Review
Immunology
Jing Zhang, Ling Chen, Yang Yang, Xiao Liu, Yuan Yuan, Shi-rong Song, Yue Zhao, Jian Mao
Summary: The purpose of this study was to compare the clinical and laboratory characteristics of late-onset sepsis (LOS) caused by Gram-negative and Gram-positive bacteria in preterm neonates and evaluate the diagnostic accuracy of biomarkers. The results showed that LOS caused by Gram-negative bacteria in preterm neonates had higher levels of CRP and lower platelet counts. Therefore, platelet count and CRP values may be useful biomarkers to differentiate sepsis caused by Gram-negative and Gram-positive bacteria in preterm neonates.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Infectious Diseases
Antonella Migliaccio, Maria Stabile, Maria Bagattini, Maria Triassi, Rita Berisio, Eliana De Gregorio, Raffaele Zarrilli
Summary: Resveratrol can reverse tolerance and restore susceptibility to CHX and BZK in the majority of microorganisms causing HAI. The efflux pump inhibitor reduced the MIC and MBC of CHX and BZK in most strains, while resveratrol dose-dependently decreased the MIC and MBC of the biocides.
Article
Microbiology
Ana Silva-Dias, Blanca Perez-Viso, Ines Martins-Oliveira, Rosario Gomes, Acacio G. Rodrigues, Rafael Canton, Cidalia Pina-Vaz
Summary: The FASTinov flow cytometry kits were assessed in two locations for direct evaluation, demonstrating high sensitivity for positive blood cultures and the ability to provide rapid and personalized antibiotic management.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kefurong Deng, Yachao Li, Xiaoyu Liang, Cheng Shen, Zenan Zeng, Xianghui Xu
Summary: This study developed virus-inspired nanodrugs for high-efficiency antibiotic delivery and enhanced antibacterial effects, demonstrating their potential application in antibacterial treatment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Infectious Diseases
A. Infante, V. Ortiz de la Tabla, C. Martin, G. Gazquez, F. Bunuel
Summary: Shortening the turnaround time of antimicrobial susceptibility testing (AST) of bacteria can significantly reduce patient morbidity, mortality, and cost. Directly obtaining faster AST results from positive blood cultures can provide reliable and accurate results 1 day earlier, offering a simple, fast, and cheap method for identification and antimicrobial susceptibility testing.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Aliya Fazal, Sajida Ara, Muhammad Tayab Ishaq, Kalsoom Sughra
Summary: The study focuses on the green synthesis of copper oxide nanoparticles using vegetable peels, with an ecofriendly approach and low fabrication temperature. It also explores the antibacterial efficacy of the nanoparticles, showing a more significant biocidal effect on Gram-negative bacteria compared to Gram-positive bacteria. The research highlights the potential of utilizing biowaste for the production of useful products.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Jianxing Wang, Jie Li, Zipeng Shen, Dong Wang, Ben Zhong Tang
Summary: In this study, phospholipid-mimetic aggregation induced emission luminogens (AIEgens) were developed to selectively eliminate both Gram-positive and Gram-negative bacteria. By utilizing the different structure of two bacterial membranes and the regulated length of substituted alkyl chains of AIEgens, these AIEgens can anchor onto the bacterial membrane and kill bacteria. AIEgens with short alkyl chains exhibit selective ablation to Gram-positive bacteria, while AIEgens with long alkyl chains selectively destroy the membranes of Gram-negative bacteria. Fluorescent imaging and in vitro/in vivo experiments confirm the extraordinary antibacterial selectivity of these AIEgens towards both types of bacteria. This research could contribute to the development of species-specific antibacterial agents.
Article
Biotechnology & Applied Microbiology
Sarabjot Kaur, Rushikesh Tambat, Vikas Pathania, Hemraj Nandanwar, Sanjeev Soni
Summary: This study demonstrates that photo-thermally enhanced triangular silver nanoplates have strong antimicrobial efficacy and can eradicate various pathogens in a short period of time, which is significant for a wide range of antibacterial and antifungal applications.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Edwin Esau Hernandez-Arvizu, Teresa Monserrat Silis-Moreno, Jose Alejandro Garcia-Arredondo, Angelina Rodriguez-Torres, Jose Antonio Cervantes-Chavez, Juan Mosqueda
Summary: Anti-microbial peptides play a crucial role in the defense mechanisms of various organisms. In this study, a cathelicidin-like peptide called Aquiluscidin was identified for the first time in Crotalus aquilus, exhibiting remarkable inhibitory activity against multiple bacteria. It has the potential to be a candidate for further antimicrobial research.
Review
Engineering, Environmental
Meera Varghese, Manoj Balachandran
Summary: CDs, known for their nontoxic characteristics and inherent antibacterial potency, have gained significant attention as potential alternative antibiotics due to the increasing antibiotic resistance of bacterial strains. The light-driven antibacterial action of CDs is safe and effective with minimal side effects, and their direct interaction with bacterial cells contributes to their overall antibacterial activity. The unique and complex mechanisms of antibacterial activity of CDs involve ROS generation, degeneration of cell structure, and cytoplasm leakage, among other factors, providing insights for significant future research in this area.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Review
Fisheries
Hien Van Doan, Mehdi Soltani, Einar Ringo
Summary: Gram-positive probiotic bacteria have been shown to be effective in preventing disease outbreaks in aquaculture by producing bioactive compounds that can inhibit potential pathogenic Gram-negative bacteria. They can also enhance host immune-physiological functions and improve disease resistance. Further research is needed to optimize probiotic dosages and understand the in vivo effects of Gram-positive probiotics.
Editorial Material
Infectious Diseases
Katharina Bach, Birgit Edel, Steffen Hoering, Lucie Bartonickova, Stefan Gloeckner, Bettina Loeffler, Christina Bahrs, Juergen Roedel
Summary: The LAMP-based eazyplex(R) BloodScreen GN is a reliable molecular assay for rapid detection of frequent Gram-negatives directly from positive blood culture (BC) bottles. The assay demonstrated excellent sensitivity and specificity for various bacterial strains, with a quick turnaround time of 8 to 16 minutes plus sample preparation time of about 6 minutes.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Ophthalmology
Anakin Chu Kwan Lai, John C. Buchan, Jonathan Cheuk-Hung Chan, Winifred Nolan
Summary: This study investigates the risk factors for late presentation of glaucoma patients in Hong Kong. The study finds that male gender and primary angle-closure glaucoma (PACG) have a higher likelihood of late presentation. Patients with PACG also have higher intraocular pressure (IOP) compared to patients with primary open-angle glaucoma (POAG).
Article
Immunology
Yasmine H. Tartor, Rasha M. A. Gharieb, Norhan K. Abd El-Aziz, Hend M. El Damaty, Shymaa Enany, Eman Khalifa, Amira S. A. Attia, Samah S. Abdellatif, Hazem Ramadan
Summary: A significant rise in bacterial resistance to colistin, a crucial last-resort treatment for severe infections, has been observed globally. The use of colistin in livestock farming is believed to be a key factor in the spread of mobilized colistin resistance (mcr) genes. In Egypt, a study on colistin-resistant Gram-negative bacteria from mastitic cows' milk and raw unpasteurized milk revealed high levels of multidrug resistance and the presence of mcr genes, highlighting the urgent need to ban colistin in food animals to combat extensively drug-resistant (XDR) and multidrug-resistant (MDR) bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Charlotte M. J. Wesseling, Nathaniel I. Martin
Summary: New approaches targeting Gram-negative bacteria are crucial in combating antibiotic resistance. This review focuses on peptide-based and small organic compounds that disrupt the outer membrane of Gram-negative bacteria and synergize with clinically used antibiotics. The review also assesses the hemolytic activity of these compounds and their selectivity towards Gram-negative bacteria.
ACS INFECTIOUS DISEASES
(2022)
Article
Immunology
Kenneth Siu-Sing Leung, Gilman Kit-Hang Siu, Kingsley King-Gee Tam, Sabrina Wai-Chi To, Rahim Rajwani, Pak-Leung Ho, Samson Sai-Yin Wong, Wei W. Zhao, Oliver Chiu-Kit Ma, Wing-Cheong Yam
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Critical Care Medicine
Keertan Dheda, Tawanda Gumbo, Gary Maartens, Kelly E. Dooley, Ruth McNerney, Megan Murray, Jennifer Furin, Edward A. Nardell, Leslie London, Erica Lessem, Grant Theron, Paul van Helden, Stefan Niemann, Matthias Merker, David Dowdy, Annelies Van Rie, Gilman K. H. Siu, Jotam G. Pasipanodya, Camilla Rodrigues, Taane G. Clark, Frik A. Sirgel, Aliasgar Esmail, Hsien-Ho Lin, Sachin R. Atre, H. Simon Schaaf, Kwok Chiu Chang, Christoph Lange, Payam Nahid, Zarir F. Udwadia, C. Robert Horsburgh, Gavin J. Churchyard, Dick Menzies, Anneke C. Hesseling, Eric Nuermberger, Helen McIlleron, Kevin P. Fennelly, Eric Goemaere, Ernesto Jaramillo, Marcus Low, Carolina Moran Jara, Nesri Padayatchi, Robin M. Warren
LANCET RESPIRATORY MEDICINE
(2017)
Article
Immunology
Rahim Rajwani, Wing Cheong Yam, Ying Zhang, Yu Kang, Barry Kin Chung Wong, Kenneth Siu Sing Leung, Kingsley King Gee Tam, Ketema Tafess Tulu, Li Zhu, Gilman Kit Hang Siu
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Microbiology
Annie W. T. Lee, Johnson K. S. Lam, Ricky K. W. Lam, Wan H. Ng, Ella N. L. Lee, Vicky T. Y. Lee, Po P. Sze, Rahim Rajwani, Kitty S. C. Fung, Wing K. To, Rodney A. Lee, Dominic N. C. Tsang, Gilman K. H. Siu
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Rabin Rajwani, Sheeba Shehzad, Gilman Kit Hang Siu
Article
Microbiology
Yanping Luo, Gilman K. H. Siu, Amy S. F. Yeung, Jonathan H. K. Chen, Pak Leung Ho, K. W. Leung, Jacqueline L. Y. Tsang, Vincent C. C. Chen, Ling Guo, Jiyong Yang, Liyan Ye, Wing-Cheong Yam
JOURNAL OF MEDICAL MICROBIOLOGY
(2015)
Article
Immunology
Kenneth Siu-Sing Leung, Gilman Kit-Hang Siu, Kingsley King-Gee Tam, Pak-Leung Ho, Samson Sai-Yin Wong, Eunice Ka-Chun Leung, Shi Hui Yu, Oliver Chiu-Kit Ma, Wing-Cheong Yam
Article
Immunology
Kenneth Siu-Sing Leung, Sabrina Wai-Chi To, Jonathan Hon-Kwan Chen, Gilman Kit-Hang Siu, Kenny Chi-Wai Chan, Wing-Cheong Yam
CURRENT HIV RESEARCH
(2019)
Article
Multidisciplinary Sciences
Lorna K. P. Suen, Vanessa Y. T. Lung, Maureen Boost, Cypher H. Au-Yeung, Gilman K. H. Siu
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Jasper Fuk-Woo Chan, Gilman Kit-Hang Siu, Shuofeng Yuan, Jonathan Daniel Ip, Jian-Piao Cai, Allen Wing-Ho Chu, Wan-Mui Chan, Syed Muhammad Umer Abdullah, Cuiting Luo, Brian Pui-Chun Chan, Terrence Tsz-Tai Yuen, Lin-Lei Chen, Kenn Ka-Heng Chik, Ronghui Liang, Hehe Cao, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kit-Hang Leung, Anthony Raymond Tam, Owen Tak-Yin Tsang, Jacky Man-Chun Chan, Wing-Kin To, Bosco Hoi-Shiu Lam, Lam-Kwong Lee, Hazel Wing-Hei Lo, Ivan Tak-Fai Wong, Jake Siu-Lun Leung, Evelyn Yin-Kwan Wong, Hin Chu, Cyril Chik-Yan Yip, Vincent Chi-Chung Cheng, Kwok-Hung Chan, Herman Tse, David Christopher Lung, Kenneth Ho-Leung Ng, Albert Ka-Wing Au, Ivan Fan-Ngai Hung, Kwok-Yung Yuen, Kelvin Kai-Wang To
Summary: This study investigated a pet shop-related COVID-19 outbreak in Hong Kong, revealing potential hamster-to-human transmission and highlighting the role of pet trading in the international spread of the pandemic virus.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Walton Chan, Franklin Wang-Ngai Chow, Chi-Ching Tsang, Xueyan Liu, Weiming Yao, Tony Tat-Yin Chan, Gilman Kit-Hang Siu, Alex Yat-Man Ho, Kristine Shik Luk, Susanna Kar-Pui Lau, Patrick Chiu-Yat Woo
Summary: This research characterized the impact of extracellular vesicles (EVs) derived from Candida auris on amphotericin B resistance. The EVs significantly increased the survival of the strain against amphotericin B, but had no effect on other antifungal drugs. Mass spectrometry analysis revealed the presence of immunogenic and drug resistance-associated proteins in the EVs. These findings provide important insights into the treatment of multidrug-resistant Candida auris.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Gilman Kit-Hang Siu, Lam-Kwong Lee, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Timothy Ting-Leung Ng, Chloe Toi-Mei Chan, Kingsley King-Gee Tam, Hiu-Yin Lao, Alan Ka-Lun Wu, Miranda Chong-Yee Yau, Yvette Wai-Man Lai, Kitty Sau-Chun Fung, Sandy Ka-Yee Chau, Barry Kin-Chung Wong, Wing-Kin To, Kristine Luk, Alex Yat-Man Ho, Tak-Lun Que, Kam-Tong Yip, Wing Cheong Yam, David Ho-Keung Shum, Shea Ping Yip
EMERGING MICROBES & INFECTIONS
(2020)
Article
Medicine, General & Internal
Ketema Tafess, Teresa Kisi Beyen, Adugna Abera, Geremew Tasew, Shimelis Mekit, Solomon Sisay, Legesse Tadesse, Gilman K. H. Siu
FRONTIERS IN MEDICINE
(2018)
Article
Infectious Diseases
Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Sabrina Wai-Chi To, Gilman Kit-Hang Siu, Terrence Chi-Kong Lau, Victor Chi-Man Shek, Cindy Wing-Sze Tse, Samson Sai-Yin Wong, Pak-Leung Ho, Wing-Cheong Yam
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2017)
Article
Biotechnology & Applied Microbiology
Lina Yuan, Yang Yu, Yanmin Zhu, Yulai Li, Changqing Li, Rujiao Li, Qin Ma, Gilman Kit-Hang Siu, Jun Yu, Taijiao Jiang, Jingfa Xiao, Yu Kang