Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
出版年份 2015 全文链接
标题
Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
作者
关键词
-
出版物
PLoS One
Volume 10, Issue 10, Pages e0139710
出版商
Public Library of Science (PLoS)
发表日期
2015-10-06
DOI
10.1371/journal.pone.0139710
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease
- (2014) Thomas A. Bayer et al. ACTA NEUROPATHOLOGICA
- A routine method for cloning, expressing and purifying Aβ(1–42) for structural NMR studies
- (2014) Daniel K. Weber et al. AMINO ACIDS
- HNCA+, HNCO+, and HNCACB+ experiments: improved performance by simultaneous detection of orthogonal coherence transfer pathways
- (2014) Sergio Gil-Caballero et al. JOURNAL OF BIOMOLECULAR NMR
- Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer´s Disease Immunotherapy
- (2013) Roxanna Perez-Garmendia et al. Current Neuropharmacology
- Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome
- (2012) Line De Kimpe et al. AGE
- Alzheimer Mechanisms and Therapeutic Strategies
- (2012) Yadong Huang et al. CELL
- Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease
- (2011) Sadim Jawhar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core
- (2011) Christopher P. Sullivan et al. NEUROSCIENCE LETTERS
- Interaction between Amyloid Beta Peptide and an Aggregation Blocker Peptide Mimicking Islet Amyloid Polypeptide
- (2011) Nasrollah Rezaei-Ghaleh et al. PLoS One
- Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease
- (2010) Erik Portelius et al. ACTA NEUROPATHOLOGICA
- Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease
- (2010) Adam P. Gunn et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease
- (2010) Oliver Wirths et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
- (2010) Bart De Strooper PHYSIOLOGICAL REVIEWS
- Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
- (2009) Oliver Wirths et al. ACTA NEUROPATHOLOGICA
- Epilepsy and Cognitive Impairments in Alzheimer Disease
- (2009) Jorge J. Palop ARCHIVES OF NEUROLOGY
- N-terminal truncated pyroglutamyl β amyloid peptide Aβpy3-42 shows a faster aggregation kinetics than the full-length Aβ1-42
- (2009) Cristina D'Arrigo et al. BIOPOLYMERS
- The Recombinant Amyloid-β Peptide Aβ1–42 Aggregates Faster and Is More Neurotoxic than Synthetic Aβ1–42
- (2009) Verena H. Finder et al. JOURNAL OF MOLECULAR BIOLOGY
- Immunodominant epitope and properties of pyroglutamate-modified Aβ-specific antibodies produced in rabbits
- (2009) G. Acero et al. JOURNAL OF NEUROIMMUNOLOGY
- Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution
- (2008) Stephan Schilling et al. BIOLOGICAL CHEMISTRY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started