Article
Multidisciplinary Sciences
Sebastian Loens, Julius Verrel, Vera-Maria Herrmann, Amrei Kienzle, Elinor Tzvi, Anne Weissbach, Johanna Junker, Alexander Muenchau, Tobias Baeumer
Summary: The study found that motor sequence learning is impaired in cervical dystonia patients overall, and unlike healthy controls, patients did not show a learning effect in the first part of the experiment. However, visuomotor adaptation and eyeblink conditioning were normal in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jae Woo Chung, Christopher A. Knight, Abigail E. Bower, Justin P. Martello, John J. Jeka, Roxana G. Burciu
Summary: This study investigated deficits in force control in Parkinson's disease, specifically in the upper and lower extremities. It found that individuals with PD demonstrated slower rates of force development and relaxation in the lower limb, and these deficits may worsen with disease progression.
Article
Multidisciplinary Sciences
Matthew J. D. Pilgrim, Zhen-Yi Andy Ou, Madeleine Sharp
Summary: Patients with Parkinson's disease may not utilize the reward value of stimuli when automatically allocating attention, and dopamine replacement therapy does not seem to modulate the effect of reward on automatic attention allocation.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Matthias Sure, Jan Vesper, Alfons Schnitzler, Esther Florin
Summary: Recent evidence suggests that beta bursts in the subthalamic nucleus (STN) play a crucial role in Parkinson's disease. This study investigated the spatio-temporal relationship between STN beta bursts and cortical activity in patients with Parkinson's disease undergoing deep brain stimulation (DBS) surgery. The results demonstrate that STN beta bursts are involved in the formation of multiple STN-cortex loops, particularly in the associative, limbic, motor, visual, and language-related areas.
Article
Neurosciences
Varoth Lilascharoen, Eric Hou-Jen Wang, Nam Do, Stefan Carl Pate, Amanda Ngoc Tran, Christopher Dabin Yoon, Jun-Hyeok Choi, Xiao-Yun Wang, Horia Pribiag, Young-Gyun Park, Kwanghun Chung, Byung Kook Lim
Summary: The study investigates the functional roles of distinct GPe-PV neuronal populations in controlling behaviors such as locomotion and reversal learning, and reveals their different contributions to various PD-related behaviors.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Elena Brazhnik, Nikolay Novikov, Alex J. McCoy, Neda M. Ilieva, Marian W. Ghraib, Judith R. Walters
Summary: In Parkinsonian models, increases in high beta power emerge gradually and are not linearly correlated with motor deficits. Earlier changes in cortical circuits may contribute to evolving plasticity supporting increased beta range synchronized activity in basal ganglia-thalamocortical circuits after loss of dopamine receptor stimulation.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Liqiang Chen, Samuel Daniels, Yerim Kim, Hong-Yuan Chu
Summary: The intrinsic excitability of pyramidal tract neurons (PTNs) in the primary motor cortical layer was greatly decreased in parkinsonism, specifically affecting M1 PTNs but not intratelencephalic neurons (ITNs). The decreased excitability may be associated with impaired function of sodium channels and potassium channels, leading to abnormal firing patterns in parkinsonian state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Yoshiko Kojima, Paul J. May
Summary: The basal ganglia have been found to influence error-based motor learning, particularly in eye movement adaptation, by enhancing the error signal, suggesting a previously unrecognized function of the basal ganglia.
Article
Multidisciplinary Sciences
Elior Drori, Shai Berman, Aviv A. Mezer
Summary: We developed a method to identify and quantify gradients of microstructure in the single human brain in vivo, and found robust spatial gradients in the striatum. We also discovered a relationship between striatal structural gradients and cortical hierarchy, as well as abnormal gradients in Parkinson's disease patients, explaining their dopaminergic loss and motor dysfunction.
Review
Cell Biology
Juan Wang, Xiaoting Wang, Hui Li, Limin Shi, Ning Song, Junxia Xie
Summary: In this review, the latest information related to movement disorders and modulations in Parkinson's disease (PD) is provided, with a focus on brain regions and neuronal circuits. Updates on deep brain stimulation (DBS) and other factors for motor improvement in PD are also discussed.
AGEING RESEARCH REVIEWS
(2023)
Article
Computer Science, Artificial Intelligence
Jhielson M. Pimentel, Renan C. Moioli, Mariana F. P. de Araujo, Caetano M. Ranieri, Roseli A. F. Romero, Frank Broz, Patricia A. Vargas
Summary: The study introduces a new neurorobotics model that embeds a computational model of Parkinson's Disease in a real robot, allowing for further exploration of the disease dynamics and potential testing of new therapies. The model demonstrates the capability of performing simple tasks with different levels of motor disturbance in both healthy and parkinsonian conditions. It serves as a foundation for the development of more sophisticated models that could aid in reducing animal use in research and improving PD treatments.
FRONTIERS IN NEUROROBOTICS
(2021)
Article
Neurosciences
Christina Andica, Koji Kamagata, Yuya Saito, Wataru Uchida, Shohei Fujita, Akifumi Hagiwara, Toshiaki Akashi, Akihiko Wada, Takashi Ogawa, Taku Hatano, Nobutaka Hattori, Shigeki Aoki
Summary: In this study, fiber-specific white matter alterations in nonmedicated patients with early-stage Parkinson's disease were assessed using fixel-based analysis. The results showed significantly increased fiber cross-section in tremor-dominant PD patients compared to healthy controls. This may suggest the presence of white matter neural compensation mechanisms in tremor-dominant PD patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Cell Biology
Ling Guo, Sravani Kondapavulur, Stefan M. Lemke, Seok Joon Won, Karunesh Ganguly
Summary: The study reveals the importance of consistent neural activity patterns across brain structures during recovery poststroke, and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function.
Review
Neurosciences
Joshua Kearney, John-Stuart Brittain
Summary: Sensory attenuation describes the modulation of sensory input caused by motor intent, which appears to be altered in Parkinson's disease. The role of task-relevance in modulating sensory input is crucial. Paradigms of sensory attenuation across different sensory modalities reveal how two identical stimuli can elicit different perceptual experiences based on predictions and context.
Article
Multidisciplinary Sciences
Anna Krotinger, Psyche Loui
Summary: Dance classes for individuals with Parkinson's disease show significant improvements in symptoms, particularly in enhancing sensorimotor coupling abilities. Patients with prior dance experience exhibit better performance post-intervention.
Article
Biochemistry & Molecular Biology
Carine Chassain, Christophe Melon, Pascal Salin, Flora Vitale, Sebastien Couraud, Franck Durif, Lydia Kerkerian-Le Goff, Paolo Gubellini
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Neurosciences
Samira Ztaou, Nicolas Maurice, Jeremy Camon, Gaelle Guiraudie-Capraz, Lydia Kerkerian-Le Goff, Corinne Beurrier, Martine Liberge, Marianne Amalric
JOURNAL OF NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Marie-Catherine Tiveron, Corinne Beurrier, Claire Ceni, Naly Andriambao, Alexis Combes, Muriel Koehl, Nicolas Maurice, Evelina Gatti, Dhoher Nora Abrous, Lydia Kerkerian-Le Goff, Philippe Pierre, Harold Cremer
Article
Anatomy & Morphology
Aurelie Leplus, Inger Lauritzen, Christophe Melon, Lydia Kerkerian-Le Goff, Denys Fontaine, Frederic Checler
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Neurosciences
Dorian Chabbert, Xavier Caubit, Pierre L. Roubertoux, Michele Carlier, Bianca Habermann, Bernard Jacq, Pascal Salin, Mehdi Metwaly, Christina Frahm, Ahmed Fatmi, Alistair N. Garratt, Dany Severac, Emeric Dubois, Lydia Kerkerian-Le Goff, Laurent Fasano, Paolo Gubellini
BIOLOGICAL PSYCHIATRY
(2019)
Article
Behavioral Sciences
Pierre L. Roubertoux, Sylvie Tordjman, Xavier Caubit, Julie Di Cristopharo, Adeline Ghata, Laurent Fasano, Lydia Kerkerian-Le Goff, Paolo Gubellini, Michele Carlier
Article
Clinical Neurology
Yvan Vachez, Carole Carcenac, Robin Magnard, Lydia Kerkerian-Le Goff, Pascal Salin, Marc Savasta, Sebastien Carnicella, Sabrina Boulet
MOVEMENT DISORDERS
(2020)
Article
Neurosciences
Jean-Pierre Kessler, Pascal Salin, Lydia Kerkerian-Le Goff
Letter
Clinical Neurology
Yvan Vachez, Carole Carcenac, Robin Magnard, Lydia Kerkerian-Le Goff, Pascal Salin, Marc Savasta, Sebastien Carnicella, Sabrina Boulet
MOVEMENT DISORDERS
(2020)
Article
Biochemical Research Methods
P. Salin, D. Blondel, L. Kerkerian-Le Goff, P. Coulon
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Cell & Tissue Engineering
Serena Corti, Remi Bonjean, Thomas Legier, Diane Rattier, Christophe Melon, Pascal Salin, Erik A. Toso, Michael Kyba, Lydia Kerkerian-Le Goff, Flavio Maina, Rosanna Dono
Summary: Downregulation of GPC4 in human induced pluripotent stem cells (hiPSC) enhances their differentiation potential into ventral midbrain dopaminergic (VMDA) neuron progenitors, while maintaining self-renewal and pluripotency in vitro and reducing tumorigenesis risk in vivo. This approach shows promise in generating VMDA neurons and establishing hiPSC lines suitable for translational applications.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Emilie Dinh, Thomas Rival, Alice Carrier, Noemi Asfogo, Olga Corti, Christophe Melon, Pascal Salin, Sylviane Lortet, Lydia Kerkerian-Le Goff
Summary: TP53INP1/dDOR plays a neuroprotective role in maintaining neuronal homeostasis, regulating autophagy and mitophagy in neurons. This has significant implications for neuroprotection and treatment of neurological disorders.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Maroua Hanini-Daoud, Florence Jaouen, Pascal Salin, Lydia Kerkerian-Le Goff, Nicolas Maurice
Summary: Accumulating evidence suggests that the parafascicular nucleus of the thalamus plays a crucial role in basal ganglia functions and pathologies. This study investigated the functional connections between the parafascicular nucleus and different components of the basal ganglia using optogenetic techniques. The results revealed diverse neural responses in the substantia nigra pars reticulata, the main output structure of the basal ganglia, upon activation of parafascicular nucleus neurons connecting to the striatum, subthalamic nucleus, or substantia nigra. These findings underscore the importance of the parafascicular nucleus in regulating basal ganglia output.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Psychiatry
Xavier Caubit, Paolo Gubellini, Pierre L. Roubertoux, Michele Carlier, Jordan Molitor, Dorian Chabbert, Mehdi Metwaly, Pascal Salin, Ahmed Fatmi, Yasmine Belaidouni, Lucie Brosse, Lydia Kerkerian-Le Goff, Laurent Fasano
Summary: The study provides evidence that TSHZ3 haploinsufficiency is linked to autism spectrum disorder (ASD) and identifies cortical projection neurons (CPNs) and striatal cholinergic interneurons (SCINs) as key players in the TSHZ3-linked ASD syndrome. Dysfunction in either CPNs or SCINs is associated with distinct ASD behavioral traits, providing novel insights into the implications of the corticostriatal circuitry in ASD.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Cell Biology
Gwenaelle Laverne, Jonathan Pesce, Ana Reynders, Etienne Combrisson, Eduardo Gascon, Christophe Melon, Lydia Kerkerian-Le Goff, Nicolas Maurice, Corinne Beurrier
Summary: Striatal cholinergic interneurons (CINs) play an important regulatory role in cortico-striatal transmission and striatal-dependent motor-skill learning, which is dependent on the integrity of dopaminergic inputs.