Article
Genetics & Heredity
Yimeng Liang, Heming Liu, Zhenjie Gao, Qi Li, Guoran Li, Jian Zhao, Xiaoguang Wang
Summary: The ocular phenotype of the Southern Han Chinese population, including eyelid fold and canthal index, was investigated in this study. Several SNPs were found to be associated with eyelid fold and canthal index. The predictive models based on these SNPs showed moderate-to-high accuracy for predicting eyelid fold and mild accuracy for predicting canthal index.
Article
Developmental Biology
Guifeng Ding, Yan Li, Jianrong Gao, Wenxia Wang, Huijuan Wang, Guiqin Bai
Summary: This study investigated the associations between angiotensinogen, methylenetetrahydrofolate reductase, vascular endothelial growth factor gene polymorphisms, and preeclampsia in the Han Chinese population. The results suggest that a specific variant in the MTHFR gene may increase the risk of preeclampsia in pregnant women, while polymorphisms in the AGT and VEGF genes may not play a significant role in the development of preeclampsia.
Article
Clinical Neurology
Dong Guan, Yichun Ji, Xiaoyun Lu, Weiyi Feng, Wenbing Ma
Summary: Genetic variation in the MTHFR gene may contribute to the development of cerebral infarction. This study aimed to analyze the effect of MTHFR gene polymorphism on serum lipid and homocysteine levels among Chinese Han population with cerebral infarction. Results showed that the TT genotype and T allele frequencies were significantly higher among CI patients, and CT/TT carriers had higher homocysteine levels and lower HDL-C and ApoA-I levels.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Jinghong Rao, Youfang Chen, Xuan Chen, Ruoying Wu, Shimu Luo, Qingfan Lin, Zhenzhu Dong, Jingying Huang
Summary: This study investigated the impact of polymorphisms in the eNOS and MTHFR genes on preeclampsia. The results showed that the frequency of the eNOS -786 C C genotype and MTHFR 677 TT genotype were higher in women with preeclampsia, leading to lower NO levels and higher Hcy levels.
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Hongjing Yan, Ruoyi Guo, Weifeng Chen, Xutao Xi, Lianchang Wang, Jianxun Ma, Bin Li
Summary: The study investigated the correlation between IRAK1 gene polymorphisms, mRNA expression, and NMOSD risk, revealing a strong association between IRAK1 polymorphisms and NMOSD susceptibility, especially in female patients. The IRAK1 risk haplotype was found to upregulate IRAK1 mRNA expression in female NMOSD patients, suggesting IRAK1 as a potential druggable target in NMOSD disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Yuxin Wang
Summary: The study revealed that LRRC3B gene polymorphisms were associated with the risk of breast cancer, suggesting that LRRC3B variants might be helpful in predicting breast cancer progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Jingwen Yin, Xudong Luo, Qian Peng, Susu Xiong, Dong Lv, Zhun Dai, Jiawu Fu, Ying Wang, Yaxue Wei, Chunmei Liang, Xusan Xu, Dandan Zhang, Lulu Wang, Dongjian Zhu, Xia Wen, Xiaoqing Ye, Zhixiong Lin, Juda Lin, You Li, Jiafeng Wang, Guoda Ma, Keshen Li, Yajun Wang
Summary: The study found that polymorphisms within the MIR137 gene are associated with the risk of schizophrenia, especially in a Han Chinese population where a female-specific association was reported.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Virology
Yinan Yao, Yan Shen, Haifeng Shao, Yuchang Liu, Yan Ji, Guoming Du, Xiangyu Ye, Peng Huang, Haiming Chen
Summary: RLRs, specifically the DDX58 rs3824456, DHX58 rs2074160, and IFIH1 rs2111485 SNPs, may be predictive markers for spontaneous clearance of HBV in the Chinese Han population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Cell Biology
Baofeng Wang, Xiaobin Ma, Wenjie Zhang, Liang Li, Ying Zan, Jianshui Zhan, Xufeng Guo, Ming Lei, Hongbing Ma
Summary: The up-expression of NOTCH1 gene is associated with advanced liver cancer and is linked to tumor size, stage, metastasis, and invasion. This study aimed to assess the relationship between NOTCH1 genetic variants and liver cancer risk. The findings suggest that rs10521-G, rs2229971-A, and rs4489420-A may serve as protective factors against liver cancer susceptibility in the Chinese Han population.
Article
Cell Biology
Yaling Jiang, Xuewen Xiao, Yafei Wen, Meidan Wan, Lu Zhou, Xixi Liu, Xin Wang, Lina Guo, Hui Liu, Yafang Zhou, Junling Wang, Xinxin Liao, Lu Shen, Bin Jiao
Summary: The study found that the C677T and A1298C polymorphisms are associated with AD in the Chinese population. Patients with the C677T polymorphism are more likely to have an earlier onset, higher homocysteine levels, and more severe white matter lesions.
Article
Neurosciences
Gaowen Liu, Ying Duan
Summary: In this study, it was found that CYP11B1 gene polymorphisms were closely associated with ischemic stroke in the Chinese Han population. Specifically, rs5283 was associated with an increased susceptibility to ischemic stroke, while rs6410 had a protective influence on the risk of ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shuyong Yu, Guihong Yuan, Feixiang Hu, Yongyu Li, Zhuang Chen, Ronglin Zhang, Ping Li, Zhaowei Chen, Jian Song
Summary: This study found that the rs10934270 genotype of the ZBTB20 gene is associated with reduced susceptibility to esophageal cancer in the Chinese Han population.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yanmei Ruan, Jinwei Zhang, Shiqi Mai, Wenfeng Zeng, Lili Huang, Chunrong Gu, Keping Liu, Yuying Ma, Zhi Wang
Summary: Genetic factors and gene-environment interaction play an important role in the development of noise induced hearing loss (NIHL). Certain genetic polymorphisms in the CASP7 gene are associated with increased risk of NIHL, while some genotypes can reduce the risk. Workers carrying high-risk genotypes are at a higher risk of developing NIHL.
SCIENTIFIC REPORTS
(2021)