therapeutic target, with research evaluating its effects in both asthma and COPD treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Environmental Sciences
Ai Mai, Shu-Wen Ye, Jia-Yu Tu, Jun Gao, Zhan-Fang Kang, Qian-Ming Yao, Wei-Jen Ting
Summary: This study demonstrates that thymoquinone (TQ) can effectively cross the blood-brain barrier and has therapeutic potential for the treatment of glioblastoma, especially when used in combination with temozolomide (TMZ).
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Zeng, Qing Yang, Yujuan Ouyang, Yanbin Lou, Hengmin Cui, Huidan Deng, Yanqiu Zhu, Yi Geng, Ping Ouyang, Lian Chen, Zhicai Zuo, Jing Fang, Hongrui Guo
Summary: The study reveals that nickel is harmful to male reproductive system by inducing damage to the blood-testis barrier (BTB) and causing testicular histopathological damage. Co-treatment with the antioxidant N-acetylcysteine (NAC) can alleviate the damage and exert its effects through the oxidative stress-mediated p38 MAPK signaling pathway.
Article
Cell Biology
Yunzhong Zhang, Ketao Jiang, Guoqing Xie, Jie Ding, Su Peng, Xiaoyu Liu, Cheng Sun, Xin Tang
Summary: FGF21, as a metabolic stress hormone mainly secreted by the liver, has been shown to act as a negative regulator for the myelin development process in the peripheral nervous system (PNS) by activating p38 MAPK/c-Jun signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Xiaoming Huang, Jianfeng Wan, Fei Liu, Yang Liu, Lina Wang, Sidi Zhao, Tong Wu, Fengyuan Sun
Summary: This study investigates how p38 MAPK affects the progression of retinoblastoma (RB) by mediating the USP22/SIRT1/SOST axis. The expression of p38 MAPK, phosphorylated p38 MAPK (P-p38 MAPK), USP22, SIRT1, and SOST was analyzed in RB tissues and cells. The results show that p38 MAPK, P-p38 MAPK, and SOST had low expression, while USP22 and SIRT1 had high expression in RB tissues and cells. P-p38 MAPK inhibited USP22 expression, and overexpression of USP22 reversed the inhibitory effects of P-p38 MAPK on tumor growth, cell proliferation, migration, and invasion. USP22 stabilized and promoted the expression of SIRT1 through its deubiquitination function. Silencing SIRT1 expression increased the expression of SOST, thereby suppressing tumor cell growth. These findings suggest that phosphorylation of p38 MAPK regulates the SIRT1/SOST axis to protect against RB by silencing USP22.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim
Summary: This study aims to investigate the antitumor potential and molecular mechanism of Licochalcone B (LCB) in human colorectal cancer cells. The results demonstrate that LCB has a potential therapeutic effect against colorectal cancer cells through the ROS-mediated JNK/p38 MAPK signaling pathway, making it a promising anticancer therapeutic and prophylactic agent.
Review
Chemistry, Medicinal
Payal Ganguly, Tom Macleod, Chi Wong, Mark Harland, Dennis Mcgonagle
Summary: The p38-MAPK pathway is crucial in cell apoptosis, inflammation, and immunity. However, challenges faced by p38 inhibitors in treating inflammatory diseases include toxicities and efficacy issues. Blocking the downstream of p38 pathway with MK2i may be a viable strategy to alleviate inflammation without causing known toxicities.
Article
Oncology
Serina Cheung, Pallavi Jain, Jonathan So, Saeid Shahidi, Stephen Chung, Marianne Koritzinsky
Summary: Targeting the p38 MAPK protein kinase can inhibit growth and survival of castration-resistant prostate cancer cells, regardless of oxygen levels, and may prolong the survival of tumor-bearing mice. This demonstrates the potential of p38 MAPK inhibition as a therapeutic strategy for disrupting AR signaling in the heterogeneous CRPC tumor microenvironment.
Article
Biochemistry & Molecular Biology
Ahmed H. E. Hassan, Yeon Il Oh, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Md. Maqusood Alam, Sang-Eun Park, Kyung-Sook Chung, Kyung-Tae Lee, Yong Sup Lee
Summary: Phenethyl-based edelfosine-analogs with different alkoxy substituents on the phenyl ring were designed as antitumor lipids modulating p38 MAPK activity. Saturated and monounsaturated alkoxy-substituted derivatives showed the highest antitumor activity against various cancer cells. Ortho-substituted compounds were more active than meta- or ortho-substituted compounds. Compound 1b emerged as the most potent inhibitor of p38 MAPK activity. In silico study suggested that compounds 1b and 1a could potentially bind to the lipid binding pocket of p38 MAPK. Overall, compounds 1b and 1a have broad spectrum antitumor potential through p38 MAPK modulation.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Food Science & Technology
Fangyu Meng, Huiyu Hao, Zhiyi Guo, Wenpeng Liu, Shumin Zhang, Wenxuan Tang, Wendong Ma, Xuan Shang
Summary: The present study demonstrates that exposure to SiNPs affects the histological structure of the epididymis, induces sperm granuloma formation, impairs blood-epididymal barrier integrity, alters membrane protein expression, increases macrophage population, promotes pro-inflammatory molecule expression, induces oxidative stress, and activates the p38 MAPK signaling pathway in mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Neurosciences
Saisai Huang, Yingting Chen, Yue Jia, Tuo Yang, Wenfeng Su, Zhenyu Zhu, Peng Xue, Feifan Feng, Yayu Zhao, Gang Chen
Summary: The study identified the time window for therapeutic interventions by characterizing neuropathic pain and motor function recovery in a mouse sciatic nerve crush injury model. It was found that delayed delivery of a combination of ERK and p38 inhibitors at three weeks post-PNI could significantly alleviate PNI-induced neuropathic pain without affecting motor function recovery. Additionally, the combined use of these inhibitors could suppress pain more effectively than using either inhibitor alone, potentially reducing side effects and risks.
Article
Environmental Sciences
Sudhanshu Mallan, Shamsher Singh
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restrictive and repetitive behavior, impaired social interaction and communication. Prenatal exposure to Valproic acid (VPA) has been found to cause ASD-like phenotypes in animals. Syringic acid (SA), a polyphenolic compound, has shown protective effects against inflammation, oxidative stress, and neuronal damage. This study investigated the protective effect of SA in prenatal VPA-treated rats and found that SA prevented behavioral alterations, restored antioxidant enzymes and neurotransmitter levels, reduced neuroinflammation markers, and improved neuronal integrity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Yung-Lun Ni, Huan-Ting Shen, Shih-Pin Chen, Yu-Hsiang Kuan
Summary: This study found that genkwanin has a protective effect against LPS-induced ALI by inhibiting NF-kappa B pathway activation and p38 MAPK phosphorylation.
JOURNAL OF FUNCTIONAL FOODS
(2022)