Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

ACUTE EXPOSURE OFDrosophila melanogasterTO PARAQUAT CAUSES OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

(2013) Ravikumar Hosamani et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Identification of PTEN at the ER and MAMs and its regulation of Ca2+ signaling and apoptosis in a protein phosphatase-dependent manner

(2013) A Bononi et al.   CELL DEATH AND DIFFERENTIATION

Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan

(2013) A. Rana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism

(2012) Jessica P Monserrate et al.   BMC BIOLOGY

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress

(2012) A. Vincent et al.   HUMAN MOLECULAR GENETICS

PINK1 Autophosphorylation facilitates Parkin recruitment to mitochondria: New insight in the mechanisms of quality control for mitochondria in young-onset Parkinson's disease

(2012) Taku Hatano   MOVEMENT DISORDERS

The Small GTPase Rheb Affects Central Brain Neuronal Morphology and Memory Formation in Drosophila

(2012) Heather L. D. Brown et al.   PLoS One

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

Paraquat administration in Drosophila for use in metabolic studies of oxidative stress

(2011) T.Z. Rzezniczak et al.   ANALYTICAL BIOCHEMISTRY

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

(2011) Isabel Rodríguez-Escudero et al.   HUMAN MOLECULAR GENETICS

Protein Misfolding and Oxidative Stress Promote Glial-Mediated Neurodegeneration in an Alexander Disease Model

(2011) L. Wang et al.   JOURNAL OF NEUROSCIENCE

Insulin/IGF-like signalling, the central nervous system and aging

(2009) Susan Broughton et al.   BIOCHEMICAL JOURNAL

Invertebrate models of age-related muscle degeneration

(2009) Hrvoje Augustin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system

(2009) A. Tsubouchi et al.   DEVELOPMENT

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

TOR-mediated autophagy regulates cell death inDrosophilaneurodegenerative disease

(2009) Tao Wang et al.   JOURNAL OF CELL BIOLOGY

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila

(2008) N. Vereshchagina et al.   JOURNAL OF CELL SCIENCE

A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in Drosophila

(2008) Ruben J. Cauchi et al.   PLoS Genetics