Article
Genetics & Heredity
Tao Wang, Yuanyuan Guo, Shengwei Liu, Chaoxin Zhang, Tongyan Cui, Kun Ding, Peng Wang, Xibiao Wang, Zhipeng Wang
Summary: By analyzing the transcriptional data of Tibetan pigs and Rongchang pigs, it was found that lung tissue may play a crucial role in the adaptation of Tibetan pigs to high-altitude hypoxic environments, with some potential regulatory genes identified.
FRONTIERS IN GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Ying Zhang, Woyu Su, Bo Zhang, Yao Ling, Woo Kyun Kim, Hao Zhang
Summary: Through transcriptomic analysis, key differentially expressed genes, lncRNAs, and miRNAs related to angiogenesis and energy metabolism in the hypoxic adaptation of Tibetan chickens were identified, and a regulatory network was constructed.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Veterinary Sciences
Zengkui Lu, Chao Yuan, Jianye Li, Tingting Guo, Yaojing Yue, Chune Niu, Jianbin Liu, Bohui Yang
Summary: This study investigates the regulatory mechanisms of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the adaptation of Tibetan sheep to hypoxia through RNA sequencing. The differentially expressed lncRNAs and mRNAs identified in this study are involved in lipid metabolism and immune function pathways, and exhibit complex interaction networks.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.
Article
Multidisciplinary Sciences
Rupal S. Tewari, Ugo Ala, Paolo Accornero, Mario Baratta, Silvia Miretti
Summary: This study found that the plasma miRNA expression profiles may be affected by skeletal muscle growth status related to age, with specific miRNAs showing differential expression across different age groups and miR-23a potentially being consistently highly expressed in multiple age groups. Furthermore, there was a correlation between miRNA expression and animal weights across age groups.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Xinglong Gong, Min Zheng, Jian Zhang, Yourong Ye, Mengqi Duan, Yangzom Chamba, Zhongbin Wang, Peng Shang
Summary: Fat deposition traits play a crucial role in pig production and breeding. This study analyzed the differential expression of mRNA levels in dorsal adipose tissue of Tibetan and York pigs at different growth stages and identified key genes involved in regulating fat deposition in pigs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Pengfei Zhao, Shaobin Li, Zhaohua He, Fangfang Zhao, Jiqing Wang, Xiu Liu, Mingna Li, Jiang Hu, Zhidong Zhao, Yuzhu Luo
Summary: The study reveals the physiological and proteomic basis of Tibetan sheep lungs during their adaptation to high-altitude hypoxia, providing a reference for the prevention of altitude sickness in humans.
Article
Biochemistry & Molecular Biology
Runjie Yu, Fuyin Xie, Qiguo Tang
Summary: This study characterized the brain lipid profiles of Tibetan chickens (TBCs) and dwarf laying chickens (DLCs) under hypoxia and normoxia conditions. The results showed that TBCs have a better adaptation to hypoxia than DLCs, with distinct cell membrane composition and nervous system development. Specific lipid species were identified as potential markers for distinguishing between TBCs and DLCs under hypoxia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Physiology
Huifang Liu, Noryung Tenzing, Martha Tissot van Patot, Muge Qile, Ri-li Ge, Tana Wuren
Summary: The Tibetan population has adapted to the challenges of high-altitude living over thousands of years, with their placental mitochondria showing greater respiratory function compared to lower-altitude Tibetans and Han Chinese. This increased mitochondrial respiration in high-altitude Tibetans may represent an acute response that induces mitochondrial adaptations to protect against acute ischemic/hypoxic insult during labor.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Qiguo Tang, Cui Ding, Qinqin Xu, Ying Bai, Qiao Xu, Kejun Wang, Meiying Fang
Summary: Tibetan chickens are able to adapt to hypoxia by reducing aerobic metabolism and increasing glycolysis. Additionally, they enhance their survival ability by regulating mitochondrial fusion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao Li, Yujiang Wu, Bingchun Chen, Yudong Cai, Jiazhong Guo, Alexander S. Leonard, Peter Kalds, Shiwei Zhou, Jingchen Zhang, Ping Zhou, Shangqu Gan, Ting Jia, Tianchun Pu, Langda Suo, Yan Li, Ke Zhang, Lan Li, Myagmarsuren Purevdorj, Xihong Wang, Ming Li, Yu Wang, Yao Liu, Shuhong Huang, Tad Sonstegard, Ming-Shan Wang, Stephen Kemp, Hubert Pausch, Yulin Chen, Jian-Lin Han, Yu Jiang, Xiaolong Wang
Summary: Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. In this study, the researchers analyzed the genomes of domestic goats and wild caprid species living at different altitudes to uncover the genetic determinants underlying their adaptation to harsh conditions on the Qinghai-Tibetan Plateau. They found a strong association between the PAPSS2 gene and high-altitude adaptability in Tibetan goats. Transcriptomic data and functional experiments further supported the role of PAPSS2 in response to hypoxia. It was also discovered that the PAPSS2 haplotype in Tibetan goats originated from a recent hybridization event between goats and markhor.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Veterinary Sciences
Kadirvel Govindasamy, Chamniugongliu Gonmei, Ningthoujam Suraj Singh, Nakambam Manoranjan Singh
Summary: The current study investigates the effects of micro-environmental variations on indigenous, Hampshire, and crossbred pigs. The results show that seasonal changes have significant impacts on the physiological, behavioral, and serum biochemical parameters of the pigs. Indigenous pigs demonstrate better adaptability to the changing climatic conditions compared to the other genotypes.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chun-Jie Liu, Xin Fu, Mengxuan Xia, Qiong Zhang, Zhifeng Gu, An-Yuan Guo
Summary: SNVs in miRNAs can impact miRNA functions and biogenesis, affecting phenotypes. miRNASNP-v3 is a database with a vast number of SNVs and new features, offering various functions for research on miRNA-related variations.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Pengfei Zhao, Zhaohua He, Qiming Xi, Hongxian Sun, Yuzhu Luo, Jiqing Wang, Xiu Liu, Zhidong Zhao, Shaobin Li
Summary: In this study, the variation in the HIF-1 alpha gene in Tibetan sheep was investigated, and it was found that the variants may promote the ability of oxygen utilization in Tibetan sheep, contributing to their survival and reproduction in high-altitude hypoxia.
Article
Horticulture
Zixian Zhou, Lingdi Xiao, Jindong Zhao, Zhaoyang Hu, Yuelong Zhou, Shiqiang Liu, Hao Wu, Yong Zhou
Summary: Heat shock protein 70 (Hsp70) is involved in various processes in cucumber, such as plant growth and development, stress response, and regulation. This study identified 12 Hsp70 genes in cucumber and found that they are associated with different stresses and growth processes. The analysis also revealed that gene duplication and the presence of cis-regulatory elements are important factors in the expansion and regulation of CsHsp70 genes in cucumber.
Article
Evolutionary Biology
Qian Zhang, Wenyu Gou, Xiaotong Wang, Yawen Zhang, Jun Ma, Hongliang Zhang, Ying Zhang, Hao Zhang
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Bo Zhang, Peng Shang, Yangzong Qiangba, Aishi Xu, Zhixiu Wang, Hao Zhang
LIPIDS IN HEALTH AND DISEASE
(2016)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Yangzong Qiangba, Peng Shang, Yunfeng Lu, Yuzeng Yang, Zhixiu Wang, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2016)
Article
Genetics & Heredity
Bo Zhang, Peng Shang, Zhu Tao, Yangzong Qiangba, Zhixiu Wang, Hao Zhang
Article
Multidisciplinary Sciences
Bo Zhang, Yangzom Chamba, Peng Shang, Zhixiu Wang, Jun Ma, Liyuang Wang, Hao Zhang
SCIENTIFIC REPORTS
(2017)
Article
Agriculture, Dairy & Animal Science
Bo Zhang, Dongmei Ban, Xiao Gou, Yawen Zhang, Lin Yang, Yangzom Chamba, Hao Zhang
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2019)
Article
Genetics & Heredity
Peng Shang, Bo Zhang, Jian Zhang, Mengqi Duan, Lvcao Wu, Xinglong Gong, Keren Tang, Hao Zhang, Yangzom Chamba
Article
Genetics & Heredity
Ying Zhang, Hongliang Zhang, Bo Zhang, Yao Ling, Hao Zhang
Article
Multidisciplinary Sciences
Xiaotong Zheng, Bo Zhang, Yawen Zhang, Haian Zhong, Ruixue Nie, Junying Li, Hao Zhang, Changxin Wu
SCIENTIFIC REPORTS
(2020)
Article
Agriculture, Dairy & Animal Science
Mengqi Duan, Zhenmei Wang, Xinying Guo, Kejun Wang, Siyuan Liu, Bo Zhang, Peng Shang
Summary: Tibetan pigs and Yorkshire pigs exhibit significant differences in transcriptomic and proteomic expression patterns in the liver, with functional enrichment analysis indicating involvement of numerous genes in metabolic processes. Differences were also observed in small molecular biosynthesis, metabolic processes, and organic hydroxyl compound metabolic processes between the two breeds.
Article
Genetics & Heredity
Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu
Summary: High-altitude adaptation in Tibetan pigs is associated with positively-selected genes, with the BNP gene playing a critical role. The C-1780G polymorphic site in the BNP gene is advantageous for high-altitude adaptation in pigs by upregulating BNP expression. This study provides insights into the mechanism underlying the involvement of the BNP gene in high-altitude adaptation.