Article
Business, Finance
Chee Seng Cheong, Gary Tan, Ralf Zurbruegg
Summary: The study shows that childhood experiences such as major family financial loss, parents' source of income, upbringing, and birth order have an impact on individuals' willingness to trade, contributing to the understanding of how early-life experiences shape adult financial risk preferences.
FINANCE RESEARCH LETTERS
(2021)
Article
Oncology
Anne-Sophie E. Darlington, Jessica E. Morgan, Richard Wagland, Samantha C. Sodergren, David Culliford, Ashley Gamble, Bob Phillips
Summary: This study explored the experiences and decision-making of parents with a child with cancer in response to the early phase of the COVID-19 pandemic in the UK. The majority of parents were worried about SARS-CoV-2 and transmitting the virus to their child, with hospitals no longer perceived as safe places. Parents described fear, anxiety, and the psychological, social, and economic impact of isolation.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biology
Viola Introini, Gururaj Rao Kidiyoor, Giancarlo Porcella, Pietro Cicuta, Marco Cosentino Lagomarsino
Summary: The nucleus plays a central role in key cellular processes, and recent research suggests an association between nuclear mechanics and cell-cycle progression. By monitoring nuclear shape fluctuations, this study reveals an increasing inward deformation in late G2 and early prophase, which correlates with chromatin condensation and possibly links it with nuclear-envelope breakdown during mitosis. These findings provide insights into the mechanical connection between chromosome condensation and nuclear envelope dynamics.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nutrition & Dietetics
Rachel S. Berkowsky, Amanda L. Zaleski, Beth A. Taylor, Ming-Hui Chen, Kim M. Gans, Yin Wu, Paul M. Parducci, Yiming Zhang, Antonio B. Fernandez, Linda S. Pescatello
Summary: Caffeine has beneficial effects on firefighter job performance, but excessive intake may raise blood pressure. This study investigated the influence of caffeine, calcium, sodium, and cardiometabolic biomarkers on the blood pressure response among firefighters after intense physical exertion. The results showed that caffeine intake explained 24% of the adverse blood pressure response, while calcium and sodium intake each explained up to 24% of the blood pressure response.
Article
Clinical Neurology
Gregory Brusola, Amber Armstead, Carole Tucker
Summary: This study aimed to elucidate the perceptions and overall experiences of people living with early multiple sclerosis (MS) regarding physical rehabilitation. Qualitative data was collected through semi-structured interviews with 15 individuals with early MS. The study revealed poor public awareness of MS-specific rehabilitation and a need for reliable and easily accessible information and resources for individuals with early MS, particularly from their neurologists, to enhance engagement in MS-specific rehabilitation.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Sport Sciences
Kelley Pettee Gabriel, Byron C. Jaeger, Barbara Sternfeld, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Cora E. Lewis, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, James M. Shikany, Kara M. Whitaker, Stephen Sidney
Summary: This study aimed to examine the changes in maximal and submaximal cardiorespiratory fitness from early adulthood to midlife and the factors influencing these changes. The results showed that maximal fitness declined significantly with age, while submaximal heart rate increased. Gender, race, socioeconomic status, and health-related factors were found to have persistent effects on maximal fitness. Targeted intervention strategies for individuals experiencing accelerated fitness declines may help reduce cardiovascular disease risk.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Business, Finance
Ruirui Zhu, Hong Bo
Summary: This study finds that Chinese CEOs who experienced greater gender inequality during the one-child policy period tend to increase investment and invest more than their peers. Women CEOs in this group are more conservative and risk-averse in investment, while men CEOs are overconfident and risk-taking. These results are robust across several tests.
RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE
(2023)
Article
Nutrition & Dietetics
Emmy Fredriksson, Stina Boden, Magnus Domellof, Christina E. West
Summary: This study suggests that consumption of acidic fruit pouches in infancy is not associated with allergic phenotypes or IgE sensitization in early childhood.
Review
Biochemistry & Molecular Biology
Taylor S. Campbell, Katelyn M. Donoghue, Urmi Ghosh, Christina M. Nelson, Tania L. Roth
Summary: Early life stress has negative effects on brain development and increases the risk of behavioral and neuropsychiatric disorders. Aerobic exercise shows potential as a treatment to reverse these effects by promoting the expression of Brain derived neurotrophic factor (Bdnf). It is a readily available behavioral intervention that can be used to mitigate the impact of early life stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Shirong Cai, Elaine Kwang Hsia Tham, Hai-Yan Xu, Xiuju Fu, Rick Siow Mong Goh, Peter D. Gluckman, Yap-Seng Chong, Fabian Yap, Lynette Pei-Chi Shek, Oon Hoe Teoh, Joshua J. Gooley, Daniel Yam-Thiam Goh, Michael J. Meaney, Nora Schneider, Anne Rifkin-Graboi, Birit F. P. Broekman
Summary: This study examines the association between different trajectories of reported sleep duration and early childhood cognition. The results show that compared to short variable night sleep trajectory, a long consistent night sleep trajectory is associated with higher cognition scores. Moderate/long consistent night sleep trajectories are also associated with higher verbal and composite scores. Children with a long consistent total sleep trajectory have higher cognition and expressive language scores. A moderate consistent total sleep trajectory is associated with higher language and verbal scores relative to a short variable total trajectory. Children with a long variable day sleep have lower cognition and fine motor scores.
Article
Multidisciplinary Sciences
William T. Hu, Tugba Ozturk, Alexander Kollhoff, Whitney Wharton, J. Christina Howell
Summary: Neuroinflammation is observed in Alzheimer's disease. Here the authors show that 15 proteins related to inflammation found in CSF can potentially be used as a prognostic biomarker, providing predictive information independent of established Alzheimer's markers.
NATURE COMMUNICATIONS
(2021)
Article
Psychology, Multidisciplinary
Jyllenna Landry, Ajani Asokumar, Carly Crump, Hymie Anisman, Kimberly Matheson
Summary: Loneliness is a common issue among young people, and it is associated with adverse early life experiences. Childhood abuse affects social processes that contribute to loneliness in young adulthood, and this relationship is mediated by perceived social support, social connectedness, and unsupportive interactions with friends.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Wael Taji, Robert Pierson, Peter Przemyslaw Ujma
Summary: Sleep is a crucial behavior for human health and cognitive functioning. The Budapest Sleep, Experiences, and Traits Study (BSETS) was created to investigate the relationships between sleep features and daily experiences using novel remote EEG devices.
Article
Physiology
Emily M. Rogers, Nile F. Banks, Patrick M. Tomko, Christina M. Sciarrillo, Sam R. Emerson, Emily B. K. Thomas, Ashlee Taylor, T. Kent Teague, Nathaniel D. M. Jenkins
Summary: This study aimed to investigate the effects of aerobic and resistance exercise training on mental health and cardiovascular disease risk in young women with adverse childhood experiences. The results showed that exercise can lower ET-1 levels, improve positive psychological coping, and potentially improve systolic blood pressure.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Psychology, Developmental
Hayley Pierce, Melissa S. Jones, Emley A. Holcombe
Summary: Adverse childhood experiences (ACEs) are significantly associated with youth social skills, with early ACEs leading to deficits in social skills. These findings highlight the importance of early ACE exposure in the development of social skills.
JOURNAL OF YOUTH AND ADOLESCENCE
(2022)
Article
Biotechnology & Applied Microbiology
Lea Mikkola, Kaisa Kyostila, Jonas Donner, Anu K. Lappalainen, Marjo K. Hytonen, Hannes Lohi, Antti Iivanainen
Summary: This study successfully replicates many loci associated with canine hip dysplasia (CHD) in different breeds, highlighting the complex genetic architecture of the disease. Genes involved in the neddylation pathway are enriched among the validated loci, contributing to various cellular functions including inflammation. Further characterization of these associated loci could reveal CHD-relevant genes and pathways for enhanced understanding of the disease pathogenesis.
Article
Veterinary Sciences
Claudia Ottka, Katariina Vapalahti, Ann-Marie Maatta, Nanna Huuskonen, Sinikka Sarpanen, Liisa Jalkanen, Hannes Lohi
Summary: Using NMR metabolomics platform, metabolic changes associated with increased serum creatinine concentrations were identified in this study, including citrate, tyrosine, branched-chain amino acids, valine, leucine, albumin, linoleic acid, and other analytes. These findings have the potential to serve as prospective diagnostic markers and therapeutic targets for renal diseases in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Genetics & Heredity
Kaisa Kyostila, Julia E. Niskanen, Meharji Arumilli, Jonas Donner, Marjo K. Hytonen, Hannes Lohi
Summary: The anterior pituitary gland secretes essential hormones for growth and reproduction. Abnormal development can lead to isolated or combined pituitary hormone deficiency (CPHD). In dogs, a new model for CPHD has been established with a candidate POU1F1 gene defect.
Article
Biotechnology & Applied Microbiology
Jenni Harmoinen, Alina von Thaden, Jouni Aspi, Laura Kvist, Berardino Cocchiararo, Anne Jarausch, Andrea Gazzola, Teodora Sin, Hannes Lohi, Marjo K. Hytonen, Ilpo Kojola, Astrid Vik Stronen, Romolo Caniglia, Federica Mattucci, Marco Galaverni, Raquel Godinho, Aritz Ruiz-Gonzalez, Ettore Randi, Violeta Munoz-Fuentes, Carsten Nowak
Summary: This study developed a panel of 96 ancestry informative markers for wolves and dogs, using a genotyping method that accurately identifies various hybrid types across Europe. The results support the hybrid identity of suspect individuals and the non-hybrid status of individuals regarded as wolves, demonstrating the efficiency of the proposed SNP panel for detecting hybrids up to the third-generation backcrosses to wolves.
Article
Endocrinology & Metabolism
Claudia Ottka, Corinna Weber, Elisabeth Mueller, Hannes Lohi
Summary: The study aimed to identify metabolic changes in the sera of phenobarbital-treated dogs and investigate the relationship between serum phenobarbital concentration and metabolite levels. The results showed that certain metabolites were significantly associated with the phenobarbital-treated group, but no linear associations were observed between phenobarbital and metabolite concentrations.
Article
Veterinary Sciences
Claudia Ottka, Katariina Vapalahti, Jenni Puurunen, Laura Vahtera, Hannes Lohi
Summary: This study validated a quantitative NMR spectroscopy-based metabolomics platform for canine serum and plasma samples, determining optimal sample handling conditions and defining reference intervals for 123 measurands. Results showed high reproducibility and scalability, indicating great potential for clinical and research applications to enhance canine health.
VETERINARY CLINICAL PATHOLOGY
(2021)
Article
Veterinary Sciences
Hannah K. Walker, Claudia Ottka, Hannes Lohi, Ian Handel, Dylan N. Clements, Adam G. Gow, Richard J. Mellanby
Summary: The study found no clear evidence supporting the need to establish seasonal reference ranges for serum metabolites in dogs, as only a few metabolites showed statistically significant seasonal variance.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Psychiatry
Milla Salonen, Salla Mikkola, Emma Hakanen, Sini Sulkama, Jenni Puurunen, Hannes Lohi
Summary: This study examined the associations between personality traits and unwanted behavioral traits in dogs. The results showed that dog personality traits resemble human personality traits and are associated with similar patterns of unwanted behaviors. This suggests that dogs may be a suitable animal model for studying human behavior and psychiatric disorders.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Jenni Puurunen, Claudia Ottka, Milla Salonen, Julia E. Niskanen, Hannes Lohi
Summary: Metabolomics has vast potential in biomedical applications. Factors such as age, breed, sex, sterilization, diet type, and fasting time significantly affect the metabolite profiles of healthy pet dogs, with breed and age causing considerable variation in metabolite concentrations.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Sanni Somppi, Heini Tornqvist, Aija Koskela, Antti Vehkaoja, Katriina Tiira, Heli Vaataja, Veikko Surakka, Outi Vainio, Miiamaaria Kujala
Summary: The relationship between owner and dog has an impact on the emotional reactions and stress coping of the dog. Both negative and positive situations can provoke emotional arousal in dogs. The dog-owner relationship influences the dog's emotional reactions, with emotional closeness associated with a secure base effect and shared activities leading to attachment-related arousal.
Article
Biochemistry & Molecular Biology
Carolin Anna Imbery, Frank Dieterle, Claudia Ottka, Corinna Weber, Gotz Schlotterbeck, Elisabeth Mueller, Hannes Lohi, Urs Giger
Summary: The adrenal glands play a major role in metabolic processes, and abnormal serum cortisol concentrations can have serious metabolic consequences. Analysis of serum samples from untreated and treated hyperadrenocorticism and hypoadrenocorticism in dogs revealed metabolic abnormalities that tended to normalize with treatment, but not completely.
Article
Genetics & Heredity
Janelle M. Belanger, Tiina Heinonen, Thomas R. Famula, Paul J. J. Mandigers, Peter A. Leegwater, Marjo K. Hytonen, Hannes Lohi, Anita M. Oberbauer
Summary: A risk haplotype on CFA14 was found to interact with a common risk haplotype on CFA37 in Belgian shepherds, increasing the risk of idiopathic epilepsy. The ACTG haplotype on CFA14 and GG haplotype on CFA37 were associated with elevated risk, and a disruptive insertion in the RAPGEF5 gene adjacent to CFA14 haplotype was identified.
Article
Multidisciplinary Sciences
Salla Mikkola, Milla Salonen, Emma Hakenan, Hannes Lohi
Summary: Problematic behavior is a significant welfare issue in cats and a common reason for relinquishment. Fearfulness, aggression towards humans, and excessive grooming are comorbid with each other, and breed and environmental variables are associated with these behaviors. Poor socialization with humans and a history of being a rescue cat are linked to higher fearfulness.
Article
Genetics & Heredity
Tiina Heinonen, Thomas Flegel, Hanna Mueller, Alexandra Kehl, Sruthi Hundi, Kaspar Matiasek, Andrea Fischer, Jonas Donner, Oliver P. Forman, Hannes Lohi, Marjo K. Hytoenen
Summary: In this study, a Miniature Australian Shepherd family with symptoms similar to hereditary hyperekplexia in humans was reported. Whole genome sequence data analysis revealed a 36-bp deletion in the GLRA1 gene, which was found to be completely associated with the disease in pedigree samples and additional cohorts of related dog breeds. This study establishes a spontaneous large animal disease model for human hereditary hyperekplexia by associating a variant in the canine GLRA1 gene with the disorder for the first time.
Article
Multidisciplinary Sciences
Hanna Sinkko, Jenni Lehtimaki, Hannes Lohi, Lasse Ruokolainen, Anna Hielm-Bjorkman
Summary: The rising trend in non-communicable chronic inflammatory diseases coincides with changes in Western lifestyle. While changes in the human microbiota may play a central role in the development of chronic diseases, estimating the contribution of associated lifestyle factors remains challenging. We studied the influence of lifestyle factors, such as diet, antibiotic use, and residential environment, on the gut microbiota of healthy and atopic pet dogs. The results showed that diet was the most significant factor associated with gut microbiota, while antibiotic use was associated with the severity of symptoms in atopic dogs.
ROYAL SOCIETY OPEN SCIENCE
(2023)