Article
Plant Sciences
Zu-Jun Que, Yun Yang, Hai-Tao Liu, Wen-Ji Shang-Guan, Pan Yu, Li-Hua Zhu, He-Gen Li, Huai-Min Liu, Jian-Hui Tian
Summary: The study aimed to investigate the anti-metastatic mechanism of Jinfukang in lung cancer by intervening in circulating tumor cells (CTCs). Results showed that Jinfukang inhibited the proliferation, migration, and invasion of CTCs, as well as inducing anoikis through suppression of the integrin/Src pathway. This suggests that Jinfukang may exert its anti-metastatic effects in lung cancer through anoikis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Pawel A. Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin, Chia-Nung Hung, Devalingam Mahalingam, Nameer B. Kirma, Chun-Liang Chen, Josephine A. Taverna, Michael A. Liss, Ian M. Thompson, Tim H. -M. Huang, Maria E. Gaczynska
Summary: The study demonstrates that circulating tumor cells (CTCs) isolated from prostate cancer patients' blood exhibit distinct nanomechanical features compared to randomly shed tumor cells, with high adhesion as a distinguishing biophysical marker. These CTCs uniquely coisolate with tumor-associated macrophage-like cells, promoting a survival-promoting mechanical fitness phenotype based on high softness and adhesion.
Review
Biotechnology & Applied Microbiology
Can Li, Wei He, Nan Wang, Zhipeng Xi, Rongrong Deng, Xiyu Liu, Ran Kang, Lin Xie, Xin Liu
Summary: This paper reviews the recent research progress of microfluidic technology in CTCs separation and detection, discusses the potential application of microfluidic technology in the treatment of tumor metastasis, and briefly explores the development prospect of microfluidic biosensors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Oncology
Qiong Chen, Jueyao Zou, Yong He, Yanhong Pan, Gejun Yang, Han Zhao, Ying Huang, Yang Zhao, Aiyun Wang, Wenxing Chen, Yin Lu
Summary: Circulating tumor cells (CTCs) play a crucial role in tumor metastasis and can be used for tumor diagnosis, prognosis, and recurrence monitoring. Clustered CTCs have been found to have stronger metastasis ability and can bind with non-tumor cells in the blood, promoting tumor growth and development.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Funmilayo O. Adeshakin, Adeleye O. Adeshakin, Lukman O. Afolabi, Dehong Yan, Guizhong Zhang, Xiaochun Wan
Summary: Cancer cells develop mechanisms to resist anoikis, promoting invasion and metastasis. Understanding the mechanisms driving anoikis resistance is crucial for preventing tumor progression and metastasis, with metabolic pathways playing a key role in helping cells evade anoikis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin, Ping Zhou
Summary: The study revealed that lncRNA APOC1P1-3 promotes breast cancer metastasis by regulating apoptosis and anoikis resistance-related protein expression. It acts as a sponge to block the inhibition of Bcl-2 by specifically binding to miRNA-188-3p.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Ofri Doppelt-Flikshtain, Amin Younis, Tal Tamari, Ofir Ginesin, Talia Shentzer-Kutiel, David Nikomarov, Gil Bar-Sela, Benjamin R. Coyac, Yehuda G. Assaraf, Hadar Zigdon-Giladi
Summary: Despite progress in the treatment of various cancers, the prognosis for patients with metastatic osteosarcoma remains poor. This study demonstrated that endothelial progenitor cells (EPCs) play a role in promoting osteosarcoma progression and aggressiveness through non-physical interactions, and revealed a potential underlying molecular mechanism. These findings suggest the possibility of developing EPCs-targeted therapies to inhibit osteosarcoma metastasis and improve treatment efficacy.
Review
Cell Biology
Sana Khurshid Baba, Sadaf Khursheed Baba, Rashid Mir, Imadeldin Elfaki, Naseh Algehainy, Mohammad Fahad Ullah, Jameel Barnawi, Faisal H. Altemani, Mohammad Alanazi, Syed Khalid Mustafa, Tariq Masoodi, Ammira S. Alshabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha
Summary: Cancer metastasis, responsible for 90% of cancer-related deaths, is a complex process involving the spread and colonization of cancer cells in distant organs. Long non-coding RNAs (lncRNAs) play a critical role in this process by regulating signaling pathways and modulating key molecules. Understanding the molecular basis of lncRNA involvement in cancer metastasis could lead to new therapeutic and diagnostic approaches for metastatic disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Maureen Van de Velde, Marie Ebroin, Tania Durre, Marc Joiret, Lionel Gillot, Silvia Blacher, Liesbet Geris, Frederic Kridelka, Agnes Noel
Summary: This study revealed a new mechanism by which tumor exposed-LEC promote tumor cell proliferation, showcasing their role in enhancing cancer cell invasion and proliferation in vivo. The analysis of teLEC secretome identified IL6 as a key molecule modulated in teLEC, with neutralization of IL6 abolishing the mitogenic effects mediated by teLEC in vivo. The findings suggest a novel function for teLEC beyond their traditional role in lymphatic vessel formation, emphasizing their potential as key stromal determinants in future studies.
Article
Medicine, General & Internal
Chengjun Zhu, Jing Xu, Jinyu Sun, Shiyun Cui, Yue Sun, Tao Yu, Cenzhu Wang, Tianyao Wang, Yufeng Wu, Feng Ju, Jiafeng Yao, Kai Liu, Wenwen Zhang, Xiaoxiang Guan
Summary: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. The results show that CTC enumeration is significantly associated with liver metastasis in breast cancer patients, and CTCs >= 5 are a risk factor for tumor metastasis. Furthermore, high CTC levels may be associated with an increased risk of liver metastasis in patients with metastatic breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jie Zhang, Yang Hong, Liang Wang, Weiheng Hu, Guangming Tian, Di Wu, Yang Wang, Ling Dai, Ziran Zhang, Yue Yang, Jian Fang
Summary: This study aimed to detect and describe the distribution characteristics of circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with advanced lung cancer, and explore the correlation between CTC/CTEC subtypes and novel prognostic biomarkers. CTCs and CTECs derived from 52 patients with advanced lung cancer were identified using the subtraction enrichment-immunofluorescence in situ hybridization (SE-iFISH) system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Muya Zhou, Koukou Li, Kathy Qian Luo
Summary: Circulatory treatment can increase metastasis of cancer cells by inducing detachment-induced anoikis and fluidic shear stress (SS)-mediated apoptosis. A microfluidic circulatory system is used to identify SS-specific mechanosensors and investigate their role in promoting invasion and metastasis of lung cancer cells. Enriched PRSS3, PAR2, and FOSL1 in human tumor samples and their correlations with worse outcomes suggest their clinical significance in targeting metastasis-initiating CTCs.
Article
Multidisciplinary Sciences
Yiming Ma, Jun Zhang, Yunqing Tian, Yihao Fu, Shu Tian, Qingsi Li, Jing Yang, Lei Zhang
Summary: A zwitterionic microgel platform is developed to preserve circulating tumor cells in whole blood samples for noninvasive diagnostics. The platform allows blood samples to be stored for up to 7 days without compromising cell viability and RNA integrity, and reliably detects cancer-specific transcripts.
NATURE COMMUNICATIONS
(2023)
Article
Biophysics
Lei Xing, Xing Wan, Ming-Tao Yu, Yu-Jing He, Yi Wang, Tian-Jiao Zhou, Xiao-Ying Liu, Ying Sun, Jun Luo, Wen-Jia Wang, Hu-Lin Jiang
Summary: Circulating tumor cells (CTCs) play a significant role in predicting the overall survival and progression-free survival of cancer patients. However, current CTCs separation and enrichment techniques have limitations in comprehensively profiling CTC distribution and reducing metastasis. Inspired by hemodialysis, a whole blood purifier (WBP) was designed to capture, enrich and remove CTCs from systemic blood circulation, without causing any organic damages. This approach achieves the high accuracy of liquid biopsy technology and has the potential to be an effective clinical adjuvant therapy for tumor metastasis.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Oncology
Aysooda Hosseinzadeh, Faezeh Poursoleiman, Akram Naghdipour Biregani, Ahmad Esmailzadeh
Summary: Despite the complexity of cancer, natural flavonoids have shown potential as therapeutic agents by inhibiting metastasis and inducing cell death in cancer cells. This review discusses the dynamic relationship between metastasis, autophagy, anoikis, and the effects of flavonoids, suggesting that they can be effective in targeting both sensitive and resistant cancer cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Vivek R. Varma, Antoine Eskander, Stephen Y. Kang, Bhavna Kumar, Nicole V. Brown, Songzhu Zhao, Guy Brock, Amit Agrawal, Ricardo L. Carrau, Matthew O. Old, Enver Ozer, James W. Rocco, David E. Schuller, Peter T. Dziegielewski, Michael J. Cipolla, Theodoros N. Teknos
Article
Oncology
Theodoros N. Teknos, J. Grecula, A. Agrawal, M. O. Old, E. Ozer, R. Carrau, S. Kang, J. Rocco, D. Blakaj, V. Diavolitsis, B. Kumar, P. Kumar, Q. Pan, M. Palettas, L. Wei, R. Baiocchi, P. Savvides
INVESTIGATIONAL NEW DRUGS
(2019)
Review
Oncology
Dustin A. Silverman, Sidharth V. Puram, James W. Rocco, Matthew O. Old, Stephen Y. Kang
Article
Otorhinolaryngology
Jaron Densky, Antoine Eskander, Stephen Kang, Jon Chan, Ben Tweel, Jigar Sitapara, Enver Ozer, Amit Agrawal, Ricardo Carrau, James Rocco, Ted N. Teknos, Matthew Old
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2019)
Article
Otorhinolaryngology
Patrick Wald, John Grecula, Steve Walston, Lai Wei, Aashish Bhatt, Douglas Martin, Marcelo Bonomi, James Rocco, Matthew Old, Theodoros Teknos, Dukagjin Blakaj
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Letter
Otorhinolaryngology
Matthew Old
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2019)
Article
Oncology
Ramez Philips, Nolan Seim, Anna Marcinow, James Rocco, Amit Agrawal, Enver Ozer, Ricardo Carrau, Stephen Kang, Matthew Old
Review
Otorhinolaryngology
Rishabh Sethia, Zahir Allarakhia, Sidharth Puram, Stephen Kang, Enver Ozer, Amit Agrawal, Ricardo Carrau, James Rocco, Matthew Old
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Meeting Abstract
Oncology
N. Mladkova, D. L. Mitchell, M. E. Gamez, J. C. Grecula, S. R. Jhawar, E. D. Miller, M. Old, D. M. Blakaj
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Review
Oncology
Chen Lin, Sidharth Puram, Mustafa G. Bulbul, Rosh K. Sethi, James W. Rocco, Matthew O. Old, Stephen Y. Kang
Article
Oncology
Michael M. Li, Sidharth V. Puram, Dustin A. Silverman, Matthew O. Old, James W. Rocco, Stephen Y. Kang
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Kevin Y. Zhan, Sidharth Puram, Michael M. Li, Dustin A. Silverman, Amit A. Agrawal, Enver Ozer, Matthew O. Old, Ricardo L. Carrau, James W. Rocco, Kevin M. Higgins, Danny J. Enepekides, Zain Husain, Stephen Y. Kang, Antoine Eskander
Meeting Abstract
Oncology
L. Mousa, M. Issa, B. Klamer, J. Pan, M. Old, S. Kang, A. Agrawal, E. Ozer, R. Carrau, P. Bhateja, R. Rupert, S. Jhawar, D. Mitchell, M. Gamez, J. Rocco, D. Blakaj, M. R. Bonomi
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
M. Issa, L. Mousa, D. Blakaj, B. Klamer, J. Pan, M. Old, S. Kang, R. Rupert, D. Mitchell, E. Ozer, A. Agrawal, P. Bhateja, M. Gamez, E. Miller, S. Jhawar, R. Carrau, J. Rocco, M. R. Bonomi
ANNALS OF ONCOLOGY
(2019)
Article
Surgery
Krupal B. Patel, Akash N. Naik, Stephen Y. Kang, Matthew O. Old
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2019)