Review
Nutrition & Dietetics
Elvira Verduci, Maria Lorella Gianni, Giulia Vizzari, Sara Vizzuso, Jacopo Cerasani, Fabio Mosca, Gian Vincenzo Zuccotti
Summary: Human milk has benefits for both mother and infant, linking maternal diet and lifestyle to offspring's health outcomes. This link may be explained in part by epigenetics, and the aim of the paper is to update the association between maternal diet and human milk composition.
Article
Nursing
Katherine R. Standish, Ginny Combs, Marcy Mcmahon, Cheryl Slater, Lisa Zani, Christina Pindar, Karol Serafin, Margaret G. Parker, Barbara L. Philipp
Summary: Late preterm infants have lower breastfeeding rates and there are few interventions or guidelines for managing them in non-intensive nursery settings. This study developed and implemented an interdisciplinary breastfeeding support program, which increased nurses' attentiveness and confidence in caring for late preterm infants. However, well-designed clinical studies are needed to identify effective breastfeeding support practices.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Medicine, General & Internal
Do Young Shin, Jongsun Park, Dae Yong Yi
Summary: This study investigated the effect of different probiotic intake by HBM-producing mothers on the microbiota in HBM and infant feces samples, revealing complex changes in the microbiomes upon treatment. It provides a foundation for further understanding the impact of probiotics on the mother and infant microbiomes.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Nursing
Lindsay Ellsworth, Julie Sturza, Kate Stanley
Summary: The study revealed that most mothers have limited knowledge about donor human milk and milk banks, and have not received sufficient counseling from medical providers. While participants had positive attitudes towards donor human milk, they tended to choose formula over donor human milk when making decisions. Additionally, if donor human milk was the only option, they preferred milk from a relative or friend over milk banks.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Environmental Sciences
Annelise J. Blomberg, Line S. Haug, Christian Lindh, Azemira Sabaredzovic, Daniela Pineda, Kristina Jakobsson, Christel Nielsen
Summary: The concentrations of PFAS in human milk change over the course of lactation, with different PFAS showing different concentration trajectories and being influenced by colostrum levels. Models for cumulative infant exposure from breastfeeding need to take these differences into account.
ENVIRONMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Pasqua Anna Quitadamo, Laura Comegna, Giuseppina Palumbo, Massimiliano Copetti, Paola Lurdo, Federica Zambianco, Maria Assunta Gentile, Antonio Villani
Summary: The study found that the birth rate of twins in the center has almost doubled from 1.28% in 2015 to 2.48% in 2020, with 88% of twins being premature. 18.1% of babies were breastfed for more than 6 months and 6.3% were breastfed for more than 12 months. Infants with lower gestational age and weight, born to multiparous, more mature and medium-high schooling mothers tended to be breastfed for a longer period.
Review
Multidisciplinary Sciences
Melisa Medina-Rivera, Elizabeth Centeno-Tablante, Julia L. Finkelstein, Pura Rayco-Solon, Juan Pablo Pena-Rosas, Maria N. Garcia-Casal, Lisa Rogers, Pratiwi Ridwan, Sabrina Sales Martinez, Joyce Andrade, Alexander J. Layden, Juan Chang, Mildred P. Zambrano, Kate Ghezzi-Kopel, Saurabh Mehta
Summary: This systematic review examined the presence of EBOV in breast milk and the risk of viral transmission to infants through breastfeeding. The study found that most EBOV-positive breast milk samples led to EBOV infection in breastfed infants, resulting in fatality. However, due to the presence of EBOV in other bodily fluids, it is inconclusive whether breast milk is the main route of transmission.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Nutrition & Dietetics
Nelly C. Munoz-Esparza, Edgar M. Vasquez-Garibay, Elizabeth Guzman-Mercado, Alfredo Larrosa-Haro, Oriol Comas-Baste, M. Luz Latorre-Moratalla, M. Teresa Veciana-Nogues, M. Carmen Vidal-Carou
Summary: The study evaluated the influence of different breastfeeding factors on the polyamine levels in human milk, finding that polyamine levels varied significantly between mothers and tended to decrease over time. Spermidine and spermine concentrations were higher in hindmilk compared to foremilk, and decreased significantly as lactation progressed.
Article
Nutrition & Dietetics
Alessandra Coscia, Lorenzo Riboldi, Elena Spada, Enrico Bertino, Stefano Sottemano, Ignazio Barbagallo, Giovanni Livolti, Fabio Galvano, Diego Gazzolo, Chiara Peila
Summary: This study investigated the effects of preeclampsia on activin A levels and found that the lactation phase had a significant effect on the concentration of activin A, while there were no significant differences between preeclamptic and normotensive women. The results suggest that the beneficial properties of breast milk can be maintained even if preeclampsia occurs.
Article
Nutrition & Dietetics
Amy M. Moore, Jessica J. Smith, Brian K. Stansfield, Jennifer S. Savage, Justin A. Lavner
Summary: This study found that African American mothers have the lowest breast milk feeding rates in the United States, with rates decreasing significantly by 16 weeks. Predictors of breast milk feeding included prepregnancy BMI, working status, food insecurity, and participation in welfare programs.
Article
Nutrition & Dietetics
Jean-Christophe Roze, Mickael Hartweg, Laure Simon, Helene Billard, Yipu Chen, Sean Austin, Cecile Boscher, Thomas Moyon, Dominique Darmaun, Clara L. Garcia Rodenas, Clair-Yves Boquien
Summary: This study explored the impact of HMOs on growth and neurodevelopment in preterm infants. The findings showed that HMO concentrations decreased with advancing postnatal age. Total HMOs were positively correlated with neonatal length growth. Among Secretor(+) Lewis(+) mothers, LNFP-III was significantly associated with neurodevelopmental scores at 2 years.
CLINICAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Zheqing Zhang, Yingyao Wang, Xiaoguang Yang, Yiyong Cheng, Hong Zhang, Xuebing Xu, Jin Zhou, Hengying Chen, Mengyang Su, Yuexin Yang, Yixiang Su
Summary: This review compiled data on the concentrations of total fat, phospholipids, cholesterol, and individual fatty acids in human milk worldwide and investigated their variation with respect to geographical area, lactation stage, and year of sample collection. The study found that caution should be exercised when pooling data from different studies on human milk lipid profiles due to high heterogeneity. The concentration of lipids, including total fat, cholesterol, and specific fatty acids, differs in human milk according to lactation stage, geographical region, and year of sample collection.
ADVANCES IN NUTRITION
(2022)
Article
Immunology
Carlo Pietrasanta, Abbass Darwich, Andrea Ronchi, Beatrice Crippa, Elena Spada, Fabio Mosca, Lorenza Pugni, Maria Rescigno
Summary: The extent of transfer of anti-SARS-CoV-2 antibodies from mother to infant through breast milk after maternal vaccination is unclear. A study found that the BNT162b2 vaccine induced long-lasting IgG in maternal serum, but weaker antibody production in saliva and breast milk. The levels of anti-SARS-CoV-2 IgG and IgA in breast milk were 10-150 times lower compared to serum, and only IgA1 was present.
Article
Nursing
Diane DiTomasso, Karen Ann Wambach, Mary B. Roberts, Debra A. Erickson-Owens, Aimee Quigley, Jessica M. Newbury
Summary: Worry about infant weight is found to be a significant barrier to breastfeeding, impacting first-time breastfeeding, exclusive breastfeeding, use of artificial milk, and early breastfeeding cessation. Lactating mothers require anticipatory guidance on expected neonatal weight changes and interventions to alleviate worry about infant weight.
JOURNAL OF HUMAN LACTATION
(2022)
Review
Medicine, General & Internal
Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K. Chu, Jon Genuneit, Gabriel Torbahn, Timothy R. Nicholson, Dina Baimukhambetova, Aigun Mursalova, Anastasia Kolotilina, Svetlana Gadetskaya, Elena Kondrikova, Mikhail Zinchuk, Renat Akzhigitov, Robert J. Boyle, Alla Guekht, Daniel Munblit
Summary: This study systematically evaluated the association between breastfeeding and mental health disorders in mothers and children, and found limited evidence to support a protective association between breastfeeding and the development of mental health disorders in children later in life. The data regarding the association between breastfeeding and maternal mental health beyond the postnatal period is also limited.
Article
Urology & Nephrology
George Haddad, Malte Kolling, Urs A. Wegmann, Angela Dettling, Harald Seeger, Roland Schmitt, Inga Soerensen-Zender, Hermann Haller, Andreas D. Kistler, Anne Dueck, Stefan Engelhardt, Thomas Thum, Thomas F. Mueller, Rudolf P. Wuethrich, Johan M. Lorenzen
Summary: The study found that H19 is upregulated in kidney biopsies of patients with AKI, in murine ischemic kidney tissue, and in cultured and ex vivo sorted hypoxic endothelial cells (ECs) and tubular epithelial cells (TECs). The overexpression of H19 promotes angiogenesis both in vitro and in vivo, and it confers protection against renal injury by stimulating proangiogenic signaling.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Laura A. Zinsser, Kathrin Stoll, Mechthild M. Gross
Summary: This study found that primiparous women preparing for natural childbirth prefer a positive, health-focused approach rather than focusing on overcoming obstacles. Most participants reacted positively to the health-focused information leaflet, but were not optimistic about using the MCII method for childbirth preparation.
SEXUAL & REPRODUCTIVE HEALTHCARE
(2021)
Article
Urology & Nephrology
Roland Schmitt
Summary: This article reviews the pathomechanistic principles of RAAS-mediated renal damage and the pharmaceutical possibilities for inhibition of the RAAS, summarizes the evidence from clinical studies on nephroprotection, and discusses international guideline recommendations.
Article
Multidisciplinary Sciences
Jennifer Cable, Michael B. Elowitz, Ana I. Domingos, Naomi Habib, Shalev Itzkovitz, Homaira Hamidzada, Michael S. Balzer, Itai Yanai, Prisca Liberali, Jessica Whited, Aaron Streets, Long Cai, Andrew B. Stergachis, Clarice Kit Yee Hong, Leeat Keren, Martin Guilliams, Uri Alon, Alex K. Shalek, Regan Hamel, Sarah J. Pfau, Arjun Raj, Stephen R. Quake, Nancy R. Zhang, Jean Fan, Cole Trapnell, Bo Wang, Noah F. Greenwald, Roser Vento-Tormo, Silvia D. M. Santos, Sabrina L. Spencer, Hernan G. Garcia, Geethika Arekatla, Federico Gaiti, Rinat Arbel-Goren, Steffen Rulands, Jan Philipp Junker, Allon M. Klein, Samantha A. Morris, John I. Murray, Kate E. Galloway, Michael Ratz, Merrit Romeike
Summary: Single cell biology has the potential to unravel critical biological processes and diseases. New technologies are revealing the molecular diversity of cells and how differences in cell state can lead to different cell fates. Computational approaches are needed to address challenges in processing and analyzing vast amounts of data in single cell technologies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Physiology
Michael S. Balzer, Tibor Rohacs, Katalin Susztak
Summary: The kidney plays a crucial role in maintaining electrolyte, water, and acid-base balance, regulating blood pressure, and eliminating waste compounds. Different specialized cell types in the kidney work together to ensure its proper function. With the advancement of single-cell technologies, we now have new opportunities to classify kidney cells and understand their functions.
ANNUAL REVIEW OF PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Inga Soerensen-Zender, Song Rong, Hermann Haller, Roland Schmitt
Summary: This study investigated the therapeutic potential of increasing AZGP1 in treating fibrotic kidney disease. Both systemic treatment with recombinant AZGP1 and conditional overexpression of AZGP1 in proximal tubular cells showed beneficial effects, including reduced collagen deposition and improved lipid metabolism in tubular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Anke Schwarz, Roland Schmitt, Gunilla Einecke, Frieder Keller, Ulrike Bode, Hermann Haller, Hans Heinrich Guenter
Summary: After kidney transplantation, the course of pregnancy and graft function may have reciprocal interactions. Pre-pregnancy graft function plays a key role in pregnancy outcomes and graft function. Women with a low pre-pregnancy eGFR experience a significant decline in graft function during pregnancy.
Editorial Material
Urology & Nephrology
Sibylle von Vietinghoff, Roland Schmitt
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Immunology
Tomohito Doke, Amin Abedini, Daniel L. Aldridge, Ya-Wen Yang, Jihwan Park, Christina M. Hernandez, Michael S. Balzer, Rojesh Shrestra, Gaia Coppock, Juan M. Inclan Rico, Seung Yub Han, Junhyong Kim, Sheng Xin, Adrian M. Piliponsky, Marco Angelozzi, Veronique Lefebvre, Mark C. Siracusa, Christopher A. Hunter, Katalin Susztak
Summary: The study reveals that fibrotic tubular cells in the kidney recruit basophils, which contribute to immune responses and kidney fibrosis. These findings are validated in both mouse models and human kidney samples, suggesting that targeting basophils might be a potential clinical strategy for managing chronic kidney disease.
Article
Multidisciplinary Sciences
Michael S. Balzer, Tomohito Doke, Ya-Wen Yang, Daniel L. Aldridge, Hailong Hu, Hung Mai, Dhanunjay Mukhi, Ziyuan Ma, Rojesh Shrestha, Matthew B. Palmer, Christopher A. Hunter, Katalin Susztak
Summary: This study reveals the key differences between adaptive and fibrotic repair in the kidney through single-cell analysis, and identifies druggable pathways for pharmacological intervention.
NATURE COMMUNICATIONS
(2022)
Article
Nursing
Bettina E. F. Schoene, Claudia Oblasser, Kathrin Stoll, Mechthild M. Gross
Article
Cell Biology
Michael S. Balzer, Mira Pavkovic, Julia Frederick, Amin Abedini, Alexius Freyberger, Julia Vienenkotter, Ilka Mathar, Krystyna Siudak, Frank Eitner, Peter Sandner, Manuel Grundmann, Katalin Susztak
Summary: Diabetic kidney disease (DKD) is the leading cause of renal failure, and understanding animal models at the cellular level is important for therapeutic development. ZSF1 rats demonstrate similarities to human DKD on a phenotypic and transcriptomic level. Soluble guanylate cyclase (sGC), enriched in proximal tubule (PT) and stroma, shows potential as a drug target for DKD due to its role in endothelial dysfunction, oxidative stress, and nitric oxide depletion. Activation of sGC in ZSF1 rats improves oxidative stress regulation and downstream cGMP effects, suggesting its benefits for DKD treatment. Co-expression modules of sGC genes allow stratification of human kidney samples and highlight the relevance of the sGC pathway in DKD.
CELL REPORTS MEDICINE
(2023)
Article
Nursing
Janice Hill, Laura A. A. Zinsser, Anke Wiemer, Mechthild M. M. Gross, Kathrin Stoll
Summary: One-third of nulliparous women planning community birth in high-income countries are transferred during labor. This study aims to describe the prevalence of referral and factors associated with intrapartum transfer among nulliparous women in Germany.
BIRTH-ISSUES IN PERINATAL CARE
(2023)
Article
Multidisciplinary Sciences
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Summary: Recent study reveals that renal adiponectin induces gluconeogenesis through enhanced local fatty acid oxidation, while the absence of adiponectin in the kidney enhances glucose tolerance and leads to lipid accumulation.
NATURE COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Hanna Gehling, Joyce K. Edmonds, Laura A. Zinsser, Mechthild M. Gross
Summary: This study explores the transition into early labor among primiparas, focusing on their certainty and perception of labor onset symptoms. The results indicate that most primiparas can confidently identify labor onset up to four days before birth, with symptoms such as regular and irregular pain, vaginal loss, and emotional changes. However, uncertainty about labor onset persists until the day of birth.
SEXUAL & REPRODUCTIVE HEALTHCARE
(2023)